Picobirnaviridae (taxid:585893)

VIRION

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Non enveloped, capsid with T=2* icosahedral symmetry, 35-40 nm in diameter .
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GENOME

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Segmented linear dsRNA genome: 2 segments encode for 4 proteins. Segments size range from 1.7 to 2.5 kb. Genome total size is about 4 kb.

GENE EXPRESSION

Genomic segment A encodes for a polyprotein (ORF1) that self-cleaves to yield the mature coat protein and a large peptide. Also encodes another protein (ORF2).
Genomic segment B encodes for the RNA-dependent RNA polymerase.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the cytoplasm.
  2. Transcription of the dsRNA genome by viral polymerase occurs inside the virion, so that dsRNA is never exposed to the cytoplasm. This plus-strand transcript is used as template for translation.
  3. (+)RNAs are encapsidated in virion particle, inside which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  4. Mature virions are released by budding.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

3 entries grouped by protein

1 entry

Capsid protein precursor

CAPSD_HPBVH
Human picobirnavirus (strain Human/Thailand/Hy005102/-) (PBV) reference strain

1 entry

Uncharacterized ORF1 protein

ORF1_HPBVH
Human picobirnavirus (strain Human/Thailand/Hy005102/-) (PBV) reference strain

1 entry

Potential RNA-dependent RNA polymerase (EC 2.7.7.48)

RDRP_HPBVH
Human picobirnavirus (strain Human/Thailand/Hy005102/-) (PBV) reference strain
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Porcine picobirnavirus taxid:442302

Protein ModelArchive
Capsid protein ma-jd-viral-12525
Minor capsid protein ma-jd-viral-56235
RNA-dependent RNA polymerase ma-jd-viral-19301