Varicellovirus

VIRION

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Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 125 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' non-translated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter.

Transcription occurs in three steps: immediate-early, early and late. The immediate-early genes are transcribed immediately after infection and ensure the transcription of early genes, which encode the proteins necessary for the viral replication. The late genes mostly encode structural proteins.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Innate immune response inhibition

Varicella virus inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein. Several viral proteins including ORF61, ORF47 and IE62 prevent IRF3 activation and subsequent induction of IFN-beta expression .

Adaptive immune response inhibition

Infected cells show a decrease in MHC class I peptide presentation at the cell surface. Although the mechanism is not fully understood, the ORF66 participates in this process .

Autophagy modulation

Varicella virus does not seem to modulate autophagy that occur in infected cells .

Host shut-off

Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex.

Cell-cycle modulation

The HHV-1 UL24 homolog may inhibit the host cell cycle at the G2/M transition since UL24 from alpha-, beta-, and gammaherpesvirus all inhibit host cell cycle through inactivation of the cyclinB/cdc2 complex .

Apoptosis modulation

The viral protein ORF12 protein triggers phosphorylation of host ERK1/2 and inhibits apoptosis. In neurons, ORF63 also participates in the inhibition of apoptosis .

Host splicing inhibition

VZV IE4 is an alternative splicing regulator of host mRNA. It may act by binding with SR proteins .

Matching UniProtKB/Swiss-Prot entries

365 entries grouped by strain (browse by keywords)

75 entries

Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

Select_allDeselect_all
RIR1_EHV1B Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
PORTL_EHV1B Portal protein
GN_EHV1B Envelope glycoprotein N
TRM1_EHV1B Tripartite terminase subunit 1
SHUT_EHV1B Virion host shutoff protein (Vhs) (EC 3.1.27.-)
TEG3_EHV1B Tegument protein UL14 homolog
VG01_EHV1B Uncharacterized gene 1 protein
TRM3_EHV1B Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRM2_EHV1B Tripartite terminase subunit 2
UL13_EHV1B Serine/threonine-protein kinase UL13 homolog (EC 2.7.11.1)
VG59_EHV1B Uncharacterized gene 59 protein
SCP_EHV1B Small capsomere-interacting protein
UL32_EHV1B Packaging protein UL32 homolog
SCAF_EHV1B Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural gene ...
VG02_EHV1B Uncharacterized gene 2 protein
VP22_EHV1B Tegument protein VP22 (Gene 11 protein)
VG34_EHV1B Gene 34 protein
US10_EHV1B Virion protein US10 homolog (Gene 66 protein)
TEG6_EHV1B Tegument protein UL55 homolog
US9_EHV1B Envelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
PAP_EHV1B DNA polymerase processivity factor (DNA-binding gene 18 protein) (Polymerase accessory protein) ...
MB43_EHV1B Membrane protein UL43 homolog (Membrane protein ORF17)
MCP_EHV1B Major capsid protein (MCP)
NEC1_EHV1B Nuclear egress protein 1
VG75_EHV1B Uncharacterized gene 75 protein
UL20_EHV1B Protein UL20 homolog
TEG4_EHV1B Tegument protein UL21 homolog
TRX1_EHV1B Triplex capsid protein 1
US02_EHV1B Gene 68 protein
US03_EHV1B Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
PRIM_EHV1B DNA primase (EC 2.7.7.-)
RIR2_EHV1B Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
ITP_EHV1B Inner tegument protein
OBP_EHV1B Replication origin-binding protein (OriBP) (OBP)
NP03_EHV1B Nuclear phosphoprotein UL3 homolog (ORF60 protein)
GL_EHV1B Envelope glycoprotein L (gL)
ICP4_EHV1B Major viral transcription factor (155 kDa immediate-early protein)
EV45_EHV1B Envelope protein UL45 homolog
GB_EHV1B Envelope glycoprotein B (gB)
ICP22_EHV1B Transcriptional regulator ICP22 homolog (IR4 protein) (Immediate-early protein IE68) (In vitro ...
DUT_EHV1B Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
GD_EHV1B Envelope glycoprotein D (gD) (Glycoprotein 17/18)
GG_EHV1B Envelope glycoprotein G (gG)
GC_EHV1B Envelope glycoprotein C (gC) (Glycoprotein 13)
GP2_EHV1B Glycoprotein gp2 (Glycoprotein X) (GpX)
GI_EHV1B Envelope glycoprotein I
HELI_EHV1B DNA replication helicase (EC 3.6.4.-)
CEP2_EHV1B Cytoplasmic envelopment protein 2
CEP3_EHV1B Cytoplasmic envelopment protein 3
DPOL_EHV1B DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
CVC1_EHV1B Capsid vertex component 1
CEP1_EHV1B Cytoplasmic envelopment protein 1
GH_EHV1B Envelope glycoprotein H (gH)
CVC2_EHV1B Capsid vertex component 2
GE_EHV1B Envelope glycoprotein E (gE)
KITH_EHV1B Thymidine kinase (EC 2.7.1.21)
DNBI_EHV1B Major DNA-binding protein
GK_EHV1B Envelope glycoprotein K (Syncytial protein)
ICP0_EHV1B E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ICP0)
GM_EHV1B Envelope glycoprotein M (gM)
AN_EHV1B Alkaline nuclease (EC 3.1.-.-)
NEC2_EHV1B Nuclear egress protein 2
ICP27_EHV1B mRNA export factor ICP27 homolog (Transcriptional regulator IE63 homolog)
HEPA_EHV1B DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
LTP_EHV1B Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
NP04_EHV1B Nuclear protein UL4 homolog
VG67_EHV1B Uncharacterized gene 67 protein (IR6 protein)
TEG7_EHV1B Tegument protein UL51 homolog
VG03_EHV1B Gene 3 protein
VP16_EHV1B Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF)
UL24_EHV1B Protein UL24 homolog
UNG_EHV1B Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
TRX2_EHV1B Triplex capsid protein 2
TEG5_EHV1B Tegument protein UL47 homolog (GP10)
TEG1_EHV1B Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)

69 entries

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Select_allDeselect_all
ORF0_VZVD Membrane protein 0 (Membrane ORF0 protein) (ORF S/L)
TEG3_VZVD Tegument protein UL14 homolog
ORF57_VZVD Uncharacterized protein 57 (Uncharacterized ORF57 protein)
US03_VZVD Serine/threonine-protein kinase US3 homolog (Protein kinase ORF66) (EC 2.7.11.1)
TRX2_VZVD Triplex capsid protein 2
ORF1_VZVD Structural protein 1 (Structural ORF1 protein)
TRM3_VZVD Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit) [Cleaved into: Gene 42 ...
SHUT_VZVD Virion host shutoff protein (Vhs) (EC 3.1.27.-)
UL32_VZVD Packaging protein UL32
PORTL_VZVD Portal protein
LTP_VZVD Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
UL20_VZVD Protein UL20 homolog (Gene 39 membrane protein)
TRM2_VZVD Tripartite terminase subunit 2
SCP_VZVD Small capsomere-interacting protein
VP22_VZVD Tegument protein VP22 (ORF9 protein) (Tegument protein 9)
TEG7_VZVD Tegument protein UL51 homolog (ORF7 protein)
PRIM_VZVD DNA primase (EC 2.7.7.-)
US10_VZVD Virion protein US10 homolog (Genes 64/69 protein)
RIR2_VZVD Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
UL24_VZVD Protein UL24 homolog
US9_VZVD Envelope protein US9 (Envelope protein 65) (ORF65 protein)
TEG6_VZVD Tegument protein UL55 homolog
SCAF_VZVD Capsid scaffolding protein (Protease precursor) (pPR) [Cleaved into: Assemblin (EC 3.4.21.97) ...
PAP_VZVD DNA polymerase processivity factor (DNA-binding gene 16 protein) (Polymerase accessory protein) ...
IE61_VZVD E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61) (RING-type E3 ...
NEC2_VZVD Nuclear egress protein 2
MCP_VZVD Major capsid protein (MCP)
NP03_VZVD Nuclear phosphoprotein UL3 homolog (ORF58 protein)
ORF2_VZVD Membrane protein 2 (Membrane ORF2 protein)
TYSY_VZVD Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
GL_VZVD Envelope glycoprotein L (gL)
ORF32_VZVD Phosphoprotein 32 (ORF32 Phosphoprotein)
GN_VZVD Envelope glycoprotein N
CEP2_VZVD Cytoplasmic envelopment protein 2
GE_VZVD Envelope glycoprotein E (gE)
GB_VZVD Envelope glycoprotein B (gB)
KITH_VZVD Thymidine kinase (EC 2.7.1.21)
CVC2_VZVD Capsid vertex component 2
GH_VZVD Envelope glycoprotein H (gH)
GM_VZVD Envelope glycoprotein M (gM)
DPOL_VZVD DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
ICP22_VZVD Transcriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) (Transcriptional ...
CVC1_VZVD Capsid vertex component 1
AN_VZVD Alkaline nuclease (EC 3.1.-.-)
DUT_VZVD Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
GI_VZVD Envelope glycoprotein I (gI) (Glycoprotein IV) (GPIV)
ITP_VZVD Inner tegument protein
HEPA_VZVD DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
HELI_VZVD DNA replication helicase (EC 3.6.4.-)
ICP4_VZVD Major viral transcription factor ICP4 homolog (Immediate-early protein 62) (IE62)
MB43_VZVD Membrane protein UL43 homolog (Membrane protein ORF15)
ICP27_VZVD mRNA export factor ICP27 homolog (Immediate-early protein 4) (IE4) (Transcriptional transactivator ...
GC_VZVD Envelope glycoprotein C (gC) (Glycoprotein V) (gpV)
DNBI_VZVD Major DNA-binding protein
GK_VZVD Envelope glycoprotein K (Syncytial protein)
CEP3_VZVD Cytoplasmic envelopment protein 3
CEP1_VZVD Cytoplasmic envelopment protein 1
NEC1_VZVD Nuclear egress protein 1
OBP_VZVD Replication origin-binding protein (OBP) (OriBP)
NP04_VZVD Nuclear protein UL4 homolog (ORF56 protein)
TEG1_VZVD Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG5_VZVD Tegument protein UL47 homolog
UNG_VZVD Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
TRX1_VZVD Triplex capsid protein 1
VP16_VZVD Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF) (ORF10 protein) (Tegument ...
TEG4_VZVD Tegument protein UL21 homolog
TRM1_VZVD Tripartite terminase subunit 1
UL13_VZVD Serine/threonine-protein kinase UL13 homolog (Protein kinase ORF47) (EC 2.7.11.1)
RIR1_VZVD Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...

1 entry

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3) reference strain

ORF0_VZVO Membrane protein 0 (Membrane ORF0 protein) (ORF S/L)

2 entries

Cercopithecine herpesvirus 9 (strain DHV) (CeHV-9) (Simian varicella virus) reference strain

Select_allDeselect_all
IE61_CHV9D E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61)
US9_CHV9D Envelope protein US9 homolog (Envelope protein 65) (ORF65 protein)

47 entries

Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
AN_EHV1V Alkaline nuclease (EC 3.1.-.-)
SCAF_EHV1V Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
TEG1_EHV1V Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TRM1_EHV1V Tripartite terminase subunit 1
PORTL_EHV1V Portal protein
UNG_EHV1V Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL20_EHV1V Protein UL20 homolog
TRM3_EHV1V Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
PRIM_EHV1V DNA primase (EC 2.7.7.-)
SHUT_EHV1V Virion host shutoff protein (Vhs) (EC 3.1.27.-)
SCP_EHV1V Small capsomere-interacting protein
UL13_EHV1V Serine/threonine-protein kinase UL13 homolog (EC 2.7.11.1)
NP04_EHV1V Nuclear protein UL4 homolog
TRX1_EHV1V Triplex capsid protein 1
VG01_EHV1V Uncharacterized gene 1 protein
OBP_EHV1V Replication origin-binding protein (OBP) (OriBP)
GB_EHV1V Envelope glycoprotein B (gB)
GP2_EHV1V Glycoprotein gp2 (Glycoprotein X) (GpX)
GL_EHV1V Envelope glycoprotein L (gL)
CEP3_EHV1V Cytoplasmic envelopment protein 3
DPOL_EHV1V DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
ICP0_EHV1V E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Infected cell protein 0) (RING-type E3 ubiquitin ...
DNBI_EHV1V Major DNA-binding protein
HEPA_EHV1V DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
CVC2_EHV1V Capsid vertex component 2
CEP1_EHV1V Cytoplasmic envelopment protein 1
HELI_EHV1V DNA replication helicase (EC 3.6.4.-)
GG_EHV1V Envelope glycoprotein G (gG)
GN_EHV1V Envelope glycoprotein N
ICP4_EHV1V Major viral transcription factor ICP4 homolog (155 kDa immediate-early protein)
MB43_EHV1V Membrane protein UL43 homolog (Membrane protein ORF17)
MCP_EHV1V Major capsid protein (MCP)
CEP2_EHV1V Cytoplasmic envelopment protein 2
NEC2_EHV1V Nuclear egress protein 2
ITP_EHV1V Inner tegument protein
PAP_EHV1V DNA polymerase processivity factor (Polymerase accessory protein) (PAP)
NP03_EHV1V Nuclear phosphoprotein UL3 homolog (ORF60 protein)
TEG3_EHV1V Tegument protein UL14 homolog
UL24_EHV1V Protein UL24 homolog
VG75_EHV1V Uncharacterized gene 75 protein
VG59_EHV1V Uncharacterized gene 59 protein
US03_EHV1V Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
US10_EHV1V Virion protein US10 homolog (Gene 66 protein)
TEG5_EHV1V Tegument protein UL47 homolog (GP10)
US9_EHV1V Envelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
TEG4_EHV1V Tegument protein UL21 homolog
VG03_EHV1V Gene 3 protein

45 entries

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

Select_allDeselect_all
TEG5_VZVO Tegument protein UL47 homolog
ORF57_VZVO Uncharacterized protein 57 (Uncharacterized ORF57 protein)
ORF2_VZVO Membrane protein 2 (Membrane ORF2 protein)
UNG_VZVO Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
ORF32_VZVO Phosphoprotein 32 (ORF32 Phosphoprotein)
TEG1_VZVO Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
RIR1_VZVO Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
US9_VZVO Envelope protein US9 (Envelope protein 65) (ORF65 protein)
OBP_VZVO Replication origin-binding protein (OBP) (OriBP)
PAP_VZVO DNA polymerase processivity factor (DNA-binding gene 16 protein) (Polymerase accessory protein) ...
ORF1_VZVO Structural protein 1 (Structural ORF1 protein)
ICP27_VZVO mRNA export factor ICP27 homolog (Immediate-early protein 4) (IE4)
MB43_VZVO Membrane protein UL43 homolog (Membrane protein ORF15)
TEG4_VZVO Tegument protein UL21 homolog
PRIM_VZVO DNA primase (EC 2.7.7.-)
TEG6_VZVO Tegument protein UL55 homolog
UL24_VZVO Protein UL24 homolog
NP03_VZVO Nuclear phosphoprotein UL3 homolog (ORF58 protein)
RIR2_VZVO Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
GB_VZVO Envelope glycoprotein B (gB)
GK_VZVO Envelope glycoprotein K (Syncytial protein)
GH_VZVO Envelope glycoprotein H (gH)
AN_VZVO Alkaline nuclease (EC 3.1.-.-)
DNBI_VZVO Major DNA-binding protein
ICP22_VZVO Transcriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) (Transcriptional ...
GM_VZVO Envelope glycoprotein M (gM)
DUT_VZVO Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
HELI_VZVO DNA replication helicase (EC 3.6.4.-)
CEP3_VZVO Cytoplasmic envelopment protein 3
DPOL_VZVO DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
GI_VZVO Envelope glycoprotein I (gI) (Glycoprotein IV) (GPIV)
ICP4_VZVO Major viral transcription factor ICP4 homolog (Immediate-early protein 62) (IE62)
GL_VZVO Envelope glycoprotein L (gL)
HEPA_VZVO DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
GN_VZVO Envelope glycoprotein N
GE_VZVO Envelope glycoprotein E (gE)
KITH_VZVO Thymidine kinase (EC 2.7.1.21)
LTP_VZVO Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
NP04_VZVO Nuclear protein UL4 homolog (ORF56 protein)
VP16_VZVO Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF) (ORF10 protein) (Tegument ...
TEG7_VZVO Tegument protein UL51 homolog (Protein ORF7)
VP22_VZVO Tegument protein VP22 (ORF9 protein) (Tegument protein 9)
TYSY_VZVO Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
UL13_VZVO Serine/threonine-protein kinase UL13 homolog (Protein kinase ORF47) (EC 2.7.11.1)
TEG3_VZVO Tegument protein UL14 homolog

19 entries

Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))

Select_allDeselect_all
RIR2_SUHVK Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
SCAF_SUHVK Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural ...
SHUT_SUHVK Virion host shutoff protein (Vhs) (EC 3.1.27.-)
RIR1_SUHVK Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
PAP_SUHVK DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (UL42 homolog)
TEG7_SUHVK Tegument protein UL51
DUT_SUHVK Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
ICP22_SUHVK Transcriptional regulator ICP22 homolog (Immediate-early protein RSP40)
GK_SUHVK Envelope glycoprotein K (Syncytial protein)
GM_SUHVK Envelope glycoprotein M (gM)
ICP4_SUHVK Major viral transcription factor ICP4 homolog
ICP27_SUHVK mRNA export factor ICP27 homolog (Protein UL54)
KR1_SUHVK Serine/threonine-protein kinase (EC 2.7.11.1)
GH_SUHVK Envelope glycoprotein H (gH)
GN_SUHVK Envelope glycoprotein N
GL_SUHVK Envelope glycoprotein L (gL)
PRIM_SUHVK DNA primase (EC 2.7.7.-)
UNG_SUHVK Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VNUA_SUHVK Probable nuclear antigen

17 entries

Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)

Select_allDeselect_all
RIR2_EHV4 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
VP16_EHV4 Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF)
TEG5_EHV4 Tegument protein UL47 homolog (GP10)
UL24_EHV4 Protein UL24 homolog
TEG1_EHV4 Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
US9_EHV4 Envelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
RIR1_EHV4 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
KITH_EHV4 Thymidine kinase (EC 2.7.1.21)
US10_EHV4 Virion protein US10 homolog (ORF3)
VP22_EHV4 Tegument protein VP22 (Gene 11 protein)
GG_EHV4 Envelope glycoprotein G (gG)
GC_EHV4 Envelope glycoprotein C (Glycoprotein 13)
GH_EHV4 Envelope glycoprotein H (gH)
DUT_EHV4 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EV45_EHV4 Envelope protein UL45 homolog
GB_EHV4 Envelope glycoprotein B (gB)
TEG7_EHV4 Tegument protein UL51 homolog

14 entries

Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Select_allDeselect_all
RIR1_BHV1C Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
OBP_BHV1C Replication origin-binding protein (OriBP) (OBP)
RIR2_BHV1C Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
TEG5_BHV1C Tegument protein UL47
VP22_BHV1C Tegument protein VP22
SCAF_BHV1C Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
UNG_BHV1C Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
GB_BHV1C Envelope glycoprotein B (gB)
GM_BHV1C Envelope glycoprotein M (gM)
GN_BHV1C Envelope glycoprotein N
GH_BHV1C Envelope glycoprotein H (gH)
GD_BHV1C Envelope glycoprotein D (gD) (Glycoprotein IV)
GC_BHV1C Envelope glycoprotein C homolog (Glycoprotein GIII)
HEPA_BHV1C DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)

14 entries

Equine herpesvirus 1 (strain Kentucky A) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
TEG6_EHV1K Tegument protein UL55 homolog
US02_EHV1K US1 protein
VG67_EHV1K Uncharacterized gene 67 protein (IR6 protein)
US9_EHV1K Envelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
VG03_EHV1K Gene 3 protein (ORF L1)
GK_EHV1K Envelope glycoprotein K (Syncytial protein)
GG_EHV1K Envelope glycoprotein G (gG)
GD_EHV1K Envelope glycoprotein D (gD) (Glycoprotein 17/18)
GP2_EHV1K Glycoprotein gp2 (Glycoprotein X) (GpX)
ICP4_EHV1K Major viral transcription factor (155 kDa immediate-early protein)
ICP22_EHV1K Transcriptional regulator ICP22 homolog (IR4 protein) (Immediate-early protein IE68) (In vitro ...
ICP27_EHV1K mRNA export factor ICP27 homolog (Transcriptional regulator IE63 homolog)
KR1_EHV1K Serine/threonine-protein kinase (EC 2.7.11.1)
US10_EHV1K Virion protein US10 homolog (Gene 66 protein) (IR5 protein) (ORF S2-1)

8 entries

Bovine herpesvirus 1.2 (strain ST) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Select_allDeselect_all
VGLX_BHV1S Glycoprotein GX
US02_BHV1S Protein US2 homolog
GD_BHV1S Envelope glycoprotein D (gD) (Glycoprotein IV)
GI_BHV1S Envelope glycoprotein I (gI)
GE_BHV1S Envelope glycoprotein E (gE)
US03_BHV1S Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
YOR1_BHV1S Uncharacterized 16.1 kDa protein (ORF1)
US9_BHV1S Envelope protein US9

8 entries

Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

Select_allDeselect_all
TRM1_SUHVF Tripartite terminase subunit 1
UNG_SUHVF Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
GC_SUHVF Envelope glycoprotein C homolog (Glycoprotein GIII)
GB_SUHVF Envelope glycoprotein B (gB)
DNBI_SUHVF Major DNA-binding protein
ICP0_SUHVF E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Early protein 0) (EP0) (RING-type E3 ubiquitin ...
GL_SUHVF Envelope glycoprotein L (gL)
ICP4_SUHVF Major viral transcription factor ICP4 homolog

8 entries

Suid herpesvirus 1 (strain NIA-3) (SuHV-1) (Pseudorabies virus (strain NIA-3))

Select_allDeselect_all
TEG4_SUHVN Tegument protein UL21
US03_SUHVN Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
UL20_SUHVN Protein UL20
KITH_SUHVN Thymidine kinase (EC 2.7.1.21)
GH_SUHVN Envelope glycoprotein H (gH)
UL13_SUHVN Serine/threonine-protein kinase UL13 (EC 2.7.11.1)
US02_SUHVN Protein US2 homolog (28 kDa protein)
TEG3_SUHVN Tegument protein UL14

6 entries

Equine herpesvirus 1 (strain Kentucky D) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
EV45_EHV1D Envelope protein UL45 homolog
GD_EHV1D Envelope glycoprotein D (gD) (Glycoprotein 17/18)
GI_EHV1D Envelope glycoprotein I (gI)
GB_EHV1D Envelope glycoprotein B (gB)
GC_EHV1D Envelope glycoprotein C (gC) (Glycoprotein 13)
GE_EHV1D Envelope glycoprotein E (gE)

6 entries

Suid herpesvirus 1 (strain Rice) (SuHV-1) (Pseudorabies virus (strain Rice))

Select_allDeselect_all
US9_SUHVR Envelope protein US9 homolog (11 kDa protein)
GG_SUHVR Envelope glycoprotein G (gG)
GH_SUHVR Envelope glycoprotein H (gH)
GD_SUHVR Envelope glycoprotein D (gD) (Protein gp50)
GE_SUHVR Envelope glycoprotein E (gE)
GI_SUHVR Envelope glycoprotein I (Glycoprotein GP63)

3 entries

Cercopithecine herpesvirus 9 (strain DHV) (CeHV-9) (Simian varicella virus)

Select_allDeselect_all
US03_CHV9D Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
GE_CHV9D Envelope glycoprotein E (Membrane glycoprotein 2) (gE)
GI_CHV9D Envelope glycoprotein I (Membrane glycoprotein 1)

5 entries

Equine herpesvirus 1 (strain AB1) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
UL32_EHV1A Packaging protein UL32 homolog (Glycoprotein 300) (GP300)
GI_EHV1A Envelope glycoprotein I
GE_EHV1A Envelope glycoprotein E (gE)
GD_EHV1A Envelope glycoprotein D (gD) (Glycoprotein 17/18)
GB_EHV1A Envelope glycoprotein B (gB)

5 entries

Equine herpesvirus 1 (strain HVS25A) (EHV-1) (Equine abortion virus)

Select_allDeselect_all
UL24_EHV1 Protein UL24 homolog
KITH_EHV1 Thymidine kinase (EC 2.7.1.21)
GH_EHV1 Envelope glycoprotein H (gH)
GB_EHV1 Envelope glycoprotein B (gB)
TRM1_EHV1 Tripartite terminase subunit 1

4 entries

Bovine herpesvirus 1.1 (strain P8-2) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Select_allDeselect_all
TEG5_BHV1P Tegument protein UL47
GB_BHV1P Envelope glycoprotein B (gB)
GD_BHV1P Envelope glycoprotein D (gD) (Glycoprotein IV)
VP16_BHV1P Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF)

2 entries

Feline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)

Select_allDeselect_all
GH_FHV1 Envelope glycoprotein H (gH)
KITH_FHV1 Thymidine kinase (EC 2.7.1.21)

1 entry

Bovine herpesvirus 1 (strain 6660) (BoHV-1) (Infectious bovine rhinotracheitis virus)

KITH_BHV16 Thymidine kinase (EC 2.7.1.21)

1 entry

Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)

ICP0_BHV1J E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ...

1 entry

Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)

ICP0_BHV1K E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ...

1 entry

Bovine herpesvirus 1.2 (strain Q3932) (BoHV-1) (Infectious bovine rhinotracheitis virus)

KITH_BHV1Q Thymidine kinase (EC 2.7.1.21)

1 entry

Bovine herpesvirus 5 (strain N569) (BoHV-5) (Bovine encephalitis herpesvirus)

KITH_BHV5 Thymidine kinase (EC 2.7.1.21)

1 entry

Equine herpesvirus 1 (strain HH1) (EHV-1) (Equine abortion virus)

VG01_EHV1H Uncharacterized gene 1 protein

1 entry

Suid herpesvirus 1 (strain Indiana S) (SuHV-1) (Pseudorabies virus (strain Indiana S))

MCP_SUHVS Major capsid protein (MCP)