Degradation of host capsule during virus entry (kw:KW-1238)

Many cells are protected by a network of polysaccharides called glycocalyx. The glycocalyx (400 nm or more) layer protects the cell from hostile environments, and prevents viruses from reaching their entry receptor at the cell surface .
Bacterial viruses infecting encapsulated cell carry an exopolysaccharide (EPS) degrading enzymes as tailspike proteins in order to digest this sugar coat and reach the outer membrane or the peptidoglycan layer . The capsule can be composed of various EPS such as alginates, polysialic acids (PSAs), and hyaluronic acid (HA).

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Virus Family Host bacteria Surface component type Phage degrading enzyme ref.
Phage φ92 Myoviridae E.coli (K1, K5, K92), Salmonella strains PSA, capsular Endosialidase gp143
Phage K1A Podoviridae Escherichia coli PSA, capsular Endosialidase
Phage K1E Podoviridae Escherichia coli PSA, capsular Endosialidase
Phage K1F Podoviridae Escherichia coli PSA, capsular Endosialidase
Phage 63D Siphoviridae - PSA, capsular Endosialidase
Phage K1-5 Podoviridae Escherichia coli PSA, capsular Endosialidase
Phage CUS-3 Podoviridae Escherichia coli PSA, capsular Endosialidase
Phage PT-6 unclassified Pseudomonas aeruginosa Alginate, capsular Alginate lyase
Phage H4489A unclassified Streptococcus pyogenes HA, capsular Hyaluronidase
Phage 370.1 Siphoviridae Streptococcus pyogenes HA, capsular HylP1, HylP2, HylP3
Phage H10403 unclassified Streptococcus pyogenes HA, capsular Hyalurono- glucosaminidase
Phage AF Podoviridae Pseudomonas putida EPS, capsular EPS hydrolase
Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Host envelope degradation Capsule degradation
Lipopolysaccharides degradation
Peptidoglycans degradation
Links Uniprot Keyword: KW-1238
GO ontology:GO:0098996

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

39 entries grouped by protein

13 entries

Depolymerase, capsule K1-specific (EC 4.-.-.-) (Dep_kpv71) (Gene product 52) (gp52) (Probable tail spike protein)

Select_allDeselect_all
DEPOL_BPK34
Klebsiella phage KP34 (Bacteriophage KP34) reference strain

Depolymerase, capsule K63-specific (DepoKP34) (Gene product 57) (gp57) (KP34gp57) (Probable tail spike protein)

pdb 8BKE

DEPOL_BPK36
Klebsiella phage KP36 (Bacteriophage KP36) reference strain

Depolymerase, capsule K63-specific (DepoKP36) (Gene product 50) (gp50) (KP36gp50) (Tail spike protein)

DEPOL_BPK41
Klebsiella phage KN4-1 (Bacteriophage KN4-1) reference strain

Depolymerase, capsule KN4-specific (KN4dep) (Probable tail spike protein)

DEPOL_BPK51
Klebsiella phage P510 (Bacteriophage P510) reference strain

Depolymerase, capsule KL64-specific (Gene product 38) (gp38) (P510dep) (Probable tail spike protein)

DEPOL_BPK56
Klebsiella phage P560 (Bacteriophage P560) reference strain

Depolymerase, capsule KL47-specific (P560Dep) (Probable tail spike protein)

DEPOL_BPK74
Klebsiella phage vB_KpnP_KpV74 (Bacteriophage vB_KpnP_KpV74) reference strain

Depolymerase, capsule K2-specific (Dep_kpv74) (Gene product 56) (gp56) (Probable tail spike protein)

DEPOL_BPKNT
Klebsiella phage NTUH-K2044-K1-1 (Bacteriophage NTUH-K2044-K1-1) reference strain

Depolymerase, capsule K1-specific (EC 4.-.-.-) (Gene product 34) (gp34) (K1-ORF34 protein) (Probable tail spike protein)

pdb 7W1C; 7W1D; 7W1E

DEPOL_BPK05
Klebsiella phage 0507KN21 (Taipeivirus 0507KN21)

Probable tail spike protein (Depolymerase, capsule KN2-specific)

DEPOL_BPK15
Klebsiella phage SH-KP152226 (Bacteriophage SH-KP152226)

Depolymerase, capsule K47-specific (Dep42) (Gene product 42) (gp42) (Probable tail spike protein)

DEPOL_BPK71
Klebsiella phage KpV71 (Bacteriophage KpV71)
DEPOL_BPKB1
Klebsiella phage B1 (Bacteriophage B1)

Depolymerase, capsule K2-specific (DepoB1) (B1dep) (Tail spike protein)

DEPOL_BPKN1
Klebsiella phage KN1-1 (Bacteriophage KN1-1)

Depolymerase, capsule KN1-specific (KN1dep) (Probable tail spike protein)

DEPOL_BPKRA
Klebsiella phage RAD2 (Bacteriophage RAD2)

Depolymerase, capsule K2-specific (DpK2) (Gene product 2) (gp2) (Tail spike protein)

pdb 7LZJ

1 entry

Depolymerase, capsule K11-specific (Probable tail fiber protein)

DPO11_BPK64
Klebsiella phage K64-1 (Bacteriophage K64-1) reference strain

1 entry

Depolymerase, capsule KN4-specific (Probable tail spike protein)

DPO12_BPK64
Klebsiella phage K64-1 (Bacteriophage K64-1) reference strain

1 entry

Depolymerase, capsule K21-specific (Probable tail spike protein)

DPO13_BPK64
Klebsiella phage K64-1 (Bacteriophage K64-1) reference strain

1 entry

Depolymerase, capsule KN5-specific (Probable tail fiber protein)

DPO21_BPK64
Klebsiella phage K64-1 (Bacteriophage K64-1) reference strain

1 entry

Depolymerase, capsule K25-specific (Probable tail fiber protein)

DPO22_BPK64
Klebsiella phage K64-1 (Bacteriophage K64-1) reference strain

1 entry

Probable tail spike protein (Depolymerase, capsule K35-specific)

DPO23_BPK64
Klebsiella phage K64-1 (Bacteriophage K64-1) reference strain

1 entry

Depolymerase, capsule K1-specific (Probable tail fiber protein)

DPO24_BPK64
Klebsiella phage K64-1 (Bacteriophage K64-1) reference strain

1 entry

Depolymerase, capsule K64-specific (Probable tail fiber protein)

DPO25_BPK64
Klebsiella phage K64-1 (Bacteriophage K64-1) reference strain

1 entry

Depolymerase, capsule K30/K69-specific (Probable tail spike protein)

DPO26_BPK64
Klebsiella phage K64-1 (Bacteriophage K64-1) reference strain

5 entries

Depolymerase 1, capsule K3-specific (Gene product 37) (gp37) (KP32gp37) (Probable tail spike protein)

Select_allDeselect_all
DPOL1_BPK31
Klebsiella phage KN3-1 (Bacteriophage KN3-1) reference strain

Depolymerase 1, capsule KN3-specific (KN3dep) (Probable tail spike protein)

DPOL1_BPK32
Klebsiella phage KP32 (Bacteriophage KP32) reference strain
DPOL1_BPK52
Klebsiella phage K5-2 (Bacteriophage K5-2) reference strain

Depolymerase 1, capsule K30/K69-specific (Gene product 37) (gp37) (K30/K69 depolymerase) (Probable tail spike protein)

DPOL1_BPK54
Klebsiella phage K5-4 (Bacteriophage K5-4) reference strain

Depolymerase 1, capsule K8-specific (Gene product 37) (gp37) (Probable tail spike protein)

DPOL1_BPKIM
Klebsiella phage vB_KpnP_IME205 (Bacteriophage vB_KpnP_IME205) reference strain

Depolymerase 1, capsule K47-specific (Dpo42) (Gene product 42) (gp42) (Probable tail spike protein)

5 entries

Depolymerase 2, capsule K5-specific (Gene product 38) (gp38) (K5 depolymerase) (Probable tail spike protein)

Select_allDeselect_all
DPOL2_BPK31
Klebsiella phage KN3-1 (Bacteriophage KN3-1) reference strain

Depolymerase 2, capsule K56-specific (K56dep) (Probable tail spike protein)

DPOL2_BPK32
Klebsiella phage KP32 (Bacteriophage KP32) reference strain

Depolymerase 2, capsule K21-specific (Gene product 38) (gp38) (KP32gp38) (Probable tail spike protein)

pdb 6TKU

DPOL2_BPK52
Klebsiella phage K5-2 (Bacteriophage K5-2) reference strain
DPOL2_BPK54
Klebsiella phage K5-4 (Bacteriophage K5-4) reference strain
DPOL2_BPKIM
Klebsiella phage vB_KpnP_IME205 (Bacteriophage vB_KpnP_IME205) reference strain

Depolymerase 1, capsule K47-specific (Dpo43) (Gene product 43) (gp43) (Probable tail spike protein)

3 entries

Tail spike protein (Depolymerase, capsule K5-specific) (EC 4.-.-.-)

Select_allDeselect_all
FIBER_BPK1F
Escherichia phage K1F (Bacteriophage K1F) reference strain

Tail spike protein (TSP) (Endo-N-acetylneuraminidase) (Endo-N) (Endo-alpha-sialidase) (EC 3.2.1.129) (EndoNF) (G102)

pdb 1V0E; 1V0F; 3GVJ; 3GVK; 3GVL; 3GW6; 3JU4

FIBER_BPK1E
Escherichia phage K1E (Bacteriophage K1E)

Tail spike protein (TSP) (Endo-N-acetylneuraminidase) (Endo-N) (Endo-alpha-sialidase) (EC 3.2.1.129) (EndoNE)

FIBER_BPK5
Escherichia virus K5 (Bacteriophage K5)

pdb 2X3H

1 entry

Hyaluronoglucosaminidase (Hyaluronidase) (EC 3.2.1.35)

HYLP1_BPH44
Streptococcus pyogenes phage H4489A

pdb 6WV2; 6WWX; 6WXA; 6X3M

1 entry

Hyaluronoglucosaminidase (Hyaluronidase) (EC 3.2.1.35)

HYLP2_BPH45
Streptococcus pyogenes phage H10403

2 entries

Tail tubular protein A (TTPA) (Depolymerase) (EC 3.2.1.-) (Gene product 31) (gp31)

Select_allDeselect_all
TUBE1_BPK32
Klebsiella phage KP32 (Bacteriophage KP32) reference strain

pdb 5MU4

TUBE1_BPK34
Klebsiella phage KP34 (Bacteriophage KP34) reference strain

Tail tubular protein A (TTPA) (Depolymerase) (EC 3.2.1.28) (Gene product 44) (gp44)