Iridovirus

VIRION

Polyhedral virions 185 nm in diameter. The capsid displays an icosahedral symmetry T=147, with an internal lipid membrane. Virions are either externally enveloped or not depending whether they budded from the cell membrane, or were arranged in paracrystaline array in the host cell cytoplasm and were released by lysis.

GENOME

Linear, dsDNA genome of 140 to 213 kb. The genome contains terminal and redundant sequences and is circularly permuted. According to a recent estimation, IIV-6 genome might encode about 211 proteins. The genome is not methylated.

GENE EXPRESSION

there are classical or slightly modified canonical promoters and termination signals upstream and downstream of the start and stop codons of most ORFs.

REPLICATION

NUCLEO-CYTOPLASMIC

  1. Attachement of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the DNA core into the host cytoplasm.
  3. Viral DNA is transported to the cell nucleus where host macromolecular synthesis is rapidly shutdown. Transcription is initiated by virally modified host RNA polymerase II.
  4. Parental DNA is used to produce genome and greater than genome length DNA.
  5. Progeny DNA is transported into cytoplasmic viral factories where large concatamers of viral DNA are formed by recombination. Transcription of very late transcripts may also take place in the cytoplasm.
  6. Assembly of new virions in the cytoplasm.
  7. Virions exit the cell by budding or cell lysis.

Host-virus interaction

Apoptosis modulation

Chilo iridescent virus encodes a functional inhibitor of apoptosis (IAP) . The grouper iridovirus (GIV) contains an antiapoptotic B-cell lymphoma (Bcl)-2-like gene that also inhibits host apoptosis.

Matching UniProtKB/Swiss-Prot entries

221 entries grouped by strain (browse by keywords)

All proteins are shown (view only 215 complete proteome entries)

215 entries

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) reference strain

Select_allDeselect_all
RPB1_IIV6 Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC 2.7.7.6)
RPB2_IIV6 Probable DNA-directed RNA polymerase II subunit RPB2 homolog (EC 2.7.7.6)
RNC_IIV6 Putative ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III)
RIR1_IIV6 Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase large ...
RIR2_IIV6 Probable ribonucleoside-diphosphate reductase small subunit 376L (EC 1.17.4.1) (Ribonucleotide ...
VF467_IIV6 Uncharacterized protein 467R
VF050_IIV6 Uncharacterized protein 050L
VF143_IIV6 Putative kinase protein 143R (EC 2.7.-.-)
VF170_IIV6 Uncharacterized protein 170L
VF198_IIV6 Uncharacterized protein 198R
VF201_IIV6 Putative Bro-N domain-containing protein 201R
VF203_IIV6 Uncharacterized protein 203L
VF224_IIV6 Probable cysteine proteinase 224L (EC 3.4.-.-)
VF453_IIV6 Putative thioredoxin-like protein 453L
VF229_IIV6 Uncharacterized protein 229L
VF244_IIV6 Putative phosphoesterase 244L (EC 3.1.-.-)
VF282_IIV6 Putative transcription factor 282R
VF306_IIV6 Putative SWIB domain-containing protein 306R
VF307_IIV6 Uncharacterized protein 307L
VF329_IIV6 Uncharacterized protein 329R
VF342_IIV6 Uncharacterized protein 342R
VF349_IIV6 Putative transcription elongation factor S-II-like protein 349L
VF358_IIV6 Uncharacterized protein 358L
VF369_IIV6 Probable RAD2-like endonuclease 369L (EC 3.1.-.-)
VF391_IIV6 Uncharacterized protein 391R
VF415_IIV6 Uncharacterized protein 415R
VF436_IIV6 Uncharacterized protein 436R
VF439_IIV6 Probable kinase 439L (EC 2.7.-.-)
VF075_IIV6 Uncharacterized protein 075L
VF098_IIV6 Uncharacterized protein 098R
VF117_IIV6 Uncharacterized protein 117L
VF118_IIV6 Putative myristoylated protein 118L
VF145_IIV6 Uncharacterized protein 145L
VF155_IIV6 Uncharacterized protein 155L
VF157_IIV6 Putative RING finger protein 157L
VF179_IIV6 Uncharacterized protein 179R
VF184_IIV6 Putative helicase 184R (EC 3.6.4.-)
VF197_IIV6 Putative tyrosine phosphatase 197R (EC 3.1.3.-)
VF213_IIV6 Transmembrane protein 213R
VF259_IIV6 Uncharacterized protein 259R
VF357_IIV6 Uncharacterized protein 357R
VF067_IIV6 Uncharacterized protein 067R
VF030_IIV6 Uncharacterized protein 030L
VF077_IIV6 Putative zinc finger protein 077L
VF115_IIV6 Uncharacterized protein 115R
VF205_IIV6 Putative DNA ligase 205R (EC 6.5.1.2)
VF295_IIV6 Uncharacterized protein 295L
VF302_IIV6 Putative zinc finger protein 302L
VF309_IIV6 Uncharacterized protein 309L
VF335_IIV6 Uncharacterized protein 335L
VF337_IIV6 Putative membrane protein 337L
VF347_IIV6 Putative FAD-linked sulfhydryl oxidase 347L (EC 1.8.3.2)
VF350_IIV6 Uncharacterized protein 350L
VF414_IIV6 Putative hydrolase 414L (EC 3.6.1.-)
VF010_IIV6 Transmembrane protein 010R
VF019_IIV6 Uncharacterized protein 019R
VF193_IIV6 Apoptosis inhibitor 193R
VF196_IIV6 Uncharacterized protein 196R
VF219_IIV6 Uncharacterized protein 219L
VF232_IIV6 Putative ubiquitin thioesterase 232R (EC 3.4.19.12)
VF268_IIV6 Uncharacterized protein 268L
VF359_IIV6 Uncharacterized protein 359L
VF378_IIV6 Uncharacterized protein 378R
VF380_IIV6 Probable serine/threonine-protein kinase 380R (EC 2.7.11.1)
VF395_IIV6 Uncharacterized protein 395R
PARP_IIV6 Putative poly [ADP-ribose] polymerase-like 100L (EC 2.4.2.30)
HMGH_IIV6 High mobility group protein homolog
KTHY_IIV6 Putative thymidylate kinase 251L (EC 2.7.4.9) (dTMP kinase)
ICP46_IIV6 Immediate-early protein ICP-46 homolog
MCP_IIV6 Major capsid protein (MCP) (P50)
254L_IIV6 Uncharacterized protein 254L
261R_IIV6 Uncharacterized protein 261R
273R_IIV6 Uncharacterized protein 273R
301L_IIV6 Uncharacterized protein 301L
366R_IIV6 Uncharacterized protein 366R
368R_IIV6 Uncharacterized protein 368R
388R_IIV6 Putative MSV199 domain-containing protein 388R
404L_IIV6 Uncharacterized protein 404L
423L_IIV6 Uncharacterized protein 423L
437L_IIV6 Uncharacterized protein 437L
443R_IIV6 Uncharacterized protein 443R
454R_IIV6 Putative DNA-directed RNA polymerase subunit 454R
458R_IIV6 Putative myristoylated membrane protein 458R
438L_IIV6 Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
EXON_IIV6 Putative exonuclease 012L (EC 3.1.11.-)
034R_IIV6 Uncharacterized protein 034R
041L_IIV6 Uncharacterized protein 041L
042R_IIV6 Uncharacterized protein 042R
044R_IIV6 Uncharacterized protein 044R
061R_IIV6 Uncharacterized protein 061R
065R_IIV6 Uncharacterized protein 065R
084L_IIV6 Uncharacterized protein 084L
104L_IIV6 Uncharacterized protein 104L
110R_IIV6 Uncharacterized protein 110R
111R_IIV6 Uncharacterized protein 111R
120L_IIV6 Uncharacterized protein 120L
121R_IIV6 Putative RING finger protein 121R
211L_IIV6 Putative MSV199 domain-containing protein 211L
253L_IIV6 Uncharacterized protein 253L
312R_IIV6 Uncharacterized protein 312R
313L_IIV6 Putative KilA-N domain-containing protein 313L
346R_IIV6 Uncharacterized protein 346R
413R_IIV6 Putative RING finger protein 413R
441R_IIV6 Uncharacterized protein 441R
006L_IIV6 Putative KilA-N domain-containing protein 006L
032R_IIV6 Uncharacterized protein 032R
049L_IIV6 Transmembrane protein 049L
056R_IIV6 Uncharacterized protein 056R
060L_IIV6 Uncharacterized protein 060L
071L_IIV6 Uncharacterized protein 071L
082L_IIV6 Uncharacterized protein 082L
122R_IIV6 Uncharacterized protein 122R
123R_IIV6 Putative tyrosine phosphatase 123R (EC 3.1.3.-)
127L_IIV6 Uncharacterized protein 127L
130R_IIV6 Uncharacterized protein 130R
132L_IIV6 Putative zinc finger protein 132L
139L_IIV6 Uncharacterized protein 139L
140L_IIV6 Uncharacterized protein 140L
212L_IIV6 Putative MSV199 domain-containing protein 212L
249R_IIV6 Uncharacterized protein 249R
255L_IIV6 Uncharacterized protein 255L
272L_IIV6 Uncharacterized protein 272L
285L_IIV6 Uncharacterized protein 285L
289L_IIV6 Putative Bro-N domain-containing protein 289L
422L_IIV6 Uncharacterized protein 422L
009R_IIV6 Uncharacterized protein 009R
250L_IIV6 Uncharacterized protein 250L
400R_IIV6 Uncharacterized protein 400R
468L_IIV6 Putative MSV199 domain-containing protein 468L
026R_IIV6 Uncharacterized protein 026R
029R_IIV6 Uncharacterized protein 029R
083L_IIV6 Uncharacterized protein 083L
106L_IIV6 Uncharacterized protein 106L
126R_IIV6 Uncharacterized protein 126R
206L_IIV6 Uncharacterized protein 206L
235L_IIV6 Putative methyltransferase 235L (EC 2.1.1.-)
238R_IIV6 Putative MSV199 domain-containing protein 238R
240R_IIV6 Uncharacterized protein 240R
242L_IIV6 Putative GIY-YIG domain-containing protein 242L
300R_IIV6 Transmembrane protein 300R
308L_IIV6 Uncharacterized protein 308L
317L_IIV6 Uncharacterized protein 317L
325L_IIV6 Uncharacterized protein 325L
348R_IIV6 Uncharacterized protein 348R
374R_IIV6 Uncharacterized protein 374R
375R_IIV6 Uncharacterized protein 375R
385L_IIV6 Uncharacterized protein 385L
420R_IIV6 Putative MSV199 domain-containing protein 420R
148R_IIV6 Putative MSV199 domain-containing protein 148R
159L_IIV6 Uncharacterized protein 159L
160L_IIV6 Uncharacterized protein 160L
165R_IIV6 Putative metalloproteinase 165R (EC 3.4.24.-)
175R_IIV6 Putative RING finger protein 175R
192R_IIV6 Uncharacterized protein 192R
195L_IIV6 Uncharacterized protein 195L
216R_IIV6 Uncharacterized protein 216R
221L_IIV6 Uncharacterized protein 221L
247L_IIV6 Uncharacterized protein 247L
426R_IIV6 Uncharacterized protein 426R
451L_IIV6 Uncharacterized protein 451L
457L_IIV6 Uncharacterized protein 457L
460R_IIV6 Uncharacterized protein 460R
463L_IIV6 Probable lipid hydrolase 463L (EC 3.1.1.-)
DPOL_IIV6 DNA polymerase 037L (EC 2.7.7.7)
043L_IIV6 Uncharacterized protein 043L
062L_IIV6 Uncharacterized protein 062L
069L_IIV6 Putative Bro-N domain-containing protein 069L
094L_IIV6 Uncharacterized protein 094L
095L_IIV6 Putative RING finger protein 095L
096L_IIV6 Putative FAS1 domain-containing protein 096L
101L_IIV6 Uncharacterized protein 101L
107L_IIV6 Uncharacterized protein 107L
113L_IIV6 Uncharacterized protein 113L
116L_IIV6 Uncharacterized protein 116L
135R_IIV6 Uncharacterized protein 135R
137R_IIV6 Uncharacterized protein 137R
138R_IIV6 Uncharacterized protein 138R
141R_IIV6 Uncharacterized protein 141R
146R_IIV6 Putative MSV199 domain-containing protein 146R
149L_IIV6 Uncharacterized protein 149L
156R_IIV6 Uncharacterized protein 156R
162R_IIV6 Uncharacterized protein 162R
169L_IIV6 Uncharacterized protein 169L
172L_IIV6 Putative helicase 172L (EC 3.6.4.-)
200R_IIV6 Putative MSV199 domain-containing protein 200R
209R_IIV6 Uncharacterized protein 209R
218R_IIV6 Uncharacterized protein 218R
226R_IIV6 Uncharacterized protein 226R
227L_IIV6 Uncharacterized protein 227L
228L_IIV6 Uncharacterized protein 228L
234R_IIV6 Uncharacterized protein 234R
236L_IIV6 Uncharacterized protein 236L
241L_IIV6 Cysteine-rich uncharacterized protein 241L
246L_IIV6 Uncharacterized protein 246L
284R_IIV6 Uncharacterized protein 284R
287R_IIV6 Uncharacterized protein 287R
293R_IIV6 Uncharacterized protein 293R
315L_IIV6 Putative KilA-N domain-containing protein 315L
322R_IIV6 Uncharacterized protein 322R
332L_IIV6 Uncharacterized RING finger protein 332L
340R_IIV6 DRBM domain-containing protein 340R
343L_IIV6 Probable DNA-directed RNA polymerase subunit 343L (EC 2.7.7.6)
361L_IIV6 Probable cysteine proteinase 361L (EC 3.4.-.-)
373L_IIV6 Uncharacterized protein 373L
384L_IIV6 Uncharacterized protein 384L
389L_IIV6 Probable serine/threonine-protein kinase 389L (EC 2.7.11.1)
411L_IIV6 Uncharacterized protein 411L
TYSY_IIV6 Probable thymidylate synthase 225R (EC 2.1.1.45)
VF022_IIV6 Putative helicase 022L (EC 3.6.4.-)
VF136_IIV6 Uncharacterized protein 136R
VF161_IIV6 Putative helicase 161L (EC 3.6.4.-)
VF355_IIV6 Putative CTD phosphatase-like protein 355R (EC 3.1.3.-)
VF396_IIV6 Uncharacterized protein 396L
VF466_IIV6 Uncharacterized protein 466R
TOP2_IIV6 DNA topoisomerase 2 (EC 5.99.1.3) (DNA topoisomerase II)

2 entries

Simulium iridescent virus (IIV-22) (Insect iridescent virus type 22)

Select_allDeselect_all
VF015_IRV22 Uncharacterized 15.9 kDa protein in MSP 5'region
MCP_IRV22 Major capsid protein (MCP) (P50)

2 entries

Tipula iridescent virus (TIV) (Insect iridescent virus type 1)

Select_allDeselect_all
VL96_IRV1 Putative ubiquitin thioesterase L96 (EC 3.4.19.12)
MCP_IRV1 Major capsid protein (MCP) (P50)

1 entry

Costelytra zealandica iridescent virus (CzIV) (Insect iridescent virus type 16)

MCP_IRV16 Major capsid protein (MCP) (P50)

1 entry

Wiseana iridescent virus (WIV) (Insect iridescent virus type 9)

MCP_IRV9 Major capsid protein (MCP) (P50)