Lagovirus (taxid:95339)

VIRION

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Non-enveloped, capsid of about 35 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 capsid proteins. T=1 particles composed of 60 capsid proteins, about in diameter 15nm are also observed. Genomic or subgenomic RNA are encapsidated in different particles.
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GENOME

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Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5'-terminus is linked to a VPg protein and the 3'-terminus has a poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both genome and viral messenger RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the non-structural proteins and the capsid protein. ORF2 encodes a small structural protein VP2 which is expressed through RNA termination-reinitiation.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors mediates endocytosis of the virus into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.

Host-virus interaction

Apoptosis modulation

Rabbit hemorrhagic disease virus induces host cell apoptosis .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

10 entries grouped by strain

2 entries

Rabbit hemorrhagic disease virus (strain Rabbit/Germany/FRG/1989) (Ra/LV/RHDV/GH/1989/GE) (RHDV-FRG) reference strain

Select_allDeselect_all
POLG_RHDVF Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...
VP2_RHDVF Minor capsid protein VP2

2 entries

Rabbit hemorrhagic disease virus (strain AST89) (Ra/LV/RHDV/AST89/1989/SP) (RHDV-AST89)

Select_allDeselect_all
POLG_RHDVA Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...
VP2_RHDVA Minor capsid protein VP2

2 entries

Rabbit hemorrhagic disease virus (strain V-351) (Ra/LV/RHDV/V351/1991/CK) (RHDV-V351)

Select_allDeselect_all
POLG_RHDV3 Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...
VP2_RHDV3 Minor capsid protein VP2

1 entry

European brown hare syndrome virus (strain GD) (Ha/LV/EBHSV/GD/1989/FR) (EBHSV-GD)

POLG_EBHSG Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...

1 entry

Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)

CAPSD_RHDVR Subgenomic capsid protein VP60

1 entry

Rabbit hemorrhagic disease virus (strain BS89) (Ra/LV/RHDV/BS89/1989/IT) (RHDV-BS89)

POLG_RHDVB Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...

1 entry

Rabbit hemorrhagic disease virus (strain SD) (Ra/LV/RHDV/SD/1989/FR) (RHDV-SD)

POLG_RHDVS Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Rabbit calicivirus Australia 1 MIC-07 taxid:576948

Protein ModelArchive
Minor structural protein ma-jd-viral-67207