Inhibition of host complement factors by virus

The complement system is a major non-specific mechanism of humoral immunity. The activation of complement involves the sequential proteolyis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response.

Members of the herpesvirus, orthopoxvirus and retrovirus families mimic or interact with complement regulatory proteins to block complement activation and neutralization of virus particles. For example, vaccinia and variola viruses encode secreted proteins that block C3 convertase assembly. Influenza A virus instead blocks the complement pathway via M1 protein interacting with and inhibiting host C1qA protein.

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by strain (browse by keywords)

1 entry

Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

GC_EHV1B Envelope glycoprotein C (gC) (Glycoprotein 13)

1 entry

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

GC_HHV11 Envelope glycoprotein C

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

GC_HHV2H Envelope glycoprotein C

1 entry

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

ORF4_HHV8P Complement control protein (KCP)

1 entry

Turkey astrovirus 1 (TAstV-1) reference strain

CAPSD_TASV1 Capsid polyprotein VP90

1 entry

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

VCP_VACCW Complement control protein C3 (28 kDa protein) (Secretory protein 35) (Protein C3) (VCP)

1 entry

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

GC_VZVD Envelope glycoprotein C (gC) (Glycoprotein V) (gpV)

1 entry

Avian nephritis virus 1 (ANV-1)

CAPSD_ANV1 Capsid polyprotein VP90

1 entry

Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)

GC_BHV1C Envelope glycoprotein C homolog (Glycoprotein GIII)

1 entry

Equine herpesvirus 1 (strain Kentucky D) (EHV-1) (Equine abortion virus)

GC_EHV1D Envelope glycoprotein C (gC) (Glycoprotein 13)

1 entry

Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)

GC_EHV4 Envelope glycoprotein C (Glycoprotein 13)

1 entry

Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)

GC_HHV1K Envelope glycoprotein C

1 entry

Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

GC_HHV23 Envelope glycoprotein C

1 entry

Human herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)

GC_HHV2G Envelope glycoprotein C (Glycoprotein F)

1 entry

Mosquito cell fusing agent (CFA flavivirus)

POLG_MCFA Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM; ...

1 entry

Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

GC_SUHVF Envelope glycoprotein C homolog (Glycoprotein GIII)

1 entry

Turkey astrovirus 2 (TAstV-2)

CAPSD_TASV2 Capsid polyprotein VP90

1 entry

Vaccinia virus (strain Copenhagen) (VACV)

VCP_VACCC Complement control protein C3 (28 kDa protein) (Secretory protein 35) (Protein C3) (VCP)