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SARS coronavirus 2 (SARS-CoV-2) proteome

This page provides pre-release access to the SARS Coronavirus 2 protein sequences in UniProt from the current public health emergency. The data will become part of a future UniProt release and may be subject to further changes.

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COVID-19 UniProt resource image PDB structures
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Swissmodel 3d
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Annotated UniProtKB protein entries:notes
P0DTC1 Replicase polyprotein 1a (pp1a) Viral transcription/replication
P0DTD1 Replicase polyprotein 1ab (pp1ab) Viral transcription/replication, ribosomal frameshift
P0DTC2 Spike glycoprotein (S) Attachment and entry
P0DTC3 ORF3a protein (NS3a) ESCRT-independent budding
P0DTF1 ORF3b protein Unknown, host-virus modulation?
P0DTG1 ORF3c protein Unknown, host-virus modulation?
P0DTG0 ORF3d protein Unknown, host-virus modulation?
P0DTC4 Envelope small membrane protein (E) ESCRT-independent budding
P0DTC5 Membrane protein (M) Virion morphogenesis
P0DTC6 ORF6 protein Disrupts interferon signaling by preventing nuclear import of proteins.
P0DTC7 ORF7a protein Disrupts Tetherin (BST2) antiviral activity.
P0DTD8 ORF7b protein Unknown, host-virus modulation?
P0DTC8 ORF8 protein Viral Interleukin 17A , Inhibition of host MHC class I
P0DTC9 Nucleoprotein (N) Viral genome packaging
P0DTD2 ORF9b protein Disrupts host RLR innate antiviral pathway
P0DTD3 ORF9c protein Unknown, host-virus modulation?
A0A663DJA2 Hypothetical ORF10 protein Presumably not expressed