Inhibition of host JAK1 by virus

JAK1 is widely expressed membrane-associated phosphoprotein involved in the interferon-alpha/beta and -gamma signal transduction pathways. JAK1 and TYK2 participate in the interferon-alpha/beta pathway, while JAK1 and JAK2 play a role in the interferon-gamma pathway.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 LMP1 NS5 E6 VP40 LT

Several viruses have evolved specific mechanisms to prevent the establishment of an antiviral state by inhibiting key components of the signaling pathway. For instance, the polyomavirus large T antigen binds to Janus tyrosine kinase 1 and inactivated signaling through IFN receptors. The Marburg virus VP40 protein is able to prevent the tyrosine phosphorylation of JAK1 and subsequent phosphorylation of STAT1 and STAT2.

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by strain (browse by keywords)

1 entry

BK polyomavirus (strain AS) (BKPyV) reference strain

LT_POVBA Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Bovine polyomavirus (BPyV) (Bos taurus polyomavirus 1) reference strain

LT_POVBO Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Budgerigar fledgling disease virus (BFPyV) (Aves polyomavirus 1) reference strain

LT_BFPYV Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain

LT_POVHA Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

KI polyomavirus (isolate Stockholm 60) (KIPyV) reference strain

LT_POVK6 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Lake Victoria marburgvirus (strain Angola/2005) (MARV) reference strain

VP40_MABVA Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)

1 entry

Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain

VP40_MABVM Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)

1 entry

Murine polyomavirus (strain A2) (MPyV) reference strain

LT_POVMA Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Mus musculus polyomavirus 1 (MPyV) reference strain

LT_POVM1 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Simian virus 40 (SV40) reference strain

LT_SV40 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Squirrel monkey polyomavirus reference strain

LT_POVSM Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

WU polyomavirus (WUPyV) reference strain

LT_POVWU Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

B-lymphotropic polyomavirus (LPV)

LT_POVLY Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

BK polyomavirus (BKPyV) (Human polyomavirus 1)

LT_POVBK Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

JC polyomavirus (JCPyV) (JCV)

LT_POVJC Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

KI polyomavirus (isolate Stockholm 350) (KIPyV)

LT_POVKI Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

KI polyomavirus (isolate Stockholm 380) (KIPyV)

LT_POVK3 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Kunjin virus (strain MRM61C)

POLG_KUNJM Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))

VP40_MABVO Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)

1 entry

Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))

VP40_MABVP Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)

1 entry

Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

VP40_MABVR Matrix protein VP40 (Marburg VP40) (mVP40) (Membrane-associated protein VP40)

1 entry

Langat virus (strain TP21)

POLG_LANVT Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

1 entry

Murine polyomavirus (strain A3) (MPyV)

LT_POVM3 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Murine polyomavirus (strain BG) (MPyV)

LT_POVBG Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Murine polyomavirus (strain Crawford small-plaque) (MPyV)

LT_POVMC Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Murine polyomavirus (strain Kilham) (MPyV) (Murine pneumotropic virus)

LT_POVMK Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Simian virus 12 (strain wt100) (SV-12) (Baboon polyomavirus 1)

LT_POVS1 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

West Nile virus (WNV)

POLG_WNV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...