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Ebolavirus proteome

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Nucleoprotein (NP) NP Zaire ebolavirus

The nucleoprotein (NP) of Ebolavirus nucleoprotein (NP) encapsidates the viral RNA genome to form the nucleocapsid, protecting the RNA and serving as the scaffold for viral transcription and replication.

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VP35 VP35 Zaire ebolavirus

The viral protein 35 (VP35) of Ebolavirus VP35 is an essential cofactor of the viral RNA polymerase that supports viral transcription and replication by interacting with the nucleoprotein and polymerase complex. It also acts as a potent innate immune antagonist, suppressing type I interferon production by binding viral dsRNA and inhibiting host antiviral signaling.

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VP40 VP40 Zaire ebolavirus

The viral protein 40 (VP40) of Ebolavirus VP40 is the major matrix protein that drives virion assembly and budding by linking the nucleocapsid to the viral envelope and remodeling the host cell membrane.

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Glycoprotein (GP) GP Zaire ebolavirusSGPSSGPs

The glycoprotein (GP) of Ebolavirus glycoprotein (GP) is the viral surface protein that mediates attachment to host cells and membrane fusion, enabling viral entry. It is also the principal target of neutralizing antibodies and plays a major role in immune evasion and pathogenesis.

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VP30 VP30 Zaire ebolavirus

The viral protein 30 (VP30) of Ebolavirus VP30 is a viral transcription factor that activates transcription of the Ebola virus genome by the viral RNA polymerase complex.

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VP24 VP24 Zaire ebolavirus

The viral protein 24 (VP24) of Ebolavirus VP24 is a minor matrix protein that contributes to nucleocapsid assembly and virion structure. It also acts as an interferon antagonist by blocking STAT1 nuclear import, thereby suppressing host innate immune signaling.

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RdRp (L) L Zaire ebolavirus

The L protein of Ebolavirus L protein is the viral RNA-dependent RNA polymerase that carries out transcription of viral mRNAs and replication of the genome. It forms the catalytic core of the replication complex and works in association with VP35 and NP to ensure RNA synthesis and processing.

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