Thogotovirus (taxid:35323)

Thogotovirus is a genus of ssRNA- viruses in the Orthomyxoviridae family that infect mammals and are transmitted by Ticks (arbovirus). In humans, these viruses can cause fevers and encephalitis.

VIRION

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Enveloped, spherical. The virions are 80-120 nm in diameter

GENOME

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segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP) Contains 6 to 7 segments coding for 7 to 9 proteins. Segments size range from 0.9 to 2.3 kb. Genome total size is about 10 Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. Segment 6 mRNA can be alternatively spliced, giving rise to mRNA coding for M1 proteins.

ENZYMES

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though GP protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

11 entries grouped by protein

2 entries

Envelope glycoprotein

Select_allDeselect_all
ENV_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain

Envelope glycoprotein (Surface glycoprotein 75)

ENV_DHVI1
Dhori virus (strain Indian/1313/61) (Dho)

2 entries

Matrix protein (M1)

Select_allDeselect_all
M1_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain
M1_DHVI1
Dhori virus (strain Indian/1313/61) (Dho)

Matrix protein 1 (M1)

1 entry

Protein ML (ML)

ML_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain

2 entries

Nucleoprotein (Nucleocapsid protein) (Protein N)

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NCAP_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain
NCAP_DHVI1
Dhori virus (strain Indian/1313/61) (Dho)

1 entry

Polymerase acidic protein (PA) (RNA-directed RNA polymerase subunit P3)

PA_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain

1 entry

Polymerase basic protein 2 (PB2) (RNA-directed RNA polymerase subunit P3)

PB2_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain

2 entries

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (RNA-directed RNA polymerase subunit P2)

Select_allDeselect_all
RDRP_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain
RDRP_DHVI1
Dhori virus (strain Indian/1313/61) (Dho)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Thogoto virus (isolate SiAr 126) taxid:126796

Protein ModelArchive
Nucleoprotein (Nucleocapsid protein) (Protein N) ma-jd-viral-32091

Thogotovirus thogotoense taxid:11569

Protein ModelArchive
Nucleoprotein ma-jd-viral-32091