Gammaherpesvirinae

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter,T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Gamma-herpesviruses have evolved different strategies to inhibit the host adaptive immune response. For example, the EHV-2 viral interleukin-10 homolog down-regulates the expression of the TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Apoptosis modulation

Apoptosis is very often modulated (and usually inhibited) by gamma-herpesviruses. For example, Epstein-Barr, HHV-8 or AlHV-1 all possess a viral homologue of the Bcl-2 oncogene that is able to protect cells from induced apoptosis.

Autophagy modulation

Several gamma-herpesviruses are able to inhibit host autophagy process, via interaction of vBcl-2 and vFLIP with host Beclin 1 and Atg3 respectively, that impact two stages of autophagy.

Cell-cycle modulation

The UL24 protein that is present in all herpesvirus subfamilies (alpha, beta and gamma-herpesviruses) induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

Herpes viruses inhibit the cascade leading to production of interferon-beta by mainly targeting the host IRF3 protein. EBV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the BGLF4 protein kinase that directly interacts with and inhibits host IRF3. BRLF1 expression also decreases induction of IFN-beta, and reduces expression of IRF3 and IRF7.

Host splicing inhibition

Modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

521 entries grouped by strain (browse by keywords)

85 entries

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Select_allDeselect_all
TRX2_HHV8P Triplex capsid protein 2
VIL6_HHV8P Viral interleukin-6 homolog (vIL-6)
VCYCL_HHV8P viral cyclin homolog (v-cyclin)
TRM2_HHV8P Tripartite terminase subunit 2
TRM1_HHV8P Tripartite terminase subunit 1
TEG7_HHV8P Tegument protein ORF55
TRX1_HHV8P Triplex capsid protein 1
VIRF4_HHV8P Viral IRF4-like protein (vIRF-4)
UL79_HHV8P Protein UL79 homolog
TRM3_HHV8P Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
VMI2_HHV8P Viral macrophage inflammatory protein 2 (Viral macrophage inflammatory protein II) (vMIP-II) ...
UL95_HHV8P Protein UL95 homolog
VPK_HHV8P Viral protein kinase (EC 2.7.-.-)
UL92_HHV8P Protein ORF31
VGPCR_HHV8P viral G-protein coupled receptor (vGPCR) (Protein ORF74)
TYSY_HHV8P Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
VCCL3_HHV8P Protein vCCL3
UL32_HHV8P Packaging protein UL32 homolog
DUT_HHV8P Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
CEP2_HHV8P Cytoplasmic envelopment protein 2
AN_HHV8P Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
UL49_HHV8P Protein ORF66
VIRF3_HHV8P Viral IRF3-like protein (VIRF-3)
UL24_HHV8P Protein UL24 homolog
SCP_HHV8P Small capsomere-interacting protein
UNG_HHV8P Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VIRF2_HHV8P Viral IRF2-like protein (vIRF-2)
VFLIP_HHV8P Viral FLICE protein (vFLIP)
DPOL_HHV8P DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
CEP1_HHV8P Cytoplasmic envelopment protein 1
ORF49_HHV8P Protein ORF49
ORF27_HHV8P Protein ORF27
RIR2_HHV8P Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RIR1_HHV8P Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
ORF30_HHV8P Protein ORF30
NEC2_HHV8P Nuclear egress protein 2
PAP_HHV8P DNA polymerase processivity factor
PORTL_HHV8P Portal protein
OX2V_HHV8P OX-2 membrane glycoprotein homolog (Viral OX2) (vOX2)
GB_HHV8P Envelope glycoprotein B (gB)
ORF35_HHV8P Protein ORF35
GM_HHV8P Envelope glycoprotein M (gM)
LANA1_HHV8P Protein LANA1
NEC1_HHV8P Nuclear egress protein 1
ORF52_HHV8P Tegument protein ORF52
ORF75_HHV8P Protein ORF75
ORF23_HHV8P Protein ORF23
ORF28_HHV8P Protein ORF28
ORF11_HHV8P Protein ORF11
ORF58_HHV8P Protein ORF58
ORF4_HHV8P Complement control protein (KCP)
K1_HHV8P Protein K1
ORF24_HHV8P Protein ORF24
MIR2_HHV8P E3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of immune recognition 2) ...
ORF45_HHV8P Protein ORF45
ICP27_HHV8P mRNA export factor ICP27 homolog (EB2 protein homolog)
K6_HHV8P Protein K6
LTP_HHV8P Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
ORF50_HHV8P Putative transcription activator ORF50
ITP_HHV8P Inner tegument protein
ORF48_HHV8P Tegument protein ORF48
K81_HHV8P Protein K8.1
K15_HHV8P Protein K15
K12_HHV8P Protein K12
DNBI_HHV8P Major DNA-binding protein
MCP_HHV8P Major capsid protein (MCP)
MIR1_HHV8P E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (IE1B protein) (Modulator of immune recognition 1) ...
ORF10_HHV8P Protein ORF10
SCAF_HHV8P Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
PRIM_HHV8P DNA primase (EC 2.7.7.-)
KBZIP_HHV8P E3 SUMO-protein ligase K-bZIP (EC 2.3.2.-) (E3 SUMO-protein transferase K-bZIP)
HELI_HHV8P DNA replication helicase (EC 3.6.4.-)
DYR_HHV8P Putative Dihydrofolate reductase (EC 1.5.1.3)
KITH_HHV8P Thymidine kinase (EC 2.7.1.21)
HEPA_HHV8P DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
K42_HHV8P Protein K4.2
K7_HHV8P Protein K7
GL_HHV8P Envelope glycoprotein L (gL)
CVC2_HHV8P Capsid vertex component 2
GN_HHV8P Envelope glycoprotein N
GH_HHV8P Envelope glycoprotein H (gH)
CEP3_HHV8P Cytoplasmic envelopment protein 3
CVC1_HHV8P Capsid vertex component 1
ARBH_HHV8P Apoptosis regulator Bcl-2 homolog

76 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
BLRF2_EBVB9 Tegument protein BLRF2
UL24_EBVB9 Protein UL24 homolog
UL95_EBVB9 Protein BGLF3
BNL2A_EBVB9 Protein BNLF2a
BZLF1_EBVB9 Trans-activator protein BZLF1 (EB1) (Zebra)
UL92_EBVB9 Uncharacterized protein BDLF4
TRM1_EBVB9 Tripartite terminase subunit 1
TRM3_EBVB9 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
UNG_EBVB9 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
BILF2_EBVB9 Glycoprotein BILF2
CVC1_EBVB9 Capsid vertex component 1
DPOL_EBVB9 DNA polymerase catalytic subunit (EC 2.7.7.7)
BLLF2_EBVB9 Uncharacterized protein BLLF2
EBNA4_EBVB9 Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
EAD_EBVB9 DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
EBNA5_EBVB9 Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
BALF1_EBVB9 Apoptosis regulator BALF1
CEP3_EBVB9 Cytoplasmic envelopment protein 3
EAR_EBVB9 Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
CEP2_EBVB9 Cytoplasmic envelopment protein 2
BILF1_EBVB9 G-protein coupled receptor BILF1
BARF1_EBVB9 Secreted protein BARF1 (33 kDa early protein) (p33)
BDLF3_EBVB9 Glycoprotein BDLF3
CEP1_EBVB9 Cytoplasmic envelopment protein 1
BDLF2_EBVB9 Protein BDLF2
RPMS1_EBVB9 Uncharacterized protein RPMS1
UL32_EBVB9 Packaging protein UL32 homolog
TEG7_EBVB9 Tegument protein UL51 homolog
TRX2_EBVB9 Triplex capsid protein 2
TRX1_EBVB9 Triplex capsid protein 1
UL87_EBVB9 TBP-like protein BcRF1
SCP_EBVB9 Small capsomere-interacting protein
BFRF2_EBVB9 Uncharacterized protein BFRF2
BRRF2_EBVB9 Tegument protein BRRF2
CVC2_EBVB9 Capsid vertex component 2
PRIM_EBVB9 DNA primase (EC 2.7.7.-)
NEC2_EBVB9 Nuclear egress protein 2
BKRF4_EBVB9 Tegument protein BKRF4
BNL2B_EBVB9 Uncharacterized protein BNLF2b
LF1_EBVB9 Uncharacterized LF1 protein
MCP_EBVB9 Major capsid protein (MCP)
PORTL_EBVB9 Portal protein
EBNA1_EBVB9 Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
LTP_EBVB9 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
RIR1_EBVB9 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_EBVB9 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
MTP_EBVB9 Major tegument protein (MTP) (Protein p140)
LF2_EBVB9 Protein LF2
NEC1_EBVB9 Nuclear egress protein 1
ICP27_EBVB9 mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
ITP_EBVB9 Inner tegument protein
AN_EBVB9 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
IL10H_EBVB9 Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
LMP1_EBVB9 Latent membrane protein 1 (LMP-1) (Protein p63) [Cleaved into: Protein p25]
GB_EBVB9 Envelope glycoprotein B (gB)
KR2_EBVB9 Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
RTA_EBVB9 Replication and transcription activator (Rta) (Immediate-early protein Rta)
SCAF_EBVB9 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
BRRF1_EBVB9 Transcriptional activator BRRF1
LMP2_EBVB9 Latent membrane protein 2 (Terminal protein)
LF3_EBVB9 Uncharacterized protein LF3
GP350_EBVB9 Envelope glycoprotein GP350 (Membrane antigen) (MA)
DNBI_EBVB9 Major DNA-binding protein
GN_EBVB9 Envelope glycoprotein N
GL_EBVB9 Envelope glycoprotein L (gL)
KITH_EBVB9 Thymidine kinase (EC 2.7.1.21)
EBNA3_EBVB9 Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
GP42_EBVB9 Glycoprotein 42 (gp42) [Cleaved into: Soluble gp42]
GH_EBVB9 Envelope glycoprotein H (gH)
DUT_EBVB9 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
GM_EBVB9 Envelope glycoprotein M (gM)
BMRF2_EBVB9 Protein BMRF2
EBNA2_EBVB9 Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
BTRF1_EBVB9 Uncharacterized protein BTRF1
BHLF1_EBVB9 Uncharacterized protein BHLF1
EBNA6_EBVB9 Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...

75 entries

Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Select_allDeselect_all
CEP1_SHV21 Cytoplasmic envelopment protein 1
CVC2_SHV21 Capsid vertex component 2
CEP2_SHV21 Cytoplasmic envelopment protein 2
CD59_SHV21 Surface glycoprotein CD59 homolog
AN_SHV21 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
CCPH_SHV21 Complement control protein homolog (CCPH)
VG59_SHV21 Gene 59 protein
UL95_SHV21 Gene 34 protein
UL49_SHV21 Uncharacterized gene 66 protein
VG27_SHV21 Uncharacterized gene 27 protein
VG12_SHV21 Uncharacterized gene 12 protein
UL87_SHV21 Gene 24 protein
VG28_SHV21 Uncharacterized gene 28 protein
UL32_SHV21 Packaging protein UL32
VP03_SHV21 Probable membrane antigen 3 (Tegument protein)
VG10_SHV21 Uncharacterized gene 10 protein
VG40_SHV21 Uncharacterized gene 40 protein
TRX2_SHV21 Triplex capsid protein 2
SCP_SHV21 Small capsomere-interacting protein
TRM3_SHV21 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
VG49_SHV21 Uncharacterized gene 49 protein
TSTP_SHV21 Transforming protein STP
UL92_SHV21 Gene 31 protein
VG74_SHV21 G-protein coupled receptor homolog ECRF3
VG58_SHV21 Gene 58 protein
UL96_SHV21 Gene 35 protein
SCAF_SHV21 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
VIEG_SHV21 Immediate-early protein IE-G
UL24_SHV21 Protein UL24 homolog
TEG7_SHV21 Gene 55 protein
VG51_SHV21 Gene 51 glycoprotein
VG45_SHV21 Uncharacterized gene 45 protein
TRX1_SHV21 Triplex capsid protein 1
UL79_SHV21 Gene 18 protein
VG16_SHV21 Bcl-2-like gene 16 protein
VG05_SHV21 Uncharacterized gene 5 protein
PORTL_SHV21 Portal protein
UL91_SHV21 Uncharacterized gene 30 protein
VG52_SHV21 Uncharacterized gene 52 protein
VG11_SHV21 Uncharacterized gene 11 protein
VG48_SHV21 Uncharacterized gene 48 protein
TRM1_SHV21 Tripartite terminase subunit 1
VG71_SHV21 Uncharacterized gene 71 protein
TYSY_SHV21 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
UNG_SHV21 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VP75_SHV21 Probable membrane antigen 75 (Tegument protein)
VG23_SHV21 Uncharacterized gene 23 protein
VG41_SHV21 Uncharacterized gene 41 protein
CEP3_SHV21 Cytoplasmic envelopment protein 3
CGH2_SHV21 Cyclin homolog (V-cyclin)
GN_SHV21 Envelope glycoprotein N
ICP22_SHV21 Transcriptional regulator ICP22 homolog (Immediate-early protein)
PRIM_SHV21 DNA primase (EC 2.7.7.-)
DUT_SHV21 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
NEC1_SHV21 Nuclear egress protein 1
LTP_SHV21 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
RIR1_SHV21 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
NEC2_SHV21 Nuclear egress protein 2
GH_SHV21 Envelope glycoprotein H (gH)
ICP27_SHV21 mRNA export factor ICP27 homolog (52 kDa immediate-early phosphoprotein) (EB2 protein homolog)
GL_SHV21 Envelope glycoprotein L (gL)
KITH_SHV21 Thymidine kinase (EC 2.7.1.21)
HELI_SHV21 DNA replication helicase (EC 3.6.4.-)
RIR2_SHV21 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
MCP_SHV21 Major capsid protein (MCP)
CVC1_SHV21 Capsid vertex component 1
DPOL_SHV21 DNA polymerase catalytic subunit (EC 2.7.7.7)
DNBI_SHV21 Major DNA-binding protein
GM_SHV21 Envelope glycoprotein M (gM)
IL17_SHV21 Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)
ITP_SHV21 Inner tegument protein
DYR_SHV21 Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
GB_SHV21 Envelope glycoprotein B (gB)
GCVK_SHV21 Probable ganciclovir kinase (EC 2.7.1.-)
BRLF1_SHV21 Putative transcription activator BRLF1 homolog (Transcription activator EDRF1)

74 entries

Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

Select_allDeselect_all
AN_EHV2 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
TRX1_EHV2 Triplex capsid protein 1
VG58_EHV2 Gene 58 protein
VG12_EHV2 Protein E6A
VG28_EHV2 Uncharacterized gene 28 protein
UNG_EHV2 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL32_EHV2 Packaging protein UL32 homolog
UL92_EHV2 Gene 31 protein
VG59_EHV2 DNA polymerase processivity factor
UL96_EHV2 Gene 35 protein
VGE2_EHV2 Uncharacterized gene E2 protein
VG48_EHV2 Tegument protein G48
VG51_EHV2 Putative C-type lectin protein 51
TRM3_EHV2 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
VGE4_EHV2 Uncharacterized gene E4 protein
UL79_EHV2 Gene 18 protein
TRM1_EHV2 Tripartite terminase subunit 1
VG45_EHV2 Uncharacterized gene 45 protein
VGE3_EHV2 SUSHI domain-containing protein E3
TRX2_EHV2 Triplex capsid protein 2
TEG7_EHV2 Tegument protein UL51 homolog
VG52_EHV2 Gene 52 protein
VG75_EHV2 Probable membrane antigen 75 (Tegument protein)
VG49_EHV2 Uncharacterized gene 49 protein
VG13_EHV2 Protein E6C
VG11_EHV2 Uncharacterized gene 11 protein
UL95_EHV2 Gene 34 protein
VP03_EHV2 Probable membrane antigen 3 (Tegument protein)
VG10_EHV2 Uncharacterized gene 10 protein
UL91_EHV2 Uncharacterized gene 30 protein
VG27_EHV2 Uncharacterized gene 27 protein
VGE9_EHV2 Uncharacterized gene E9 protein
VCLAP_EHV2 CARD domain-containing protein E10
UL87_EHV2 Gene 24 protein
UL24_EHV2 Protein UL24 homolog
VGE1_EHV2 G-protein coupled receptor E1
CFLA_EHV2 Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)
PRIM_EHV2 DNA primase (EC 2.7.7.-)
UL49_EHV2 Uncharacterized gene 66 protein
VGE6_EHV2 G-protein coupled receptor E6
SCAF_EHV2 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
VG23_EHV2 Uncharacterized gene 23 protein
VG36_EHV2 Probable inactive protein kinase 38
TRM2_EHV2 Tripartite terminase subunit 2
TYSY_EHV2 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
VG74_EHV2 G-protein coupled receptor 74
CEP1_EHV2 Cytoplasmic envelopment protein 1
CEP3_EHV2 Cytoplasmic envelopment protein 3
CVC2_EHV2 Capsid vertex component 2
GB_EHV2 Envelope glycoprotein B (gB)
ITP_EHV2 Inner tegument protein
PORTL_EHV2 Portal protein
GH_EHV2 Envelope glycoprotein H (gH)
CVC1_EHV2 Capsid vertex component 1
SCP_EHV2 Small capsomere-interacting protein
BRLF1_EHV2 Putative transcription activator BRLF1 homolog
NEC2_EHV2 Nuclear egress protein 2
NEC1_EHV2 Nuclear egress protein 1
IE63_EHV2 Immediate-early phosphoprotein 57
GL_EHV2 Envelope glycoprotein L (gL)
GN_EHV2 Envelope glycoprotein N
MCP_EHV2 Major capsid protein (MCP)
LTP_EHV2 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
KITH_EHV2 Thymidine kinase (EC 2.7.1.21)
RIR2_EHV2 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RIR1_EHV2 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
HELI_EHV2 DNA replication helicase (EC 3.6.4.-)
IL10H_EHV2 Viral interleukin-10 homolog (vIL-10)
GM_EHV2 Envelope glycoprotein M (gM)
HEPA_EHV2 DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
DUT_EHV2 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
CEP2_EHV2 Cytoplasmic envelopment protein 2
DNBI_EHV2 Major DNA-binding protein
DPOL_EHV2 DNA polymerase catalytic subunit (EC 2.7.7.7)

70 entries

Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

Select_allDeselect_all
CVC1_ALHV1 Capsid vertex component 1
VG10_ALHV1 Uncharacterized gene 10 protein
UL96_ALHV1 Gene 35 protein
VG45_ALHV1 Uncharacterized gene 45 protein
VG11_ALHV1 Uncharacterized gene 11 protein
VG58_ALHV1 Gene 58 protein
VGA2_ALHV1 Uncharacterized protein A2
UL24_ALHV1 Protein UL24 homolog
VGA9_ALHV1 Putative apoptosis regulator A9
TEG7_ALHV1 Tegument protein UL51 homolog (Uncharacterized gene 55 protein)
VGA5_ALHV1 G-protein coupled receptor A5
SCAF_ALHV1 Capsid scaffolding protein (Capsid protein 17) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
VG41_ALHV1 Uncharacterized gene 41 protein
UL32_ALHV1 Packaging protein UL32 homolog
VGA10_ALHV1 Uncharacterized gene A10 protein
VGA6_ALHV1 Uncharacterized gene A6 protein
VG36_ALHV1 Putative tyrosine kinase 36 (EC 2.7.10.2)
VG52_ALHV1 Uncharacterized gene 52 protein
RIR1_ALHV1 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
TRM3_ALHV1 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_ALHV1 Triplex capsid protein 1
VGA7_ALHV1 Putative C-type lectin protein A7
VGA8_ALHV1 Uncharacterized gene A8 protein
VG73_ALHV1 Uncharacterized gene 73 protein
VP75_ALHV1 Probable membrane antigen 75 (Tegument protein)
VGA4_ALHV1 Uncharacterized gene A4 protein
VG40_ALHV1 Uncharacterized gene 40 protein
TRM2_ALHV1 Tripartite terminase subunit 2
VG48_ALHV1 Uncharacterized gene 48 protein
VP03_ALHV1 Probable tegument protein antigen 3
TRM1_ALHV1 Tripartite terminase subunit 1
UL87_ALHV1 Uncharacterized gene 24 protein
UL49_ALHV1 Uncharacterized gene 66 protein
VG59_ALHV1 DNA polymerase processivity factor
UL92_ALHV1 Gene 31 protein
UL91_ALHV1 Uncharacterized gene 30 protein
VG27_ALHV1 Uncharacterized gene 27 protein
CEP3_ALHV1 Cytoplasmic envelopment protein 3
CEP1_ALHV1 Cytoplasmic envelopment protein 1
CEP2_ALHV1 Cytoplasmic envelopment protein 2
UL79_ALHV1 Gene 18 protein
TRX2_ALHV1 Triplex capsid protein 2
UL95_ALHV1 Gene 34 protein
VGA1_ALHV1 Uncharacterized gene A1 protein
UNG_ALHV1 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VG23_ALHV1 Uncharacterized gene 23 protein
AN_ALHV1 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
MCP_ALHV1 Major capsid protein (MCP)
RIR2_ALHV1 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
NEC2_ALHV1 Nuclear egress protein 2
GH_ALHV1 Envelope glycoprotein H (gH)
PORTL_ALHV1 Portal protein
NEC1_ALHV1 Nuclear egress protein 1
GB_ALHV1 Envelope glycoprotein B (gB)
GN_ALHV1 Envelope glycoprotein N
HELI_ALHV1 DNA replication helicase (EC 3.6.4.-)
BRLF1_ALHV1 Putative transcription activator BRLF1 homolog
DNBI_ALHV1 Major DNA-binding protein
KITH_ALHV1 Thymidine kinase (EC 2.7.1.21)
GL_ALHV1 Envelope glycoprotein L (gL)
SCP_ALHV1 Small capsomere-interacting protein
SEMA_ALHV1 Semaphorin-like protein A3
PRIM_ALHV1 DNA primase (EC 2.7.7.-)
LTP_ALHV1 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
IE63_ALHV1 Immediate-early phosphoprotein 57
ITP_ALHV1 Inner tegument protein
CVC2_ALHV1 Capsid vertex component 2
DUT_ALHV1 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DPOL_ALHV1 DNA polymerase catalytic subunit (EC 2.7.7.7)
GM_ALHV1 Envelope glycoprotein M (gM)

56 entries

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
CEP1_EBVA8 Cytoplasmic envelopment protein 1
BLRF2_EBVA8 Tegument protein BLRF2
RTA_EBVA8 Replication and transcription activator (Rta) (Immediate-early protein Rta)
SCAF_EBVA8 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
TEG7_EBVA8 Tegument protein UL51 homolog
BNL2B_EBVA8 Uncharacterized protein BNLF2b
EBNA1_EBVA8 Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
CEP2_EBVA8 Cytoplasmic envelopment protein 2
EBNA2_EBVA8 Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
BZLF1_EBVA8 Trans-activator protein BZLF1 (EB1) (Zebra)
BDLF2_EBVA8 Protein BDLF2
CEP3_EBVA8 Cytoplasmic envelopment protein 3
UL92_EBVA8 Uncharacterized protein BDLF4
TRM3_EBVA8 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
BNL2A_EBVA8 Protein BNLF2a
BKRF4_EBVA8 Tegument protein BKRF4
BRRF1_EBVA8 Transcriptional activator BRRF1
RIR1_EBVA8 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
MTP_EBVA8 Major tegument protein (MTP) (Protein p140)
GN_EBVA8 Envelope glycoprotein N
EBNA6_EBVA8 Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
PORTL_EBVA8 Portal protein
BMRF2_EBVA8 Protein BMRF2
LMP1_EBVA8 Latent membrane protein 1 (LMP-1) (Protein p63)
DUT_EBVA8 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
BARF1_EBVA8 Secreted protein BARF1 (33 kDa early protein) (p33)
KITH_EBVA8 Thymidine kinase (EC 2.7.1.21)
NEC1_EBVA8 Nuclear egress protein 1
ICP27_EBVA8 mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
ITP_EBVA8 Inner tegument protein
LF1_EBVA8 Uncharacterized LF1 protein
EAR_EBVA8 Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
MCP_EBVA8 Major capsid protein (MCP)
GL_EBVA8 Envelope glycoprotein L (gL)
LTP_EBVA8 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
RIR2_EBVA8 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
KR2_EBVA8 Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
LF2_EBVA8 Protein LF2
LMP2_EBVA8 Latent membrane protein 2 (Terminal protein)
CVC2_EBVA8 Capsid vertex component 2
EBNA3_EBVA8 Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
AN_EBVA8 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
EBNA5_EBVA8 Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
IL10H_EBVA8 Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
GP42_EBVA8 Glycoprotein 42 (gp42)
GH_EBVA8 Envelope glycoprotein H (gH)
GB_EBVA8 Envelope glycoprotein B (gB)
GM_EBVA8 Envelope glycoprotein M (gM)
EAD_EBVA8 DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
EBNA4_EBVA8 Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
GP350_EBVA8 Envelope glycoprotein GP350 (Membrane antigen) (MA)
BRRF2_EBVA8 Tegument protein BRRF2
DPOL_EBVA8 DNA polymerase catalytic subunit (EC 2.7.7.7)
BTRF1_EBVA8 Uncharacterized protein BTRF1
BLLF2_EBVA8 Uncharacterized protein BLLF2
DNBI_EBVA8 Major DNA-binding protein

3 entries

Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain

Select_allDeselect_all
LTP_MHV68 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MIR1_MHV68 E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (MK3) (Modulator of immune recognition 1 homolog) ...
ARBH_MHV68 Apoptosis regulator Bcl-2 homolog (vBcl-2) (Protein M11)

3 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

Select_allDeselect_all
YEC4_EBVB9 Uncharacterized protein EC-RF4
YBL2_EBVB9 Uncharacterized protein BBLF2
HELI_EBVB9 DNA replication helicase (EC 3.6.4.-)

56 entries

Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Select_allDeselect_all
RIR1_EBVG Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RTA_EBVG Replication and transcription activator (Rta) (Immediate-early protein Rta)
RPMS1_EBVG Uncharacterized protein RPMS1
EAD_EBVG DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
CEP1_EBVG Cytoplasmic envelopment protein 1
DNBI_EBVG Major DNA-binding protein
EBNA4_EBVG Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
DUT_EBVG Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
BZLF1_EBVG Trans-activator protein BZLF1 (EB1) (Zebra)
EBNA1_EBVG Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
BALF1_EBVG Apoptosis regulator BALF1
CEP2_EBVG Cytoplasmic envelopment protein 2
BNL2B_EBVG Uncharacterized protein BNLF2b
BTRF1_EBVG Uncharacterized protein BTRF1
BDLF2_EBVG Protein BDLF2
TRM3_EBVG Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
SCAF_EBVG Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
TEG7_EBVG Tegument protein UL51 homolog
BKRF4_EBVG Tegument protein BKRF4
BRRF1_EBVG Transcriptional activator BRRF1
BLRF2_EBVG Tegument protein BLRF2
BMRF2_EBVG Protein BMRF2
GH_EBVG Envelope glycoprotein H (gH)
MTP_EBVG Major tegument protein (MTP) (Protein p140)
ITP_EBVG Inner tegument protein
KITH_EBVG Thymidine kinase (EC 2.7.1.21)
LTP_EBVG Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
EAR_EBVG Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
PORTL_EBVG Portal protein
AN_EBVG Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
LMP2_EBVG Latent membrane protein 2 (Terminal protein)
BNL2A_EBVG Protein BNLF2a
BARF1_EBVG Secreted protein BARF1 (33 kDa early protein) (p33)
LMP1_EBVG Latent membrane protein 1 (LMP-1) (Protein p63)
GM_EBVG Envelope glycoprotein M (gM)
EBNA2_EBVG Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
MCP_EBVG Major capsid protein (MCP)
RIR2_EBVG Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
EBNA6_EBVG Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
ICP27_EBVG mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
KR2_EBVG Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
LF3_EBVG Uncharacterized protein LF3
LF1_EBVG Uncharacterized LF1 protein
LF2_EBVG Protein LF2
DPOL_EBVG DNA polymerase catalytic subunit (EC 2.7.7.7)
GB_EBVG Envelope glycoprotein B (gB)
IL10H_EBVG Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
CVC2_EBVG Capsid vertex component 2
GN_EBVG Envelope glycoprotein N
GP350_EBVG Envelope glycoprotein GP350 (Membrane antigen) (MA)
BRRF2_EBVG Tegument protein BRRF2
GP42_EBVG Glycoprotein 42 (gp42) [Cleaved into: Soluble gp42]
GL_EBVG Envelope glycoprotein L (gL)
EBNA3_EBVG Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
EBNA5_EBVG Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
BLLF2_EBVG Uncharacterized protein BLLF2

6 entries

Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

Select_allDeselect_all
STP_SHV2C Saimiri transformation-associated protein (Collagen-like protein) (stpC)
YDH3_SHV2C Uncharacterized 9.5 kDa protein in DHFR 3'region (ORF3)
YDH4_SHV2C Uncharacterized 9.9 kDa protein in DHFR 3'region (ORF4)
TIP_SHV2C Tyrosine-protein kinase-interacting protein (Tip)
DYR_SHV2C Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
IL17_SHV2C Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)

3 entries

Bovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)

Select_allDeselect_all
VIE1_BHV4D Probable E3 ubiquitin-protein ligase IE1 (EC 2.3.2.27) (32.7 kDa immediate early protein IE1) ...
GCNT3_BHV4D Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...
BRLF1_BHV4D Putative transcription activator BRLF1 homolog

3 entries

Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)

Select_allDeselect_all
STP_SHV24 Saimiri transformation-associated protein (Collagen-like protein) (stpC)
TIP_SHV24 Tyrosine-protein kinase-interacting protein (Tip)
DYR_SHV24 Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)

1 entry

Alcelaphine herpesvirus 1 (strain WC11) (AlHV-1) (Malignant catarrhal fever virus)

KITH_AHV1W Thymidine kinase (EC 2.7.1.21)

1 entry

Ateline herpesvirus 3 (AtHV-3) (Herpesvirus ateles)

TIO_ATHV3 Protein tio

1 entry

Bovine herpesvirus 4 (BoHV-4) (Movar virus)

GCNT3_BHV4 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Bovine herpesvirus 4 (strain LVR140) (BoHV-4) (Movar virus)

GCNT3_BHV4L Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Bovine herpesvirus 4 (strain V. test) (BoHV-4) (Movar virus)

GCNT3_BHV4V Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)

LMP1_EBVC Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Epstein-Barr virus (strain P3HR-1) (HHV-4) (Human herpesvirus 4)

VGP3_EBVP3 Envelope glycoprotein GP340 (Membrane antigen) (MA)

1 entry

Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

LMP1_EBVR Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Equine herpesvirus 2 (strain T400/3) (EHV-2)

IL10H_EHV2T Viral interleukin-10 homolog (vIL-10)

1 entry

Herpesvirus ateles

TYSY_HSVAT Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

1 entry

Saimiriine herpesvirus 2 (strain 484) (SaHV-2) (Herpesvirus saimiri)

TIP_SHV48 Tyrosine protein kinase-interacting protein (Tip) (TipC484)