Jonvirus (taxid:2501997)

VIRION

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Enveloped, sphericalwith a 80nm diameter. Some virions have a tubular morphology of about 60 nm ???? up to 600 nm.

GENOME

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Segmented Negative-stranded RNA linear genome, for a total of 13.7 kb. Encodes for four proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching .

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds, presumably releasing the virion by exocytosis.