Modulation of host cell cycle by virus (kw:KW-1121)
The "normal" cell cycle is characterized by the series of events that take place in a cell leading to its division. Resting cells that are not dividing are in a phase called G0. During division, the cell undergoes 4 distinct stages termed G1, S, G2, and M. In G1, the cell grows in size and prepares for DNA synthesis. During the S phase, the DNA replication takes place. In G2, the cell continues to grow and prepare for division that occurs in the M (mitosis) phase which is the process by which the cell separates the chromosomes in its cell nucleus into two identical sets, followed by cytokinesis, which divides the nuclei, cytoplasm, organelles and cell membrane into two daughter cells.

Many viruses subvert the cell cycle to their advantage. They usually target specific steps of the cycle to improve viral replication. For instance, some viruses are able to induce a G1 to S phase transition in order to replicate their genome at the same time of cellular DNA synthesis. Other viruses can induce a G2/M arrest in some cases to provide an optimized cellular environment for maximal levels of viral replication.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)412 entries grouped by protein
3 entries
Lytic switch protein BZLF1 (EB1) (Protein Z) (Trans-activator protein BZLF1) (Zebra) (Zta) (bZIP transcription factor ZEBRA)
3 entries
Cytoplasmic envelopment protein 2 (Tegument protein BGLF2)
1 entry
Cyclin homolog (V-cyclin)
1 entry
Retroviral cyclin (Rv-cyclin) (ORF-A protein)
1 entry
G2/M cell-cycle inhibitor DR6
14 entries
Early E1A protein (Early E1A 20 kDa protein)
1 entry
Occlusion-derived virus envelope protein E27 (ODV-E27)
1 entry
Probable early E4 13 kDa protein
3 entries
DNA polymerase processivity factor BMRF1 (Early Antigen Diffused) (EA-D) (Polymerase accessory subunit)
3 entries
Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
3 entries
Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) (EBNA-3C) (EBV nuclear antigen 3C) (Epstein-Barr nuclear antigen 4B) (EBNA-4B) (EBV nuclear antigen 4B)
2 entries
GemA protein (Gene product 16) (gp16)
1 entry
Gene product 168 (gp168)
1 entry
Gene product 8 (gp8)
7 entries
E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ubiquitin transferase ICP0)
5 entries
mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)
1 entry
45 kDa immediate-early protein 2 (IE2)
1 entry
E3 SUMO-protein ligase K-bZIP (EC 2.3.2.-) (E3 SUMO-protein transferase K-bZIP)
20 entries
Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
1 entry
Protein MC007
1 entry
Oncoprotein MEQ (MEQ)
1 entry
Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)
2 entries
Nucleoprotein (N protein) (Nucleocapsid protein) (p38) (p40)
7 entries
Nucleoid disruption protein (Nuclear disruption protein)
11 entries
Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) (Non-structural protein 1) (Non-structural protein NS1)
4 entries
Non-structural protein 3b (ns3b) (Accessory protein 3b)
6 entries
Protein 7a (Accessory protein 7a)
1 entry
Non-structural protein NS-S (NSs)
1 entry
Occlusion-derived virus envelope protein E27 (ODV-E27)
1 entry
Non-structural protein ORF4a (ORF4a)
3 entries
Ankyrin repeat domain-containing protein OPG023 (Host range protein 1)
32 entries
Genome polyprotein
2 entries
Protein pp71
1 entry
Protein Rep68 (EC 3.6.4.12)
1 entry
Protein Rep78
14 entries
Replication-associated protein A (RepA) (EC 3.1.21.-)
3 entries
Protein sigma-1-small (Sigma1s) (Sigma-s) (Sigma1NS) (Sigma1bNS) (p14)
7 entries
Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of HTLV-1)
4 entries
Protein UL24 homolog
1 entry
Protein UL27
2 entries
Protein UL76
4 entries
Serine/threonine protein kinase M97 (EC 2.7.11.1)
29 entries
Protein E4
79 entries
Protein E7
2 entries
Host translation inhibitor E66L (pE66L)
3 entries
Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
4 entries
Viral transcription factor IE2 (IE2) (Protein UL122)
1 entry
Immediate-early protein 3 (IE3)
5 entries
Apoptin
52 entries
Protein Vpr (R ORF protein) (Viral protein R)
55 entries