Iridovirus

VIRION

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Polyhedral virions 185 nm in diameter. The capsid displays an icosahedral symmetry T=147, with an internal lipid membrane. Virions are either externally enveloped or not depending whether they budded from the cell membrane, or were arranged in paracrystaline array in the host cell cytoplasm and were released by lysis.

GENOME

Linear, dsDNA genome of 140 to 213 kb. The genome contains terminal and redundant sequences and is circularly permuted. According to a recent estimation, IIV-6 genome might encode about 211 proteins. The genome is not methylated.

GENE EXPRESSION

there are classical or slightly modified canonical promoters and termination signals upstream and downstream of the start and stop codons of most ORFs.

REPLICATION

NUCLEO-CYTOPLASMIC

  1. Attachement of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the DNA core into the host cytoplasm.
  3. Viral DNA is transported to the cell nucleus where host macromolecular synthesis is rapidly shutdown. Transcription is initiated by virally modified host RNA polymerase II.
  4. Parental DNA is used to produce genome and greater than genome length DNA.
  5. Progeny DNA is transported into cytoplasmic viral factories where large concatamers of viral DNA are formed by recombination. Transcription of very late transcripts may also take place in the cytoplasm.
  6. Assembly of new virions in the cytoplasm.
  7. Virions exit the cell by budding or cell lysis.

Host-virus interaction

Apoptosis modulation

Chilo iridescent virus encodes a functional inhibitor of apoptosis (IAP) . The grouper iridovirus (GIV) contains an antiapoptotic B-cell lymphoma (Bcl)-2-like gene that also inhibits host apoptosis.

Matching UniProtKB/Swiss-Prot entries

218 entries grouped by strain (browse by keywords)

215 entries

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) reference strain

Select_allDeselect_all
VF022_IIV6 Putative helicase 022L (EC 3.6.4.-)
VF157_IIV6 Putative RING finger protein 157L
VF213_IIV6 Transmembrane protein 213R
VF415_IIV6 Uncharacterized protein 415R
VF342_IIV6 Uncharacterized protein 342R
VF439_IIV6 Probable kinase 439L (EC 2.7.-.-)
VF268_IIV6 Uncharacterized protein 268L
VF244_IIV6 Putative phosphoesterase 244L (EC 3.1.-.-)
VF203_IIV6 Uncharacterized protein 203L
VF309_IIV6 Uncharacterized protein 309L
VF350_IIV6 Uncharacterized protein 350L
VF355_IIV6 Putative CTD phosphatase-like protein 355R (EC 3.1.3.-)
107L_IIV6 Uncharacterized protein 107L
127L_IIV6 Uncharacterized protein 127L
293R_IIV6 Uncharacterized protein 293R
026R_IIV6 Uncharacterized protein 026R
006L_IIV6 Putative KilA-N domain-containing protein 006L
165R_IIV6 Putative metalloproteinase 165R (EC 3.4.24.-)
130R_IIV6 Uncharacterized protein 130R
ICP46_IIV6 Immediate-early protein ICP-46 homolog
VF329_IIV6 Uncharacterized protein 329R
VF282_IIV6 Putative transcription factor 282R
VF357_IIV6 Uncharacterized protein 357R
VF098_IIV6 Uncharacterized protein 098R
RPB1_IIV6 Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC 2.7.7.6)
RIR2_IIV6 Probable ribonucleoside-diphosphate reductase small subunit 376L (EC 1.17.4.1) (Ribonucleotide ...
RNC_IIV6 Putative ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III)
PARP_IIV6 Putative poly [ADP-ribose] polymerase-like 100L (EC 2.4.2.30)
VF466_IIV6 Uncharacterized protein 466R
VF067_IIV6 Uncharacterized protein 067R
RIR1_IIV6 Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase large ...
MCP_IIV6 Major capsid protein (MCP) (P50)
VF205_IIV6 Putative DNA ligase 205R (EC 6.5.1.2)
VF196_IIV6 Uncharacterized protein 196R
VF197_IIV6 Putative tyrosine phosphatase 197R (EC 3.1.3.-)
VF306_IIV6 Putative SWIB domain-containing protein 306R
VF136_IIV6 Uncharacterized protein 136R
KTHY_IIV6 Putative thymidylate kinase 251L (EC 2.7.4.9) (dTMP kinase)
VF369_IIV6 Probable RAD2-like endonuclease 369L (EC 3.1.-.-)
VF378_IIV6 Uncharacterized protein 378R
VF224_IIV6 Probable cysteine proteinase 224L (EC 3.4.-.-)
VF414_IIV6 Putative hydrolase 414L (EC 3.6.1.-)
VF118_IIV6 Putative myristoylated protein 118L
VF229_IIV6 Uncharacterized protein 229L
RPB2_IIV6 Probable DNA-directed RNA polymerase II subunit RPB2 homolog (EC 2.7.7.6)
VF295_IIV6 Uncharacterized protein 295L
VF201_IIV6 Putative Bro-N domain-containing protein 201R
VF198_IIV6 Uncharacterized protein 198R
VF019_IIV6 Uncharacterized protein 019R
VF380_IIV6 Probable serine/threonine-protein kinase 380R (EC 2.7.11.1)
VF170_IIV6 Uncharacterized protein 170L
VF335_IIV6 Uncharacterized protein 335L
VF232_IIV6 Putative ubiquitin thioesterase 232R (EC 3.4.19.12)
VF179_IIV6 Uncharacterized protein 179R
VF436_IIV6 Uncharacterized protein 436R
VF395_IIV6 Uncharacterized protein 395R
VF259_IIV6 Uncharacterized protein 259R
VF396_IIV6 Uncharacterized protein 396L
VF161_IIV6 Putative helicase 161L (EC 3.6.4.-)
VF347_IIV6 Putative FAD-linked sulfhydryl oxidase 347L (EC 1.8.3.2)
VF453_IIV6 Putative thioredoxin-like protein 453L
VF184_IIV6 Putative helicase 184R (EC 3.6.4.-)
VF467_IIV6 Uncharacterized protein 467R
VF155_IIV6 Uncharacterized protein 155L
VF359_IIV6 Uncharacterized protein 359L
TYSY_IIV6 Probable thymidylate synthase 225R (EC 2.1.1.45)
VF115_IIV6 Uncharacterized protein 115R
TOP2_IIV6 DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
VF075_IIV6 Uncharacterized protein 075L
VF050_IIV6 Uncharacterized protein 050L
VF010_IIV6 Transmembrane protein 010R
VF117_IIV6 Uncharacterized protein 117L
VF391_IIV6 Uncharacterized protein 391R
VF077_IIV6 Putative zinc finger protein 077L
VF349_IIV6 Putative transcription elongation factor S-II-like protein 349L
VF337_IIV6 Putative membrane protein 337L
VF145_IIV6 Uncharacterized protein 145L
VF219_IIV6 Uncharacterized protein 219L
VF143_IIV6 Putative kinase protein 143R (EC 2.7.-.-)
VF193_IIV6 Apoptosis inhibitor 193R
VF030_IIV6 Uncharacterized protein 030L
VF302_IIV6 Putative zinc finger protein 302L
VF358_IIV6 Uncharacterized protein 358L
VF307_IIV6 Uncharacterized protein 307L
EXON_IIV6 Putative exonuclease 012L (EC 3.1.11.-)
411L_IIV6 Uncharacterized protein 411L
120L_IIV6 Uncharacterized protein 120L
458R_IIV6 Putative myristoylated membrane protein 458R
404L_IIV6 Uncharacterized protein 404L
375R_IIV6 Uncharacterized protein 375R
332L_IIV6 Uncharacterized RING finger protein 332L
368R_IIV6 Uncharacterized protein 368R
254L_IIV6 Uncharacterized protein 254L
113L_IIV6 Uncharacterized protein 113L
451L_IIV6 Uncharacterized protein 451L
249R_IIV6 Uncharacterized protein 249R
273R_IIV6 Uncharacterized protein 273R
422L_IIV6 Uncharacterized protein 422L
346R_IIV6 Uncharacterized protein 346R
044R_IIV6 Uncharacterized protein 044R
287R_IIV6 Uncharacterized protein 287R
340R_IIV6 DRBM domain-containing protein 340R
463L_IIV6 Probable lipid hydrolase 463L (EC 3.1.1.-)
361L_IIV6 Probable cysteine proteinase 361L (EC 3.4.-.-)
065R_IIV6 Uncharacterized protein 065R
313L_IIV6 Putative KilA-N domain-containing protein 313L
221L_IIV6 Uncharacterized protein 221L
141R_IIV6 Uncharacterized protein 141R
373L_IIV6 Uncharacterized protein 373L
400R_IIV6 Uncharacterized protein 400R
246L_IIV6 Uncharacterized protein 246L
212L_IIV6 Putative MSV199 domain-containing protein 212L
094L_IIV6 Uncharacterized protein 094L
211L_IIV6 Putative MSV199 domain-containing protein 211L
284R_IIV6 Uncharacterized protein 284R
301L_IIV6 Uncharacterized protein 301L
226R_IIV6 Uncharacterized protein 226R
322R_IIV6 Uncharacterized protein 322R
HMGH_IIV6 High mobility group protein homolog
009R_IIV6 Uncharacterized protein 009R
348R_IIV6 Uncharacterized protein 348R
238R_IIV6 Putative MSV199 domain-containing protein 238R
441R_IIV6 Uncharacterized protein 441R
454R_IIV6 Putative DNA-directed RNA polymerase subunit 454R
218R_IIV6 Uncharacterized protein 218R
175R_IIV6 Putative RING finger protein 175R
049L_IIV6 Transmembrane protein 049L
029R_IIV6 Uncharacterized protein 029R
261R_IIV6 Uncharacterized protein 261R
420R_IIV6 Putative MSV199 domain-containing protein 420R
216R_IIV6 Uncharacterized protein 216R
071L_IIV6 Uncharacterized protein 071L
140L_IIV6 Uncharacterized protein 140L
148R_IIV6 Putative MSV199 domain-containing protein 148R
104L_IIV6 Uncharacterized protein 104L
384L_IIV6 Uncharacterized protein 384L
062L_IIV6 Uncharacterized protein 062L
095L_IIV6 Putative RING finger protein 095L
DPOL_IIV6 DNA polymerase 037L (EC 2.7.7.7)
172L_IIV6 Putative helicase 172L (EC 3.6.4.-)
149L_IIV6 Uncharacterized protein 149L
156R_IIV6 Uncharacterized protein 156R
300R_IIV6 Transmembrane protein 300R
385L_IIV6 Uncharacterized protein 385L
228L_IIV6 Uncharacterized protein 228L
389L_IIV6 Probable serine/threonine-protein kinase 389L (EC 2.7.11.1)
083L_IIV6 Uncharacterized protein 083L
253L_IIV6 Uncharacterized protein 253L
234R_IIV6 Uncharacterized protein 234R
122R_IIV6 Uncharacterized protein 122R
325L_IIV6 Uncharacterized protein 325L
041L_IIV6 Uncharacterized protein 041L
388R_IIV6 Putative MSV199 domain-containing protein 388R
272L_IIV6 Uncharacterized protein 272L
043L_IIV6 Uncharacterized protein 043L
135R_IIV6 Uncharacterized protein 135R
426R_IIV6 Uncharacterized protein 426R
209R_IIV6 Uncharacterized protein 209R
061R_IIV6 Uncharacterized protein 061R
195L_IIV6 Uncharacterized protein 195L
437L_IIV6 Uncharacterized protein 437L
247L_IIV6 Uncharacterized protein 247L
032R_IIV6 Uncharacterized protein 032R
121R_IIV6 Putative RING finger protein 121R
227L_IIV6 Uncharacterized protein 227L
169L_IIV6 Uncharacterized protein 169L
132L_IIV6 Putative zinc finger protein 132L
413R_IIV6 Putative RING finger protein 413R
255L_IIV6 Uncharacterized protein 255L
312R_IIV6 Uncharacterized protein 312R
101L_IIV6 Uncharacterized protein 101L
438L_IIV6 Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
241L_IIV6 Cysteine-rich uncharacterized protein 241L
084L_IIV6 Uncharacterized protein 084L
235L_IIV6 Putative methyltransferase 235L (EC 2.1.1.-)
374R_IIV6 Uncharacterized protein 374R
460R_IIV6 Uncharacterized protein 460R
060L_IIV6 Uncharacterized protein 060L
042R_IIV6 Uncharacterized protein 042R
159L_IIV6 Uncharacterized protein 159L
343L_IIV6 Probable DNA-directed RNA polymerase subunit 343L (EC 2.7.7.6)
146R_IIV6 Putative MSV199 domain-containing protein 146R
126R_IIV6 Uncharacterized protein 126R
056R_IIV6 Uncharacterized protein 056R
116L_IIV6 Uncharacterized protein 116L
457L_IIV6 Uncharacterized protein 457L
423L_IIV6 Uncharacterized protein 423L
096L_IIV6 Putative FAS1 domain-containing protein 096L
123R_IIV6 Putative tyrosine phosphatase 123R (EC 3.1.3.-)
110R_IIV6 Uncharacterized protein 110R
137R_IIV6 Uncharacterized protein 137R
308L_IIV6 Uncharacterized protein 308L
250L_IIV6 Uncharacterized protein 250L
366R_IIV6 Uncharacterized protein 366R
315L_IIV6 Putative KilA-N domain-containing protein 315L
206L_IIV6 Uncharacterized protein 206L
285L_IIV6 Uncharacterized protein 285L
034R_IIV6 Uncharacterized protein 034R
111R_IIV6 Uncharacterized protein 111R
160L_IIV6 Uncharacterized protein 160L
443R_IIV6 Uncharacterized protein 443R
082L_IIV6 Uncharacterized protein 082L
317L_IIV6 Uncharacterized protein 317L
200R_IIV6 Putative MSV199 domain-containing protein 200R
106L_IIV6 Uncharacterized protein 106L
240R_IIV6 Uncharacterized protein 240R
468L_IIV6 Putative MSV199 domain-containing protein 468L
138R_IIV6 Uncharacterized protein 138R
139L_IIV6 Uncharacterized protein 139L
236L_IIV6 Uncharacterized protein 236L
069L_IIV6 Putative Bro-N domain-containing protein 069L
242L_IIV6 Putative GIY-YIG domain-containing protein 242L
162R_IIV6 Uncharacterized protein 162R
289L_IIV6 Putative Bro-N domain-containing protein 289L
192R_IIV6 Uncharacterized protein 192R

2 entries

Tipula iridescent virus (TIV) (Insect iridescent virus type 1)

Select_allDeselect_all
VL96_IRV1 Putative ubiquitin thioesterase L96 (EC 3.4.19.12)
MCP_IRV1 Major capsid protein (MCP) (P50)

1 entry

Costelytra zealandica iridescent virus (CzIV) (Insect iridescent virus type 16)

MCP_IRV16 Major capsid protein (MCP) (P50)