Modulation of host ubiquitin pathway by virus (kw:KW-1130)
Numerous cellular processes are regulated by the reversible conjugation of ubiquitin (UB) or ubiquitin-like (UBL) proteins to substrates. Typically, a ubiquitin-activating enzyme (E1) binds ubiquitin in an adenosine triphosphate dependent manner. Ubiquitin is then transferred to a ubiquitin-conjugating enzyme (E2). A ubiquitin ligase (E3) helps transfer ubiquitin to the target substrate. In turn, polyubiquitination targets proteins to a cellular organelle known as the 26S proteasome where substrates are degraded into small peptides. Proteasomal degradation is critical component of many cellular processes including cell cycle regulation,induction of the inflammatory response and antigen presentation.

Viruses have evolved different strategies to modulate host cell ubiquitin machinery. The reasons of this manipulation are multiple including modulation of the host cell cycle, viral replication, inhibition of the host immune system or viral budding. The modification of the ub system includes the modulation of cellular E3 ligases, the synthesis of viral E3 ligases, viral deubiquitinases, or viral ubiquitin-like proteins that will perturb normal host Ub pathways.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)155 entries grouped by strain
3 entries
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) reference strain
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Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
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Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
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Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
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Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
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Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
2 entries
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain
2 entries
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain
2 entries
Human coronavirus 229E (HCoV-229E) reference strain
2 entries
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1) reference strain
2 entries
Human coronavirus NL63 (HCoV-NL63) reference strain
2 entries
Human coronavirus OC43 (HCoV-OC43) reference strain
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Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
2 entries
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
2 entries
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1) reference strain
2 entries
Monkeypox virus reference strain
2 entries
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
2 entries
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
2 entries
Myxoma virus (strain Lausanne) (MYXV) reference strain
2 entries
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
2 entries
Severe acute respiratory syndrome coronavirus (SARS-CoV) reference strain
2 entries
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain
2 entries
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain
2 entries
White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV) (White spot bacilliform virus) reference strain
1 entry
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain
1 entry
Camelpox virus (strain CMS) reference strain
1 entry
Cercopithecine herpesvirus 9 (strain DHV) (CeHV-9) (Simian varicella virus) reference strain
1 entry
Choristoneura fumiferana nuclear polyhedrosis virus (CfMNPV) reference strain
1 entry
Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV) reference strain
1 entry
Dugbe virus (isolate ArD44313) (DUGV) reference strain
1 entry
Equine arteritis virus (strain Bucyrus) (EAV) reference strain
1 entry
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain
1 entry
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
1 entry
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain
1 entry
Grapevine fleck virus (isolate Italy/MT48) (GFkV) reference strain
1 entry
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain
1 entry
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain
1 entry
Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40) reference strain
1 entry
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
1 entry
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
1 entry
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
1 entry
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
1 entry
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
1 entry
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
1 entry
Maize rayado fino virus (isolate Costa Rica/Guapiles) (MRFV) reference strain
1 entry
Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus) reference strain
1 entry
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain
1 entry
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1 entry
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1 entry
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain
1 entry
Rachiplusia ou multiple nucleopolyhedrovirus (strain R1) (RoMNPV) reference strain
1 entry
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
1 entry
Simian virus 40 (SV40) reference strain
1 entry
Turnip yellow mosaic virus reference strain
1 entry
Vaccinia virus (strain Copenhagen) (VACV) reference strain
1 entry
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
1 entry
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain
1 entry
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain
4 entries
Cowpox virus (strain Brighton Red) (CPV)
3 entries
Cowpox virus (strain GRI-90 / Grishak) (CPV)
3 entries
Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)
2 entries
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
2 entries
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
2 entries
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
2 entries
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
2 entries
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
2 entries
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
2 entries
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
2 entries
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
2 entries
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
2 entries
Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)
2 entries
Horsepox virus (HSPV)
2 entries
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1)
2 entries
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
2 entries
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
2 entries
Porcine epidemic diarrhea virus (strain CV777) (PEDV)
1 entry
Bombyx mori nuclear polyhedrosis virus (BmNPV)
1 entry
Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
1 entry
Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)
1 entry
Cowpox virus (CPV)
1 entry
Eggplant mosaic virus
1 entry
Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)
1 entry
Erysimum latent virus (ELV)
1 entry
Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)
1 entry
Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)
1 entry
Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)
1 entry
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)
1 entry
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
1 entry
Hyphantria cunea nuclear polyhedrosis virus (HcNPV)
1 entry
Kennedya yellow mosaic virus (strain Jervis bay) (KYMV)
1 entry
Lumpy skin disease virus (LSDV)
1 entry
Monkeypox virus (strain Zaire-96-I-16) (MPX)
1 entry
Ononis yellow mosaic virus
1 entry
Porcine reproductive and respiratory syndrome virus (PRRSV)
1 entry
Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)
1 entry
Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)
1 entry
Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV)
1 entry
Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)
1 entry
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))
1 entry
Swinepox virus (strain Kasza) (SWPV)
1 entry
Turnip yellow mosaic virus (isolate Australia)
1 entry
Turnip yellow mosaic virus (isolate TYMC)
1 entry
Vaccinia virus (strain LC16m0) (VACV)
1 entry
Vaccinia virus (strain LC16m8) (VACV)
1 entry
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)
1 entry