Human adenovirus type C virion
Virion structure 
| Protein name | Copies per virion * | Localization | Function | |
| Hexon protein | 720 | Major capsid protein that assembles as 240 homotrimers | Pseudo T=25 icosahedral capsid , Microtubular inwards viral transport |
|
| Penton protein | 60 | Major capsid protein that forms the penton complexes at each virion vertex | Pseudo T=25 icosahedral capsid , Viral attachment to host host entry receptor, Clathrin-mediated endocytosis of virus by host |
|
| Fiber protein | 36 | Major capsid protein that forms the fiber spikes at the surface of the capsid | Viral attachment to host adhesion receptor | |
| Capsid vertex protein IIIa | 60 | Cement protein that surrounds the border of each facet on the exterior |
Hexon stabilization genome packaging |
|
| Pre-protein VI, Endosome lysis protein, Protease cofactor | 360 | Cement protein that binds the peripentonal hexons and links the viral genome to the capsid (with VIII and V) | Pre-protein VI: Scaffolding of icosahedron/Nuclear capsid assembly? Endosome lysis protein: Viral penetration via permeabilization of host endosomal membrane, peripentonal hexons stabilization Protease cofactor: Virion maturation |
|
| Hexon-linking protein VIII | 120 | Cement protein that binds the peripentonal hexons and links the viral genome to the capsid (with V and VI) | Peripentonal hexons stabilization | |
| Hexon-interlacing protein IX | 240 | Cement protein that binds the hexons on the capsid exterior |
Hexons stabilization Viral penetration into host nucleus | Packaging protein 1 / IVa2 | 6-8 | Localizes at a unique vertex |
Genome packaging |
| Protease | 20 | Virion interior | Virion maturation | |
| Core-capsid bridging protein V | 157 | DNA-binding protein thatlinks the viral genome to the capsid (with VIII and VI) | Forms a ternary complex with proteins VI and V that interacts with the peripentonal hexons and links the viral genome Nuclear capsid assembly? | |
| Histone-like nucleoprotein VII | 814-852 | DNA-binding protein | Histone-like nucleoprotein, DNA binding/condensation | |
| Core protein X | 125-160 | DNA-binding protein | Nucleoprotein, DNA binding/condensation | |
| Terminal protein | 2 | Located at each DNA end | DNA synthesis priming, Strand displacement replication |
- Ref. Bergstroem et al. 2012 Perez-Vargas et al. 2014