Last update: 8 June 2022

The table below provides a non-exhaustive list of known host-vacciniavirus interactions, and with the Monkexpox reference sequence homologs. This list is not exhaustive, and will be updated. Genes are named according to Universal nomenclature (UN), Vaccinia virus strain Copenhagen nomenclature and Monkeypox (MPV) nomenclature .

Gene	Vaccinia- Cop gene	Monkeypox gene	Vaccinia protein	Monkeypox homolog	Viral protein name	Host proteins
FUNCTION: ENTRY
OPG095	L1R	M1R	P07612	Q5IXU5	Protein L1	May bind a host entry receptor
OPG120	D8L	E8L	P04195	A0A0F6N859	Cell surface-binding protein	Glycan chondroitin sulfate
OPG108	H3L	H3L	P07240	A0A0F6N9X0	Envelope protein H3	Heparan sulfate
FUNCTION: EXIT
OPG164	A36R	A38R	P68619	A0A0F6N7S2	IEV transmembrane phosphoprotein	NCK1 KLC1 ITSN1 and EPS15
OPG062	F17R	C23R	P07396	Q5IXX6	Phosphoprotein F17	RICTOR and RPTOR
OPG056	F12L	C18L	Q80HX6	A0A2L0AQR3	Protein F12	KLC2
FUNCTION: HOST IMMUNE MODULATION

Gene	Vaccinia- Cop gene	Monkeypox gene	Vaccinia protein	Monkeypox homolog	Viral protein name	Host proteins	GO-CAM model
OPG001	C23L	J3R	Q805H7	Q6WYZ8	Chemokine binding protein
OPG002	C22L	J2L	Q76ZJ3	O57102	TNF receptor (CrmB)	TNF, LTA, CCL28, CCL25, CXCL12, CXCL13 and CXCl14	GO-CAM
OPG025	C9L	D9L	P17372	A0A0F6N8R3	IFN evasion protein	SCF complex (CUL1)	GO-CAM
OPG065	E3L	F3L	P21605	Q5IXX3	RNA-binding protein E3	ISG15 EIF2AK2/PKR ZBP1	GO-CAM
OPG106	H1L	H1L	P07239	Q5IXT4	Dual specificity protein phosphatase H1	STAT1 dephosphorylation	GO-CAM
OPG019	C11R	D3R	P01136	A0A0F6N8I4	Viral epidermal growth factor	EGFR
OPG029	C6L	D11L	P17362	Q3T6C8	Protein C6	TANK, TBKBP1 AND AZI2 , STAT2	GO-CAM
OPG045	F1L	C7L	P24356	A0A0F6N8S5	Protein F1	BCL2L11, NLRP1 , BAK .	GO-CAM
OPG204	B19R	B16R	P25213	A0A0F6NA19	Soluble interferon alpha/beta receptor	IFNalpha	GO-CAM
OPG039	K1L	C1L	P04297	Q5IXZ7	Interferon antagonist K1L	?
OPG200	C16L	B13R	P24772	Q5IXK3	Protein B13	IKBKB	GO-CAM
OPG193	B8R	B9R	P24770	A0A2L0AR39	Soluble interferon gamma receptor B8	IFNG	GO-CAM
OPG035	N1L	P1L	P17361	Q5QC75	Protein N1	BAD and BAX
OPG044	K7R	C6R	P68466	Q3T781	Protein K7	DDX3	GO-CAM
OPG163	A35R	A37R	Q01232	A0A0F6N9C	MHC modulating protein	?
OPG170	A41L	A41L	P24766	A0A2L0ARG9	Protein A41	Chemokines (CCL21, CCL25, CCL26 and CCL28)
OPG176	A46R	A47R	P26672	A0A2L0ARH6	TLR inactivating protein	MYD88, TRAM	GO-CAM
OPG188	B2R		Q01225	A0A0F7G945	Poxin, DNA sensing inhibitor	2',3'-cGAMP degradation	GO-CAM
OPG022	D6L		P17357	A0A0F6N7E6	Interleukin-18-binding protein	Il-18	GO-CAM

Source: Uniprot.org

OPG032C3LP68638not foundComplement control protein C3C3b and C4b ?B15RP25212A0A650BUZ5Interleukin-1-binding proteinIl1b

OPG179A49RP31037TruncatedProtein A49RBTRC OPG041K3LP18378TruncatedProtein K3PKR OPG182A52RQ01220not foundProtein A52TRAF6 and IRAK2