Siphoviridae

VIRION

Non-enveloped, head-tail structure. The head is about 60 nm in diameter. The long tail is non-contractile and has 6 fibers although some siphoviruses have only 3 or 4. The capsid is icosahedral with a T=7 symmetry. image

GENOME

Linear, dsDNA genome of about 50 kb, containing about 70 genes.

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Adsorption: The phage attaches to target cell adhesion receptors through its tail fibers.
  2. Ejection of the viral DNA into host cell cytoplasm by long flexible tail ejection system.
  3. Transcription and translation of early genes.
  4. Replication of genomic DNA.
  5. Transcription and translation of late genes
  6. Assembly of an empty procapsid and packaging of the genome.
  7. Viral tail fiber assembly and viral tail assembly.
  8. Mature virions are released from the cell by lysis.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

77 entries grouped by protein

2 entries

L-alanyl-D-glutamate peptidase (EC 3.4.24.-)

Select_allDeselect_all
AEPE_BPA18
Listeria phage A118 (Bacteriophage A118) reference strain
AEPE_BPA50
Listeria phage A500 (Bacteriophage A500)

3 entries

Lysin (EC 3.5.1.28) (Cell wall hydrolase) (Lytic amidase) (N-acetylmuramoyl-L-alanine amidase)

Select_allDeselect_all
ALYS_BPR1T
Lactococcus phage r1t (Bacteriophage r1t) reference strain

N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28)

ALYS_BPDP1
Pneumococcus phage Dp-1 (Bacteriophage Dp-1)
ALYS_BPHB3
Streptococcus pneumoniae phage HB-3

Lytic amidase (EC 3.5.1.28) (N-acetylmuramoyl-L-alanine amidase)

2 entries

Mono-ADP-ribosyltransferase C3 (EC 2.4.2.-) (Exoenzyme C3)

Select_allDeselect_all
ARC3_CBCP
Clostridium botulinum C phage (Clostridium botulinum C bacteriophage)
ARC3_CBDP
Clostridium botulinum D phage (Clostridium botulinum D bacteriophage)

1 entry

Botulinum neurotoxin type C (BoNT/C) (Bontoxilysin-C1) (BoNT/C1) (Botulinum neurotoxin type C1)

BXC_CBCP
Clostridium botulinum C phage (Clostridium botulinum C bacteriophage)

1 entry

Non-toxic nonhemagglutinin type C (NTNHA) (ANTP139) (Botulinum neurotoxin type C non-toxic component) (Botulinum neurotoxin type C1 non-toxic component)

BXCN_CBCP
Clostridium botulinum C phage (Clostridium botulinum C bacteriophage)

1 entry

Botulinum neurotoxin type D (BoNT/D) (Bontoxilysin-D)

BXD_CBDP
Clostridium botulinum D phage (Clostridium botulinum D bacteriophage)

1 entry

Non-toxic nonhemagglutinin type D (NTNHA) (Botulinum neurotoxin type D non-toxic component)

BXDN_CBDP
Clostridium botulinum D phage (Clostridium botulinum D bacteriophage)

1 entry

Major capsid protein (Gene product 13) (gp13)

CAPSD_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Major capsid protein (ORF3 protein) (Protein Gp34)

COAT_BPLLH
Lactococcus phage LL-H (Lactococcus delbrueckii bacteriophage LL-H) reference strain

1 entry

Tail completion protein gp17 (Gene product 17) (gp17) (Head-tail joining protein gp17) (Tail-to-head joining protein)

COMPL_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

3 entries

dATP triphosphohydrolase (dATPase)

Select_allDeselect_all
DATPH_BPPMB
Salmonella phage PMBT28 reference strain
DATPH_BPS2L
Cyanophage S-2L (Cyanobacteria phage S-2L) reference strain

dATP triphosphohydrolase (dATPase) (DatZ)

DATPH_BPSHA
Acinetobacter phage SH-Ab 15497 reference strain

1 entry

Decoration protein gp12 (Gene product 12) (gp12)

DECO_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

3 entries

dATP/dGTP diphosphohydrolase (EC 3.6.1.9) (dATP/dGTP pyrophosphohydrolase)

Select_allDeselect_all
DGTPH_BPPMB
Salmonella phage PMBT28 reference strain
DGTPH_BPS2L
Cyanophage S-2L (Cyanobacteria phage S-2L) reference strain
DGTPH_BPSHA
Acinetobacter phage SH-Ab 15497 reference strain

1 entry

Distal tail protein (Dit) (Gene product 19.1) (Gp19.1)

DIT_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

2 entries

DNA polymerase DpoZ

Select_allDeselect_all
DPOZ_BPPMB
Salmonella phage PMBT28 reference strain
DPOZ_BPSHA
Acinetobacter phage SH-Ab 15497 reference strain

2 entries

Endolysin (EC 3.2.1.17) (Lysis protein) (Lysozyme) (Muramidase)

Select_allDeselect_all
ENLYS_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

Endolysin (EC 3.5.1.-) (LysSPP1) (Putative N-acetylmuramoyl-L-alanine amidase)

ENLYS_BPPHV
Lactococcus phage phivML3 (Lactococcus bacteriophage phi-vML3)

1 entry

Tail spike protein (TSP) (Gene product 21) (Gp21)

FIBER_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Minor head protein GP7 (Accessory head protein gp7)

GP7_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Bactoprenol-linked glucose translocase

GTRA_BPSFX
Shigella phage SfX (Shigella flexneri bacteriophage X) (Bacteriophage SfX)

1 entry

Bactoprenol glucosyl transferase (EC 2.4.1.-)

GTRB_BPSFX
Shigella phage SfX (Shigella flexneri bacteriophage X) (Bacteriophage SfX)

1 entry

Hemagglutinin component HA-17 type C (ANTP17) (HA 17 kDa subunit) (HA2)

HA17C_CBCP
Clostridium botulinum C phage (Clostridium botulinum C bacteriophage)

1 entry

Hemagglutinin component HA-17 type D (ANTP17) (HA 17 kDa subunit) (HA2)

HA17D_CBDP
Clostridium botulinum D phage (Clostridium botulinum D bacteriophage)

1 entry

Main hemagglutinin component type C (ANTP33) (HA 33 kDa subunit) (HA1)

HA33C_CBCP
Clostridium botulinum C phage (Clostridium botulinum C bacteriophage)

1 entry

Main hemagglutinin component type D (HA 33 kDa subunit) (HA1)

HA33D_CBDP
Clostridium botulinum D phage (Clostridium botulinum D bacteriophage)

1 entry

Hemagglutinin components HA-70 type C (HA3) (Hemagglutinin components HA-22/23/53 type C) (Hemagglutinin components HA-22/23/53 type C1)

HA70C_CBCP
Clostridium botulinum C phage (Clostridium botulinum C bacteriophage)

1 entry

Hemagglutinin component HA-70 type D (HA3)

HA70D_CBDP
Clostridium botulinum D phage (Clostridium botulinum D bacteriophage)

1 entry

Head completion protein gp15 (HCP) (Connector protein gp15) (Gene product 15) (Gp15)

HCP15_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Head completion protein gp16 (Connector protein gp16) (Gene product 16) (Gp16) (Stopper protein gp16)

HCP16_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Holin-like protein 24.1 (Gene product 24.1) (gp24.1)

HOL24_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Putative antiholin

HOL26_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

4 entries

Holin

Select_allDeselect_all
HOLIN_BPA18
Listeria phage A118 (Bacteriophage A118) reference strain

Putative antiholin

HOLIN_BPR1T
Lactococcus phage r1t (Bacteriophage r1t) reference strain
HOLIN_BPA50
Listeria phage A500 (Bacteriophage A500)

Antiholin

HOLIN_BPDP1
Pneumococcus phage Dp-1 (Bacteriophage Dp-1)

1 entry

Putative lysozyme (EC 3.2.1.17)

LY_BPSF6
Bacillus phage SF6 (Bacteriophage SF6)

1 entry

Orphan methyltransferase M.SPRI (M.SPRI) (EC 2.1.1.37) (Cytosine-specific methyltransferase SPRI) (Modification methylase SPRI)

MTBS_BPSPR
Bacillus phage SPR (Bacteriophage SPR)

1 entry

Portal protein (Gene product 6) (gp6) (Portal vertex protein)

PORTL_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

3 entries

N6-succino-2-amino-2'-deoxyadenylate synthase (EC 6.3.4.25) (2-amino-2'-deoxyadenylo-succinate synthase) (PurZ)

Select_allDeselect_all
PURZ_BPPMB
Salmonella phage PMBT28 reference strain
PURZ_BPS2L
Cyanophage S-2L (Cyanobacteria phage S-2L) reference strain
PURZ_BPSHA
Acinetobacter phage SH-Ab 15497 reference strain

1 entry

Restriction inhibitor protein ral (Antirestriction protein)

RAL_BPPH3
Enterobacteria phage phi21 (Bacteriophage phi-21)

1 entry

Probable regulatory protein N

REGN_BPPH3
Enterobacteria phage phi21 (Bacteriophage phi-21)

1 entry

Repressor protein C

RPC_BP163
Rhizobium phage 16-3 (Bacteriophage 16-3) reference strain

1 entry

Crossover junction endodeoxyribonuclease rusA (EC 3.1.21.10) (Holliday junction nuclease rusA) (Holliday junction resolvase)

RUSA_BPR1T
Lactococcus phage r1t (Bacteriophage r1t) reference strain

1 entry

Staphylokinase (Sak42D)

SAK_BPP42
Staphylococcus phage 42D (Bacteriophage P42D)

2 entries

Capsid assembly scaffolding protein (Gene product 11) (Gp11) (Head morphogenesis protein) (Scaffold protein)

Select_allDeselect_all
SCAF_BPLLH
Lactococcus phage LL-H (Lactococcus delbrueckii bacteriophage LL-H) reference strain

Capsid assembly scaffolding protein (Head morphogenesis protein) (Minor structural protein Gp20) (ORF2 protein) (Scaffold protein)

SCAF_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Exotoxin type A (Erythrogenic toxin) (SPE A) (Scarlet fever toxin)

SPEA_BPT12
Streptococcus pyogenes phage T12 (Bacteriophage T12)

1 entry

Terminase, large subunit (DNA-packaging protein) (Gene product 2) (gp2)

TERL_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

3 entries

Terminase small subunit (G1P)

Select_allDeselect_all
TERS_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

Terminase small subunit (G1P) (Terminase, small subunit gp1)

TERS_BPRH5
Bacillus phage rho15 (Bacteriophage rho-15)
TERS_BPSF6
Bacillus phage SF6 (Bacteriophage SF6)

Terminase small subunit (G1P) (Terminase, small subunit)

2 entries

Tail tape measure protein gp18 (Gene product 18) (gp18)

Select_allDeselect_all
TMP_BPDP1
Pneumococcus phage Dp-1 (Bacteriophage Dp-1) reference strain

Tape measure protein (TMP)

TMP_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Tail tube protein gp17.1* (TTP) (Gene product 17.1) (gp17.1) (Major tail protein) (MTP)

TUBE_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

DNA-binding protein TubR (Centromere-binding protein) (CBP)

TUBR_CBCP
Clostridium botulinum C phage (Clostridium botulinum C bacteriophage) reference strain

1 entry

Regulator protein TubY

TUBY_CBCP
Clostridium botulinum C phage (Clostridium botulinum C bacteriophage) reference strain

1 entry

Tubulin-like protein TubZ (EC 3.6.5.-) (Tubulin/FtsZ-like protein TubZ)

TUBZ_CBCP
Clostridium botulinum C phage (Clostridium botulinum C bacteriophage) reference strain

1 entry

Protein Gp66

VG66_BPA18
Listeria phage A118 (Bacteriophage A118) reference strain

1 entry

Integrase (EC 2.7.7.-) (EC 3.1.-.-)

VINT_BPL54
Staphylococcus phage L54a (Bacteriophage L54a)

1 entry

Structural protein (ORF1 protein) (ORF371)

VSP1_BPLLH
Lactococcus phage LL-H (Lactococcus delbrueckii bacteriophage LL-H) reference strain

1 entry

Excisionase

VXIS_BPL54
Staphylococcus phage L54a (Bacteriophage L54a)

1 entry

Uncharacterized protein ORF4

YG34_BPLLH
Lactococcus phage LL-H (Lactococcus delbrueckii bacteriophage LL-H) reference strain

1 entry

Uncharacterized protein ORF5 (ORF118)

YG35_BPLLH
Lactococcus phage LL-H (Lactococcus delbrueckii bacteriophage LL-H) reference strain

1 entry

Uncharacterized 8.5 kDa protein in GP2-GP6 intergenic region (ORF 3)

YOR3_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Uncharacterized 10.2 kDa protein in GP2-GP6 intergenic region (ORF 4)

YOR4_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Uncharacterized 10.3 kDa protein in GP2-GP6 intergenic region (ORF 5)

YOR5_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain