VIRION
Enveloped, spherical. Diameter from 100 to 130 nm.
GENOME
Negative-stranded RNA linear genome, about 12 kb in size. Encodes for three to five proteins.
GENE EXPRESSION
The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.
ENZYMES
- RNA-dependent RNA polymerase [L]
- Mononega-type capping
- RNA TPase, GTase, N7 Mtase, 2'O Mtase [L]
REPLICATION
NUCLEAR or CYTOPLASMIC?
- Attachement of the viral glycoproteins to host receptors.
- Fusion of virus membrane with the vesicle membrane.
- Sequential transcription.
- Replication .
- Cytoplasmic ribo-nucleocapsids buds out of the cell,releasing new virions.