Eukaryotic host gene expression shutoff by virus (kw:KW-1262)
Viruses are in competition with the host for the cellular translation machinery, prompting some viruses to inhibit host cell gene expression. Preventing the expression of host proteins is also a strategy to counteract the antiviral response .

Some viruses encode proteins which prevent host gene expression by blocking host transcription, suppressing mRNAs or translation.
Virus-induced host gene shutoff in animals and plants.
Aranda M, Maule A.
Virology. 1998 Apr 10;243(2):261-7. Review. PubMed PMID: 9568025
Aranda M, Maule A.
Virology. 1998 Apr 10;243(2):261-7. Review. PubMed PMID: 9568025
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)789 entries grouped by protein
6 entries
Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
5 entries
mRNA-decapping protein g5R (g5Rp) (EC 3.1.3.-) (ASFV-DP) (Diphosphoinositol polyphosphate phosphohydrolase) (DIPP) (EC 3.6.1.52)
2 entries
Early E1A protein (Early E1A 32 kDa protein)
3 entries
Transcriptional regulator ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)
3 entries
mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)
6 entries
Matrix protein (M protein)
5 entries
Nucleoprotein (Nucleocapsid protein) (Protein N)
119 entries
Non-structural protein 1 (NS1) (NS1A)
3 entries
Host translation inhibitor 5b (ns5b) (Accessory protein 5b)
6 entries
Non-structural protein NS-S
98 entries
Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
90 entries
Protein PA-X
97 entries
Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
2 entries
Protein OPG173
75 entries
Gag-Pol polyprotein (Pr160Gag-Pol)
59 entries
Genome polyprotein
25 entries
Polyprotein P1234 (P1234) (Non-structural polyprotein)
12 entries
Structural polyprotein (p130)
6 entries
Gag-Pro polyprotein (Pr76Gag-Pro)
21 entries
Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
21 entries
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
99 entries
RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)
1 entry
RNAP inhibitory protein (RIP) (ORF145)
22 entries
Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
1 entry
Small t antigen (ST) (ST-AG)
2 entries