Wupedeviridae (taxid:2501941)

VIRION

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Unknown, discovered using viral metagenomics. Presumably enveloped.

GENOME

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Segmented Negative-stranded RNA linear genome, L segment is about 12 kb, M segment about 7 kb and S segment 2 kb. Encodes at least three proteins.

Enzymes: RNA dependent RNA polymerase, endonuclease? (Cap snatching).

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching .

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though glycoprotein, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds, presumably releasing the virion by exocytosis.