Gammaherpesvirinae

VIRION

image

Enveloped, spherical to pleomorphic, 150-200 nm in diameter,T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Gamma-herpesviruses have evolved different strategies to inhibit the host adaptive immune response. For example, the EHV-2 viral interleukin-10 homolog down-regulates the expression of the TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Apoptosis modulation

Apoptosis is very often modulated (and usually inhibited) by gamma-herpesviruses. For example, Epstein-Barr, HHV-8 or AlHV-1 all possess a viral homologue of the Bcl-2 oncogene that is able to protect cells from induced apoptosis.

Autophagy modulation

Several gamma-herpesviruses are able to inhibit host autophagy process, via interaction of vBcl-2 and vFLIP with host Beclin 1 and Atg3 respectively, that impact two stages of autophagy.

Cell-cycle modulation

The UL24 protein that is present in all herpesvirus subfamilies (alpha, beta and gamma-herpesviruses) induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

Herpes viruses inhibit the cascade leading to production of interferon-beta by mainly targeting the host IRF3 protein. EBV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the BGLF4 protein kinase that directly interacts with and inhibits host IRF3. BRLF1 expression also decreases induction of IFN-beta, and reduces expression of IRF3 and IRF7.

Host splicing inhibition

Modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

521 entries grouped by strain (browse by keywords)

85 entries

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Select_allDeselect_all
ORF24_HHV8P Protein ORF24
PAP_HHV8P DNA polymerase processivity factor
PORTL_HHV8P Portal protein
ORF27_HHV8P Protein ORF27
ORF50_HHV8P Putative transcription activator ORF50
SCP_HHV8P Small capsomere-interacting protein
TEG7_HHV8P Tegument protein ORF55
RIR2_HHV8P Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
VIRF4_HHV8P Viral IRF4-like protein (vIRF-4)
VIL6_HHV8P Viral interleukin-6 homolog (vIL-6)
TYSY_HHV8P Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
VGPCR_HHV8P viral G-protein coupled receptor (vGPCR) (Protein ORF74)
ORF11_HHV8P Protein ORF11
TRX2_HHV8P Triplex capsid protein 2
OX2V_HHV8P OX-2 membrane glycoprotein homolog (Viral OX2) (vOX2)
ORF23_HHV8P Protein ORF23
ORF75_HHV8P Protein ORF75
UNG_HHV8P Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL95_HHV8P Protein UL95 homolog
VCYCL_HHV8P viral cyclin homolog (v-cyclin)
ORF28_HHV8P Protein ORF28
ORF58_HHV8P Protein ORF58
HELI_HHV8P DNA replication helicase (EC 3.6.4.-)
MIR1_HHV8P E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (IE1B protein) (Modulator of immune recognition 1) ...
MIR2_HHV8P E3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of immune recognition 2) ...
K6_HHV8P Protein K6
NEC2_HHV8P Nuclear egress protein 2
ORF4_HHV8P Complement control protein (KCP)
NEC1_HHV8P Nuclear egress protein 1
LTP_HHV8P Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
ORF45_HHV8P Protein ORF45
ORF35_HHV8P Protein ORF35
UL32_HHV8P Packaging protein UL32 homolog
TRM2_HHV8P Tripartite terminase subunit 2
VIRF2_HHV8P Viral IRF2-like protein (vIRF-2)
UL24_HHV8P Protein UL24 homolog
VPK_HHV8P Viral protein kinase (EC 2.7.11.1)
RIR1_HHV8P Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
ORF48_HHV8P Tegument protein ORF48
ITP_HHV8P Inner tegument protein
LANA1_HHV8P Protein LANA1
ORF49_HHV8P Protein ORF49
K12_HHV8P Protein K12
DPOL_HHV8P DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
HEPA_HHV8P DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
GL_HHV8P Envelope glycoprotein L (gL)
K15_HHV8P Protein K15
GN_HHV8P Envelope glycoprotein N
AN_HHV8P Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
GM_HHV8P Envelope glycoprotein M (gM)
CEP1_HHV8P Cytoplasmic envelopment protein 1
CVC1_HHV8P Capsid vertex component 1
K7_HHV8P Protein K7
K81_HHV8P Protein K8.1
GH_HHV8P Envelope glycoprotein H (gH)
CVC2_HHV8P Capsid vertex component 2
CEP3_HHV8P Cytoplasmic envelopment protein 3
CEP2_HHV8P Cytoplasmic envelopment protein 2
DUT_HHV8P Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DYR_HHV8P Putative Dihydrofolate reductase (EC 1.5.1.3)
DNBI_HHV8P Major DNA-binding protein
ARBH_HHV8P Apoptosis regulator Bcl-2 homolog
K1_HHV8P Protein K1
K42_HHV8P Protein K4.2
KITH_HHV8P Thymidine kinase (EC 2.7.1.21)
MCP_HHV8P Major capsid protein (MCP)
GB_HHV8P Envelope glycoprotein B (gB)
ORF52_HHV8P Tegument protein ORF52
ORF30_HHV8P Protein ORF30
ICP27_HHV8P mRNA export factor ICP27 homolog (EB2 protein homolog)
ORF10_HHV8P Protein ORF10
KBZIP_HHV8P E3 SUMO-protein ligase K-bZIP (EC 2.3.2.-) (E3 SUMO-protein transferase K-bZIP)
PRIM_HHV8P DNA primase (EC 2.7.7.-)
UL49_HHV8P Protein ORF66
TRM3_HHV8P Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
VIRF3_HHV8P Viral IRF3-like protein (VIRF-3)
UL92_HHV8P Protein ORF31
VCCL3_HHV8P Protein vCCL3
VMI2_HHV8P Viral macrophage inflammatory protein 2 (Viral macrophage inflammatory protein II) (vMIP-II) ...
UL79_HHV8P Protein UL79 homolog
SCAF_HHV8P Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
VFLIP_HHV8P Viral FLICE protein (vFLIP)
TRX1_HHV8P Triplex capsid protein 1
TRM1_HHV8P Tripartite terminase subunit 1

76 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
PRIM_EBVB9 DNA primase (EC 2.7.7.-)
RPMS1_EBVB9 Uncharacterized protein RPMS1
BRRF1_EBVB9 Transcriptional activator BRRF1
SCAF_EBVB9 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
RIR2_EBVB9 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
UL32_EBVB9 Packaging protein UL32 homolog
TRX1_EBVB9 Triplex capsid protein 1
UL95_EBVB9 Protein BGLF3
RIR1_EBVB9 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
TEG7_EBVB9 Tegument protein UL51 homolog
LMP1_EBVB9 Latent membrane protein 1 (LMP-1) (Protein p63) [Cleaved into: Protein p25]
TRX2_EBVB9 Triplex capsid protein 2
SCP_EBVB9 Small capsomere-interacting protein
UL92_EBVB9 Uncharacterized protein BDLF4
UL87_EBVB9 TBP-like protein BcRF1
RTA_EBVB9 Replication and transcription activator (Rta) (Immediate-early protein Rta)
ICP27_EBVB9 mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
MCP_EBVB9 Major capsid protein (MCP)
LMP2_EBVB9 Latent membrane protein 2 (Terminal protein)
NEC1_EBVB9 Nuclear egress protein 1
ITP_EBVB9 Inner tegument protein
GP42_EBVB9 Glycoprotein 42 (gp42) [Cleaved into: Soluble gp42]
EBNA1_EBVB9 Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
GB_EBVB9 Envelope glycoprotein B (gB)
GL_EBVB9 Envelope glycoprotein L (gL)
CVC2_EBVB9 Capsid vertex component 2
EBNA3_EBVB9 Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
BDLF2_EBVB9 Protein BDLF2
GP350_EBVB9 Envelope glycoprotein GP350 (Membrane antigen) (MA)
KR2_EBVB9 Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
CEP1_EBVB9 Cytoplasmic envelopment protein 1
CEP3_EBVB9 Cytoplasmic envelopment protein 3
EAR_EBVB9 Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
BILF2_EBVB9 Glycoprotein BILF2
BHLF1_EBVB9 Uncharacterized protein BHLF1
DNBI_EBVB9 Major DNA-binding protein
AN_EBVB9 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BLLF2_EBVB9 Uncharacterized protein BLLF2
CEP2_EBVB9 Cytoplasmic envelopment protein 2
BFRF2_EBVB9 Uncharacterized protein BFRF2
BMRF2_EBVB9 Protein BMRF2
BDLF3_EBVB9 Glycoprotein BDLF3
BZLF1_EBVB9 Trans-activator protein BZLF1 (EB1) (Zebra)
BILF1_EBVB9 G-protein coupled receptor BILF1
BKRF4_EBVB9 Tegument protein BKRF4
BNL2B_EBVB9 Uncharacterized protein BNLF2b
LTP_EBVB9 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
KITH_EBVB9 Thymidine kinase (EC 2.7.1.21)
EBNA2_EBVB9 Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
GH_EBVB9 Envelope glycoprotein H (gH)
LF1_EBVB9 Uncharacterized LF1 protein
DPOL_EBVB9 DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_EBVB9 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
GM_EBVB9 Envelope glycoprotein M (gM)
GN_EBVB9 Envelope glycoprotein N
EBNA4_EBVB9 Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
EBNA5_EBVB9 Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
EBNA6_EBVB9 Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
EAD_EBVB9 DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
BLRF2_EBVB9 Tegument protein BLRF2
BTRF1_EBVB9 Uncharacterized protein BTRF1
BALF1_EBVB9 Apoptosis regulator BALF1
BNL2A_EBVB9 Protein BNLF2a
BARF1_EBVB9 Secreted protein BARF1 (33 kDa early protein) (p33)
CVC1_EBVB9 Capsid vertex component 1
BRRF2_EBVB9 Tegument protein BRRF2
LF2_EBVB9 Protein LF2
PORTL_EBVB9 Portal protein
LF3_EBVB9 Uncharacterized protein LF3
MTP_EBVB9 Major tegument protein (MTP) (Protein p140)
NEC2_EBVB9 Nuclear egress protein 2
IL10H_EBVB9 Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
UL24_EBVB9 Protein UL24 homolog
TRM1_EBVB9 Tripartite terminase subunit 1
UNG_EBVB9 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
TRM3_EBVB9 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

75 entries

Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Select_allDeselect_all
RIR1_SHV21 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
BRLF1_SHV21 Putative transcription activator BRLF1 homolog (Transcription activator EDRF1)
UL79_SHV21 Gene 18 protein
UL91_SHV21 Uncharacterized gene 30 protein
PORTL_SHV21 Portal protein
VG41_SHV21 Uncharacterized gene 41 protein
UL49_SHV21 Uncharacterized gene 66 protein
SCP_SHV21 Small capsomere-interacting protein
SCAF_SHV21 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
UL32_SHV21 Packaging protein UL32
UNG_SHV21 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL24_SHV21 Protein UL24 homolog
VG49_SHV21 Uncharacterized gene 49 protein
TRM1_SHV21 Tripartite terminase subunit 1
VG52_SHV21 Uncharacterized gene 52 protein
VG05_SHV21 Uncharacterized gene 5 protein
PRIM_SHV21 DNA primase (EC 2.7.7.-)
ITP_SHV21 Inner tegument protein
NEC1_SHV21 Nuclear egress protein 1
MCP_SHV21 Major capsid protein (MCP)
VG45_SHV21 Uncharacterized gene 45 protein
VG10_SHV21 Uncharacterized gene 10 protein
VG16_SHV21 Bcl-2-like gene 16 protein
VG59_SHV21 Gene 59 protein
VG74_SHV21 G-protein coupled receptor homolog ECRF3
TYSY_SHV21 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
VG51_SHV21 Gene 51 glycoprotein
TSTP_SHV21 Transforming protein STP
TRX2_SHV21 Triplex capsid protein 2
VG23_SHV21 Uncharacterized gene 23 protein
VG28_SHV21 Uncharacterized gene 28 protein
RIR2_SHV21 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
HELI_SHV21 DNA replication helicase (EC 3.6.4.-)
IL17_SHV21 Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)
GCVK_SHV21 Probable ganciclovir kinase (EC 2.7.1.-)
DPOL_SHV21 DNA polymerase catalytic subunit (EC 2.7.7.7)
GN_SHV21 Envelope glycoprotein N
ICP27_SHV21 mRNA export factor ICP27 homolog (52 kDa immediate-early phosphoprotein) (EB2 protein homolog)
CVC1_SHV21 Capsid vertex component 1
DNBI_SHV21 Major DNA-binding protein
GM_SHV21 Envelope glycoprotein M (gM)
CEP3_SHV21 Cytoplasmic envelopment protein 3
CD59_SHV21 Surface glycoprotein CD59 homolog
DUT_SHV21 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
CEP1_SHV21 Cytoplasmic envelopment protein 1
DYR_SHV21 Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
AN_SHV21 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
CVC2_SHV21 Capsid vertex component 2
KITH_SHV21 Thymidine kinase (EC 2.7.1.21)
GH_SHV21 Envelope glycoprotein H (gH)
GB_SHV21 Envelope glycoprotein B (gB)
GL_SHV21 Envelope glycoprotein L (gL)
ICP22_SHV21 Transcriptional regulator ICP22 homolog (Immediate-early protein)
CCPH_SHV21 Complement control protein homolog (CCPH)
CGH2_SHV21 Cyclin homolog (V-cyclin)
CEP2_SHV21 Cytoplasmic envelopment protein 2
NEC2_SHV21 Nuclear egress protein 2
LTP_SHV21 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
VG11_SHV21 Uncharacterized gene 11 protein
VG27_SHV21 Uncharacterized gene 27 protein
TRX1_SHV21 Triplex capsid protein 1
VG58_SHV21 Gene 58 protein
UL95_SHV21 Gene 34 protein
VIEG_SHV21 Immediate-early protein IE-G
VG71_SHV21 Uncharacterized gene 71 protein
TEG7_SHV21 Gene 55 protein
VG48_SHV21 Uncharacterized gene 48 protein
VG12_SHV21 Uncharacterized gene 12 protein
VP75_SHV21 Probable membrane antigen 75 (Tegument protein)
TRM3_SHV21 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
VG40_SHV21 Uncharacterized gene 40 protein
VP03_SHV21 Probable membrane antigen 3 (Tegument protein)
UL87_SHV21 Gene 24 protein
UL92_SHV21 Gene 31 protein
UL96_SHV21 Gene 35 protein

74 entries

Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

Select_allDeselect_all
SCP_EHV2 Small capsomere-interacting protein
UL79_EHV2 Gene 18 protein
UL96_EHV2 Gene 35 protein
TRM3_EHV2 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
VG75_EHV2 Probable membrane antigen 75 (Tegument protein)
TEG7_EHV2 Tegument protein UL51 homolog
VP03_EHV2 Probable membrane antigen 3 (Tegument protein)
TRX1_EHV2 Triplex capsid protein 1
VG23_EHV2 Uncharacterized gene 23 protein
VG10_EHV2 Uncharacterized gene 10 protein
VG58_EHV2 Gene 58 protein
UL32_EHV2 Packaging protein UL32 homolog
PRIM_EHV2 DNA primase (EC 2.7.7.-)
VGE2_EHV2 Uncharacterized gene E2 protein
VG28_EHV2 Uncharacterized gene 28 protein
VGE6_EHV2 G-protein coupled receptor E6
TRX2_EHV2 Triplex capsid protein 2
RIR1_EHV2 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
VG74_EHV2 G-protein coupled receptor 74
UL87_EHV2 Gene 24 protein
UL92_EHV2 Gene 31 protein
SCAF_EHV2 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
PORTL_EHV2 Portal protein
MCP_EHV2 Major capsid protein (MCP)
NEC2_EHV2 Nuclear egress protein 2
LTP_EHV2 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
UL95_EHV2 Gene 34 protein
VGE1_EHV2 G-protein coupled receptor E1
VGE4_EHV2 Uncharacterized gene E4 protein
VG27_EHV2 Uncharacterized gene 27 protein
VGE9_EHV2 Uncharacterized gene E9 protein
VG51_EHV2 Putative C-type lectin protein 51
ITP_EHV2 Inner tegument protein
RIR2_EHV2 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
HELI_EHV2 DNA replication helicase (EC 3.6.4.-)
CVC2_EHV2 Capsid vertex component 2
IE63_EHV2 Immediate-early phosphoprotein 57
GM_EHV2 Envelope glycoprotein M (gM)
GL_EHV2 Envelope glycoprotein L (gL)
BRLF1_EHV2 Putative transcription activator BRLF1 homolog
DNBI_EHV2 Major DNA-binding protein
DUT_EHV2 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
GN_EHV2 Envelope glycoprotein N
DPOL_EHV2 DNA polymerase catalytic subunit (EC 2.7.7.7)
HEPA_EHV2 DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
GB_EHV2 Envelope glycoprotein B (gB)
AN_EHV2 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
CEP2_EHV2 Cytoplasmic envelopment protein 2
CFLA_EHV2 Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)
CEP3_EHV2 Cytoplasmic envelopment protein 3
GH_EHV2 Envelope glycoprotein H (gH)
KITH_EHV2 Thymidine kinase (EC 2.7.1.21)
NEC1_EHV2 Nuclear egress protein 1
CVC1_EHV2 Capsid vertex component 1
CEP1_EHV2 Cytoplasmic envelopment protein 1
IL10H_EHV2 Viral interleukin-10 homolog (vIL-10)
VG59_EHV2 DNA polymerase processivity factor
VGE3_EHV2 SUSHI domain-containing protein E3
VG52_EHV2 Gene 52 protein
VG48_EHV2 Tegument protein G48
UL91_EHV2 Uncharacterized gene 30 protein
VG49_EHV2 Uncharacterized gene 49 protein
VG45_EHV2 Uncharacterized gene 45 protein
VG36_EHV2 Probable inactive protein kinase 38
UL24_EHV2 Protein UL24 homolog
TRM2_EHV2 Tripartite terminase subunit 2
VG13_EHV2 Protein E6C
VG11_EHV2 Uncharacterized gene 11 protein
VG12_EHV2 Protein E6A
TYSY_EHV2 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
UL49_EHV2 Uncharacterized gene 66 protein
UNG_EHV2 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
TRM1_EHV2 Tripartite terminase subunit 1
VCLAP_EHV2 CARD domain-containing protein E10

70 entries

Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

Select_allDeselect_all
RIR2_ALHV1 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
PORTL_ALHV1 Portal protein
SCP_ALHV1 Small capsomere-interacting protein
TRM3_ALHV1 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRM2_ALHV1 Tripartite terminase subunit 2
VG48_ALHV1 Uncharacterized gene 48 protein
VGA9_ALHV1 Putative apoptosis regulator A9
VG36_ALHV1 Putative tyrosine kinase 36 (EC 2.7.10.2)
SCAF_ALHV1 Capsid scaffolding protein (Capsid protein 17) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
UL32_ALHV1 Packaging protein UL32 homolog
PRIM_ALHV1 DNA primase (EC 2.7.7.-)
VGA1_ALHV1 Uncharacterized gene A1 protein
UL49_ALHV1 Uncharacterized gene 66 protein
VGA5_ALHV1 G-protein coupled receptor A5
UL79_ALHV1 Gene 18 protein
VG45_ALHV1 Uncharacterized gene 45 protein
UL24_ALHV1 Protein UL24 homolog
VG59_ALHV1 DNA polymerase processivity factor
TEG7_ALHV1 Tegument protein UL51 homolog (Uncharacterized gene 55 protein)
RIR1_ALHV1 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
SEMA_ALHV1 Semaphorin-like protein A3
IE63_ALHV1 Immediate-early phosphoprotein 57
MCP_ALHV1 Major capsid protein (MCP)
VG41_ALHV1 Uncharacterized gene 41 protein
VG11_ALHV1 Uncharacterized gene 11 protein
VG58_ALHV1 Gene 58 protein
VP75_ALHV1 Probable membrane antigen 75 (Tegument protein)
DPOL_ALHV1 DNA polymerase catalytic subunit (EC 2.7.7.7)
GH_ALHV1 Envelope glycoprotein H (gH)
BRLF1_ALHV1 Putative transcription activator BRLF1 homolog
GN_ALHV1 Envelope glycoprotein N
GL_ALHV1 Envelope glycoprotein L (gL)
DUT_ALHV1 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
KITH_ALHV1 Thymidine kinase (EC 2.7.1.21)
CVC1_ALHV1 Capsid vertex component 1
CEP3_ALHV1 Cytoplasmic envelopment protein 3
CEP1_ALHV1 Cytoplasmic envelopment protein 1
AN_ALHV1 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
DNBI_ALHV1 Major DNA-binding protein
GM_ALHV1 Envelope glycoprotein M (gM)
ITP_ALHV1 Inner tegument protein
HELI_ALHV1 DNA replication helicase (EC 3.6.4.-)
GB_ALHV1 Envelope glycoprotein B (gB)
CVC2_ALHV1 Capsid vertex component 2
CEP2_ALHV1 Cytoplasmic envelopment protein 2
LTP_ALHV1 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
NEC2_ALHV1 Nuclear egress protein 2
NEC1_ALHV1 Nuclear egress protein 1
VG27_ALHV1 Uncharacterized gene 27 protein
VGA10_ALHV1 Uncharacterized gene A10 protein
TRX1_ALHV1 Triplex capsid protein 1
VG40_ALHV1 Uncharacterized gene 40 protein
TRM1_ALHV1 Tripartite terminase subunit 1
VG23_ALHV1 Uncharacterized gene 23 protein
VGA4_ALHV1 Uncharacterized gene A4 protein
VP03_ALHV1 Probable tegument protein antigen 3
VG10_ALHV1 Uncharacterized gene 10 protein
TRX2_ALHV1 Triplex capsid protein 2
UNG_ALHV1 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL92_ALHV1 Gene 31 protein
UL96_ALHV1 Gene 35 protein
VG52_ALHV1 Uncharacterized gene 52 protein
UL87_ALHV1 Uncharacterized gene 24 protein
VGA2_ALHV1 Uncharacterized protein A2
VG73_ALHV1 Uncharacterized gene 73 protein
VGA8_ALHV1 Uncharacterized gene A8 protein
UL91_ALHV1 Uncharacterized gene 30 protein
UL95_ALHV1 Gene 34 protein
VGA6_ALHV1 Uncharacterized gene A6 protein
VGA7_ALHV1 Putative C-type lectin protein A7

56 entries

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
RIR2_EBVA8 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
BRRF1_EBVA8 Transcriptional activator BRRF1
RTA_EBVA8 Replication and transcription activator (Rta) (Immediate-early protein Rta)
TEG7_EBVA8 Tegument protein UL51 homolog
RIR1_EBVA8 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
SCAF_EBVA8 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
KR2_EBVA8 Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
PORTL_EBVA8 Portal protein
MCP_EBVA8 Major capsid protein (MCP)
KITH_EBVA8 Thymidine kinase (EC 2.7.1.21)
LMP1_EBVA8 Latent membrane protein 1 (LMP-1) (Protein p63)
NEC1_EBVA8 Nuclear egress protein 1
LF1_EBVA8 Uncharacterized LF1 protein
EAR_EBVA8 Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
GP42_EBVA8 Glycoprotein 42 (gp42)
GM_EBVA8 Envelope glycoprotein M (gM)
ITP_EBVA8 Inner tegument protein
GB_EBVA8 Envelope glycoprotein B (gB)
IL10H_EBVA8 Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
DNBI_EBVA8 Major DNA-binding protein
GL_EBVA8 Envelope glycoprotein L (gL)
BKRF4_EBVA8 Tegument protein BKRF4
EBNA2_EBVA8 Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
BRRF2_EBVA8 Tegument protein BRRF2
GP350_EBVA8 Envelope glycoprotein GP350 (Membrane antigen) (MA)
EBNA3_EBVA8 Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
EBNA4_EBVA8 Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
BLRF2_EBVA8 Tegument protein BLRF2
CEP3_EBVA8 Cytoplasmic envelopment protein 3
CVC2_EBVA8 Capsid vertex component 2
BMRF2_EBVA8 Protein BMRF2
BNL2A_EBVA8 Protein BNLF2a
BDLF2_EBVA8 Protein BDLF2
CEP1_EBVA8 Cytoplasmic envelopment protein 1
BZLF1_EBVA8 Trans-activator protein BZLF1 (EB1) (Zebra)
DPOL_EBVA8 DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_EBVA8 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
BARF1_EBVA8 Secreted protein BARF1 (33 kDa early protein) (p33)
GN_EBVA8 Envelope glycoprotein N
GH_EBVA8 Envelope glycoprotein H (gH)
ICP27_EBVA8 mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
LTP_EBVA8 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MTP_EBVA8 Major tegument protein (MTP) (Protein p140)
EBNA1_EBVA8 Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
EBNA5_EBVA8 Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
EBNA6_EBVA8 Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
EAD_EBVA8 DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
BTRF1_EBVA8 Uncharacterized protein BTRF1
BNL2B_EBVA8 Uncharacterized protein BNLF2b
AN_EBVA8 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
CEP2_EBVA8 Cytoplasmic envelopment protein 2
BLLF2_EBVA8 Uncharacterized protein BLLF2
LMP2_EBVA8 Latent membrane protein 2 (Terminal protein)
LF2_EBVA8 Protein LF2
UL92_EBVA8 Uncharacterized protein BDLF4
TRM3_EBVA8 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

3 entries

Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain

Select_allDeselect_all
MIR1_MHV68 E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (MK3) (Modulator of immune recognition 1 homolog) ...
ARBH_MHV68 Apoptosis regulator Bcl-2 homolog (vBcl-2) (Protein M11)
LTP_MHV68 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Ateline herpesvirus 3 (AtHV-3) (Herpesvirus ateles) reference strain

TIO_ATHV3 Protein tio

3 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

Select_allDeselect_all
YBL2_EBVB9 Uncharacterized protein BBLF2
YEC4_EBVB9 Uncharacterized protein EC-RF4
HELI_EBVB9 DNA replication helicase (EC 3.6.4.-)

56 entries

Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Select_allDeselect_all
BNL2A_EBVG Protein BNLF2a
RIR1_EBVG Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RTA_EBVG Replication and transcription activator (Rta) (Immediate-early protein Rta)
SCAF_EBVG Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
RIR2_EBVG Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
TEG7_EBVG Tegument protein UL51 homolog
RPMS1_EBVG Uncharacterized protein RPMS1
MCP_EBVG Major capsid protein (MCP)
MTP_EBVG Major tegument protein (MTP) (Protein p140)
TRM3_EBVG Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
KR2_EBVG Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
GP42_EBVG Glycoprotein 42 (gp42) [Cleaved into: Soluble gp42]
GB_EBVG Envelope glycoprotein B (gB)
GN_EBVG Envelope glycoprotein N
BKRF4_EBVG Tegument protein BKRF4
GM_EBVG Envelope glycoprotein M (gM)
BMRF2_EBVG Protein BMRF2
EBNA1_EBVG Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
DUT_EBVG Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EBNA2_EBVG Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
GP350_EBVG Envelope glycoprotein GP350 (Membrane antigen) (MA)
EBNA3_EBVG Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
DPOL_EBVG DNA polymerase catalytic subunit (EC 2.7.7.7)
CEP1_EBVG Cytoplasmic envelopment protein 1
DNBI_EBVG Major DNA-binding protein
EAR_EBVG Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
AN_EBVG Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BZLF1_EBVG Trans-activator protein BZLF1 (EB1) (Zebra)
BNL2B_EBVG Uncharacterized protein BNLF2b
CEP2_EBVG Cytoplasmic envelopment protein 2
BRRF2_EBVG Tegument protein BRRF2
BDLF2_EBVG Protein BDLF2
CVC2_EBVG Capsid vertex component 2
BLRF2_EBVG Tegument protein BLRF2
BARF1_EBVG Secreted protein BARF1 (33 kDa early protein) (p33)
LF1_EBVG Uncharacterized LF1 protein
ICP27_EBVG mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
LF2_EBVG Protein LF2
GL_EBVG Envelope glycoprotein L (gL)
ITP_EBVG Inner tegument protein
GH_EBVG Envelope glycoprotein H (gH)
EBNA4_EBVG Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
EBNA5_EBVG Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
EBNA6_EBVG Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
EAD_EBVG DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
BALF1_EBVG Apoptosis regulator BALF1
BRRF1_EBVG Transcriptional activator BRRF1
BLLF2_EBVG Uncharacterized protein BLLF2
BTRF1_EBVG Uncharacterized protein BTRF1
LMP1_EBVG Latent membrane protein 1 (LMP-1) (Protein p63)
LTP_EBVG Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
LMP2_EBVG Latent membrane protein 2 (Terminal protein)
IL10H_EBVG Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
PORTL_EBVG Portal protein
LF3_EBVG Uncharacterized protein LF3
KITH_EBVG Thymidine kinase (EC 2.7.1.21)

6 entries

Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

Select_allDeselect_all
YDH3_SHV2C Uncharacterized 9.5 kDa protein in DHFR 3'region (ORF3)
STP_SHV2C Saimiri transformation-associated protein (Collagen-like protein) (stpC)
TIP_SHV2C Tyrosine-protein kinase-interacting protein (Tip)
IL17_SHV2C Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)
DYR_SHV2C Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
YDH4_SHV2C Uncharacterized 9.9 kDa protein in DHFR 3'region (ORF4)

3 entries

Bovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)

Select_allDeselect_all
BRLF1_BHV4D Putative transcription activator BRLF1 homolog
GCNT3_BHV4D Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...
VIE1_BHV4D Probable E3 ubiquitin-protein ligase IE1 (EC 2.3.2.27) (32.7 kDa immediate early protein IE1) ...

3 entries

Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)

Select_allDeselect_all
STP_SHV24 Saimiri transformation-associated protein (Collagen-like protein) (stpC)
TIP_SHV24 Tyrosine-protein kinase-interacting protein (Tip)
DYR_SHV24 Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)

1 entry

Alcelaphine herpesvirus 1 (strain WC11) (AlHV-1) (Malignant catarrhal fever virus)

KITH_AHV1W Thymidine kinase (EC 2.7.1.21)

1 entry

Bovine herpesvirus 4 (BoHV-4) (Movar virus)

GCNT3_BHV4 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Bovine herpesvirus 4 (strain LVR140) (BoHV-4) (Movar virus)

GCNT3_BHV4L Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Bovine herpesvirus 4 (strain V. test) (BoHV-4) (Movar virus)

GCNT3_BHV4V Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)

LMP1_EBVC Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Epstein-Barr virus (strain P3HR-1) (HHV-4) (Human herpesvirus 4)

VGP3_EBVP3 Envelope glycoprotein GP340 (Membrane antigen) (MA)

1 entry

Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

LMP1_EBVR Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Equine herpesvirus 2 (strain T400/3) (EHV-2)

IL10H_EHV2T Viral interleukin-10 homolog (vIL-10)

1 entry

Herpesvirus ateles

TYSY_HSVAT Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

1 entry

Saimiriine herpesvirus 2 (strain 484) (SaHV-2) (Herpesvirus saimiri)

TIP_SHV48 Tyrosine protein kinase-interacting protein (Tip) (TipC484)