Modulation of host ubiquitin pathway by virus

Numerous cellular processes are regulated by the reversible conjugation of ubiquitin (UB) or ubiquitin-like (UBL) proteins to substrates. Typically, a ubiquitin-activating enzyme (E1) binds ubiquitin in an adenosine triphosphate dependent manner. Ubiquitin is then transferred to a ubiquitin-conjugating enzyme (E2). A ubiquitin ligase (E3) helps transfer ubiquitin to the target substrate. In turn, polyubiquitination targets proteins to a cellular organelle known as the 26S proteasome where substrates are degraded into small peptides. Proteasomal degradation is critical component of many cellular processes including cell cycle regulation,induction of the inflammatory response and antigen presentation.

Viruses have evolved different strategies to modulate host cell ubiquitin machinery. The reasons of this manipulation are multiple including modulation of the host cell cycle, viral replication, inhibition of the host immune system or viral budding. The modification of the ub system includes the modulation of cellular E3 ligases, the synthesis of viral E3 ligases, viral deubiquitinases, or viral ubiquitin-like proteins that will perturb normal host Ub pathways.

Matching UniProtKB/Swiss-Prot entries

144 entries grouped by strain (browse by keywords)

3 entries

Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) reference strain

Select_allDeselect_all
UBIL_NPVOP Ubiquitin-like protein
VIE2_NPVOP E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...
IAP3_NPVOP E3 ubiquitin-protein ligase IAP-3 (EC 2.3.2.27) (IAP-3) (RING-type E3 ubiquitin transferase IAP-3)

2 entries

Autographa californica nuclear polyhedrosis virus (AcMNPV) reference strain

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UBIL_NPVAC viral Ubiquitin
IE2_NPVAC E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...

2 entries

Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005) reference strain

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R1A_BC133 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_BC133 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain

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R1A_BC512 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_BC512 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...

2 entries

Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain

Select_allDeselect_all
R1AB_BCHK4 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_BCHK4 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...

2 entries

Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain

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R1A_BCHK5 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_BCHK5 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain

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R1AB_BCHK9 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_BCHK9 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...

2 entries

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

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LMP2_EBVA8 Latent membrane protein 2 (Terminal protein)
LTP_EBVA8 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

2 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
LTP_EBVB9 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
LMP2_EBVB9 Latent membrane protein 2 (Terminal protein)

2 entries

Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

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ICP0_EHV1B E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ICP0)
LTP_EHV1B Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

2 entries

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

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E1A_ADE02 Early E1A protein (Early E1A 32 kDa protein)
E434_ADE02 Early 4 ORF6 protein (E4-ORF6) (Early 4 34 kDa protein) (E4-34k)

2 entries

Human coronavirus 229E (HCoV-229E) reference strain

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R1A_CVH22 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVH22 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...

2 entries

Human coronavirus HKU1 (isolate N5) (HCoV-HKU1) reference strain

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R1A_CVHN5 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVHN5 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

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ICP0_HHV11 E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Alpha-0 protein) (Immediate-early protein IE110) ...
LTP_HHV11 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

2 entries

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

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ICP0_HHV2H E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferaseICP0) (VMW118 ...
LTP_HHV2H Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

2 entries

Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain

Select_allDeselect_all
R1A_CVM2 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVM2 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain

Select_allDeselect_all
R1AB_CVMA5 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_CVMA5 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...

2 entries

Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus) reference strain

Select_allDeselect_all
R1A_CVMJH Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVMJH Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Myxoma virus (strain Lausanne) (MYXV) reference strain

Select_allDeselect_all
LAP_MYXVL E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...
MT5_MYXVL Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)

2 entries

Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain

Select_allDeselect_all
R1AB_CVPPU Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...
R1A_CVPPU Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...

2 entries

Severe acute respiratory syndrome coronavirus (SARS-CoV) reference strain

Select_allDeselect_all
R1A_SARS Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_SARS Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

Select_allDeselect_all
R1A_SARS2 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Host translation inhibitor nsp1 ...
R1AB_SARS2 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

pdb 5R7Y; 5R7Z; 5R80; 5R81; 5R82; 5R83; 5R84; 5R8T; 5RE4; 5RE5; 5RE6; 5RE7; 5RE8; 5RE9; 5REA; 5REB; 5REC; 5RED; 5REE; 5REF; 5REG; 5REH; 5REI; 5REJ; 5REK; 5REL; 5REM; 5REN; 5REO; 5REP; 5RER; 5RES; 5RET; 5REU; 5REV; 5REW; 5REX; 5REY; 5REZ; 5RF0; 5RF1; 5RF2; 5RF3; 5RF4; 5RF5; 5RF6; 5RF7; 5RF8; 5RF9; 5RFA; 5RFB; 5RFC; 5RFD; 5RFE; 5RFF; 5RFG; 5RFH; 5RFI; 5RFJ; 5RFK; 5RFL; 5RFM; 5RFN; 5RFO; 5RFP; 5RFQ; 5RFR; 5RFS; 5RFT; 5RFU; 5RFV; 5RFW; 5RFX; 5RFY; 5RFZ; 5RG0; 5RG1; 5RG2; 5RG3; 5RGG; 5RGH; 5RGI; 5RGJ; 5RGK; 5RGL; 5RGM; 5RGN; 5RGO; 5RGP; 5RGQ; 5RGR; 5RGS; 5RGT; 5RGU; 5RGV; 5RGW; 5RGX; 5RGY; 5RGZ; 5RH0; 5RH1; 5RH2; 5RH3; 5RH4; 5RH5; 5RH6; 5RH7; 5RH8; 5RH9; 5RHA; 5RHB; 5RHC; 5RHD; 5RHE; 5RHF; 5RL0; 5RL1; 5RL2; 5RL3; 5RL4; 5RL5; 5RL6; 5RL7; 5RL8; 5RL9; 5RLB; 5RLC; 5RLD; 5RLE; 5RLF; 5RLG; 5RLH; 5RLI; 5RLJ; 5RLK; 5RLL; 5RLM; 5RLN; 5RLO; 5RLP; 5RLQ; 5RLR; 5RLS; 5RLT; 5RLU; 5RLV; 5RLW; 5RLY; 5RLZ; 5RM0; 5RM1; 5RM2; 5RM3; 5RM4; 5RM5; 5RM6; 5RM7; 5RM8; 5RM9; 5RMA; 5RMB; 5RMC; 5RMD; 5RME; 5RMF; 5RMG; 5RMH; 5RMI; 5RMJ; 5RMK; 5RML; 5RMM; 5RS7; 5RS8; 5RS9; 5RSB; 5RSC; 5RSD; 5RSE; 5RSF; 5RSG; 5RSH; 5RSI; 5RSJ; 5RSK; 5RSL; 5RSM; 5RSN; 5RSO; 5RSP; 5RSQ; 5RSR; 5RSS; 5RST; 5RSU; 5RSV; 5RSW; 5RSX; 5RSY; 5RSZ; 5RT0; 5RT1; 5RT2; 5RT3; 5RT4; 5RT5; 5RT6; 5RT7; 5RT8; 5RT9; 5RTA; 5RTB; 5RTC; 5RTD; 5RTE; 5RTF; 5RTG; 5RTH; 5RTI; 5RTJ; 5RTK; 5RTL; 5RTM; 5RTN; 5RTO; 5RTP; 5RTQ; 5RTR; 5RTS; 5RTT; 5RTU; 5RTV; 5RTW; 5RTX; 5RTY; 5RTZ; 5RU0; 5RU1; 5RU2; 5RU3; 5RU4; 5RU5; 5RU6; 5RU7; 5RU8; 5RU9; 5RUA; 5RUC; 5RUD; 5RUE; 5RUF; 5RUG; 5RUH; 5RUI; 5RUJ; 5RUK; 5RUL; 5RUM; 5RUN; 5RUO; 5RUP; 5RUQ; 5RUR; 5RUS; 5RUT; 5RUU; 5RUV; 5RUW; 5RUX; 5RUY; 5RUZ; 5RV0; 5RV1; 5RV2; 5RV3; 5RV4; 5RV5; 5RV6; 5RV7; 5RV8; 5RV9; 5RVA; 5RVB; 5RVC; 5RVD; 5RVE; 5RVF; 5RVG; 5RVH; 5RVI; 5RVJ; 5RVK; 5RVL; 5RVM; 5RVN; 5RVO; 5RVP; 5RVQ; 5RVR; 5RVS; 5RVT; 5RVU; 5RVV; 5S18; 5S1A; 5S1C; 5S1E; 5S1G; 5S1I; 5S1K; 5S1M; 5S1O; 5S1Q; 5S1S; 5S1U; 5S1W; 5S1Y; 5S20; 5S22; 5S24; 5S26; 5S27; 5S28; 5S29; 5S2A; 5S2B; 5S2C; 5S2D; 5S2E; 5S2F; 5S2G; 5S2H; 5S2I; 5S2J; 5S2K; 5S2L; 5S2M; 5S2N; 5S2O; 5S2P; 5S2Q; 5S2R; 5S2S; 5S2T; 5S2U; 5S2V; 5S2W; 5S2X; 5S2Y; 5S2Z; 5S30; 5S31; 5S32; 5S33; 5S34; 5S35; 5S36; 5S37; 5S38; 5S39; 5S3A; 5S3B; 5S3C; 5S3D; 5S3E; 5S3F; 5S3G; 5S3H; 5S3I; 5S3J; 5S3K; 5S3L; 5S3M; 5S3N; 5S3O; 5S3P; 5S3Q; 5S3R; 5S3S; 5S3T; 5S3U; 5S3V; 5S3W; 5S3X; 5S3Y; 5S3Z; 5S40; 5S41; 5S42; 5S43; 5S44; 5S45; 5S46; 5S47; 5S48; 5S49; 5S4A; 5S4B; 5S4C; 5S4D; 5S4E; 5S4F; 5S4G; 5S4H; 5S4I; 5S4J; 5S4K; 5S6X; 5S6Y; 5S6Z; 5S70; 5S71; 5S72; 5S73; 5S74; 6LU7; 6LZE; 6M03; 6M0K; 6M2N; 6M2Q; 6M71; 6VWW; 6VXS; 6W01; 6W02; 6W4B; 6W4H; 6W61; 6W63; 6W6Y; 6W75; 6W9C; 6W9Q; 6WC1; 6WCF; 6WEN; 6WEY; 6WIQ; 6WJT; 6WKQ; 6WKS; 6WLC; 6WNP; 6WOJ; 6WQ3; 6WQD; 6WQF; 6WRH; 6WRZ; 6WTC; 6WTJ; 6WTK; 6WTM; 6WTT; 6WUU; 6WVN; 6WX4; 6WXC; 6WXD; 6WZU; 6X1B; 6X4I; 6XA4; 6XA9; 6XAA; 6XB0; 6XB1; 6XB2; 6XBG; 6XBH; 6XBI; 6XCH; 6XDH; 6XFN; 6XG3; 6XHM; 6XHU; 6XIP; 6XKF; 6XKH; 6XKM; 6XMK; 6XOA; 6XQS; 6XQT; 6XQU; 6XR3; 6Y2E; 6Y2F; 6Y2G; 6Y84; 6YB7; 6YNQ; 6YVA; 6YVF; 6YWK; 6YWL; 6YWM; 6YYT; 6YZ1; 6YZ6; 6Z2E; 6Z5T; 6Z6I; 6Z72; 6ZCT; 6ZLW; 6ZM7; 6ZME; 6ZMI; 6ZMO; 6ZMT; 6ZN5; 6ZOJ; 6ZOK; 6ZON; 6ZP4; 6ZPE; 6ZRT; 6ZRU; 6ZSL; 7A1U; 7ABU; 7ADW; 7AF0; 7AGA; 7AHA; 7AK4; 7AKU; 7ALH; 7ALI; 7AMJ; 7ANS; 7AP6; 7APH; 7AQI; 7AQJ; 7AR5; 7AR6; 7ARF; 7AVD; 7AWR; 7AWS; 7AWU; 7AWW; 7AX6; 7AXM; 7AXO; 7AY7; 7B3E; 7B83; 7BF3; 7BF4; 7BF5; 7BF6; 7BQ7; 7BQY; 7BRO; 7BRP; 7BTF; 7BUY; 7BV1; 7BV2; 7BZF; 7C2I; 7C2J; 7C2K; 7C2Q; 7C2Y; 7C6S; 7C6U; 7C7P; 7C8B; 7C8R; 7C8T; 7C8U; 7CBT; 7CJD; 7CJM; 7CMD; 7COM; 7CWB; 7CWC; 7CX9; 7D1M; 7D1O; 7JFQ; 7JHE; 7JIB; 7JKV; 7JME; 7JOY; 7JP1; 7JPE; 7JPY; 7JPZ; 7JQ0; 7JQ1; 7JQ2; 7JQ3; 7JQ4; 7JQ5; 7JQB; 7JQC; 7JR3; 7JR4; 7JU7; 7JUN; 7JVZ; 7JYC; 7JYY; 7JZ0; 7K1L; 7K1O; 7K3N; 7K3T; 7K40; 7K5I; 7K6D; 7K6E; 7K7P; 7K9P; 7KAG; 7KEG; 7KEH; 7KF4; 7KFI; 7KFJ; 7KG3; 7KHP; 7KOA; 7KPH; 7KQO; 7KQP; 7KQW; 7KR0; 7KR1; 7KS5; 7KVL; 7KVR; 7KX5; 7KYU; 7L5D; 7L6R; 7L6T; 7LDX

2 entries

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Select_allDeselect_all
IE61_VZVD E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61) (RING-type E3 ...
LTP_VZVD Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

2 entries

White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV) (White spot bacilliform virus) reference strain

Select_allDeselect_all
UB403_WSSVS RING finger containing E3 ubiquitin-protein ligase WSV403 (EC 2.3.2.27) (RING-type E3 ubiquitin ...
UB222_WSSVS RING finger containing E3 ubiquitin-protein ligase WSV222 (EC 2.3.2.27) (RING-type E3 ubiquitin ...

1 entry

Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

LTP_ALHV1 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Camelpox virus (strain CMS) reference strain

KBTB1_CAMPS Kelch repeat and BTB domain-containing protein 1

1 entry

Cercopithecine herpesvirus 9 (strain DHV) (CeHV-9) (Simian varicella virus) reference strain

IE61_CHV9D E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61)

1 entry

Choristoneura fumiferana nuclear polyhedrosis virus (CfMNPV) reference strain

VIE2_NPVCF E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...

1 entry

Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV) reference strain

L_CCHFI RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

1 entry

Dugbe virus (isolate ArD44313) (DUGV) reference strain

L_DUGBA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

1 entry

Equine arteritis virus (strain Bucyrus) (EAV) reference strain

RPOA_EAVBU Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 papain-like cysteine proteinase ...

1 entry

Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

LTP_EHV2 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain

R1AB_FIPV Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...

1 entry

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain

LTP_GAHVM Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

LTP_HCMVA Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

LTP_HCMVM Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

LTP_HHV6U Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

LTP_HHV6Z Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

LTP_HHV7J Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

LTP_HHV8P Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus) reference strain

LTP_MUHVK Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain

LTP_MHV68 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV) reference strain

RPOA_PRRSB Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain

RPOA_PRRSL Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain

LTP_PSHV1 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

LAP_RFVKA E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Rachiplusia ou multiple nucleopolyhedrovirus (strain R1) (RoMNPV) reference strain

VIE2_NPVR1 E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...

1 entry

Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

LTP_SHV21 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Simian virus 40 (SV40) reference strain

LT_SV40 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Turnip yellow mosaic virus reference strain

POLR_TYMV RNA replicase polyprotein (206 kDa polyprotein) [Cleaved into: Methyltransferase/Protease (EC ...

1 entry

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

KBTB1_VACCW Kelch repeat and BTB domain-containing protein A55

1 entry

Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

P28_VAR67 E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (D4R protein) (RING-type E3 ubiquitin transferase ...

1 entry

Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

LAP_YMTV5 E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Yaba-like disease virus (YLDV) reference strain

LAP_YLDV E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

4 entries

Cowpox virus (strain Brighton Red) (CPV)

Select_allDeselect_all
KBTB1_CWPXB Kelch repeat and BTB domain-containing protein 1
P28_CWPXB E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein CPXV023) (RING-type E3 ubiquitin ...
KBTB2_CWPXB Kelch repeat and BTB domain-containing protein 2
CP77_CWPXB Ankyrin repeat domain-containing protein CP77 (Host range protein 1)

3 entries

Cowpox virus (strain GRI-90 / Grishak) (CPV)

Select_allDeselect_all
P28_CWPXG E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein C7R) (RING-type E3 ubiquitin transferase ...
KBTB2_CWPXG Kelch repeat and BTB domain-containing protein 2
KBTB1_CWPXG Kelch repeat and BTB domain-containing protein 1

3 entries

Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)

Select_allDeselect_all
P28_ECTVM E3 ubiquitin-protein ligase p28 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase p28-like)
KBTB2_ECTVM Kelch repeat and BTB domain-containing protein 2
KBTB1_ECTVM Kelch repeat and BTB domain-containing protein 1

2 entries

Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)

Select_allDeselect_all
R1A_BC279 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_BC279 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)

Select_allDeselect_all
R1AB_BCHK3 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_BCHK3 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...

2 entries

Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)

Select_allDeselect_all
R1AB_BCRP3 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_BCRP3 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...

2 entries

Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)

Select_allDeselect_all
R1AB_CVBEN Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_CVBEN Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...

2 entries

Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)

Select_allDeselect_all
R1A_CVBLU Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVBLU Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Bovine coronavirus (strain Mebus) (BCoV) (BCV)

Select_allDeselect_all
R1A_CVBM Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVBM Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Bovine coronavirus (strain Quebec) (BCoV) (BCV)

Select_allDeselect_all
R1A_CVBQ Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVBQ Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Select_allDeselect_all
LMP2_EBVG Latent membrane protein 2 (Terminal protein)
LTP_EBVG Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

2 entries

Horsepox virus (HSPV)

Select_allDeselect_all
KBTB1_HSPV Kelch repeat and BTB domain-containing protein 1
KBTB2_HSPV Kelch repeat and BTB domain-containing protein 2

2 entries

Human coronavirus HKU1 (isolate N1) (HCoV-HKU1)

Select_allDeselect_all
R1A_CVHN1 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVHN1 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)

Select_allDeselect_all
R1AB_CVHN2 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_CVHN2 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...

2 entries

Human coronavirus NL63 (HCoV-NL63)

Select_allDeselect_all
R1A_CVHNL Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVHNL Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...

2 entries

Human coronavirus OC43 (HCoV-OC43)

Select_allDeselect_all
R1AB_CVHOC Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_CVHOC Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...

2 entries

Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1)

Select_allDeselect_all
R1A_MERS1 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Host translation inhibitor nsp1 ...
R1AB_MERS1 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

2 entries

Porcine epidemic diarrhea virus (strain CV777) (PEDV)

Select_allDeselect_all
R1A_PEDV7 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_PEDV7 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...

1 entry

Bombyx mori nuclear polyhedrosis virus (BmNPV)

VIE2_NPVBM E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...

1 entry

Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)

ICP0_BHV1J E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ...

1 entry

Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)

ICP0_BHV1K E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ...

1 entry

Cowpox virus (CPV)

CP77_COWPX Ankyrin repeat domain-containing protein CP77 (Host range protein 1)

1 entry

Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)

ICP0_EHV1V E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Infected cell protein 0) (RING-type E3 ubiquitin ...

1 entry

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

E1A_ADE12 Early E1A protein (Early E1A 29.5 kDa protein)

1 entry

Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

E1A_ADE07 Early E1A protein (Early E1A 28 kDa protein)

1 entry

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)

E1A_ADE05 Early E1A protein (Early E1A 32 kDa protein)

1 entry

Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

E1A_ADE04 Early E1A protein (Early E1A 28 kDa protein)

1 entry

Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)

E1A_ADE40 Early E1A protein (Early E1A 27 kDa protein)

1 entry

Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

E1A_ADE41 Early E1A protein (Early E1A 27 kDa protein)

1 entry

Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

LTP_HCMVT Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

LTP_HHV6G Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

1 entry

Hyphantria cunea nuclear polyhedrosis virus (HcNPV)

VIE2_NPVHC E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...

1 entry

Lumpy skin disease virus (LSDV)

LAP_LSDV E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Monkeypox virus (strain Zaire-96-I-16) (MPX)

P28_MONPZ E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein D5R) (RING-type E3 ubiquitin transferase ...

1 entry

Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)

RPOA_PRRSS Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)

RPOA_PRRS1 Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)

RPOA_PRRSR Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

ICP0_SUHVF E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Early protein 0) (EP0) (RING-type E3 ubiquitin ...

1 entry

Swinepox virus (strain Kasza) (SWPV)

LAP_SWPVK E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Vaccinia virus (strain Copenhagen) (VACV)

KBTB1_VACCC Kelch repeat and BTB domain-containing protein 1

1 entry

Vaccinia virus (strain LC16m0) (VACV)

P28_VACC0 E3 ubiquitin ligase p28-like (EC 2.3.2.-) (E3 ubiquitin transferase p28-like)

1 entry

Vaccinia virus (strain LC16m8) (VACV)

P28_VACC8 E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (RING-type E3 ubiquitin transferase p28-like)

1 entry

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

LTP_VZVO Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)