Inhibition of host pre-mRNA processing by virus

Host mRNAs poly(A) tail is added in two steps. First, pre-mRNAs are cleaved and a short poly(A) tail is added. Subsequent elongation of this short poly(A) tail requires poly(A)-binding protein II, CPSF complex and PAP (PABII), which facilitate rapid, processive poly(A) addition. PABII also plays a role in nuclear export of host mRNAs.

Some viruses interfere with host pre-mRNA processing function. Incompletely processed mRNA are non-functional leading to shutoff of host proteins expression. This gives viruses transcripts a competitive edge for access to the cellular translation machinery. Preventing the expression of host proteins is also a strategy to counteract the antiviral response. Some viruses have been shown to inhibit host pre-mRNA processing by blocking cellular splicing or polyadenylation.

Herpesvirus protein ICP27 mediates the inhibition of cellular splicing. Early in infection, ICP27 interacts with several splicing factors, including members of a family of essential splicing factors termed SR proteins, and affects their phosphorylation. This results in the blockage of the pre-spliceosome assembly, which in turn contributes to the shutoff of host protein synthesis because of incomplete cellular pre-mRNAs processing.

Influenza virus NS1 can bind to CPSF30 and PABII and thus inhibits host pre-mRNA processing.
NS1 of the 2009 Pandemic H1N1 has a truncated C-terminus and has apparently lost the ability to bind PABII

Viruses inhibiting host mRNA splicing:

Family Virus Viral protein mRNA processing inhibition strategy references
Orthomyxoviridae Influenza A virus NS1 Inhibition of polyadenylation via binding to CPSF30 and PABII
Herpesviridae HHV1, HHV2 ICP27 Inhibition of splicing
Retroviridae HIV-1 VPR Inhibition of splicing

Matching UniProtKB/Swiss-Prot entries

121 entries grouped by protein (browse by keywords)

3 entries

mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)

Select_allDeselect_all
ICP27_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP27_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP27_HHV1E
Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27)

118 entries

Non-structural protein 1 (NS1) (NS1A)

Select_allDeselect_all
NS1_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
NS1_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2) reference strain
NS1_I72A5
Influenza A virus (strain A/Shearwater/Australia/1972 H6N5) reference strain
NS1_I78A3
Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2) reference strain
NS1_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2) reference strain
NS1_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
NS1_I000W
Influenza A virus (strain A/Wa-182)
NS1_I000X
Influenza A virus (strain A/X-31 H3N2)
NS1_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
NS1_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
NS1_I01A0
Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
NS1_I01A1
Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
NS1_I01A2
Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
NS1_I01A3
Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
NS1_I02A0
Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
NS1_I02A1
Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
NS1_I02A2
Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
NS1_I02A3
Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
NS1_I02A4
Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
NS1_I02A5
Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
NS1_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
NS1_I03A0
Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
NS1_I03A1
Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
NS1_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
NS1_I07A0
Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
NS1_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
NS1_I30A0
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
NS1_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
NS1_I34A0
Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
NS1_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
NS1_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
NS1_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
NS1_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
NS1_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
NS1_I47A0
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
NS1_I49A0
Influenza A virus (strain A/Chicken/Germany/n/1949 H10N7)
NS1_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7)
NS1_I50A0
Influenza A virus (strain A/Fort Warren/1/1950 H1N1)
NS1_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
NS1_I54A0
Influenza A virus (strain A/Leningrad/1/1954 H1N1)
NS1_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
NS1_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
NS1_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
NS1_I56A3
Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)
NS1_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
NS1_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
NS1_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
NS1_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
NS1_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2)
NS1_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
NS1_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
NS1_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
NS1_I63A1
Influenza A virus (strain A/Turkey/Canada/1963 H6N8)
NS1_I66A0
Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
NS1_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
NS1_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
NS1_I68A0
Influenza A virus (strain A/Aichi/2/1968 H3N2)
NS1_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
NS1_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
NS1_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
NS1_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
NS1_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
NS1_I71A2
Influenza A virus (strain A/Turkey/Oregon/1971 H7N3)
NS1_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
NS1_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
NS1_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
NS1_I72A6
Influenza A virus (strain A/Tern/Turkmenia/18/1972 H3N3)
NS1_I73A4
Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
NS1_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
NS1_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
NS1_I76A0
Influenza A virus (strain A/Anas acuta/Primorje/695/1976 H2N3)
NS1_I76A2
Influenza A virus (strain A/Duck/Alberta/60/1976 H12N5)
NS1_I76A5
Influenza A virus (strain A/Mallard/Alberta/88/1976 H3N8)
NS1_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
NS1_I77A0
Influenza A virus (strain A/Alaska/6/1977 H3N2)
NS1_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
NS1_I77A9
Influenza A virus (strain A/Equine/New Market/1/1977 H7N7)
NS1_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
NS1_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
NS1_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
NS1_I77AG
Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)
NS1_I78A1
Influenza A virus (strain A/Mallard/Alberta/827/1978 H8N4)
NS1_I78A4
Influenza A virus (strain A/Mallard/New York/6874/1978 H3N2)
NS1_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
NS1_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
NS1_I78AA
Influenza A virus (strain A/Pintail/Alberta/268/1978 H6N2)
NS1_I78AC
Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
NS1_I78AF
Influenza A virus (strain A/Gull/Maryland/1824/1978 H13N6)
NS1_I79A1
Influenza A virus (strain A/Pintail/Alberta/119/1979 H4N6)
NS1_I79A2
Influenza A virus (strain A/Pintail/Alberta/121/1979 H7N8)
NS1_I79A3
Influenza A virus (strain A/Pintail/Alberta/358/1979 H3N6)
NS1_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
NS1_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
NS1_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
NS1_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
NS1_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
NS1_I80AC
Influenza A virus (strain A/Gull/Massachusetts/26/1980 H13N6)
NS1_I80AD
Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
NS1_I82A3
Influenza A virus (strain A/Seal/Massachusetts/133/1982 H4N5)
NS1_I82A8
Influenza A virus (strain A/Turkey/Bethlehem-Glilit/1492-B/1982 H1N1)
NS1_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
NS1_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
NS1_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
NS1_I83A6
Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)
NS1_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
NS1_I84A2
Influenza A virus (strain A/Whale/Maine/328/1984 H13N2)
NS1_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
NS1_I85A7
Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
NS1_I86A3
Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
NS1_I87A1
Influenza A virus (strain A/Mallard/Ohio/556/1987 H5N9)
NS1_I88A4
Influenza A virus (strain A/Herring gull/DE/677/1988 H2N8)
NS1_I89A1
Influenza A virus (strain A/Beijing/352/1989 H3N2)
NS1_I89A7
Influenza A virus (strain A/Equine/Jillin/1/1989 H3N8)
NS1_I91A0
Influenza A virus (strain A/Equine/Alaska/1/1991 H3N8)
NS1_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
NS1_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
NS1_I97A0
Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
NS1_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)