Varicellovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 125 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' non-translated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter.

Transcription occurs in three steps: immediate-early, early and late. The immediate-early genes are transcribed immediately after infection and ensure the transcription of early genes, which encode the proteins necessary for the viral replication. The late genes mostly encode structural proteins.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Innate immune response inhibition

Varicella virus inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein. Several viral proteins including ORF61, ORF47 and IE62 prevent IRF3 activation and subsequent induction of IFN-beta expression .

Adaptive immune response inhibition

Infected cells show a decrease in MHC class I peptide presentation at the cell surface. Although the mechanism is not fully understood, the ORF66 participates in this process .

Autophagy modulation

Varicella virus does not seem to modulate autophagy that occur in infected cells .

Host shut-off

Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex.

Cell-cycle modulation

The HHV-1 UL24 homolog may inhibit the host cell cycle at the G2/M transition since UL24 from alpha-, beta-, and gammaherpesvirus all inhibit host cell cycle through inactivation of the cyclinB/cdc2 complex .

Apoptosis modulation

The viral protein ORF12 protein triggers phosphorylation of host ERK1/2 and inhibits apoptosis. In neurons, ORF63 also participates in the inhibition of apoptosis .

Host splicing inhibition

VZV IE4 is an alternative splicing regulator of host mRNA. It may act by binding with SR proteins .

Matching UniProtKB/Swiss-Prot entries

365 entries grouped by strain (browse by keywords)

All proteins are shown (view only 240 complete proteome entries)

69 entries

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Select_allDeselect_all
NP04_VZVD Nuclear protein UL4 homolog (ORF56 protein)
CEP2_VZVD Cytoplasmic envelopment protein 2
CEP1_VZVD Cytoplasmic envelopment protein 1
CEP3_VZVD Cytoplasmic envelopment protein 3
ORF57_VZVD Uncharacterized protein 57 (Uncharacterized ORF57 protein)
ORF1_VZVD Structural protein 1 (Structural ORF1 protein)
ORF2_VZVD Membrane protein 2 (Membrane ORF2 protein)
ORF32_VZVD Phosphoprotein 32 (ORF32 Phosphoprotein)
ORF0_VZVD Membrane protein 0 (Membrane ORF0 protein) (ORF S/L)
PRIM_VZVD DNA primase (EC 2.7.7.-)
PAP_VZVD DNA polymerase processivity factor (DNA-binding gene 16 protein) (Polymerase accessory protein) ...
NP03_VZVD Nuclear phosphoprotein UL3 homolog (ORF58 protein)
NEC1_VZVD Nuclear egress protein 1
PORTL_VZVD Portal protein
SCP_VZVD Small capsomere-interacting protein
SHUT_VZVD Virion host shutoff protein (Vhs) (EC 3.1.27.-)
RIR2_VZVD Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
TEG5_VZVD Tegument protein UL47 homolog
TEG1_VZVD Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG7_VZVD Tegument protein UL51 homolog (ORF7 protein)
TEG4_VZVD Tegument protein UL21 homolog
TEG6_VZVD Tegument protein UL55 homolog
SCAF_VZVD Capsid scaffolding protein (Protease precursor) (pPR) [Cleaved into: Assemblin (EC 3.4.21.97) ...
TRM2_VZVD Tripartite terminase subunit 2
TRM3_VZVD Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit) [Cleaved into: Gene 42 ...
TRX1_VZVD Triplex capsid protein 1
TRM1_VZVD Tripartite terminase subunit 1
RIR1_VZVD Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
OBP_VZVD Replication origin-binding protein (OBP) (OriBP)
NEC2_VZVD Nuclear egress protein 2
DNBI_VZVD Major DNA-binding protein
DUT_VZVD Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
CVC2_VZVD Capsid vertex component 2
DPOL_VZVD DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
AN_VZVD Alkaline nuclease (EC 3.1.-.-)
CVC1_VZVD Capsid vertex component 1
ICP27_VZVD mRNA export factor ICP27 homolog (Immediate-early protein 4) (IE4) (Transcriptional transactivator ...
IE61_VZVD E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61) (RING-type E3 ...
ICP22_VZVD Transcriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) (Transcriptional ...
ICP4_VZVD Major viral transcription factor ICP4 homolog (Immediate-early protein 62) (IE62)
GH_VZVD Envelope glycoprotein H (gH)
GN_VZVD Envelope glycoprotein N
GL_VZVD Envelope glycoprotein L (gL)
GB_VZVD Envelope glycoprotein B (gB)
GC_VZVD Envelope glycoprotein C (gC) (Glycoprotein V) (gpV)
ITP_VZVD Inner tegument protein
LTP_VZVD Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MB43_VZVD Membrane protein UL43 homolog (Membrane protein ORF15)
MCP_VZVD Major capsid protein (MCP)
KITH_VZVD Thymidine kinase (EC 2.7.1.21)
HEPA_VZVD DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
TRX2_VZVD Triplex capsid protein 2
VP22_VZVD Tegument protein VP22 (ORF9 protein) (Tegument protein 9)
UL20_VZVD Protein UL20 homolog (Gene 39 membrane protein)
GE_VZVD Envelope glycoprotein E (gE)
GI_VZVD Envelope glycoprotein I (gI) (Glycoprotein IV) (GPIV)
GM_VZVD Envelope glycoprotein M (gM)
GK_VZVD Envelope glycoprotein K (Syncytial protein)
HELI_VZVD DNA replication helicase (EC 3.6.4.-)
TEG3_VZVD Tegument protein UL14 homolog
US03_VZVD Serine/threonine-protein kinase US3 homolog (Protein kinase ORF66) (EC 2.7.11.1)
VP16_VZVD Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF) (ORF10 protein) (Tegument ...
UL13_VZVD Serine/threonine-protein kinase UL13 homolog (Protein kinase ORF47) (EC 2.7.11.1)
UL32_VZVD Packaging protein UL32
UNG_VZVD Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US9_VZVD Envelope protein US9 (Envelope protein 65) (ORF65 protein)
US10_VZVD Virion protein US10 homolog (Genes 64/69 protein)
TYSY_VZVD Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
UL24_VZVD Protein UL24 homolog

1 entry

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3) reference strain

ORF0_VZVO Membrane protein 0 (Membrane ORF0 protein) (ORF S/L)

1 entry

Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus) reference strain

TEG1_EHV4 Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)

2 entries

Cercopithecine herpesvirus 9 (strain DHV) (CeHV-9) (Simian varicella virus) reference strain

Select_allDeselect_all
IE61_CHV9D E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61)
US9_CHV9D Envelope protein US9 homolog (Envelope protein 65) (ORF65 protein)

75 entries

Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
CEP3_EHV1B Cytoplasmic envelopment protein 3
CEP1_EHV1B Cytoplasmic envelopment protein 1
CEP2_EHV1B Cytoplasmic envelopment protein 2
OBP_EHV1B Replication origin-binding protein (OriBP) (OBP)
RIR2_EHV1B Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
PAP_EHV1B DNA polymerase processivity factor (DNA-binding gene 18 protein) (Polymerase accessory protein) ...
NEC2_EHV1B Nuclear egress protein 2
NP03_EHV1B Nuclear phosphoprotein UL3 homolog (ORF60 protein)
NP04_EHV1B Nuclear protein UL4 homolog
PORTL_EHV1B Portal protein
PRIM_EHV1B DNA primase (EC 2.7.7.-)
SCP_EHV1B Small capsomere-interacting protein
SHUT_EHV1B Virion host shutoff protein (Vhs) (EC 3.1.27.-)
TEG1_EHV1B Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG3_EHV1B Tegument protein UL14 homolog
TEG5_EHV1B Tegument protein UL47 homolog (GP10)
TEG7_EHV1B Tegument protein UL51 homolog
TEG6_EHV1B Tegument protein UL55 homolog
SCAF_EHV1B Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural gene ...
TRM3_EHV1B Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_EHV1B Triplex capsid protein 1
TRM2_EHV1B Tripartite terminase subunit 2
RIR1_EHV1B Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
NEC1_EHV1B Nuclear egress protein 1
DNBI_EHV1B Major DNA-binding protein
DPOL_EHV1B DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
DUT_EHV1B Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EV45_EHV1B Envelope protein UL45 homolog
CVC1_EHV1B Capsid vertex component 1
CVC2_EHV1B Capsid vertex component 2
ICP4_EHV1B Major viral transcription factor (155 kDa immediate-early protein)
ICP27_EHV1B mRNA export factor ICP27 homolog (Transcriptional regulator IE63 homolog)
ICP22_EHV1B Transcriptional regulator ICP22 homolog (IR4 protein) (Immediate-early protein IE68) (In vitro ...
ICP0_EHV1B E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ICP0)
GC_EHV1B Envelope glycoprotein C (gC) (Glycoprotein 13)
GK_EHV1B Envelope glycoprotein K (Syncytial protein)
GL_EHV1B Envelope glycoprotein L (gL)
GM_EHV1B Envelope glycoprotein M (gM)
GP2_EHV1B Glycoprotein gp2 (Glycoprotein X) (GpX)
GN_EHV1B Envelope glycoprotein N
GD_EHV1B Envelope glycoprotein D (gD) (Glycoprotein 17/18)
ITP_EHV1B Inner tegument protein
KITH_EHV1B Thymidine kinase (EC 2.7.1.21)
LTP_EHV1B Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_EHV1B Major capsid protein (MCP)
MB43_EHV1B Membrane protein UL43 homolog (Membrane protein ORF17)
GB_EHV1B Envelope glycoprotein B (gB)
GE_EHV1B Envelope glycoprotein E (gE)
GI_EHV1B Envelope glycoprotein I
HEPA_EHV1B DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
AN_EHV1B Alkaline nuclease (EC 3.1.-.-)
VG59_EHV1B Uncharacterized gene 59 protein
TRX2_EHV1B Triplex capsid protein 2
US10_EHV1B Virion protein US10 homolog (Gene 66 protein)
UL13_EHV1B Serine/threonine-protein kinase UL13 homolog (EC 2.7.11.1)
UL32_EHV1B Packaging protein UL32 homolog
VG03_EHV1B Gene 3 protein
GG_EHV1B Envelope glycoprotein G (gG)
GH_EHV1B Envelope glycoprotein H (gH)
HELI_EHV1B DNA replication helicase (EC 3.6.4.-)
TEG4_EHV1B Tegument protein UL21 homolog
VP22_EHV1B Tegument protein VP22 (Gene 11 protein)
VG01_EHV1B Uncharacterized gene 1 protein
VG02_EHV1B Uncharacterized gene 2 protein
US02_EHV1B Gene 68 protein
VG67_EHV1B Uncharacterized gene 67 protein (IR6 protein)
VP16_EHV1B Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF)
US03_EHV1B Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
VG75_EHV1B Uncharacterized gene 75 protein
UNG_EHV1B Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US9_EHV1B Envelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
TRM1_EHV1B Tripartite terminase subunit 1
VG34_EHV1B Gene 34 protein
UL24_EHV1B Protein UL24 homolog
UL20_EHV1B Protein UL20 homolog

47 entries

Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
CEP1_EHV1V Cytoplasmic envelopment protein 1
CEP2_EHV1V Cytoplasmic envelopment protein 2
CEP3_EHV1V Cytoplasmic envelopment protein 3
OBP_EHV1V Replication origin-binding protein (OBP) (OriBP)
PRIM_EHV1V DNA primase (EC 2.7.7.-)
PAP_EHV1V DNA polymerase processivity factor (Polymerase accessory protein) (PAP)
NP03_EHV1V Nuclear phosphoprotein UL3 homolog (ORF60 protein)
NP04_EHV1V Nuclear protein UL4 homolog
PORTL_EHV1V Portal protein
SHUT_EHV1V Virion host shutoff protein (Vhs) (EC 3.1.27.-)
TEG4_EHV1V Tegument protein UL21 homolog
TEG1_EHV1V Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG5_EHV1V Tegument protein UL47 homolog (GP10)
TEG3_EHV1V Tegument protein UL14 homolog
SCP_EHV1V Small capsomere-interacting protein
SCAF_EHV1V Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
TRX1_EHV1V Triplex capsid protein 1
TRM3_EHV1V Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRM1_EHV1V Tripartite terminase subunit 1
NEC2_EHV1V Nuclear egress protein 2
DNBI_EHV1V Major DNA-binding protein
DPOL_EHV1V DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
CVC2_EHV1V Capsid vertex component 2
AN_EHV1V Alkaline nuclease (EC 3.1.-.-)
ICP0_EHV1V E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Infected cell protein 0) (RING-type E3 ubiquitin ...
ICP4_EHV1V Major viral transcription factor ICP4 homolog (155 kDa immediate-early protein)
GG_EHV1V Envelope glycoprotein G (gG)
GL_EHV1V Envelope glycoprotein L (gL)
GN_EHV1V Envelope glycoprotein N
GP2_EHV1V Glycoprotein gp2 (Glycoprotein X) (GpX)
ITP_EHV1V Inner tegument protein
MB43_EHV1V Membrane protein UL43 homolog (Membrane protein ORF17)
MCP_EHV1V Major capsid protein (MCP)
GB_EHV1V Envelope glycoprotein B (gB)
HEPA_EHV1V DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
VG75_EHV1V Uncharacterized gene 75 protein
UL13_EHV1V Serine/threonine-protein kinase UL13 homolog (EC 2.7.11.1)
UL24_EHV1V Protein UL24 homolog
HELI_EHV1V DNA replication helicase (EC 3.6.4.-)
US03_EHV1V Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
US10_EHV1V Virion protein US10 homolog (Gene 66 protein)
VG03_EHV1V Gene 3 protein
US9_EHV1V Envelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
VG01_EHV1V Uncharacterized gene 1 protein
VG59_EHV1V Uncharacterized gene 59 protein
UL20_EHV1V Protein UL20 homolog
UNG_EHV1V Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

45 entries

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

Select_allDeselect_all
NP04_VZVO Nuclear protein UL4 homolog (ORF56 protein)
CEP3_VZVO Cytoplasmic envelopment protein 3
ORF1_VZVO Structural protein 1 (Structural ORF1 protein)
ORF2_VZVO Membrane protein 2 (Membrane ORF2 protein)
RIR1_VZVO Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
PAP_VZVO DNA polymerase processivity factor (DNA-binding gene 16 protein) (Polymerase accessory protein) ...
ORF57_VZVO Uncharacterized protein 57 (Uncharacterized ORF57 protein)
NP03_VZVO Nuclear phosphoprotein UL3 homolog (ORF58 protein)
PRIM_VZVO DNA primase (EC 2.7.7.-)
TEG5_VZVO Tegument protein UL47 homolog
TEG7_VZVO Tegument protein UL51 homolog (Protein ORF7)
TEG1_VZVO Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG4_VZVO Tegument protein UL21 homolog
TEG6_VZVO Tegument protein UL55 homolog
RIR2_VZVO Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
OBP_VZVO Replication origin-binding protein (OBP) (OriBP)
ORF32_VZVO Phosphoprotein 32 (ORF32 Phosphoprotein)
DNBI_VZVO Major DNA-binding protein
DPOL_VZVO DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
DUT_VZVO Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
ICP4_VZVO Major viral transcription factor ICP4 homolog (Immediate-early protein 62) (IE62)
ICP22_VZVO Transcriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) (Transcriptional ...
GK_VZVO Envelope glycoprotein K (Syncytial protein)
GM_VZVO Envelope glycoprotein M (gM)
GN_VZVO Envelope glycoprotein N
GB_VZVO Envelope glycoprotein B (gB)
ICP27_VZVO mRNA export factor ICP27 homolog (Immediate-early protein 4) (IE4)
MB43_VZVO Membrane protein UL43 homolog (Membrane protein ORF15)
LTP_VZVO Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
KITH_VZVO Thymidine kinase (EC 2.7.1.21)
GI_VZVO Envelope glycoprotein I (gI) (Glycoprotein IV) (GPIV)
AN_VZVO Alkaline nuclease (EC 3.1.-.-)
VP16_VZVO Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF) (ORF10 protein) (Tegument ...
UL13_VZVO Serine/threonine-protein kinase UL13 homolog (Protein kinase ORF47) (EC 2.7.11.1)
UNG_VZVO Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
TYSY_VZVO Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
GE_VZVO Envelope glycoprotein E (gE)
HELI_VZVO DNA replication helicase (EC 3.6.4.-)
GH_VZVO Envelope glycoprotein H (gH)
GL_VZVO Envelope glycoprotein L (gL)
HEPA_VZVO DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
TEG3_VZVO Tegument protein UL14 homolog
US9_VZVO Envelope protein US9 (Envelope protein 65) (ORF65 protein)
VP22_VZVO Tegument protein VP22 (ORF9 protein) (Tegument protein 9)
UL24_VZVO Protein UL24 homolog

19 entries

Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))

Select_allDeselect_all
RIR1_SUHVK Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_SUHVK Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
PAP_SUHVK DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (UL42 homolog)
PRIM_SUHVK DNA primase (EC 2.7.7.-)
SHUT_SUHVK Virion host shutoff protein (Vhs) (EC 3.1.27.-)
TEG7_SUHVK Tegument protein UL51
SCAF_SUHVK Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural ...
DUT_SUHVK Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
ICP27_SUHVK mRNA export factor ICP27 homolog (Protein UL54)
ICP4_SUHVK Major viral transcription factor ICP4 homolog
GK_SUHVK Envelope glycoprotein K (Syncytial protein)
GL_SUHVK Envelope glycoprotein L (gL)
ICP22_SUHVK Transcriptional regulator ICP22 homolog (Immediate-early protein RSP40)
KR1_SUHVK Serine/threonine-protein kinase (EC 2.7.11.1)
GH_SUHVK Envelope glycoprotein H (gH)
UNG_SUHVK Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
GM_SUHVK Envelope glycoprotein M (gM)
GN_SUHVK Envelope glycoprotein N
VNUA_SUHVK Probable nuclear antigen

16 entries

Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)

Select_allDeselect_all
RIR2_EHV4 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
TEG7_EHV4 Tegument protein UL51 homolog
TEG5_EHV4 Tegument protein UL47 homolog (GP10)
RIR1_EHV4 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
DUT_EHV4 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EV45_EHV4 Envelope protein UL45 homolog
GG_EHV4 Envelope glycoprotein G (gG)
KITH_EHV4 Thymidine kinase (EC 2.7.1.21)
GB_EHV4 Envelope glycoprotein B (gB)
VP22_EHV4 Tegument protein VP22 (Gene 11 protein)
UL24_EHV4 Protein UL24 homolog
GH_EHV4 Envelope glycoprotein H (gH)
GC_EHV4 Envelope glycoprotein C (Glycoprotein 13)
US9_EHV4 Envelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
VP16_EHV4 Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF)
US10_EHV4 Virion protein US10 homolog (ORF3)

14 entries

Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Select_allDeselect_all
OBP_BHV1C Replication origin-binding protein (OriBP) (OBP)
TEG5_BHV1C Tegument protein UL47
SCAF_BHV1C Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
RIR1_BHV1C Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_BHV1C Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
GC_BHV1C Envelope glycoprotein C homolog (Glycoprotein GIII)
GD_BHV1C Envelope glycoprotein D (gD) (Glycoprotein IV)
GB_BHV1C Envelope glycoprotein B (gB)
GH_BHV1C Envelope glycoprotein H (gH)
HEPA_BHV1C DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
UNG_BHV1C Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
GM_BHV1C Envelope glycoprotein M (gM)
GN_BHV1C Envelope glycoprotein N
VP22_BHV1C Tegument protein VP22

14 entries

Equine herpesvirus 1 (strain Kentucky A) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
TEG6_EHV1K Tegument protein UL55 homolog
ICP27_EHV1K mRNA export factor ICP27 homolog (Transcriptional regulator IE63 homolog)
ICP4_EHV1K Major viral transcription factor (155 kDa immediate-early protein)
ICP22_EHV1K Transcriptional regulator ICP22 homolog (IR4 protein) (Immediate-early protein IE68) (In vitro ...
GD_EHV1K Envelope glycoprotein D (gD) (Glycoprotein 17/18)
GP2_EHV1K Glycoprotein gp2 (Glycoprotein X) (GpX)
GG_EHV1K Envelope glycoprotein G (gG)
KR1_EHV1K Serine/threonine-protein kinase (EC 2.7.11.1)
GK_EHV1K Envelope glycoprotein K (Syncytial protein)
US10_EHV1K Virion protein US10 homolog (Gene 66 protein) (IR5 protein) (ORF S2-1)
US9_EHV1K Envelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
US02_EHV1K US1 protein
VG03_EHV1K Gene 3 protein (ORF L1)
VG67_EHV1K Uncharacterized gene 67 protein (IR6 protein)

8 entries

Bovine herpesvirus 1.2 (strain ST) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Select_allDeselect_all
GE_BHV1S Envelope glycoprotein E (gE)
US03_BHV1S Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
VGLX_BHV1S Glycoprotein GX
GD_BHV1S Envelope glycoprotein D (gD) (Glycoprotein IV)
GI_BHV1S Envelope glycoprotein I (gI)
US9_BHV1S Envelope protein US9
US02_BHV1S Protein US2 homolog
YOR1_BHV1S Uncharacterized 16.1 kDa protein (ORF1)

8 entries

Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

Select_allDeselect_all
TRM1_SUHVF Tripartite terminase subunit 1
DNBI_SUHVF Major DNA-binding protein
ICP0_SUHVF E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Early protein 0) (EP0) (RING-type E3 ubiquitin ...
ICP4_SUHVF Major viral transcription factor ICP4 homolog
GL_SUHVF Envelope glycoprotein L (gL)
GC_SUHVF Envelope glycoprotein C homolog (Glycoprotein GIII)
GB_SUHVF Envelope glycoprotein B (gB)
UNG_SUHVF Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

8 entries

Suid herpesvirus 1 (strain NIA-3) (SuHV-1) (Pseudorabies virus (strain NIA-3))

Select_allDeselect_all
TEG4_SUHVN Tegument protein UL21
KITH_SUHVN Thymidine kinase (EC 2.7.1.21)
US02_SUHVN Protein US2 homolog (28 kDa protein)
UL13_SUHVN Serine/threonine-protein kinase UL13 (EC 2.7.11.1)
GH_SUHVN Envelope glycoprotein H (gH)
TEG3_SUHVN Tegument protein UL14
US03_SUHVN Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
UL20_SUHVN Protein UL20

6 entries

Equine herpesvirus 1 (strain Kentucky D) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
EV45_EHV1D Envelope protein UL45 homolog
GD_EHV1D Envelope glycoprotein D (gD) (Glycoprotein 17/18)
GB_EHV1D Envelope glycoprotein B (gB)
GC_EHV1D Envelope glycoprotein C (gC) (Glycoprotein 13)
GE_EHV1D Envelope glycoprotein E (gE)
GI_EHV1D Envelope glycoprotein I (gI)

6 entries

Suid herpesvirus 1 (strain Rice) (SuHV-1) (Pseudorabies virus (strain Rice))

Select_allDeselect_all
GD_SUHVR Envelope glycoprotein D (gD) (Protein gp50)
GE_SUHVR Envelope glycoprotein E (gE)
GG_SUHVR Envelope glycoprotein G (gG)
GH_SUHVR Envelope glycoprotein H (gH)
GI_SUHVR Envelope glycoprotein I (Glycoprotein GP63)
US9_SUHVR Envelope protein US9 homolog (11 kDa protein)

3 entries

Cercopithecine herpesvirus 9 (strain DHV) (CeHV-9) (Simian varicella virus)

Select_allDeselect_all
GI_CHV9D Envelope glycoprotein I (Membrane glycoprotein 1)
GE_CHV9D Envelope glycoprotein E (Membrane glycoprotein 2) (gE)
US03_CHV9D Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)

5 entries

Equine herpesvirus 1 (strain AB1) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
GB_EHV1A Envelope glycoprotein B (gB)
GD_EHV1A Envelope glycoprotein D (gD) (Glycoprotein 17/18)
GI_EHV1A Envelope glycoprotein I
GE_EHV1A Envelope glycoprotein E (gE)
UL32_EHV1A Packaging protein UL32 homolog (Glycoprotein 300) (GP300)

5 entries

Equine herpesvirus 1 (strain HVS25A) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
TRM1_EHV1 Tripartite terminase subunit 1
KITH_EHV1 Thymidine kinase (EC 2.7.1.21)
GB_EHV1 Envelope glycoprotein B (gB)
UL24_EHV1 Protein UL24 homolog
GH_EHV1 Envelope glycoprotein H (gH)

4 entries

Bovine herpesvirus 1.1 (strain P8-2) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Select_allDeselect_all
TEG5_BHV1P Tegument protein UL47
GB_BHV1P Envelope glycoprotein B (gB)
GD_BHV1P Envelope glycoprotein D (gD) (Glycoprotein IV)
VP16_BHV1P Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF)

2 entries

Feline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)

Select_allDeselect_all
KITH_FHV1 Thymidine kinase (EC 2.7.1.21)
GH_FHV1 Envelope glycoprotein H (gH)

1 entry

Bovine herpesvirus 1 (strain 6660) (BoHV-1) (Infectious bovine rhinotracheitis virus)

KITH_BHV16 Thymidine kinase (EC 2.7.1.21)

1 entry

Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)

ICP0_BHV1J E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ...

1 entry

Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)

ICP0_BHV1K E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ...

1 entry

Bovine herpesvirus 1.2 (strain Q3932) (BoHV-1) (Infectious bovine rhinotracheitis virus)

KITH_BHV1Q Thymidine kinase (EC 2.7.1.21)

1 entry

Bovine herpesvirus 5 (strain N569) (BoHV-5) (Bovine encephalitis herpesvirus)

KITH_BHV5 Thymidine kinase (EC 2.7.1.21)

1 entry

Equine herpesvirus 1 (strain HH1) (EHV-1) (Equine abortion virus)

VG01_EHV1H Uncharacterized gene 1 protein

1 entry

Suid herpesvirus 1 (strain Indiana S) (SuHV-1) (Pseudorabies virus (strain Indiana S))

MCP_SUHVS Major capsid protein (MCP)