Alphacoronavirus

VIRION

Enveloped, spherical, about 120 nm in diameter. The RNA genome is associated with the N protein to form the nucleocapsid. see Neuman BW et al. for virion cryo-electron microscopy analysis.

GENOME

Monopartite, linear ssRNA(+) genome of 27-32kb in size (the largest of all RNA virus genomes). Capped, and polyadenylated. The leader RNA (65-89 bp) at the 5' end of the genome is also present at the end of each subgenomic RNAs.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Genomic RNA encodes for ORF1a, as for ORF1b, it is translated by ribosomal frameshifting. Resulting polyproteins pp1a and pp1ab are processed into the viral polymerase (RdRp) and other non-structural proteins involved in RNA synthesis. Structural proteins are expressed as subgenomic RNAs. Each RNA (genomic and subgenomic) is translated to yield only the protein encoded by the 5'-most ORF.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the endosomal membrane (probably mediated by S2), ssRNA(+) genome is released into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Synthesis of structural proteins encoded by subgenomic mRNAs.
  7. Assembly and budding at membranes of the endoplasmic reticulum (ER), the intermediate compartments, and/or the Golgi complex.
  8. Release of new virions by exocytosis.

Host-virus interaction

Innate immune response inhibition

TGEV protein 7 may counteract host antiviral response, possibly by modulating PP1 activity .

Matching UniProtKB/Swiss-Prot entries

48 entries grouped by protein (browse by keywords)

Only complete proteome entries are shown (view all 92 entries)

6 entries

Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

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NCAP_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
NCAP_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
NCAP_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
NCAP_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
NCAP_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
NCAP_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

3 entries

Non-structural protein 3 (ns3) (Accessory protein 3a)

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NS3_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
NS3_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain

Non-structural protein 3 (Protein 3) (ns3) (Accessory protein 3a)

NS3_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

2 entries

Non-structural protein 3a (ns3a) (Accessory protein 3a)

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NS3A_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain

Non-structural protein 3a (ns3a) (Accessory protein 3a) (X2a protein)

NS3A_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain

2 entries

Putative non-structural protein 3b (ns3b) (Accessory protein 3b) (Non-structural protein 3-1) (X2b protein)

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NS3B_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
NS3B_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain

Putative truncated non-structural protein 3b (ns3b) (Accessory protein 3b)

1 entry

Non-structural protein 3x (ns3x) (Accessory protein 3x) (ns3b)

NS3X_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain

1 entry

Non-structural protein 4a (ns4a) (Accessory protein 4a)

NS4A_CVH22
Human coronavirus 229E (HCoV-229E) reference strain

1 entry

Non-structural protein 4b (ns4b) (Accessory protein 4b)

NS4B_CVH22
Human coronavirus 229E (HCoV-229E) reference strain

2 entries

Non-structural protein 7 (ns7) (9 kDa hydrophobic protein) (HP) (Accessory protein 7) (X3 protein)

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NS7_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
NS7_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain

Non-structural protein 7a (ns7a) (11 kDa protein) (Accessory protein 7a)

1 entry

Non-structural protein 7b (ns7b) (Accessory protein 7b)

NS7B_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain

5 entries

Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)

Select_allDeselect_all
R1A_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1A_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1A_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
R1A_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1A_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

6 entries

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

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R1AB_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1AB_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1AB_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
R1AB_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1AB_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
R1AB_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

6 entries

Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

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SPIKE_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
SPIKE_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
SPIKE_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
SPIKE_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
SPIKE_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
SPIKE_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

6 entries

Envelope small membrane protein (E protein) (sM protein)

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VEMP_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
VEMP_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
VEMP_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
VEMP_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
VEMP_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
VEMP_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

6 entries

Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

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VME1_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
VME1_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
VME1_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
VME1_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
VME1_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
VME1_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain