Non enveloped, capsid with T=2* icosahedral symmetry, 35-40 nm in diameter .


Segmented linear dsRNA genome: 2 segments encode for a total of 3 to 4 proteins. Segments size range from 1.7 to 2.5 kb. Genome total size is about 4 kb.


Genomic segment 1 encodes for a polyprotein (ORF1) that self-cleaves to yield the mature coat protein and a large peptide. Also encodes another protein (ORF2).
Genomic segment 2 encodes for the RNA-dependent RNA polymerase.



  1. Virus penetrates into the cytoplasm.
  2. Transcription of the dsRNA genome by viral polymerase occurs inside the virion, so that dsRNA is never exposed to the cytoplasm. This plus-strand transcript is used as template for translation.
  3. (+)RNAs are encapsidated in virion particle, inside which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  4. Mature virions are released by budding.

Matching UniProtKB/Swiss-Prot entries

3 entries grouped by strain (browse by keywords)

3 entries

Human picobirnavirus (strain Human/Thailand/Hy005102/-) (PBV) reference strain

RDRP_HPBVH Potential RNA-dependent RNA polymerase (EC
ORF1_HPBVH Uncharacterized ORF1 protein
CAPSD_HPBVH Capsid protein precursor [Cleaved into: 7 kDa polypeptide; Capsid protein (CP)]