Degradation of host lipopolysaccharides during virus entry

Some bacterial viruses carry an enzymatic activity to degrade the lipopolysaccharides (LPS) of Gram-negative bacteria. This activity is often associated with the tailspike proteins. LPS degradation may be utilized by the bacteriophage to clear a path through the bacterial LPS to gain access to the entry receptor on the cell surface. Interestingly, LPS degrading viruses can also use LPS as attachment receptor. In that case an alternative theory is that LPS degradation may act to release progeny phage particles from cellular debris at the end of a lytic cycle.

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Virus Family Host bacteria Surface component type Phage degrading enzyme Ref.
Phage HK620 Podoviridae Escherichia coli H LPS Tail spike endo-N-acetylglucosaminidase
Phage P27 Unclassified Salmonella typhimurium LPS Endorhamnosidase
Phage 9NA Unclassified Salmonella typhimurium LPS Endorhamnosidase
Phage KB-1 Unclassified Salmonella typhimurium LPS Endorhamnosidase
Phage Det7 Myoviridae Salmonella typhimurium LPS Endorhamnosidase
Phage P22 Podoviridae Salmonella typhimurium LPS Endorhamnosidase
Phage Sf6 Podoviridae Shigella flexneri LPS Endorhamnosidase
Phage & epsilon 15 Podoviridae LPS Endorhamnosidase

Matching UniProtKB/Swiss-Prot entries

3 entries grouped by strain (browse by keywords)

1 entry

Salmonella phage P22 (Bacteriophage P22) reference strain

FIBER_BPP22 Tail spike protein (TSP) (Endo-1,3-alpha-L-rhamnosidase) (EC 3.2.1.-) (Endorhamnosidase) (Gene ...

1 entry

Salmonella phage epsilon15 reference strain

FIBER_BPE15 Tail spike protein (TSP) (Endorhamnosidase) (EC 3.2.1.-) (Gene product 20) (gp20)

1 entry

Shigella phage Sf6 (Shigella flexneri bacteriophage VI) (Bacteriophage SfVI)

FIBER_BPSFV Tail spike protein (TSP) (Endo-1,3-alpha-L-rhamnosidase) (EC 3.2.1.-) (Endorhamnosidase)