Degradation of host capsule during virus entry (kw:KW-1238)

Many cells are protected by a network of polysaccharides called glycocalyx. The glycocalyx (400 nm or more) layer protects the cell from hostile environments, and prevents viruses from reaching their entry receptor at the cell surface .
Bacterial viruses infecting encapsulated cell carry an exopolysaccharide (EPS) degrading enzymes as tailspike proteins in order to digest this sugar coat and reach the outer membrane or the peptidoglycan layer . The capsule can be composed of various EPS such as alginates, polysialic acids (PSAs), and hyaluronic acid (HA).

Virus	Family	Host bacteria	Surface component type	Phage degrading enzyme	ref.
Phage φ92	Myoviridae	E.coli (K1, K5, K92), Salmonella strains	PSA, capsular	Endosialidase gp143
Phage K1A	Podoviridae	Escherichia coli	PSA, capsular	Endosialidase
Phage K1E	Podoviridae	Escherichia coli	PSA, capsular	Endosialidase
Phage K1F	Podoviridae	Escherichia coli	PSA, capsular	Endosialidase
Phage 63D	Siphoviridae	-	PSA, capsular	Endosialidase
Phage K1-5	Podoviridae	Escherichia coli	PSA, capsular	Endosialidase
Phage CUS-3	Podoviridae	Escherichia coli	PSA, capsular	Endosialidase
Phage PT-6	unclassified	Pseudomonas aeruginosa	Alginate, capsular	Alginate lyase
Phage H4489A	unclassified	Streptococcus pyogenes	HA, capsular	Hyaluronidase
Phage 370.1	Siphoviridae	Streptococcus pyogenes	HA, capsular	HylP1, HylP2, HylP3
Phage H10403	unclassified	Streptococcus pyogenes	HA, capsular	Hyalurono- glucosaminidase
Phage AF	Podoviridae	Pseudomonas putida	EPS, capsular	EPS hydrolase

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

39 entries grouped by protein

reorder by strain

13 entries

Depolymerase, capsule K1-specific (EC 4.-.-.-) (Dep_kpv71) (Gene product 52) (gp52) (Probable tail spike protein)

DEPOL_BPK34

Klebsiella phage KP34 (Bacteriophage KP34) reference strain

Depolymerase, capsule K63-specific (DepoKP34) (Gene product 57) (gp57) (KP34gp57) (Probable tail spike protein)

8BKE

DEPOL_BPK36

Klebsiella phage KP36 (Bacteriophage KP36) reference strain

Depolymerase, capsule K63-specific (DepoKP36) (Gene product 50) (gp50) (KP36gp50) (Tail spike protein)

DEPOL_BPK41

Klebsiella phage KN4-1 (Bacteriophage KN4-1) reference strain

Depolymerase, capsule KN4-specific (KN4dep) (Probable tail spike protein)

DEPOL_BPK51

Klebsiella phage P510 (Bacteriophage P510) reference strain

Depolymerase, capsule KL64-specific (Gene product 38) (gp38) (P510dep) (Probable tail spike protein)

DEPOL_BPK56

Klebsiella phage P560 (Bacteriophage P560) reference strain

Depolymerase, capsule KL47-specific (P560Dep) (Probable tail spike protein)

DEPOL_BPKNT

Klebsiella phage NTUH-K2044-K1-1 (Bacteriophage NTUH-K2044-K1-1) reference strain

Depolymerase, capsule K1-specific (EC 4.-.-.-) (Gene product 34) (gp34) (K1-ORF34 protein) (Probable tail spike protein)

7W1C; 7W1D; 7W1E

DEPOL_BPK05

Klebsiella phage 0507-KN2-1 (Taipeivirus 0507KN21)

Probable tail spike protein (Depolymerase, capsule KN2-specific)

DEPOL_BPK15

Klebsiella phage SH-KP152226 (Bacteriophage SH-KP152226)

Depolymerase, capsule K47-specific (Dep42) (Gene product 42) (gp42) (Probable tail spike protein)

DEPOL_BPK71

Klebsiella phage KpV71 (Bacteriophage KpV71)

DEPOL_BPK74

Klebsiella phage vB_KpnP_KpV74 (Bacteriophage vB_KpnP_KpV74)

Depolymerase, capsule K2-specific (Dep_kpv74) (Gene product 56) (gp56) (Probable tail spike protein)

DEPOL_BPKB1

Klebsiella phage B1 (Bacteriophage B1)

Depolymerase, capsule K2-specific (DepoB1) (B1dep) (Tail spike protein)

DEPOL_BPKN1

Klebsiella phage KN1-1 (Bacteriophage KN1-1)

Depolymerase, capsule KN1-specific (KN1dep) (Probable tail spike protein)

DEPOL_BPKRA

Klebsiella phage RAD2 (Bacteriophage RAD2)

Depolymerase, capsule K2-specific (DpK2) (Gene product 2) (gp2) (Tail spike protein)

7LZJ

1 entry

Depolymerase, capsule K11-specific (Probable tail fiber protein)

1 entry

Depolymerase, capsule KN4-specific (Probable tail spike protein)

1 entry

Depolymerase, capsule K21-specific (Probable tail spike protein)

1 entry

Depolymerase, capsule KN5-specific (Probable tail fiber protein)

1 entry

Depolymerase, capsule K25-specific (Probable tail fiber protein)

1 entry

Probable tail spike protein (Depolymerase, capsule K35-specific)

1 entry

Depolymerase, capsule K1-specific (Probable tail fiber protein)

1 entry

Depolymerase, capsule K64-specific (Probable tail fiber protein)

1 entry

Depolymerase, capsule K30/K69-specific (Probable tail spike protein)

5 entries

Depolymerase 1, capsule K3-specific (Gene product 37) (gp37) (KP32gp37) (Probable tail spike protein)

DPOL1_BPK31

Klebsiella phage KN3-1 (Bacteriophage KN3-1) reference strain

Depolymerase 1, capsule KN3-specific (KN3dep) (Probable tail spike protein)

DPOL1_BPK32

Klebsiella phage KP32 (Bacteriophage KP32) reference strain

DPOL1_BPK52

Klebsiella phage K5-2 (Bacteriophage K5-2) reference strain

Depolymerase 1, capsule K30/K69-specific (Gene product 37) (gp37) (K30/K69 depolymerase) (Probable tail spike protein)

DPOL1_BPKIM

Klebsiella phage vB_KpnP_IME205 (Bacteriophage vB_KpnP_IME205) reference strain

Depolymerase 1, capsule K47-specific (Dpo42) (Gene product 42) (gp42) (Probable tail spike protein)

DPOL1_BPK54

Klebsiella phage K5-4 (Bacteriophage K5-4)

Depolymerase 1, capsule K8-specific (Gene product 37) (gp37) (Probable tail spike protein)

5 entries

Depolymerase 2, capsule K5-specific (Gene product 38) (gp38) (K5 depolymerase) (Probable tail spike protein)

DPOL2_BPK31

Klebsiella phage KN3-1 (Bacteriophage KN3-1) reference strain

Depolymerase 2, capsule K56-specific (K56dep) (Probable tail spike protein)

DPOL2_BPK32

Klebsiella phage KP32 (Bacteriophage KP32) reference strain

Depolymerase 2, capsule K21-specific (Gene product 38) (gp38) (KP32gp38) (Probable tail spike protein)

6TKU

DPOL2_BPK52

Klebsiella phage K5-2 (Bacteriophage K5-2) reference strain

DPOL2_BPKIM

Klebsiella phage vB_KpnP_IME205 (Bacteriophage vB_KpnP_IME205) reference strain

Depolymerase 1, capsule K47-specific (Dpo43) (Gene product 43) (gp43) (Probable tail spike protein)

DPOL2_BPK54

Klebsiella phage K5-4 (Bacteriophage K5-4)

3 entries

Tail spike protein (Depolymerase, capsule K5-specific) (EC 4.-.-.-)

FIBER_BPK1E

Escherichia phage K1E (Bacteriophage K1E) reference strain

Tail spike protein (TSP) (Endo-N-acetylneuraminidase) (Endo-N) (Endo-alpha-sialidase) (EC 3.2.1.129) (EndoNE)

FIBER_BPK1F

Escherichia phage K1F (Bacteriophage K1F) reference strain

Tail spike protein (TSP) (Endo-N-acetylneuraminidase) (Endo-N) (Endo-alpha-sialidase) (EC 3.2.1.129) (EndoNF) (G102)

1V0E; 1V0F; 3GVJ; 3GVK; 3GVL; 3GW6; 3JU4

FIBER_BPK5

Escherichia virus K5 (Bacteriophage K5)

2X3H

1 entry

Hyaluronoglucosaminidase (Hyaluronidase) (EC 3.2.1.35)

1 entry

Hyaluronoglucosaminidase (Hyaluronidase) (EC 3.2.1.35)

2 entries

Tail tubular protein A (TTPA) (Depolymerase) (EC 3.2.1.-) (Gene product 31) (gp31)

TUBE1_BPK32

Klebsiella phage KP32 (Bacteriophage KP32) reference strain

5MU4

TUBE1_BPK34

Klebsiella phage KP34 (Bacteriophage KP34) reference strain

Tail tubular protein A (TTPA) (Depolymerase) (EC 3.2.1.28) (Gene product 44) (gp44)