Eukaryotic host transcription shutoff by virus (kw:KW-1191)

Host RNA polymerase II (RNA pol-II) is the major enzyme responsible for transcription of mRNA from a DNA template strand.

Some viruses interfere with host RNA pol-II function. They may either mediate its ubiquitination and subsequent proteasomal degradation, or inhibit RNA pol-II phosphorylation thereby lowering its efficiency. They can as well interfere with initiation factors. Inhibiting host transcription eventually leads to shutoff of host proteins expression and gives viruses transcripts a competitive edge for access to the cellular translation machinery. Preventing the expression of host proteins is also a strategy to counteract the antiviral response.

Viruses inhibiting transcription:

Family	Virus	Viral protein	Transcription inhibition strategy	references
Herpesviridae	HHV-1	ICP22	Counteracts CTD Ser-2 phosphorylation
Bunyaviridae	Bunyamwera virus	NSs	Counteracts CTD Ser-2 phosphorylation
Orthomyxoviridae	Influenza virus	Polymerase PB1, PB2, PA	RNA pol-II ubiquitination and proteasomal degradation
Papillomaviridae, alphapapillomavirus	HPV16	E7	Inhibition of TBP
Picornaviridae	Poliovirus	3C	Cleavage of TBP
Bunyaviridae, Phlebovirus	Rift valley fever virus	NSs	Downregulates TFIIH subunit p62
Herpesviridae, Varicellovirus	Varicella virus	IE63	Disruption of the transcriptional pre-initiation complex

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

348 entries grouped by protein

reorder by strain

2 entries

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE02

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

E1A_ADE05

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

2KJE; 2R7G; 6H6D; 6H6H

3 entries

Transcriptional regulator ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

ICP22_HHV11

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

ICP22_VZVD

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Transcriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) (Transcriptional regulator IE63)

ICP22_VZVO

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

Transcriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) (Transcriptional transactivator IE63)

6 entries

Non-structural protein NS-S

NSS_BUNL8

Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain

NSS_BUNLC

Bunyavirus La Crosse reference strain

NSS_BUNYW

Bunyamwera virus (BUNV) reference strain

NSS_RVFVZ

Rift valley fever virus (strain ZH-548 M12) (RVFV) reference strain

Non-structural protein S (NSs)

2N0Y; 5OOO; 8T2M; 8T2N

NSS_BUNGE

Bunyavirus germiston

NSS_BUNSH

Bunyavirus snowshoe hare

98 entries

Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

PA_I34A1

Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

2ZNL; 4YYL; 4ZHZ; 4ZI0; 4ZQQ; 5FDD; 5FDG; 5I13; 5JHT; 5JHV; 7XGC

PA_I96A0

Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain

3EBJ; 3HW3; 3HW4; 3HW5; 3HW6; 8H69; 8KCV

PA_INBLE

Influenza B virus (strain B/Lee/1940) reference strain

PA_INCAA

Influenza C virus (strain C/Ann Arbor/1/1950) reference strain

PA_I000X

Influenza A virus (strain A/X-31 H3N2)

PA_I00A0

Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)

PA_I00A1

Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)

PA_I01A0

Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)

PA_I01A3

Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)

6IRL

PA_I02A0

Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)

PA_I02A1

Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)

PA_I02A2

Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)

PA_I02A4

Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

PA_I02A5

Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)

PA_I02A6

Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)

PA_I04A1

Influenza A virus (strain A/Vietnam/1203/2004 H5N1)

4E5E; 4E5F; 4E5G; 4E5H; 4E5I; 4E5J; 4E5L

PA_I05A1

Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)

PA_I06A0

Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)

PA_I07A0

Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)

PA_I09A0

Influenza A virus (strain swl A/California/04/2009 H1N1)

4AVG; 4AVL; 4AVQ; 4AWF; 4AWG; 4AWH; 4AWK; 4AWM; 5CCY; 5CGV; 5CL0; 5CZN; 5D2O; 5D42; 5D4G; 5D8U; 5D9J; 5DBS; 5DEB; 5DES; 5EGA; 5VP8; 5VPT; 5VPX; 5VQN; 5VRJ; 5W3I; 5W44; 5W73; 5W7U; 5W92; 5W9G; 5WA6; 5WA7; 5WAP; 5WB3; 5WCS; 5WCT; 5WDC; 5WDN; 5WDW; 5WE7; 5WE9; 5WEB; 5WEF; 5WEI; 5WF3; 5WFM; 5WFW; 5WFZ; 5WG9; 6DCY; 6DCZ; 6DZQ; 6E0Q; 6E3M; 6E3N; 6E3O; 6E3P; 6E4C; 6E6V; 6E6W; 6E6X; 6FS6; 6FS7; 7K0W; 7LM4; 7ML8; 7MPF; 7MTY; 7MX0; 7MY5; 7N47; 7N55; 7N68; 7N8F; 7RKP; 7V04; 8CTF; 8DAL; 8DDB; 8DDE; 8DHN; 8DJV; 8DJY; 8T5V; 8T5W; 8T5Z; 8T67; 8T6Z; 8T81; 8T94; 8VGZ

PA_I18A0

Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))

7NHA; 7NHC; 7NHX; 7NI0; 7NIK; 7NIL; 7NIR; 7NIS; 7NJ3; 7NJ4; 7NJ5; 7NJ7; 7NK1; 7NK2; 7NK4; 7NK6; 7NK8; 7NKA; 7NKC; 7NKI; 7NKR; 8R60; 8R65

PA_I30A0

Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)

1YN6; 1YN7; 3PQY

PA_I33A0

Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))

4IUJ; 5IEQ; 5IF2; 5IF5; 5IF7; 5IF8; 5IFB; 5IFC; 5IFD; 5V0U; 6CFP

PA_I34A0

Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)

PA_I35A3

Influenza A virus (strain A/USA:Phila/1935 H1N1)

PA_I36A0

Influenza A virus (strain A/Henry/1936 H1N1)

PA_I40A0

Influenza A virus (strain A/Hickox/1940 H1N1)

PA_I43A0

Influenza A virus (strain A/USA:Iowa/1943 H1N1)

PA_I45A0

Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)

PA_I47A0

Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)

PA_I49A1

Influenza A virus (strain A/Duck/Germany/1949 H10N7)

PA_I51A0

Influenza A virus (strain A/USA:Albany/12/1951 H1N1)

PA_I54A2

Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)

PA_I56A1

Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)

PA_I56A2

Influenza A virus (strain A/Duck/England/1/1956 H11N6)

PA_I57A0

Influenza A virus (strain A/Japan/305/1957 H2N2)

PA_I57A1

Influenza A virus (strain A/Leningrad/134/1957 H2N2)

PA_I57A2

Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)

PA_I57A3

Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)

PA_I57A5

Influenza A virus (strain A/Singapore/1/1957 H2N2)

PA_I59A0

Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)

PA_I60A0

Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)

PA_I61A1

Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)

PA_I66A1

Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)

PA_I67A0

Influenza A virus (strain A/Tokyo/3/1967 H2N2)

PA_I67A2

Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)

PA_I68A3

Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)

PA_I68A4

Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

PA_I68A5

Influenza A virus (strain A/Korea/426/1968 H2N2)

PA_I68A6

Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))

6QPG; 6QX3; 6QX8; 6QXE; 6RR7; 8Y7M; 8Y7O

PA_I69A0

Influenza A virus (strain A/England/878/1969 H3N2)

PA_I70A0

Influenza A virus (strain A/Qu/7/1970 H3N2)

PA_I71A1

Influenza A virus (strain A/Memphis/1/1971 H3N2)

PA_I72A2

Influenza A virus (strain A/Udorn/307/1972 H3N2)

PA_I72A3

Influenza A virus (strain A/Memphis/102/1972 H3N2)

PA_I72A4

Influenza A virus (strain A/Memphis/101/1972 H3N2)

PA_I73A4

Influenza A virus (strain A/Equine/London/1416/1973 H7N7)

PA_I73A5

Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)

PA_I75A0

Influenza A virus (strain A/Beijing/39/1975 H3N2)

PA_I75A3

Influenza A virus (strain A/Victoria/3/1975 H3N2)

2W69

PA_I76A6

Influenza A virus (strain A/Memphis/110/1976 H3N2)

PA_I77A4

Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)

PA_I77AA

Influenza A virus (strain A/Brazil/11/1978 H1N1)

PA_I77AB

Influenza A virus (strain A/USSR/90/1977 H1N1)

PA_I77AD

Influenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)

PA_I77AF

Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)

PA_I78A3

Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)

PA_I78A7

Influenza A virus (strain A/Memphis/2/1978 H3N2)

PA_I78A8

Influenza A virus (strain A/Memphis/18/1978 H3N2)

PA_I78A9

Influenza A virus (strain A/Swine/Hong Kong/81/1978 H3N2)

PA_I78AC

Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)

PA_I79A1

Influenza A virus (strain A/Pintail/Alberta/119/1979 H4N6)

PA_I79A7

Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)

PA_I80A2

Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)

PA_I80A4

Influenza A virus (strain A/Memphis/4/1980 H3N2)

PA_I80A6

Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)

4W9S

PA_I80A8

Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)

PA_I80AA

Influenza A virus (strain A/India/6263/1980 H1N1)

PA_I80AD

Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)

PA_I82A4

Influenza A virus (strain A/Swine/Hong Kong/126/1982 H3N2)

PA_I83A1

Influenza A virus (strain A/Chile/1/1983 H1N1)

PA_I83A4

Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)

PA_I83A5

Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)

PA_I83A8

Influenza A virus (strain A/Hong Kong/5/1983 H3N2)

PA_I85A3

Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)

PA_I85A7

Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)

PA_I86A3

Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)

PA_I93A0

Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)

PA_I96A2

Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)

PA_I96A3

Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)

PA_I97A0

Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)

PA_I97A1

Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

7N4K; 7N5C; 7N5P; 7N5Q

PA_INBAC

Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])

PA_INBAD

Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])

PA_INBP9

Influenza B virus (strain B/Panama/45/1990)

6QWL

PA_INBSI

Influenza B virus (strain B/Singapore/222/1979)

PA_INCJH

Influenza C virus (strain C/Johannesburg/1/1966)

5D98; 5D9A; 6F5P; 6XZD; 6XZG; 6XZP; 6XZQ; 6XZR; 6Y0C

PA_INCJJ

Influenza C virus (strain C/JJ/1950)

97 entries

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

PB2_I34A1

Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

2ZTT; 3A1G; 3CW4; 3WI0; 3WI1; 4ENF; 4J2R; 4U6O; 7JYW; 7JYX

PB2_I96A0

Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain

8H69; 9BL5; 9BL6

PB2_INBLE

Influenza B virus (strain B/Lee/1940) reference strain

5EF9; 5EFA; 5EFC; 6XQA

PB2_INCAA

Influenza C virus (strain C/Ann Arbor/1/1950) reference strain

PB2_I000F

Influenza A virus (strain A/Chicken/Weybridge H7N7) (Influenza A virus (strain A/FPV/Weybridge H7N7))

PB2_I000X

Influenza A virus (strain A/X-31 H3N2)

PB2_I00A0

Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)

PB2_I00A1

Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)

PB2_I02A0

Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)

PB2_I02A5

Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)

PB2_I02A6

Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)

5EG9; 9I2O

PB2_I02A7

Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)

PB2_I03A0

Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)

PB2_I03A1

Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)

PB2_I05A1

Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)

PB2_I06A0

Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)

PB2_I07A0

Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)

PB2_I18A0

Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))

7NHA; 7NHC; 7NHX; 7NI0; 7NIK; 7NIL; 7NIR; 7NIS; 7NJ3; 7NJ4; 7NJ5; 7NJ7; 7NK1; 7NK2; 7NK4; 7NK6; 7NK8; 7NKA; 7NKC; 7NKI; 7NKR; 8R60; 8R65

PB2_I30A0

Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)

PB2_I33A0

Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))

PB2_I34A0

Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)

PB2_I35A3

Influenza A virus (strain A/USA:Phila/1935 H1N1)

PB2_I36A0

Influenza A virus (strain A/Henry/1936 H1N1)

PB2_I40A0

Influenza A virus (strain A/Hickox/1940 H1N1)

PB2_I43A0

Influenza A virus (strain A/USA:Iowa/1943 H1N1)

PB2_I45A0

Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)

PB2_I47A0

Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)

PB2_I49A1

Influenza A virus (strain A/Duck/Germany/1949 H10N7)

PB2_I51A0

Influenza A virus (strain A/USA:Albany/12/1951 H1N1)

PB2_I54A2

Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)

PB2_I56A1

Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)

PB2_I56A2

Influenza A virus (strain A/Duck/England/1/1956 H11N6)

PB2_I56A3

Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)

PB2_I57A0

Influenza A virus (strain A/Japan/305/1957 H2N2)

PB2_I57A1

Influenza A virus (strain A/Leningrad/134/1957 H2N2)

PB2_I57A2

Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)

PB2_I57A3

Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)

PB2_I57A5

Influenza A virus (strain A/Singapore/1/1957 H2N2)

PB2_I59A0

Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)

PB2_I60A0

Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)

PB2_I61A1

Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)

PB2_I66A0

Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)

PB2_I66A1

Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)

PB2_I67A0

Influenza A virus (strain A/Tokyo/3/1967 H2N2)

PB2_I67A2

Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)

PB2_I68A3

Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)

PB2_I68A4

Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

4EQK

PB2_I68A5

Influenza A virus (strain A/Korea/426/1968 H2N2)

PB2_I68A6

Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))

6QNW; 6QPG; 6QX3; 6QX8; 6QXE; 6RR7; 8Y7M; 8Y7O

PB2_I69A0

Influenza A virus (strain A/England/878/1969 H3N2)

PB2_I70A0

Influenza A virus (strain A/Qu/7/1970 H3N2)

PB2_I71A1

Influenza A virus (strain A/Memphis/1/1971 H3N2)

PB2_I72A2

Influenza A virus (strain A/Udorn/307/1972 H3N2)

5WL0

PB2_I72A3

Influenza A virus (strain A/Memphis/102/1972 H3N2)

PB2_I72A4

Influenza A virus (strain A/Memphis/101/1972 H3N2)

PB2_I73A4

Influenza A virus (strain A/Equine/London/1416/1973 H7N7)

PB2_I73A5

Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)

PB2_I75A0

Influenza A virus (strain A/Beijing/39/1975 H3N2)

4YD0; 5BUH; 5F79; 5JUN; 5JUR

PB2_I75A3

Influenza A virus (strain A/Victoria/3/1975 H3N2)

2GMO; 2JDQ; 2VQZ; 2VY6; 2VY7; 2VY8; 4NCE; 4NCM; 4P1U; 4UAD; 4UAE; 4UAF; 6EUV; 6EUY; 7XME

PB2_I76A6

Influenza A virus (strain A/Memphis/110/1976 H3N2)

PB2_I77A4

Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)

PB2_I77AA

Influenza A virus (strain A/Brazil/11/1978 H1N1)

PB2_I77AB

Influenza A virus (strain A/USSR/90/1977 H1N1)

PB2_I77AC

Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)

PB2_I77AF

Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)

PB2_I77AG

Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)

PB2_I78A3

Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)

PB2_I78A7

Influenza A virus (strain A/Memphis/2/1978 H3N2)

PB2_I78A8

Influenza A virus (strain A/Memphis/18/1978 H3N2)

PB2_I79A4

Influenza A virus (strain A/Kiev/59/1979 H1N1)

PB2_I79A7

Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)

PB2_I80A2

Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)

PB2_I80A4

Influenza A virus (strain A/Memphis/4/1980 H3N2)

PB2_I80A6

Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)

PB2_I80A8

Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)

PB2_I80AA

Influenza A virus (strain A/India/6263/1980 H1N1)

PB2_I80AD

Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)

PB2_I82A3

Influenza A virus (strain A/Seal/Massachusetts/133/1982 H4N5)

PB2_I83A1

Influenza A virus (strain A/Chile/1/1983 H1N1)

PB2_I83A4

Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)

PB2_I83A5

Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)

PB2_I83A8

Influenza A virus (strain A/Hong Kong/5/1983 H3N2)

PB2_I84A4

Influenza A virus (strain A/Gull/Astrakhan/227/1984 H13N6)

PB2_I85A3

Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)

PB2_I85A7

Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)

PB2_I86A2

Influenza A virus (strain A/Equine/Kentucky/2/1986 H3N8)

PB2_I88A3

Influenza A virus (strain A/Memphis/8/1988 H3N2)

PB2_I93A0

Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)

PB2_I96A2

Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)

PB2_I96A3

Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)

PB2_I97A1

Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

PB2_INBAC

Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])

PB2_INBAD

Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])

PB2_INBP9

Influenza B virus (strain B/Panama/45/1990)

6QWL

PB2_INCBE

Influenza C virus (strain C/Berlin/1/1985)

PB2_INCJH

Influenza C virus (strain C/Johannesburg/1/1966)

5D98; 5D9A; 6F5P; 6XZD; 6XZG; 6XZP; 6XZQ; 6XZR; 6Y0C

PB2_INCJJ

Influenza C virus (strain C/JJ/1950)

5 entries

Genome polyprotein

POLG_POL1S

Poliovirus type 1 (strain Sabin)

8E8Z

POLG_POL2L

Poliovirus type 2 (strain Lansing)

1EAH; 3EPF

POLG_POL2W

Poliovirus type 2 (strain W-2)

POLG_POL32

Poliovirus type 3 (strain 23127)

POLG_POL3L

Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

1PIV; 1PVC; 1VBA; 1VBB; 1VBC; 1VBE; 3EPD; 3IYB; 3IYC; 5O5B; 5O5P; 8E8R; 8E8X

25 entries

Polyprotein P1234 (P1234) (Non-structural polyprotein)

POLN_CHIKS

Chikungunya virus (strain S27-African prototype) (CHIKV) reference strain

3GPG; 3GPO; 3GPQ; 3TRK; 4TU0; 5I22; 6VUQ; 6W7H; 6W8K; 6W8M; 6W8Q; 6W8Y; 6W8Z; 6W91; 6Z0U; 6Z0V; 7DOP; 7FGG; 7FGH; 7FGI; 7H6J; 7H6K; 7H6L; 7H6M; 7H6N; 7H6O; 7H6P; 7H6Q; 7H6R; 7H6S; 7H6T; 7H6U; 7H6V; 7H6W; 7H6X; 7H6Y; 7H6Z; 7H70; 7H71; 7H72; 7H73; 7H74; 7H75; 7H76; 7H77; 7H78; 7H79; 7H7A; 7H7B; 7H7C; 7H7D; 7H7E; 7H7F; 7H7G; 7H7H; 7H7I; 7H7J; 7H7K; 7H7L; 7H7M; 7H7N; 7H7O; 7H7P; 7H7Q; 7H7R; 7H7S; 7H7T; 7H7U; 7H7V; 7H7W; 7H7X; 7H7Y; 7H7Z; 7H80; 7H81; 7H82; 7H83; 7H84; 7H85; 7H86; 7H87; 7H88; 7H89; 7H8A; 7H8B; 7H8C; 7H8D; 7H8E; 7H8F; 7H8G; 7H8H; 7H8I; 7H8J; 7H8K; 7H8L; 7H8M; 7H8N; 7H8O; 7H8P; 7H8Q; 7H8R; 7H8S; 7H8T; 7H8U; 7H8V; 7H8W; 7H8X; 7H8Y; 7H8Z; 7H90; 7H91; 7H92; 7H93; 7H94; 7H95; 7H96; 7H97; 7H98; 7H99; 7H9A; 7H9B; 7H9C; 7H9D; 7H9E; 7H9F; 7H9G; 7H9H; 7H9I; 7H9J; 7HIA; 7HIB; 7HIC; 7HID; 7HIE; 7HIF; 7HIG; 7HIH; 7HII; 7HIJ; 7HIK; 7HIL; 7HIM; 7HIN; 7HIO; 7HIP; 7HIQ; 7HIR; 7HIS; 7HIT; 7HIU; 7HIV; 7HIW; 7HIX; 7P27; 7X01; 8AOV; 8AOW; 8AOX; 8APX; 8AXV; 8JCE; 8PHZ; 8PK7

POLN_SFV

Semliki forest virus (SFV) reference strain

1FW5; 5DRV; 5FW5

POLN_SINDV

Sindbis virus (SINV) reference strain

Polyprotein P1234 (P1234) (Non-structural polyprotein) (p270 nonstructural polyprotein)

4GUA; 7VB4; 7VW5

POLN_AURAV

Aura virus (AURAV)

POLN_BFV

Barmah forest virus (BFV)

POLN_CHIK3

Chikungunya virus (strain 37997) (CHIKV)

6W0T

POLN_EEEV1

Eastern equine encephalitis virus (strain PE-0.0155) (EEEV) (Eastern equine encephalomyelitis virus)

7OJ9

POLN_EEEV8

Eastern equine encephalitis virus (strain PE-3.0815) (EEEV) (Eastern equine encephalomyelitis virus)

POLN_EEEVF

Eastern equine encephalitis virus (strain Florida 91-469) (EEEV) (Eastern equine encephalomyelitis virus)

POLN_EEVV

Venezuelan equine encephalitis virus (VEEV)

POLN_EEVV3

Venezuelan equine encephalitis virus (strain 3880) (VEEV)

POLN_EEVVM

Venezuelan equine encephalitis virus (strain Mena II) (VEEV)

POLN_EEVVP

Venezuelan equine encephalitis virus (strain P676) (VEEV)

3GQE; 3GQO; 5ISN; 5MQX

POLN_EEVVT

Venezuelan equine encephalitis virus (strain Trinidad donkey) (VEEV)

2HWK; 5EZQ; 5EZS; 6BCM; 8DUF; 8T8N

POLN_GETV

Getah virus (GETV)

6QZU; 6R0F; 6R0G; 6R0P; 6R0R; 6R0T

POLN_MAYAB

Mayaro virus (strain Brazil) (MAYV)

5IQ5

POLN_ONNVG

O'nyong-nyong virus (strain Gulu) (ONNV)

POLN_ONNVI

O'nyong-nyong virus (strain Igbo Ora) (ONNV) (Igbo Ora virus)

POLN_ONNVS

O'nyong-nyong virus (strain SG650) (ONNV)

7Y38

POLN_RRVN

Ross river virus (strain NB5092) (RRV)

POLN_SAGV

Sagiyama virus (SAGV)

POLN_SAV1

Alphavirus salmon subtype 1 (SAV1) (Salmon pancreas disease virus subtype 1)

POLN_SAV2

Alphavirus salmon subtype 2 (SAV2) (Sleeping disease virus)

POLN_SINDO

Sindbis virus subtype Ockelbo (strain Edsbyn 82-5) (OCKV) (Ockelbo virus)

POLN_WEEV

Western equine encephalitis virus (WEEV)

12 entries

Structural polyprotein (p130)

POLS_EEEV

Eastern equine encephalitis virus (EEEV) (Eastern equine encephalomyelitis virus)

6XO4; 6XOB; 8DWO; 8UA4; 8UA9; 8UFA; 8UFB; 8UFC

POLS_EEEV1

Eastern equine encephalitis virus (strain PE-0.0155) (EEEV) (Eastern equine encephalomyelitis virus)

POLS_EEEV3

Eastern equine encephalitis virus (strain va33[ten broeck]) (EEEV) (Eastern equine encephalomyelitis virus)

6MX4; 6MX7

POLS_EEEV8

Eastern equine encephalitis virus (strain PE-3.0815) (EEEV) (Eastern equine encephalomyelitis virus)

POLS_EEEVF

Eastern equine encephalitis virus (strain Florida 91-469) (EEEV) (Eastern equine encephalomyelitis virus)

6MW9; 6MWC; 6MWV; 6MWX; 6MX4; 6ODF; 6XO4; 6XOB; 7N69; 7N6A; 7V0N; 7V0O; 7V0P; 8XI4; 8XI5; 8YS2; 8YS4

POLS_EEVV3

Venezuelan equine encephalitis virus (strain 3880) (VEEV)

POLS_EEVV8

Venezuelan equine encephalitis virus (strain TC-83) (VEEV)

1EP5; 1EP6; 3J0C; 3J0G; 7FFE; 7FFF; 7FFL; 7FFN; 7FFO; 7FFQ; 7N1I; 7SFU; 7SFV; 7SFW; 8DEQ; 8DER; 8EEU; 8EEV

POLS_EEVVE

Venezuelan equine encephalitis virus (strain Everglades Fe3-7c) (VEEV)

POLS_EEVVM

Venezuelan equine encephalitis virus (strain Mena II) (VEEV)

POLS_EEVVP

Venezuelan equine encephalitis virus (strain P676) (VEEV)

POLS_EEVVT

Venezuelan equine encephalitis virus (strain Trinidad donkey) (VEEV)

3VE6

POLS_WEEV

Western equine encephalitis virus (WEEV)

8DEC; 8DED; 8DEE; 8DEF; 8DUL; 8DUN; 8SQN

99 entries

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)

RDRP_I34A1

Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

2ZNL; 2ZTT; 3A1G; 9IM6

RDRP_I96A0

Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain

3J9B; 8H69; 8WO9

RDRP_INBLE

Influenza B virus (strain B/Lee/1940) reference strain

RDRP_INCAA

Influenza C virus (strain C/Ann Arbor/1/1950) reference strain

RDRP_I000X

Influenza A virus (strain A/X-31 H3N2)

RDRP_I00A0

Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)

RDRP_I00A1

Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)

RDRP_I01A0

Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)

RDRP_I01A3

Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)

RDRP_I02A2

Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)

RDRP_I02A3

Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)

RDRP_I02A4

Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

RDRP_I02A6

Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)

RDRP_I02A7

Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)

RDRP_I03A0

Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)

RDRP_I03A1

Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)

RDRP_I05A1

Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)

RDRP_I06A0

Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)

RDRP_I07A0

Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)

RDRP_I18A0

Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))

7NHA; 7NHC; 7NHX; 7NI0; 7NIK; 7NIL; 7NIR; 7NIS; 7NJ3; 7NJ4; 7NJ5; 7NJ7; 7NK1; 7NK2; 7NK4; 7NK6; 7NK8; 7NKA; 7NKC; 7NKI; 7NKR; 8R60; 8R65

RDRP_I33A0

Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))

RDRP_I35A3

Influenza A virus (strain A/USA:Phila/1935 H1N1)

RDRP_I36A0

Influenza A virus (strain A/Henry/1936 H1N1)

RDRP_I40A0

Influenza A virus (strain A/Hickox/1940 H1N1)

RDRP_I43A0

Influenza A virus (strain A/USA:Iowa/1943 H1N1)

RDRP_I45A0

Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)

RDRP_I47A0

Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)

RDRP_I49A1

Influenza A virus (strain A/Duck/Germany/1949 H10N7)

RDRP_I51A0

Influenza A virus (strain A/USA:Albany/12/1951 H1N1)

RDRP_I54A2

Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)

RDRP_I56A0

Influenza A virus (strain A/Beijing/11/1956 H1N1)

RDRP_I56A1

Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)

RDRP_I56A2

Influenza A virus (strain A/Duck/England/1/1956 H11N6)

RDRP_I57A0

Influenza A virus (strain A/Japan/305/1957 H2N2)

RDRP_I57A1

Influenza A virus (strain A/Leningrad/134/1957 H2N2)

RDRP_I57A2

Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)

RDRP_I57A3

Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)

RDRP_I57A5

Influenza A virus (strain A/Singapore/1/1957 H2N2)

RDRP_I59A0

Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)

RDRP_I60A0

Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)

RDRP_I61A1

Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)

RDRP_I66A0

Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)

RDRP_I66A1

Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)

RDRP_I67A0

Influenza A virus (strain A/Tokyo/3/1967 H2N2)

RDRP_I67A2

Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)

RDRP_I68A3

Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)

RDRP_I68A4

Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

6QX3; 8Y7M; 8Y7O

RDRP_I68A5

Influenza A virus (strain A/Korea/426/1968 H2N2)

RDRP_I68A6

Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))

6QNW; 6QPG; 6QX8; 6QXE; 6RR7

RDRP_I69A0

Influenza A virus (strain A/England/878/1969 H3N2)

RDRP_I70A0

Influenza A virus (strain A/Qu/7/1970 H3N2)

RDRP_I71A1

Influenza A virus (strain A/Memphis/1/1971 H3N2)

RDRP_I72A2

Influenza A virus (strain A/Udorn/307/1972 H3N2)

RDRP_I72A3

Influenza A virus (strain A/Memphis/102/1972 H3N2)

RDRP_I72A4

Influenza A virus (strain A/Memphis/101/1972 H3N2)

RDRP_I73A4

Influenza A virus (strain A/Equine/London/1416/1973 H7N7)

RDRP_I73A5

Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)

RDRP_I73A6

Influenza A virus (strain A/Dunedin/4/1973 H3N2)

RDRP_I75A0

Influenza A virus (strain A/Beijing/39/1975 H3N2)

RDRP_I75A3

Influenza A virus (strain A/Victoria/3/1975 H3N2)

RDRP_I76A6

Influenza A virus (strain A/Memphis/110/1976 H3N2)

RDRP_I77A4

Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)

RDRP_I77AA

Influenza A virus (strain A/Brazil/11/1978 H1N1)

RDRP_I77AB

Influenza A virus (strain A/USSR/90/1977 H1N1)

RDRP_I77AD

Influenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)

RDRP_I77AF

Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)

RDRP_I78A3

Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)

RDRP_I78A7

Influenza A virus (strain A/Memphis/2/1978 H3N2)

RDRP_I78A8

Influenza A virus (strain A/Memphis/18/1978 H3N2)

8RNH

RDRP_I78AC

Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)

RDRP_I79A4

Influenza A virus (strain A/Kiev/59/1979 H1N1)

RDRP_I79A7

Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)

RDRP_I80A2

Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)

RDRP_I80A4

Influenza A virus (strain A/Memphis/4/1980 H3N2)

RDRP_I80A6

Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)

RDRP_I80A8

Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)

RDRP_I80AA

Influenza A virus (strain A/India/6263/1980 H1N1)

RDRP_I80AD

Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)

RDRP_I81A4

Influenza A virus (strain A/Swine/Ontario/2/1981 H1N1)

RDRP_I82A4

Influenza A virus (strain A/Swine/Hong Kong/126/1982 H3N2)

RDRP_I83A1

Influenza A virus (strain A/Chile/1/1983 H1N1)

RDRP_I83A4

Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)

RDRP_I83A5

Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)

RDRP_I83A6

Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)

RDRP_I83A8

Influenza A virus (strain A/Hong Kong/5/1983 H3N2)

RDRP_I85A3

Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)

RDRP_I86A3

Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)

RDRP_I88A3

Influenza A virus (strain A/Memphis/8/1988 H3N2)

RDRP_I88A7

Influenza A virus (strain A/Wisconsin/3523/1988 H1N1)

RDRP_I93A0

Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)

RDRP_I96A2

Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)

RDRP_I96A3

Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)

RDRP_I97A0

Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)

RDRP_I97A1

Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

3CM8; 7WT4; 7WT5

RDRP_INBAC

Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])

RDRP_INBAD

Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])

RDRP_INBP9

Influenza B virus (strain B/Panama/45/1990)

6QWL

RDRP_INCJH

Influenza C virus (strain C/Johannesburg/1/1966)

5D98; 5D9A; 6F5P; 6XZD; 6XZG; 6XZP; 6XZQ; 6XZR; 6Y0C

RDRP_INCJJ

Influenza C virus (strain C/JJ/1950)

1 entry

Eukaryotic host transcription shutoff by virus (kw:KW-1191)

Viruses inhibiting transcription:

Matching UniProtKB/Swiss-Prot entries

Early E1A protein (Early E1A 32 kDa protein)

Transcriptional regulator ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

Non-structural protein NS-S

Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

Genome polyprotein

Polyprotein P1234 (P1234) (Non-structural polyprotein)

Structural polyprotein (p130)

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)

RNAP inhibitory protein (RIP) (ORF145)