Respirovirus (taxid:186938)
VIRION
Enveloped, spherical. Diameter from about 150 nm.
GENOME
Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.
GENE EXPRESSION
The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The C'/C/Y1/Y2 proteins are expressed by leaky scanning, and V/W proteins by mRNA editing.
ENZYMES
- RNA-dependent RNA polymerase [L]
- Mononega-type capping
- RNA TPase, GTase, N7 Mtase, 2'O Mtase [L]
- Neuraminidase [HN]
REPLICATION
CYTOPLASMIC
- Virus attaches to host cell surface receptors through HN glycoprotein.
- Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
- Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
- Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
- The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.
Host
Ecology and disease
Host-virus interaction
Inhibition of host Interferon induction
The V protein plays a role in inhibition of MDA-5 antiviral signaling 
The C protein plays a role in inhibition of STAT1 antiviral signaling
Species
Synonyms
| 2016 naming | Other common name |
|---|---|
| Human respirovirus 1 | Human parainfluenza virus 1 (HPIV-1) |
| Human respirovirus 3 | Human parainfluenza virus 3 (HPIV-3) |
| Bovine respirovirus 3 | Human herpesvirus 3 (HHV-3) |
| Murine respirovirus | Sendai virus (SeV) |
| Porcine respirovirus 1 | Porcine parainfluenza virus 1 (PPIV-1) |
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)83 entries grouped by protein
13 entries
Protein C'
8 entries
Fusion glycoprotein F0 (Protein F)
14 entries
Hemagglutinin-neuraminidase (EC 3.2.1.18)
6 entries
RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)
10 entries
Matrix protein (M protein)
10 entries
Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
12 entries
Phosphoprotein (Protein P)
5 entries
Protein V
5 entries
Protein W
Caprine parainfluenza virus 3 taxid:1529392
Human parainfluenza virus 1 strain Washington/1964 taxid:188538
Human respirovirus 1 taxid:12730
| Protein | ModelArchive |
| Fusion glycoprotein F0 | ma-jd-viral-43015 |
| Hemagglutinin | ma-jd-viral-13174 |