Alphapolyomavirus (taxid:1891713)

Alphapolyomavirus is a genus of dsDNA viruses in the family Polyomaviridae that infect mammals. Infections in humans are usually asymptomatic, but in rare cases may be associated with skin cancer, lymphoma or renal disease.

VIRION

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Non-enveloped capsid with a T=7d icosahedral symmetry, about 50 nm in diameter.
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GENOME

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Circular dsDNA about 5 kb in size, associated with cellular histones in a chromatin-like complex. Encodes for 5-6 proteins.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly/exit). 5-6 proteins are expressed from the two pre-MRNA by alternative splicing. All genes are transcribed by host RNA pol II.

REPLICATION

NUCLEAR

  1. Attachement of the viral proteins to host receptors triggers lipid-mediated endocytosis of the virus into the host cell.
  2. Virion transits through endoplasmic reticulum where host protein disulfide isomerases rearrange its capsid structure
  3. Export of misfolded virion to the cytoplasm possibly through host ERAD pathway
  4. Loss of VP1 in the low-calcium conditions of the cytosol
  5. Import of genomic DNA into host nucleus.
  6. Transcription of early genes (LT and sT genes)
  7. Replication of the DNA genome in the nucleus.
  8. Transcription of late genes encoding for structural proteins (VP1, VP2 and VP3).
  9. Assembly of new virions in nuclear viral factories.
  10. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

25 entries grouped by strain

4 entries

Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain

Select_allDeselect_all
LT_POVHA Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP2_POVHA Minor capsid protein VP2 (Minor structural protein VP2)
MT_POVHA Middle T antigen (MT) (MT-AG)
ST_POVHA Small t antigen (ST) (ST-AG)

5 entries

Murine polyomavirus (strain A2) (MPyV) reference strain

Select_allDeselect_all
LT_POVMA Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
MT_POVMA Middle T antigen (MT) (MT-AG)
VP2_POVMA Minor capsid protein VP2 (Minor structural protein VP2)
VP1_POVMA Major capsid protein VP1 (Major structural protein VP1)
ST_POVMA Small t antigen (ST) (ST-AG)

1 entry

Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1)

VP1_POVHA Major capsid protein VP1 (Major structural protein VP1)

5 entries

Murine polyomavirus (strain A3) (MPyV)

Select_allDeselect_all
VP2_POVM3 Minor capsid protein VP2 (Minor structural protein VP2)
LT_POVM3 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP1_POVM3 Major capsid protein VP1 (Major structural protein VP1)
MT_POVM3 Middle T antigen (MT) (MT-AG)
ST_POVM3 Small t antigen (ST) (ST-AG)

5 entries

Murine polyomavirus (strain Crawford small-plaque) (MPyV)

Select_allDeselect_all
LT_POVMC Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
VP2_POVMC Minor capsid protein VP2 (Minor structural protein VP2)
ST_POVMC Small t antigen (ST) (ST-AG)
MT_POVMC Middle T antigen (MT) (MT-AG)
VP1_POVMC Major capsid protein VP1 (Major structural protein VP1)

2 entries

Murine polyomavirus (strain BG) (MPyV)

Select_allDeselect_all
LT_POVBG Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
MT_POVBG Middle T antigen (MT) (MT-AG)

2 entries

Mus musculus polyomavirus 1 (MPyV)

Select_allDeselect_all
LT_POVM1 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
MT_POVM1 Middle T antigen (MT) (MT-AG)

1 entry

Murine polyomavirus (strain P16 small-plaque) (MPyV)

VP1_POVMP Capsid protein VP1
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Alphapolyomavirus apaniscus taxid:1236391

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14775
Large T antigen ma-jd-viral-21185
Minor capsid protein ma-jd-viral-29844
Small T antigen ma-jd-viral-16548

Alphapolyomavirus chlopygerythrus taxid:1891719

Protein ModelArchive
Large T antigen ma-jd-viral-21219
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48379
Small T antigen ma-jd-viral-16545
VP1 major capsid protein ma-jd-viral-14755

Alphapolyomavirus molossi taxid:1606504

Protein ModelArchive
Large T-antigen ma-jd-viral-21172
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48377
Small t-antigen ma-jd-viral-16603
VP1 structural protein ma-jd-viral-14810

Alphapolyomavirus quartipanos taxid:1891736

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14785
Large T antigen ma-jd-viral-21121
Minor capsid protein ma-jd-viral-29757
Small T antigen ma-jd-viral-16567

Alphapolyomavirus quintipanos taxid:1891737

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14761
Large T antigen ma-jd-viral-21214
Minor capsid protein ma-jd-viral-29808
Small T antigen ma-jd-viral-16576

Alphapolyomavirus septipanos taxid:1891739

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14712
Large T antigen ma-jd-viral-21178
Minor capsid protein ma-jd-viral-31166
Small T antigen ma-jd-viral-16628

Alphapolyomavirus sextipanos taxid:1891738

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14705
Large T antigen ma-jd-viral-21119
Minor capsid protein ma-jd-viral-31161
Small T antigen ma-jd-viral-16645

Alphapolyomavirus tertichlopygerythrus taxid:1891720

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14756
Large T antigen ma-jd-viral-21104
Minor capsid protein ma-jd-viral-31144
Minor capsid protein ma-jd-viral-29767
Small T antigen ma-jd-viral-16541

Alphapolyomavirus tertipanos taxid:1891735

Protein ModelArchive
Large T antigen ma-jd-viral-21111
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48364
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48392
Small T antigen ma-jd-viral-16592
VP1 ma-jd-viral-14707

Bat polyomavirus 5a taxid:1623687

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14735
Large T antigen ma-jd-viral-21140
Minor capsid protein ma-jd-viral-29843
Small t antigen ma-jd-viral-16632

Bornean orang-utan polyomavirus taxid:1604874

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14768
Large T antigen ma-jd-viral-21134
Minor capsid protein ma-jd-viral-29836
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29770
Small T antigen ma-jd-viral-16633

Chimpanzee polyomavirus Bob taxid:2035845

Protein ModelArchive
Large T antigen ma-jd-viral-21166
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48363
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48384
Small T antigen ma-jd-viral-16562
VP1 protein ma-jd-viral-14734

Gorilla gorilla gorilla polyomavirus 1 taxid:928214

Protein ModelArchive
Large T antigen ma-jd-viral-21154
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48386
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48391
Small T antigen ma-jd-viral-16653
VP1 ma-jd-viral-14721

Hamster polyomavirus taxid:1891729

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14736
Capsid protein VP1 ma-jd-viral-14736
Large T antigen ma-jd-viral-21170
Middle T antigen ma-jd-viral-09787
Middle T antigen (MT) (MT-AG) ma-jd-viral-09787
Minor capsid protein ma-jd-viral-31167
Minor capsid protein ma-jd-viral-29839
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-31167
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29839
Small T antigen ma-jd-viral-16594
Small t antigen (ST) (ST-AG) ma-jd-viral-16594

Human polyomavirus 9 taxid:943908

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14805
Capsid protein VP1 ma-jd-viral-14805
Gp5 protein (Small T antigen) ma-jd-viral-16566
Large T antigen ma-jd-viral-21136
Minor capsid protein ma-jd-viral-31159
Minor capsid protein ma-jd-viral-29778

Macaca fascicularis polyomavirus 1 taxid:1236398

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14725
Large T antigen ma-jd-viral-21115
Minor capsid protein ma-jd-viral-31140
Small T antigen ma-jd-viral-16583

Merkel cell polyomavirus taxid:493803

Protein ModelArchive
Capsid protein (Major capsid protein) (VP1) ma-jd-viral-14698
Large T antigen (T antigen) ma-jd-viral-21218
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48371
Small T antigen (T antigen) ma-jd-viral-16589

Murine polyomavirus (strain BG) taxid:179241

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14714
Large T antigen (LT) (LT-AG) (EC 3.6.4.-) ma-jd-viral-21155
Middle T antigen (MT) (MT-AG) ma-jd-viral-09788
Minor capsid protein ma-jd-viral-29753
Minor capsid protein ma-jd-viral-29764
Small T antigen ma-jd-viral-16585

New Jersey polyomavirus-2013 taxid:1497391

Protein ModelArchive
Alternative T antigen ma-jd-viral-45454
Large T antigen ma-jd-viral-21220
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48361
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48378
Small T antigen ma-jd-viral-16553
VP1 ma-jd-viral-14739

Otomops polyomavirus KY156 taxid:2035998

Protein ModelArchive
Large T antigen ma-jd-viral-21131
Major structural protein VP1 ma-jd-viral-14773
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48365
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48397
Small T antigen ma-jd-viral-16652

Otomops polyomavirus KY157 taxid:2035999

Protein ModelArchive
Large T antigen ma-jd-viral-21216
Major structural protein VP1 ma-jd-viral-14704
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48362
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48389
Small T antigen ma-jd-viral-16579

Pan troglodytes verus polyomavirus 1a taxid:928211

Protein ModelArchive
Large T antigen ma-jd-viral-21213
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48382
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48396
Small T antigen ma-jd-viral-16588
VP1 ma-jd-viral-14717

Piliocolobus rufomitratus polyomavirus 1 taxid:1236407

Protein ModelArchive
Large T antigen ma-jd-viral-21207
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48367
Small T antigen ma-jd-viral-16616
VP1 ma-jd-viral-14784

Raccoon polyomavirus taxid:1219896

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14748
Large T antigen ma-jd-viral-21199
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48374
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48393
Small T antigen ma-jd-viral-21196

Rattus norvegicus polyomavirus 1 taxid:1679933

Protein ModelArchive
195 T antigen ma-jd-viral-16647
95 T antigen ma-jd-viral-34865
Capsid protein VP1 ma-jd-viral-14752
Large T antigen ma-jd-viral-21204
Middle T antigen ma-jd-viral-09790
Minor capsid protein ma-jd-viral-31178
Minor capsid protein ma-jd-viral-29815
Small T antigen ma-jd-viral-16618

Sumatran orang-utan polyomavirus taxid:1604875

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14738
Large T antigen ma-jd-viral-21106
Minor capsid protein ma-jd-viral-29827
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29800
Small T antigen ma-jd-viral-16564

Trichodysplasia spinulosa-associated polyomavirus taxid:862909

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14780
Large T antigen ma-jd-viral-21187
Minor capsid protein ma-jd-viral-29754
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29776
Small T antigen ma-jd-viral-16630

Yellow baboon polyomavirus 1 taxid:1286213

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14789
Large T antigen ma-jd-viral-21193
Minor capsid protein ma-jd-viral-29758
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-31143
Small T antigen ma-jd-viral-16571

bat polyomavirus 4b taxid:2758138

Protein ModelArchive
Large T antigen ma-jd-viral-21105
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-48398
Small t-antigen ma-jd-viral-16614
VP1 structural protein ma-jd-viral-14776