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Andes virus references and variants

This page describes circulating Andes 2026 outbreak variant - Last updated 12/May/2026. Back to Andes virus resource
Glycoprotein mutations affect both tropism (receptor binding) and immune evasion and are therefore the focus of surveillance. However, other viral protein mutations can also have effects on pathogenesis, cellular tropism and transmission.
  • Andes virus Glycoprotein:
  • Click to highlight 3D structure regions of interest
  • Gn chain
  • Gc chain
    • ANDV: 2026 cruise ship outbreak variants (Switzerland sequence)
  • image

    The main reference sequence for Andes virus (ANDV) is the Chile-9717869/1997 sequence. Moreover the Orthohantavirus andesense species comprises three additional references to cover species diversity.

    Variant Virus name Acronym Species Isolate Year Genome Proteins Genome coverage
    2026 cruise ship outbreak
    		 Andes virus ANDV Orthohantavirus andesense ANDV/Switzerland/Hu-3337/2026 2026 image L
    GPC
    N
    NSs     		Complete genome
    Andes virus reference
    ICTV exemplar     		Andes virus ANDV Orthohantavirus andesense Chile-9717869 1997 L: NC_003468
    M: NC_003467
    S: NC_003466
    Assembly: GCF_000850405     		L
    GPC
    N
    NSs     		Complete genome
    ICTV Additional isolate Castelo dos Sonhos virus CASV Orthohantavirus andesense 769 2010 L: KF581136; M: KF581136; S: KF581134
    Assembly: GCA_031580465     		L
    GPC
    N
    NSs not annotated     		Complete genome
    ICTV Additional isolate Lechiguanas virus LECV; LECHV Orthohantavirus andesense Of22819 1992-1996 M: AF028022; S: AF482714 L not sequenced
    GPC
    N
    NSs not annotated     		Partial genome
    ICTV Additional isolate Oran virus ORNV Orthohantavirus andesense OL22996 1992-1996 M: AF028024; S: AF482715 L not sequenced
    GPC
    N
    NSs not annotated     		Partial genome