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Inhibition of host JAK1 by virus (kw:KW-1096)

JAK1 is widely expressed membrane-associated phosphoprotein involved in the interferon-alpha/beta and -gamma signal transduction pathways. JAK1 and TYK2 participate in the interferon-alpha/beta pathway, while JAK1 and JAK2 play a role in the interferon-gamma pathway.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 LMP1 NS5 E6 VP40 LT

Several viruses have evolved specific mechanisms to prevent the establishment of an antiviral state by inhibiting key components of the signaling pathway. For instance, the polyomavirus large T antigen binds to Janus tyrosine kinase 1 and inactivated signaling through IFN receptors. The Marburg virus VP40 protein is able to prevent the tyrosine phosphorylation of JAK1 and subsequent phosphorylation of STAT1 and STAT2.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Inhibition of interferon signaling Inhibition of host STAT1
Inhibition of host STAT2
Inhibition of host IRF9
Inhibition of host TYK2
Inhibition of host JAK1
Inhibition of host interferon receptors
Links Uniprot Keyword: KW-1096
GO ontology: GO:0039576
Virus -Marburg virus
(Filoviridae ,Marburgvirus)
-Polyomavirus
(Polyomaviridae ,Polyomavirus)
-Human cytomegalovirus
(Herpesviridae ,Cytomegalovirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

31 entries grouped by strain

1 entry

B-lymphotropic polyomavirus (LPV) reference strain

LT_POVLY Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

Bovine polyomavirus (BPyV) (Bos taurus polyomavirus 1) reference strain

LT_POVBO Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

Budgerigar fledgling disease virus (BFPyV) (Aves polyomavirus 1) reference strain

LT_BFPYV Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain

LT_POVHA Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

JC polyomavirus (JCPyV) (JCV) reference strain

LT_POVJC Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

pdb 4LIF; 4LMD; 4NBP; 5CYN; 5J40; 5J47; 5J4V; 5J4Y; 8SUD

1 entry

Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain

VP40_MABVM Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)

pdb 5B0V

1 entry

Murine polyomavirus (strain A2) (MPyV) reference strain

LT_POVMA Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

Simian virus 40 (SV40) reference strain

LT_SV40 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

pdb 1EJL; 1GH6; 1N25; 1Q1S; 1Q1T; 1SVL; 1SVM; 1SVO; 1TBD; 1Z1D; 2FUF; 2H1L; 2IF9; 2IPR; 2ITJ; 2ITL; 2NL8; 2NTC; 2TBD; 3QK2; 3QN2; 4E2I; 4FGN; 4GDF; 4RXH; 5D9I; 9EVH; 9EVP; 9EXD; 9F3T; 9F3U; 9F5I; 9F73; 9F74; 9F75; 9F7N; 9F9N; 9F9O; 9F9W; 9F9X; 9FA1; 9FA2; 9FB0; 9FB4; 9FB5; 9FB6; 9KAE; 9KAK

1 entry

Squirrel monkey polyomavirus reference strain

LT_POVSM Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

WU polyomavirus (WUPyV) reference strain

LT_POVWU Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

pdb 8TUS

1 entry

African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)

5057R_ASFM2 Protein MGF 505-7R

1 entry

African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)

5057R_ASFP4 Protein MGF 505-7R

1 entry

African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)

5057R_ASFWA Protein MGF 505-7R

1 entry

BK polyomavirus (BKPyV) (Human polyomavirus 1)

LT_POVBK Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

BK polyomavirus (strain AS) (BKPyV)

LT_POVBA Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

KI polyomavirus (isolate Stockholm 350) (KIPyV)

LT_POVKI Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

KI polyomavirus (isolate Stockholm 380) (KIPyV)

LT_POVK3 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

KI polyomavirus (isolate Stockholm 60) (KIPyV)

LT_POVK6 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

pdb 8Q8K

1 entry

Kunjin virus (strain MRM61C)

POLG_KUNJM Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1SFK; 2HCN; 2HCS; 2HFZ; 2OF6; 2QEQ

1 entry

Lake Victoria marburgvirus (strain Angola/2005) (MARV)

VP40_MABVA Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)

1 entry

Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))

VP40_MABVO Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)

1 entry

Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))

VP40_MABVP Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)

1 entry

Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

VP40_MABVR Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)

1 entry

Langat virus (strain TP21)

POLG_LANVT Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1Z66; 2GG1; 7WNJ; 8YNJ; 9FK0; 9H28

1 entry

Murine polyomavirus (strain A3) (MPyV)

LT_POVM3 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

pdb 1FAF

1 entry

Murine polyomavirus (strain BG) (MPyV)

LT_POVBG Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

pdb 4FB3

1 entry

Murine polyomavirus (strain Crawford small-plaque) (MPyV)

LT_POVMC Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

Murine polyomavirus (strain Kilham) (MPyV) (Murine pneumotropic virus)

LT_POVMK Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

Mus musculus polyomavirus 1 (MPyV)

LT_POVM1 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

Simian virus 12 (strain wt100) (SV-12) (Baboon polyomavirus 1)

LT_POVS1 Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)

1 entry

West Nile virus (WNV)

POLG_WNV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 2FP7; 2GGV; 2IJO; 2P5P; 2YOL; 3E90; 3I50; 5IDK