Gyrovirus (taxid:227307)

VIRION

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Non-enveloped, round, T=1 icosahedral symmetry, about 25 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentamers.

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GENOME

Monopartite, circular, ssDNA genome of about 2300 bp.
The genome is replicated through double-stranded intermediates. A replication Rep-like protein would initiates rolling circle replication.

GENE EXPRESSION

One mRNA is transcribed by cellular RNA polymerase II and encodes for three proteins: VP1, VP2 and VP3 probably through leaky scanning mechanism.

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. Viral ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. Viral mRNAs are translated to produce viral proteins.
  5. Replication may be mediated by a Rep protein, and would occur by rolling circle replication producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Host-virus interaction

Apoptosis modulation

Chicken anemia virus VP3 protein induces apoptosis observed in CAV infection. Virus-induced apoptosis accounts for the severe depletion of cortical thymocytes and erythroblastoid cells in the bone marrow .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

16 entries grouped by strain

3 entries

Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) reference strain

Select_allDeselect_all
VP2_CAVC1 Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)
VP3_CAVC1 Apoptin
CAPSD_CAVC1 Capsid protein (CA1) (Coat protein)

3 entries

Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)

Select_allDeselect_all
CAPSD_CAVCA Capsid protein (CA1) (Coat protein)
VP2_CAVCA Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)
VP3_CAVCA Apoptin

3 entries

Chicken anemia virus (isolate Japan 82-2) (CAV)

Select_allDeselect_all
CAPSD_CAV82 Capsid protein (CA1) (Coat protein)
VP2_CAV82 Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)
VP3_CAV82 Apoptin

3 entries

Chicken anemia virus (isolate USA 26p4) (CAV)

Select_allDeselect_all
CAPSD_CAV26 Capsid protein (CA1) (Coat protein)
VP2_CAV26 Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)
VP3_CAV26 Apoptin

3 entries

Chicken anemia virus (isolate USA CIA-1) (CAV)

Select_allDeselect_all
CAPSD_CAVCI Capsid protein (CA1) (Coat protein)
VP2_CAVCI Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)
VP3_CAVCI Apoptin

1 entry

Chicken anemia virus (isolate Australia) (CAV)

CAPSD_CAVAU Capsid protein (CA1) (Coat protein)