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Inhibition of host IRF7 by virus (kw:KW-1093)

IRF7 is a key transcriptional factor involved in the signaling pathway leading to establishment of antiviral state in infected cells. Under normal conditions, IRF7 exists in a latent form in the cytoplasm. Viral infection triggers the phosphorylation of IRF7 C-terminal region. The activated IRF7 migrates to the nucleus leading to the transcriptional activation of the IFN-alpha and IFN-beta genes. IRF7 is predominantly expressed in the spleen, thymus and primary blood lymphocytes(PBL) as a lymphoid-specific factor.

RIGI RIGI STING TRIM25 MAVS TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB

Several viral proteins interfere with IRF7 activity thus modulating the response to the virus induced in the infected cell. For example, VP35 from ebola virus exploits the cellular SUMOylation machinery for its advantage and increase IRF7 SUMOylation thereby disabling its activity.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Inhibition of MDA5/RIG-I pathway Inhibition of RIG-I
Inhibition of MDA5
Inhibition of MAVS
Inhibition of IKKepsilon
Inhibition of host IRF3
Inhibition of host IRF7
Links Uniprot Keyword: KW-1093
GO ontology: GO:0039557
Virus -Ebola Zaire virus
(Mononegavirales, Ebola-like viruses)

-Epstein-Barr virus
(Herpesviridae, Lymphocryptovirus)

Human herpesvirus 8
(Herpesviridae, Rhadinovirus)

-Rotavirus
(Reoviridae, Rotavirus)

-Thogoto virus
(Orthomyxoviridae, Thogotovirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

78 entries grouped by strain

2 entries

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

Select_allDeselect_all
NS1_BRSVA Non-structural protein 1 (Non-structural protein 1C)
NS2_BRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)

2 entries

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Select_allDeselect_all
ORF45_HHV8P Protein ORF45

pdb 7OPM; 7OPO

VIRF4_HHV8P Viral IRF4-like protein (vIRF-4)

pdb 2XXN

2 entries

Human respiratory syncytial virus B (strain B1) reference strain

Select_allDeselect_all
NS2_HRSVB Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_HRSVB Non-structural protein 1 (Non-structural protein 1C)

1 entry

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

BZLF1_EBVB9 Lytic switch protein BZLF1 (EB1) (Protein Z) (Trans-activator protein BZLF1) (Zta) (bZIP ...

pdb 1ZSD; 2AK4; 2AXF; 2AXG; 2C9L; 2C9N; 2NX5; 3KWW; 3KXF; 3SPV; 3VFN; 3VFO; 3VFP; 3VFR; 5SZX; 7NX5

1 entry

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

V_MEASC Non-structural protein V

1 entry

Monkeypox virus reference strain

PG065_MONPV RNA-binding protein OPG065

1 entry

Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) (Simian Agent 11 (isolate SI/South Africa/H96/58)) reference strain

NSP1_ROTSH Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A) reference strain

NSP1_ROTAD Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both)) reference strain

NSP1_ROTS1 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C) reference strain

NSP1_ROTHC Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Seneca Valley virus (isolate -/United States/SSV-001/2002) (SVV) reference strain

POLG_SVV1 Genome polyprotein [Cleaved into: Leader protein; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 ...

pdb 3CJI; 6ADL; 6CX1; 6L0T

1 entry

Thogoto virus (isolate SiAr 126) (Tho) reference strain

ML_THOGV Protein ML (ML)

pdb 5I5N; 5I5O

1 entry

Vaccinia virus (strain Copenhagen) (VACV) reference strain

PG065_VACCC RNA-binding protein OPG065 (RNA-binding protein E3) (p25)

1 entry

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

PG065_VACCW RNA-binding protein OPG065 (RNA-binding protein E3) (p25)

pdb 7C0I; 8I9J

1 entry

Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

PG065_VAR67 RNA-binding protein OPG065 (Protein E3)

1 entry

Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain

VP35_EBOZM Polymerase cofactor VP35 (Ebola VP35) (eVP35)

pdb 3FKE; 3L25; 3L26; 3L27; 3L28; 3L29; 4IBB; 4IBC; 4IBD; 4IBE; 4IBF; 4IBG; 4IBI; 4IBJ; 4IBK; 4IJE; 4IJF; 4YPI; 4ZTA; 4ZTG; 4ZTI; 6GBO; 6GBP; 8USN; 8UST

2 entries

Human respiratory syncytial virus

Select_allDeselect_all
NS2_HRSV Non-structural protein 2 (NS2) (Non-structural protein 1B)

pdb 7LDK

NS1_HRSV Non-structural protein 1 (Non-structural protein 1C)

2 entries

Human respiratory syncytial virus A (strain A2)

Select_allDeselect_all
NS1_HRSVA Non-structural protein 1 (NS1) (Non-structural protein 1C)
NS2_HRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)

2 entries

Human respiratory syncytial virus B (strain 18537)

Select_allDeselect_all
NS1_HRSV1 Non-structural protein 1 (Non-structural protein 1C)
NS2_HRSV1 Non-structural protein 2 (NS2) (Non-structural protein 1B)

2 entries

Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

Select_allDeselect_all
NS1_ORSVW Non-structural protein 1 (Non-structural protein 1C)
NS2_ORSVW Non-structural protein 2 (NS2) (Non-structural protein 1B)

1 entry

African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)

36011_ASFK5 Protein MGF 360-11L

1 entry

African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)

36011_ASFM2 Protein MGF 360-11L

1 entry

African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)

36011_ASFP4 Protein MGF 360-11L

1 entry

Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

NS1_HRSS2 Non-structural protein 1 (NS1) (Non-structural protein 1C)

1 entry

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASE Non-structural protein V

1 entry

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASA Non-structural protein V

1 entry

Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASW Non-structural protein V

1 entry

Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASI Non-structural protein V

1 entry

Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASY Non-structural protein V

1 entry

Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)

VP35_EBORE Polymerase cofactor VP35

1 entry

Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)

VP35_EBORR Polymerase cofactor VP35

pdb 3KS4; 3KS8; 3L2A; 4LG2; 6GBQ; 6GBR

1 entry

Rotavirus A (isolate RVA/Cat/Japan/FRV64/1989/G3P5B[3]) (RV-A)

NSP1_ROTF6 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Cow/South/Africa/Offal agent/1965/G8P6[1]) (RV-A)

NSP1_ROTAP Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Cow/Thailand/A44/1988/G10P8[11]) (RV-A)

NSP1_ROTBA Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11]) (RV-A)

NSP1_ROTBB Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Dog/United States/K9/1981/G3P5A[3]) (RV-A)

NSP1_ROTD9 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Equine/United Kingdom/H2/1976/G3P4[12]) (RV-A) (Rotavirus A (isolate H-2))

NSP1_ROTEH Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Equine/United Kingdom/L338/1988/G13P12[18]) (RV-A)

NSP1_ROTEL Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus A (isolate B4106))

NSP1_ROT41 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Human/India/116E/1986/G9P8[11]) (RV-A)

NSP1_ROTHU Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Human/Japan/IGV-80-3/XXXX/GXP[X]) (RV-A)

NSP1_ROTHI Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)

NSP1_ROTH7 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)

NSP1_ROTWI Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Monkey/United States/TUCH/2003/G3P[24]) (RV-A)

NSP1_ROTTU Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Mouse/Brazil/EHP/1981/G16P[20]) (RV-A)

NSP1_ROTME Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Cow/France/RF/1975/G6P6[1]) (RV-A)

NSP1_ROTRF Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)

NSP1_ROTBU Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Cow/United States/B641/XXXX/G6P7[5]) (RV-A)

NSP1_ROTB4 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Cow/United States/WC3/1981/G6P7[5]) (RV-A) (Rotavirus (strain Wistar calf 3))

NSP1_ROTW3 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)

NSP1_ROTH6 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)

NSP1_ROTH3 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)

NSP1_ROTHJ Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)

NSP1_ROTHK Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)

NSP1_ROTHL Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) (Rotavirus A (strain St. Thomas 3))

NSP1_ROTHT Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) (Rotavirus A (strain DS1))

NSP1_ROTHD Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)

NSP1_ROTHP Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)

NSP1_ROTHW Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Venezuela/M37/1982/G1P2A[6]) (RV-A)

NSP1_ROTHM Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Monkey/United States/RRV/1975/G3P5B[3]) (RV-A)

NSP1_ROTRH Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Pig/Mexico/YM/1983/G11P9[7]) (RV-A)

NSP1_ROTPY Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Pig/United States/Gottfried/1983/G4P2B[6]) (RV-A)

NSP1_ROTPG Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A (strain Ohio State University))

NSP1_ROTP5 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Rabbit/United States/ALA/XXXX/G3P11[14]) (RV-A) (Rotavirus A (strain Alabama))

NSP1_ROTRA Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))

NSP1_ROTS4 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

pdb 5JEO; 5JER

1 entry

Rotavirus A (strain RVA/SA11-FEM/G3P6[1]) (RV-A) (Simian Agent 11 (strain FEM))

NSP1_ROTSF Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/SA11-Patton/G3P[X]) (RV-A) (Simian Agent 11 (strain Patton))

NSP1_ROTSP Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus C (strain RVC/Pig/United States/Cowden/1980) (RV-C)

NSP1_ROTPC Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus)

VP35_EBOSU Polymerase cofactor VP35

pdb 6OAF

1 entry

Yaba-like disease virus (YLDV)

E3_YLDV Protein E3 homolog (Protein E3L homolog)

pdb 1SFU

1 entry

Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)

VP35_EBOZ5 Polymerase cofactor VP35 (Ebola VP35) (eVP35)

pdb 5BPV; 7D35