Human adenovirus type C virion

Virion structure

	Protein name	Copies per virion *	Localization	Function
capsid shell	Hexon protein	720	240 homotrimers	Pseudo T=25 icosahedral capsid , Microtubular inwards viral transport
capsid shell	Penton protein	60	Major capsid protein that forms the penton complexes at each virion vertex	Pseudo T=25 icosahedral capsid , Viral attachment to host host entry receptor, Clathrin-mediated endocytosis of virus by host
capsid shell	Fiber protein	36	Major capsid protein that forms the fiber spikes at the surface of the capsid	Viral attachment to host adhesion receptor
capsid shell	Capsid vertex protein IIIa	60	Cement protein that surrounds the border of each facet on the exterior	Hexon stabilization genome packaging
capsid shell	Pre-protein VI, Endosome lysis protein, Protease cofactor	360	Cement protein that binds the peripentonal hexons and links the viral genome to the capsid (with VIII and V)	Pre-protein VI: Scaffolding of icosahedron/Nuclear capsid assembly? Endosome lysis protein: Viral penetration via permeabilization of host endosomal membrane, peripentonal hexons stabilization Protease cofactor: Virion maturation
capsid shell	Hexon-linking protein VIII	120	Cement protein that binds the peripentonal hexons and links the viral genome to the capsid (with V and VI)	Peripentonal hexons stabilization
capsid shell	Hexon-interlacing protein IX	240	Cement protein that binds the hexons on the capsid exterior	Hexons stabilization Viral penetration into host nucleus
capsid shell	Packaging protein 1 / IVa2	6-8	Localizes at a unique vertex	Genome packaging
Core	Protease	20	Virion interior	Virion maturation
Core	Core-capsid bridging protein V	157	DNA-binding protein thatlinks the viral genome to the capsid (with VIII and VI)	Forms a ternary complex with proteins VI and V that interacts with the peripentonal hexons and links the viral genome Nuclear capsid assembly?
Core	Histone-like nucleoprotein VII	814-852	DNA-binding protein	Histone-like nucleoprotein, DNA binding/condensation
Core	Core protein X	125-160	DNA-binding protein	Nucleoprotein, DNA binding/condensation
Core	Terminal protein	2	Located at each DNA end	DNA synthesis priming, Strand displacement replication

Ref. Bergstroem et al. 2012 Perez-Vargas et al. 2014