Respirovirus

VIRION

Enveloped, spherical. Diameter from about 150 nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The C'/C/Y1/Y2 proteins are expressed by leaky scanning, and V/W proteins by mRNA editing.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The C protein plays a role in inhibition of STAT1 antiviral signaling

Species

Synonyms

2016 namingOther common name
Human respirovirus 1Human parainfluenza virus 1 (HPIV-1)
Human respirovirus 3Human parainfluenza virus 3 (HPIV-3)
Bovine respirovirus 3Human herpesvirus 3 (HHV-3)
Murine respirovirusSendai virus (SeV)
Porcine respirovirus 1Porcine parainfluenza virus 1 (PPIV-1)

Matching UniProtKB/Swiss-Prot entries

83 entries grouped by strain (browse by keywords)

8 entries

Sendai virus (strain Hamamatsu) (SeV) reference strain

Select_allDeselect_all
PHOSP_SENDA Phosphoprotein (Protein P)
HN_SENDA Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)
NCAP_SENDA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_SENDA Protein V
MATRX_SENDA Matrix protein (M protein)
C_SENDA Protein C'
L_SENDA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
FUS_SENDA Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

7 entries

Sendai virus (strain Ohita) (SeV) reference strain

Select_allDeselect_all
PHOSP_SENDO Phosphoprotein (Protein P)
HN_SENDO Hemagglutinin-neuraminidase (HN protein) (Protein HANA) (EC 3.2.1.18)
NCAP_SENDO Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
FUS_SENDO Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
MATRX_SENDO Matrix protein (M protein)
L_SENDO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
C_SENDO Protein C'

7 entries

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

Select_allDeselect_all
V_SENDZ Protein V
PHOSP_SENDZ Phosphoprotein (Protein P)
NCAP_SENDZ Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
W_SENDZ Protein W
MATRX_SENDZ Matrix protein (M protein)
C_SENDZ C' protein
FUS_SENDZ Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

6 entries

Bovine parainfluenza 3 virus (BPIV-3) reference strain

Select_allDeselect_all
NCAP_PI3B Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI3B Phosphoprotein (Protein P)
MATRX_PI3B Matrix protein
HN_PI3B Hemagglutinin-neuraminidase (EC 3.2.1.18)
C_PI3B Protein C
FUS_PI3B Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

9 entries

Sendai virus (strain Fushimi) (SeV)

Select_allDeselect_all
PHOSP_SENDF Phosphoprotein (Protein P)
V_SENDF Protein V
W_SENDF Protein W
HN_SENDF Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)
NCAP_SENDF Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
C_SENDF Protein C'
L_SENDF RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_SENDF Matrix protein (M protein)
FUS_SENDF Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

Sendai virus (strain Hamamatsu) (SeV)

W_SENDA Protein W

2 entries

Sendai virus (strain Ohita) (SeV)

Select_allDeselect_all
W_SENDO Protein W
V_SENDO Protein V

2 entries

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

Select_allDeselect_all
L_SENDZ RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
HN_SENDZ Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)

7 entries

Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

Select_allDeselect_all
L_PI3H4 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_PI3H4 Phosphoprotein (Protein P)
HN_PI3H4 Hemagglutinin-neuraminidase (EC 3.2.1.18)
NCAP_PI3H4 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
C_PI3H4 Protein C (VP18 protein)
FUS_PI3H4 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
MATRX_PI3H4 Matrix protein

7 entries

Sendai virus (strain Harris) (SeV)

Select_allDeselect_all
W_SENDH Protein W
MATRX_SENDH Matrix protein (M protein)
FUS_SENDH Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
PHOSP_SENDH Phosphoprotein (Protein P)
V_SENDH Protein V
HN_SENDH Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)
C_SENDH Protein C'

5 entries

Human parainfluenza 1 virus (strain C39) (HPIV-1)

Select_allDeselect_all
MATRX_PI1HC Matrix protein
PHOSP_PI1HC Phosphoprotein (Protein P)
NCAP_PI1HC Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
C_PI1HC Protein C
FUS_PI1HC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

3 entries

Sendai virus (strain Enders) (SeV)

Select_allDeselect_all
L_SENDE RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_SENDE Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
MATRX_SENDE Matrix protein (M protein)

2 entries

Human parainfluenza 1 virus (strain C35) (HPIV-1)

Select_allDeselect_all
PHOSP_PI1HB Phosphoprotein (Protein P)
C_PI1HB Protein C

2 entries

Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)

Select_allDeselect_all
PHOSP_PI1HE Phosphoprotein (Protein P)
C_PI1HE Protein C

2 entries

Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)

Select_allDeselect_all
PHOSP_PI1HD Phosphoprotein (Protein P)
C_PI1HD Protein C

2 entries

Human parainfluenza 1 virus (strain Washington/1957) (HPIV-1)

Select_allDeselect_all
NCAP_PI1HW Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
HN_PI1HW Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Human parainfluenza 1 virus (strains A1426 / 86-315 / 62m-753) (HPIV-1)

Select_allDeselect_all
NCAP_PI1HA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
MATRX_PI1HA Matrix protein

2 entries

Sendai virus (strain 6/94) (SeV)

Select_allDeselect_all
PHOSP_SEND6 Phosphoprotein (Protein P)
C_SEND6 Protein C'

1 entry

Human parainfluenza 3 virus (strain Aus/124854/74) (HPIV-3)

HN_PI3HA Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Human parainfluenza 3 virus (strain Tex/12677/83) (HPIV-3)

HN_PI3HV Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Human parainfluenza 3 virus (strain Tex/545/80) (HPIV-3)

HN_PI3HT Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Human parainfluenza 3 virus (strain Tex/9305/82) (HPIV-3)

HN_PI3HU Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Human parainfluenza 3 virus (strain Wash/1511/73) (HPIV-3)

HN_PI3HX Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Human parainfluenza 3 virus (strain Wash/641/79) (HPIV-3)

HN_PI3HW Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Sendai virus (strain Nagoya) (SeV)

C_SENDN Protein C'