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Inhibition of host MDA5 by virus (kw:KW-1089)

Upon viral infection, the cytosolic receptor MDA5 recognizes long viral dsRNAs and initiates an antiviral signaling cascade by interacting with the downstream partner MAVS, located to the mitochondria. This signaling pathway leads to the establishment of an antiviral state characterized by expression of antiviral cytokines and interferons. The MDA5 protein belongs to the RNA helicase family. ISGylation of MDA5 would be crutial for its function .

RIGI RIGI TRIM25 MAVS STING TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB

Several viruses encode proteins that directly interfere with MDA5 to decrease interferon production by infected cells. For example, all viruses from paramyxovirinae subfamily encode a protein V able to interact with MDA5 and block MDA5 interaction with MAVS, its downstream partner in the cascade. The interaction has been investigated in detail and the C-terminal domain of the V proteins is responsible for the binding of the helicase domain of protein V.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Inhibition of MDA5/RIG-I pathway Inhibition of RIG-I
Inhibition of MDA5
Inhibition of MAVS
Inhibition of IKKepsilon
Inhibition of host IRF3
Inhibition of host IRF7
Links Uniprot Keyword: KW-1089
GO ontology: GO:0039554
Virus -Paramyxovirus V proteins
(Parayxoviridae, Paramyxovirinae)

-SARS-CoV-2 PLpro nsp3 (Coronaviridae, Betacoronavirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

56 entries grouped by strain

1 entry

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

NCAP_BRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

V_HENDH Non-structural protein V

1 entry

Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain

POLN_HEVCH Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...

1 entry

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

RNB_HHV11 Accessory factor US11 (Vmw21)

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

RNB_HHV2H Probable RNA-binding protein

1 entry

Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

V_PI2HT Non-structural protein V

1 entry

Human respiratory syncytial virus B (strain B1) reference strain

NCAP_HRSVB Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

V_MEASC Non-structural protein V

1 entry

Mumps virus genotype B (strain Miyahara vaccine) (MuV) reference strain

V_MUMPM Non-structural protein V (Non-structural protein NS1)

1 entry

Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

V_NDVB1 Protein V

1 entry

Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

V_PIV5 Non-structural protein V

pdb 2B5L; 2HYE; 2K48; 4I1S

1 entry

Poliovirus type 1 (strain Mahoney) reference strain

POLG_POL1M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 1AL2; 1AR6; 1AR7; 1AR8; 1AR9; 1ASJ; 1DGI; 1FPT; 1HXS; 1L1N; 1NG7; 1NN8; 1PO1; 1PO2; 1POV; 1RA6; 1RA7; 1RAJ; 1RDR; 1TQL; 1VBD; 1XYR; 2BBL; 2BBP; 2IJD; 2IJF; 2ILY; 2ILZ; 2IM0; 2IM1; 2IM2; 2IM3; 2PLV; 3EPC; 3IYB; 3IYC; 3J3O; 3J3P; 3J48; 3J8F; 3J9F; 3JBC; 3JBD; 3JBE; 3JBF; 3JBG; 3OL7; 4DCD; 4K4S; 4K4T; 4K4U; 4K4V; 4K4W; 4NLO; 4NLP; 4NLQ; 4NLR; 4NLS; 4NLT; 4NLU; 4NLV; 4NLW; 4NLX; 4NLY; 4R0E; 5KTZ; 5KU0; 5KU2; 5KWL; 5Z3Q; 6HLV; 6P9O; 6P9W; 6PSZ; 9FQ2

1 entry

Simian virus 41 (SV41) reference strain

V_SV41 Non-structural protein V

1 entry

Tupaia paramyxovirus (TPMV) reference strain

V_TPMV Non-structural protein V

1 entry

Bovine respiratory syncytial virus (strain 391-2) (BRS)

NCAP_BRSV3 Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Bovine respiratory syncytial virus (strain Rb94) (BRS)

NCAP_BRSVR Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Coxsackievirus A16 (strain G-10)

POLG_CX16G Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 7H2T; 7H2U; 7H2V; 7H2W; 7H2X; 7H2Y; 7H2Z; 7H30; 7H31; 7H32; 7H33; 7H34; 7H35; 7H36; 7H37; 7H38; 7H39; 7H3A; 7H3B; 7H3C; 7H3D; 7H3E; 7H3F; 7H3G; 7H3H; 7H3I; 7H3J; 7H3K; 7H3L; 7H3M; 7H3N; 7H3O; 7H3P; 7H3Q; 7H3R; 7H3S; 7H3T; 7H3U; 7H3V; 7H3W; 7H3X; 7H3Y; 7H3Z; 7H40; 7H41; 7H42; 7H43; 7H44; 7H45; 7H46; 7H47; 7H48; 7H49; 7H4A; 7H4B; 7H4C; 7H4D; 7H4E; 7H4F; 7H4G; 7H4H; 7H4I; 7H4J; 7H4K; 7H4L; 7H4M; 7H4N; 7H4O; 7H4P; 7H4Q; 7H4R; 7H4S; 7H4T; 7H4U; 7H4V; 7H4W; 7H4X; 7H4Y; 7H4Z; 7H50; 7H51; 7H52; 7H53; 7H54; 7H55; 7HOC; 7HOD; 7HOE; 7HOF; 7HOG; 7HOH; 7HOI; 7HUF; 7HUG; 7HUH; 7HUI; 7HUJ; 7HUK; 7HUL; 7HUN; 7HUO; 7HUP; 7HUQ; 7HUR; 7HUS; 7HUT; 7HUU; 7HUV; 7HUW; 7HUX; 7HUY; 7HUZ; 7HV0; 7HV1; 7HV2; 7HV3; 7HV4; 7HV5; 7HV6; 7HV7; 7HV8; 7HV9; 7HVA; 7HVB; 7HVC; 7HVD; 7HVE; 7HVF; 7HVG; 7HVH; 7HVI; 7HVJ; 7HVK; 7HVL; 7HVM; 7HVN; 7HVO; 7HVQ; 7HVR; 7HVS; 7HVT; 7HVU; 7HVV; 7HVW; 7HVX; 7HVY; 7HVZ; 7HW0; 7HW1; 7HW3; 7HW4; 7HW5; 7HW6; 7HW8; 7HW9; 7HWA; 7HWB; 7HWC; 7HWD; 7HWE; 7HWF; 7HWG; 7HWH; 7HWI; 7HWJ; 7HWK; 7HWL; 7HWM; 7HWN; 7HWO; 7HWP; 7HWQ; 7HWR; 7HWS; 7HWT; 7HWU; 7HWV; 7HWW; 7HWX; 7HWY; 7HWZ; 7HX0; 7HX1; 7HX2; 7HX3; 7HX4; 7HX5; 7HX6; 7HX7; 7HX8; 7HX9; 7HXA; 7HXB; 7HXC; 7HXD; 7HXE; 7HXF; 7HXG; 7HXH; 7HXI; 7HXJ; 7HXK; 7HXL; 7HXM; 7HXN; 7HXO; 7HXP; 7HXQ; 7HXR; 7HXS; 7HXT; 7HXU; 7HXV; 7HXW; 7HXX; 7HXY; 7HXZ; 7HY0; 7HY1; 7HY2; 7HY3; 7HY4; 7HY5; 7HY6; 7HY7; 7HY8; 7HY9; 7HYA; 7HYB; 7HYC; 7HYD; 7HYE; 7HYF; 7HYG; 7HYH; 7HYI; 7HYJ; 7HYK; 7HYL; 7HYM; 7HYN; 7HYO; 7HYP; 7HYQ; 7HYR; 7HYS; 7HYT; 7HYU; 7HYV; 7HYW; 7HYX; 7HYY; 7HYZ; 7HZ0; 7HZ1; 7HZ2; 7HZ3; 7HZ4; 7HZ5; 7HZ6; 7HZ7; 7HZ8; 7HZ9; 7HZA; 7HZB; 7HZC; 7HZD; 7HZE; 7HZF; 7HZG; 7HZH; 7HZI; 7HZJ; 7HZK; 7HZL; 7HZM; 7HZN; 7HZO; 7HZP; 7HZQ; 7HZR; 7HZS; 7HZT; 7HZU; 8POA

1 entry

Coxsackievirus A16 (strain Tainan/5079/98)

POLG_CX16T Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 4MG3; 5C8C; 6LHT; 7Y7M; 7YMS

1 entry

Coxsackievirus B3 (strain Nancy)

POLG_CXB3N Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 2VB0; 2ZTX; 2ZTY; 2ZTZ; 2ZU1; 2ZU3; 3CDU; 3CDW; 4WFX; 4WFY; 4WFZ; 4Y2A; 6S3A; 6T3W; 7LMS; 7QUW; 7W0Q; 7W0S; 7W0T; 8S6F; 8Y2T

1 entry

Coxsackievirus B3 (strain Woodruff)

POLG_CXB3W Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 1COV; 1JEW; 3JD7

1 entry

Human enterovirus 71 (EV71) (EV-71)

POLG_HE71 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 5GQ1; 5GRB; 8A5L

1 entry

Human enterovirus 71 (strain 7423/MS/87) (EV71) (EV-71)

POLG_HE71M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 3W95; 6HLW; 6I2K

1 entry

Human enterovirus 71 (strain USA/BrCr/1970) (EV71) (EV-71)

POLG_HE71B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus D68 (EV68) (EV-68)

POLG_HED68 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 4WM7; 4WM8; 5BNN; 5BNO; 5BNP; 6HLN; 6HMV; 7GNV; 7GNW; 7GNX; 7GNY; 7GNZ; 7GO0; 7GO1; 7GO2; 7GO3; 7GO4; 7GO5; 7GO6; 7GO7; 7GO8; 7GO9; 7GOA; 7GOB; 7GOC; 7GOD; 7GOE; 7GOF; 7GOG; 7GOH; 7GOI; 7GOJ; 7GOK; 7GOL; 7GOM; 7GON; 7GOO; 7GOP; 7GOQ; 7GOR; 7GOS; 7GOT; 7GOU; 7GOV; 7GOW; 7GOX; 7GOY; 7GOZ; 7GP0; 7GP1; 7GP2; 7GP3; 7GP4; 7GP5; 7GP6; 7GP7; 7GP8; 7GP9; 7GPA; 7GPC; 7GPD; 7GPE; 7GPF; 7GPG; 7GPH; 7GPI; 7GPJ; 7GPK; 7GPL; 7GPM; 7GPN; 7GPO; 7GPP; 7GPQ; 7GPR; 7GPS; 7GPT; 7GPU; 7GPV; 7GPW; 7GPX; 7GPY; 7GPZ; 7GQ0; 7GQ1; 7GQ2; 7GQ3; 7GQ4; 7GQ5; 7GQ6; 7GQ7; 7GQ8; 7GQ9; 7GQA; 7GQB; 7GQC; 7GQD; 7GQE; 7GQF; 7GQG; 7GQH; 7GQI; 7GQJ; 7GQK; 7GQL; 7GQM; 7GQN; 7GQO; 7GQP; 7GQQ; 7GQR; 7JRE; 8CNX

1 entry

Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)

RNB_HHV1M RNA-binding protein (Vmw21)

1 entry

Human parainfluenza 2 virus (HPIV-2)

V_PI2H Non-structural protein V

1 entry

Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)

V_PI4HA Non-structural protein V

1 entry

Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)

V_PI4HB Non-structural protein V

1 entry

Human respiratory syncytial virus

NCAP_HRSV Nucleoprotein (Protein N) (Nucleocapsid protein)

pdb 4V5V

1 entry

Human respiratory syncytial virus A (strain A2)

NCAP_HRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)

pdb 2WJ8; 2YHM; 4BKK; 4UC6; 4UC7; 4UC8; 4UC9; 4UCA; 4UCB; 4UCC; 4UCD; 4UCE; 6YJL; 8OOU; 8OP1; 8OP2

1 entry

Human respiratory syncytial virus B (strain 18537)

NCAP_HRSV1 Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASE Non-structural protein V

1 entry

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASA Non-structural protein V

1 entry

Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASW Non-structural protein V

1 entry

Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASI Non-structural protein V

1 entry

Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASY Non-structural protein V

1 entry

Mumps virus (strain Enders) (MuV)

V_MUMPE Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus (strain SBL) (MuV)

V_MUMPS Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus (strain SBL-1) (MuV)

V_MUMP1 Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus genotype A (strain Jeryl-Lynn) (MuV)

V_MUMPJ Non-structural protein V

1 entry

Mumps virus genotype N (strain L-Zagreb vaccine) (MuV)

V_MUMPZ Non-structural protein V (Non-structural protein NS1)

1 entry

Newcastle disease virus (strain Ulster/2C) (NDV)

V_NDVU2 Non-structural protein V

1 entry

Nipah virus

V_NIPAV Non-structural protein V

1 entry

Phocine distemper virus (PDV)

V_PHODV Non-structural protein V

1 entry

Poliovirus type 1 (strain Sabin)

POLG_POL1S Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 8E8Z

1 entry

Poliovirus type 2 (strain Lansing)

POLG_POL2L Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 1EAH; 3EPF

1 entry

Poliovirus type 2 (strain W-2)

POLG_POL2W Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 3 (strain 23127)

POLG_POL32 Genome polyprotein [Cleaved into: P3; Protein 3AB; P1; Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

POLG_POL3L Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 1PIV; 1PVC; 1VBA; 1VBB; 1VBC; 1VBE; 3EPD; 3IYB; 3IYC; 5O5B; 5O5P; 8E8R; 8E8X

1 entry

Rinderpest virus (strain Kabete O) (RDV)

V_RINDK Non-structural protein V

1 entry

Rinderpest virus (strain RBOK) (RDV)

V_RINDR Non-structural protein V

1 entry

Sendai virus (strain Fushimi) (SeV)

V_SENDF Protein V

1 entry

Sendai virus (strain Hamamatsu) (SeV)

V_SENDA Protein V

1 entry

Sendai virus (strain Harris) (SeV)

V_SENDH Protein V

1 entry

Sendai virus (strain Ohita) (SeV)

V_SENDO Protein V

1 entry

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

V_SENDZ Protein V