Mastadenovirus replication cycle

Human adenovirus type C replication cycle

adhesion receptor Entry receptor Clathrin endocytosis Penetration into host nucleus Microtubular inward transport Hexon Protein IX Endosome lysis protein Cell cycle modulation E1A E1B55k PML modulation transcription Apoptosis modulation E4orf3 E4orf6 Tapasis inhibitor Strand displacement replication Nuclear capsid assembly Viral genome packaging ribosomal shunt Alternative splicing Host translation shutoff 100k Cell lysis Virion maturation Protease ADP POL DBP splicing factor 33K IVa2 22k 52K Penton E318.5k E1B19k E314.7 E3RIDalpha E3RIDbeta E3CR1alpha IX iVa2 33K