Iridovirus

VIRION

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Polyhedral virions 185 nm in diameter. The capsid displays an icosahedral symmetry T=147, with an internal lipid membrane. Virions are either externally enveloped or not depending whether they budded from the cell membrane, or were arranged in paracrystaline array in the host cell cytoplasm and were released by lysis.

GENOME

Linear, dsDNA genome of 140 to 213 kb. The genome contains terminal and redundant sequences and is circularly permuted. According to a recent estimation, IIV-6 genome might encode about 211 proteins. The genome is not methylated.

GENE EXPRESSION

there are classical or slightly modified canonical promoters and termination signals upstream and downstream of the start and stop codons of most ORFs.

REPLICATION

NUCLEO-CYTOPLASMIC

  1. Attachement of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the DNA core into the host cytoplasm.
  3. Viral DNA is transported to the cell nucleus where host macromolecular synthesis is rapidly shutdown. Transcription is initiated by virally modified host RNA polymerase II.
  4. Parental DNA is used to produce genome and greater than genome length DNA.
  5. Progeny DNA is transported into cytoplasmic viral factories where large concatamers of viral DNA are formed by recombination. Transcription of very late transcripts may also take place in the cytoplasm.
  6. Assembly of new virions in the cytoplasm.
  7. Virions exit the cell by budding or cell lysis.

Host-virus interaction

Apoptosis modulation

Chilo iridescent virus encodes a functional inhibitor of apoptosis (IAP) . The grouper iridovirus (GIV) contains an antiapoptotic B-cell lymphoma (Bcl)-2-like gene that also inhibits host apoptosis.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

218 entries grouped by strain (browse by keywords)

215 entries

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) reference strain

Select_allDeselect_all
374R_IIV6 Uncharacterized protein 374R
206L_IIV6 Uncharacterized protein 206L
227L_IIV6 Uncharacterized protein 227L
216R_IIV6 Uncharacterized protein 216R
234R_IIV6 Uncharacterized protein 234R
235L_IIV6 Putative methyltransferase 235L (EC 2.1.1.-)
236L_IIV6 Uncharacterized protein 236L
254L_IIV6 Uncharacterized protein 254L
255L_IIV6 Uncharacterized protein 255L
137R_IIV6 Uncharacterized protein 137R
293R_IIV6 Uncharacterized protein 293R
273R_IIV6 Uncharacterized protein 273R
400R_IIV6 Uncharacterized protein 400R
404L_IIV6 Uncharacterized protein 404L
146R_IIV6 Putative MSV199 domain-containing protein 146R
159L_IIV6 Uncharacterized protein 159L
162R_IIV6 Uncharacterized protein 162R
138R_IIV6 Uncharacterized protein 138R
139L_IIV6 Uncharacterized protein 139L
261R_IIV6 Uncharacterized protein 261R
130R_IIV6 Uncharacterized protein 130R
426R_IIV6 Uncharacterized protein 426R
437L_IIV6 Uncharacterized protein 437L
451L_IIV6 Uncharacterized protein 451L
463L_IIV6 Probable lipid hydrolase 463L (EC 3.1.1.-)
148R_IIV6 Putative MSV199 domain-containing protein 148R
149L_IIV6 Uncharacterized protein 149L
009R_IIV6 Uncharacterized protein 009R
049L_IIV6 Transmembrane protein 049L
095L_IIV6 Putative RING finger protein 095L
123R_IIV6 Putative tyrosine phosphatase 123R (EC 3.1.3.-)
061R_IIV6 Uncharacterized protein 061R
209R_IIV6 Uncharacterized protein 209R
253L_IIV6 Uncharacterized protein 253L
284R_IIV6 Uncharacterized protein 284R
132L_IIV6 Putative zinc finger protein 132L
285L_IIV6 Uncharacterized protein 285L
135R_IIV6 Uncharacterized protein 135R
287R_IIV6 Uncharacterized protein 287R
289L_IIV6 Putative Bro-N domain-containing protein 289L
141R_IIV6 Uncharacterized protein 141R
413R_IIV6 Putative RING finger protein 413R
457L_IIV6 Uncharacterized protein 457L
420R_IIV6 Putative MSV199 domain-containing protein 420R
156R_IIV6 Uncharacterized protein 156R
301L_IIV6 Uncharacterized protein 301L
006L_IIV6 Putative KilA-N domain-containing protein 006L
340R_IIV6 DRBM domain-containing protein 340R
313L_IIV6 Putative KilA-N domain-containing protein 313L
026R_IIV6 Uncharacterized protein 026R
032R_IIV6 Uncharacterized protein 032R
029R_IIV6 Uncharacterized protein 029R
043L_IIV6 Uncharacterized protein 043L
062L_IIV6 Uncharacterized protein 062L
361L_IIV6 Probable cysteine proteinase 361L (EC 3.4.-.-)
107L_IIV6 Uncharacterized protein 107L
101L_IIV6 Uncharacterized protein 101L
110R_IIV6 Uncharacterized protein 110R
111R_IIV6 Uncharacterized protein 111R
113L_IIV6 Uncharacterized protein 113L
116L_IIV6 Uncharacterized protein 116L
121R_IIV6 Putative RING finger protein 121R
389L_IIV6 Probable serine/threonine-protein kinase 389L (EC 2.7.11.1)
060L_IIV6 Uncharacterized protein 060L
169L_IIV6 Uncharacterized protein 169L
192R_IIV6 Uncharacterized protein 192R
368R_IIV6 Uncharacterized protein 368R
065R_IIV6 Uncharacterized protein 065R
069L_IIV6 Putative Bro-N domain-containing protein 069L
071L_IIV6 Uncharacterized protein 071L
373L_IIV6 Uncharacterized protein 373L
384L_IIV6 Uncharacterized protein 384L
388R_IIV6 Putative MSV199 domain-containing protein 388R
056R_IIV6 Uncharacterized protein 056R
160L_IIV6 Uncharacterized protein 160L
348R_IIV6 Uncharacterized protein 348R
034R_IIV6 Uncharacterized protein 034R
104L_IIV6 Uncharacterized protein 104L
226R_IIV6 Uncharacterized protein 226R
228L_IIV6 Uncharacterized protein 228L
211L_IIV6 Putative MSV199 domain-containing protein 211L
212L_IIV6 Putative MSV199 domain-containing protein 212L
218R_IIV6 Uncharacterized protein 218R
246L_IIV6 Uncharacterized protein 246L
247L_IIV6 Uncharacterized protein 247L
221L_IIV6 Uncharacterized protein 221L
250L_IIV6 Uncharacterized protein 250L
238R_IIV6 Putative MSV199 domain-containing protein 238R
240R_IIV6 Uncharacterized protein 240R
126R_IIV6 Uncharacterized protein 126R
241L_IIV6 Cysteine-rich uncharacterized protein 241L
127L_IIV6 Uncharacterized protein 127L
272L_IIV6 Uncharacterized protein 272L
454R_IIV6 Putative DNA-directed RNA polymerase subunit 454R
422L_IIV6 Uncharacterized protein 422L
423L_IIV6 Uncharacterized protein 423L
300R_IIV6 Transmembrane protein 300R
315L_IIV6 Putative KilA-N domain-containing protein 315L
308L_IIV6 Uncharacterized protein 308L
325L_IIV6 Uncharacterized protein 325L
332L_IIV6 Uncharacterized RING finger protein 332L
343L_IIV6 Probable DNA-directed RNA polymerase subunit 343L (EC 2.7.7.6)
346R_IIV6 Uncharacterized protein 346R
041L_IIV6 Uncharacterized protein 041L
042R_IIV6 Uncharacterized protein 042R
084L_IIV6 Uncharacterized protein 084L
094L_IIV6 Uncharacterized protein 094L
106L_IIV6 Uncharacterized protein 106L
083L_IIV6 Uncharacterized protein 083L
MCP_IIV6 Major capsid protein (MCP) (P50)
KTHY_IIV6 Putative thymidylate kinase 251L (EC 2.7.4.9) (dTMP kinase)
ICP46_IIV6 Immediate-early protein ICP-46 homolog
385L_IIV6 Uncharacterized protein 385L
DPOL_IIV6 DNA polymerase 037L (EC 2.7.7.7)
458R_IIV6 Putative myristoylated membrane protein 458R
172L_IIV6 Putative helicase 172L (EC 3.6.4.-)
175R_IIV6 Putative RING finger protein 175R
165R_IIV6 Putative metalloproteinase 165R (EC 3.4.24.-)
312R_IIV6 Uncharacterized protein 312R
366R_IIV6 Uncharacterized protein 366R
096L_IIV6 Putative FAS1 domain-containing protein 096L
PARP_IIV6 Putative poly [ADP-ribose] polymerase-like 100L (EC 2.4.2.30)
EXON_IIV6 Putative exonuclease 012L (EC 3.1.11.-)
RIR2_IIV6 Probable ribonucleoside-diphosphate reductase small subunit 376L (EC 1.17.4.1) (Ribonucleotide ...
RPB1_IIV6 Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC 2.7.7.6)
HMGH_IIV6 High mobility group protein homolog
375R_IIV6 Uncharacterized protein 375R
200R_IIV6 Putative MSV199 domain-containing protein 200R
242L_IIV6 Putative GIY-YIG domain-containing protein 242L
249R_IIV6 Uncharacterized protein 249R
140L_IIV6 Uncharacterized protein 140L
438L_IIV6 Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
441R_IIV6 Uncharacterized protein 441R
411L_IIV6 Uncharacterized protein 411L
443R_IIV6 Uncharacterized protein 443R
468L_IIV6 Putative MSV199 domain-containing protein 468L
460R_IIV6 Uncharacterized protein 460R
195L_IIV6 Uncharacterized protein 195L
317L_IIV6 Uncharacterized protein 317L
322R_IIV6 Uncharacterized protein 322R
044R_IIV6 Uncharacterized protein 044R
082L_IIV6 Uncharacterized protein 082L
120L_IIV6 Uncharacterized protein 120L
122R_IIV6 Uncharacterized protein 122R
VF309_IIV6 Uncharacterized protein 309L
RPB2_IIV6 Probable DNA-directed RNA polymerase II subunit RPB2 homolog (EC 2.7.7.6)
VF415_IIV6 Uncharacterized protein 415R
TYSY_IIV6 Probable thymidylate synthase 225R (EC 2.1.1.45)
VF232_IIV6 Putative ubiquitin thioesterase 232R (EC 3.4.19.12)
VF329_IIV6 Uncharacterized protein 329R
VF359_IIV6 Uncharacterized protein 359L
VF184_IIV6 Putative helicase 184R (EC 3.6.4.-)
VF350_IIV6 Uncharacterized protein 350L
VF306_IIV6 Putative SWIB domain-containing protein 306R
VF466_IIV6 Uncharacterized protein 466R
VF010_IIV6 Transmembrane protein 010R
VF229_IIV6 Uncharacterized protein 229L
VF467_IIV6 Uncharacterized protein 467R
VF378_IIV6 Uncharacterized protein 378R
VF219_IIV6 Uncharacterized protein 219L
VF436_IIV6 Uncharacterized protein 436R
VF143_IIV6 Putative kinase protein 143R (EC 2.7.-.-)
VF369_IIV6 Probable RAD2-like endonuclease 369L (EC 3.1.-.-)
VF213_IIV6 Transmembrane protein 213R
RNC_IIV6 Putative ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III)
VF342_IIV6 Uncharacterized protein 342R
VF075_IIV6 Uncharacterized protein 075L
VF019_IIV6 Uncharacterized protein 019R
VF115_IIV6 Uncharacterized protein 115R
VF295_IIV6 Uncharacterized protein 295L
VF396_IIV6 Uncharacterized protein 396L
VF337_IIV6 Putative membrane protein 337L
VF244_IIV6 Putative phosphoesterase 244L (EC 3.1.-.-)
VF380_IIV6 Probable serine/threonine-protein kinase 380R (EC 2.7.11.1)
VF198_IIV6 Uncharacterized protein 198R
VF098_IIV6 Uncharacterized protein 098R
VF282_IIV6 Putative transcription factor 282R
VF030_IIV6 Uncharacterized protein 030L
VF268_IIV6 Uncharacterized protein 268L
VF439_IIV6 Probable kinase 439L (EC 2.7.-.-)
VF395_IIV6 Uncharacterized protein 395R
VF136_IIV6 Uncharacterized protein 136R
VF302_IIV6 Putative zinc finger protein 302L
RIR1_IIV6 Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase large ...
VF355_IIV6 Putative CTD phosphatase-like protein 355R (EC 3.1.3.-)
VF145_IIV6 Uncharacterized protein 145L
VF203_IIV6 Uncharacterized protein 203L
VF196_IIV6 Uncharacterized protein 196R
VF357_IIV6 Uncharacterized protein 357R
VF358_IIV6 Uncharacterized protein 358L
VF179_IIV6 Uncharacterized protein 179R
VF224_IIV6 Probable cysteine proteinase 224L (EC 3.4.-.-)
VF022_IIV6 Putative helicase 022L (EC 3.6.4.-)
VF197_IIV6 Putative tyrosine phosphatase 197R (EC 3.1.3.48)
VF067_IIV6 Uncharacterized protein 067R
VF193_IIV6 Apoptosis inhibitor 193R
VF157_IIV6 Putative RING finger protein 157L
VF201_IIV6 Putative Bro-N domain-containing protein 201R
VF259_IIV6 Uncharacterized protein 259R
VF335_IIV6 Uncharacterized protein 335L
VF050_IIV6 Uncharacterized protein 050L
VF118_IIV6 Putative myristoylated protein 118L
VF414_IIV6 Putative hydrolase 414L (EC 3.6.1.-)
VF347_IIV6 Putative FAD-linked sulfhydryl oxidase 347L (EC 1.8.3.2)
VF155_IIV6 Uncharacterized protein 155L
VF307_IIV6 Uncharacterized protein 307L
VF453_IIV6 Putative thioredoxin-like protein 453L
VF391_IIV6 Uncharacterized protein 391R
VF349_IIV6 Putative transcription elongation factor S-II-like protein 349L
VF161_IIV6 Putative helicase 161L (EC 3.6.4.-)
VF077_IIV6 Putative zinc finger protein 077L
TOP2_IIV6 DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
VF170_IIV6 Uncharacterized protein 170L
VF117_IIV6 Uncharacterized protein 117L
VF205_IIV6 Putative DNA ligase 205R (EC 6.5.1.2)

2 entries

Tipula iridescent virus (TIV) (Insect iridescent virus type 1)

Select_allDeselect_all
MCP_IRV1 Major capsid protein (MCP) (P50)
VL96_IRV1 Putative ubiquitin thioesterase L96 (EC 3.4.19.12)

1 entry

Costelytra zealandica iridescent virus (CzIV) (Insect iridescent virus type 16)

MCP_IRV16 Major capsid protein (MCP) (P50)