VIRION
Enveloped virion of which the membrane is surrounded by a capsid with an icosahedral symmetry (T=169), 104-118 nm in diameter. Dense material are present at each 5-fold symmetry vertex
Source: Van Etten 2003 (Pubmed)
- Hexons: Double jelly roll-fold major capsid protein [G9E6G2?]
- Pentons: Single jelly roll-fold [G9E6B9?] ? [G9E5W9 G9E662 G9E5Z3 G9E5X8 G9E6C3 G9E5Z4 G9E5W4]
GENOME
GENE EXPRESSION
ENZYMES
- DNA-directed DNA polymerase family B [POL_B]
- Cell-type capping
- Helicase G9E5W3 G9E660
- Holliday junction resolvase G9E682
- Ribonuclease H [POL_B]
- HNH endoclease G9E6C1 G9E670
- DNA ligase G9E676
- dUTP diphosphatase G9E689
- Thymidine kinase G9E6A5
- Ribonucleoside-diphosphate reductase G9E648 G9E633
- Protease (Peptidase S74) G9E5X4
- Protease (Peptidase C19) G9E612
- Asparagine synthase G9E5T4
- Glycosyltransferase G9E5U5
REPLICATION
NUCLEO-CYTOPLASMIC
- Virus attaches to host receptors , inducing release of viral genome into the cell.
- Migration of the DNA core to the nucleus?
- Synthesis of early proteins.
- Replication of genomic DNA..
- Late proteins synthesis, assembly of new virions in the cytoplasm
- Cell lysis and virion release in the extracellular space.