Inhibition of host RNA polymerase II by virus

Host RNA polymerase II (RNA pol-II) is the major enzyme responsible for transcription of mRNA from a DNA template strand. It is made up of 12 subunits Rpb1 to Rpb12. Rpb1 is the largest and catalytical subunit of RNA polymerase II. The carboxy-terminal domain (CTD) of RNA pol-II plays a central role in regulating efficient transcription initiation, elongation and RNA processing. It contains 52 heptapeptide repeats (YSPTSPS) and is phosphorylated largely on Ser-2 and Ser-5 during transcription process.

Some viruses interfere with host RNA pol-II function. They may either mediate its ubiquitination and subsequent proteasomal degradation, or inhibit RNA pol-II phosphorylation thereby lowering its efficiency. Inhibiting host transcription eventually leads to shutoff of host proteins expression and gives viruses transcripts a competitive edge for access to the cellular translation machinery. Preventing the expression of host proteins is also a strategy to counteract the antiviral response.

Viruses inhibiting RNA pol-II:

Family Virus Viral protein RNA pol-II inhibition strategy references
Herpesviridae HHV-1 ICP22 Counteracts CTD Ser-2 phosphorylation
Bunyaviridae Bunyamwera virus NSs Counteracts CTD Ser-2 phosphorylation
Orthomyxoviridae Influenza virus Polymerase PB1, PB2, PA RNA pol-II ubiquitination and proteasomal degradation
Togaviridae Sindbis, Semliki Forest and Chikungunya viruses nsP2 Ubiquitination of Rpb1 subunit and proteasomal degradation

Matching UniProtKB/Swiss-Prot entries

322 entries grouped by protein (browse by keywords)

All proteins are shown (view only 195 complete proteome entries)

4 entries

Transcriptional regulator ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

Select_allDeselect_all
ICP22_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP22_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP22_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Transcriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) (Transcriptional regulator IE63)

ICP22_VZVO
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

Transcriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) (Transcriptional transactivator IE63)

1 entry

Non-structural protein NS-S

NSS_BUNYW
Bunyamwera virus (BUNV) reference strain

96 entries

Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

Select_allDeselect_all
PA_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
PA_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
PA_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PA_INBLE
Influenza B virus (strain B/Lee/1940) reference strain
PA_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
PA_I000X
Influenza A virus (strain A/X-31 H3N2)
PA_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PA_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
PA_I01A0
Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
PA_I01A3
Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
PA_I02A0
Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
PA_I02A1
Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
PA_I02A2
Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
PA_I02A4
Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
PA_I02A5
Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PA_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PA_I05A1
Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PA_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
PA_I07A0
Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
PA_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
PA_I30A0
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
PA_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
PA_I34A0
Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
PA_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
PA_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
PA_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
PA_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
PA_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
PA_I47A0
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
PA_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
PA_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
PA_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PA_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PA_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
PA_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
PA_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
PA_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
PA_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2)
PA_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PA_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PA_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
PA_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PA_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
PA_I67A2
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
PA_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PA_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
PA_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2)
PA_I68A6
Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))
PA_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
PA_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
PA_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
PA_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
PA_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
PA_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
PA_I73A4
Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
PA_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PA_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
PA_I75A3
Influenza A virus (strain A/Victoria/3/1975 H3N2)
PA_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
PA_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PA_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
PA_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
PA_I77AD
Influenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)
PA_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
PA_I78A3
Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
PA_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
PA_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
PA_I78A9
Influenza A virus (strain A/Swine/Hong Kong/81/1978 H3N2)
PA_I78AC
Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
PA_I79A1
Influenza A virus (strain A/Pintail/Alberta/119/1979 H4N6)
PA_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PA_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
PA_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
PA_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PA_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
PA_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
PA_I80AD
Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
PA_I82A4
Influenza A virus (strain A/Swine/Hong Kong/126/1982 H3N2)
PA_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
PA_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PA_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PA_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PA_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PA_I85A7
Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
PA_I86A3
Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
PA_I93A0
Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
PA_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
PA_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
PA_I97A0
Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
PA_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PA_INBAC
Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])
PA_INBAD
Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])
PA_INBP9
Influenza B virus (strain B/Panama/45/1990)
PA_INBSI
Influenza B virus (strain B/Singapore/222/1979)
PA_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
PA_INCJJ
Influenza C virus (strain C/JJ/1950)

97 entries

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

Select_allDeselect_all
PB2_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
PB2_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
PB2_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PB2_INBLE
Influenza B virus (strain B/Lee/1940) reference strain
PB2_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
PB2_I000F
Influenza A virus (strain A/Chicken/Weybridge H7N7) (Influenza A virus (strain A/FPV/Weybridge H7N7))
PB2_I000X
Influenza A virus (strain A/X-31 H3N2)
PB2_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PB2_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
PB2_I02A0
Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
PB2_I02A5
Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PB2_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PB2_I02A7
Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)
PB2_I03A0
Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
PB2_I03A1
Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
PB2_I05A1
Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PB2_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
PB2_I07A0
Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
PB2_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
PB2_I30A0
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
PB2_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
PB2_I34A0
Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
PB2_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
PB2_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
PB2_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
PB2_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
PB2_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
PB2_I47A0
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
PB2_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
PB2_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
PB2_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PB2_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PB2_I56A3
Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)
PB2_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
PB2_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
PB2_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
PB2_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
PB2_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2)
PB2_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PB2_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PB2_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
PB2_I66A0
Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
PB2_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PB2_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
PB2_I67A2
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
PB2_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PB2_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
PB2_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2)
PB2_I68A6
Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))
PB2_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
PB2_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
PB2_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
PB2_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
PB2_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
PB2_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
PB2_I73A4
Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
PB2_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PB2_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
PB2_I75A3
Influenza A virus (strain A/Victoria/3/1975 H3N2)
PB2_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
PB2_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PB2_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
PB2_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
PB2_I77AC
Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
PB2_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
PB2_I77AG
Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)
PB2_I78A3
Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
PB2_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
PB2_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
PB2_I79A4
Influenza A virus (strain A/Kiev/59/1979 H1N1)
PB2_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PB2_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
PB2_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
PB2_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PB2_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
PB2_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
PB2_I80AD
Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
PB2_I82A3
Influenza A virus (strain A/Seal/Massachusetts/133/1982 H4N5)
PB2_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
PB2_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PB2_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PB2_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PB2_I84A4
Influenza A virus (strain A/Gull/Astrakhan/227/1984 H13N6)
PB2_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PB2_I85A7
Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
PB2_I86A2
Influenza A virus (strain A/Equine/Kentucky/2/1986 H3N8)
PB2_I88A3
Influenza A virus (strain A/Memphis/8/1988 H3N2)
PB2_I93A0
Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
PB2_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
PB2_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
PB2_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PB2_INBAC
Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])
PB2_INBAD
Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])
PB2_INBP9
Influenza B virus (strain B/Panama/45/1990)
PB2_INCBE
Influenza C virus (strain C/Berlin/1/1985)
PB2_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
PB2_INCJJ
Influenza C virus (strain C/JJ/1950)

25 entries

Polyprotein P1234 (P1234) (Non-structural polyprotein)

Select_allDeselect_all
POLN_CHIKS
Chikungunya virus (strain S27-African prototype) (CHIKV) reference strain
POLN_SFV
Semliki forest virus (SFV) reference strain
POLN_SINDV
Sindbis virus (SINV) reference strain
POLN_AURAV
Aura virus (AURAV)
POLN_BFV
Barmah forest virus (BFV)
POLN_CHIK3
Chikungunya virus (strain 37997) (CHIKV)
POLN_EEEV1
Eastern equine encephalitis virus (strain PE-0.0155) (EEEV) (Eastern equine encephalomyelitis virus)
POLN_EEEV8
Eastern equine encephalitis virus (strain PE-3.0815) (EEEV) (Eastern equine encephalomyelitis virus)
POLN_EEEVF
Eastern equine encephalitis virus (strain Florida 91-469) (EEEV) (Eastern equine encephalomyelitis virus)
POLN_EEVV3
Venezuelan equine encephalitis virus (strain 3880) (VEEV)
POLN_EEVVC
Venezuelan equine encephalitis virus (strain CPA201) (VEEV)
POLN_EEVVM
Venezuelan equine encephalitis virus (strain Mena II) (VEEV)
POLN_EEVVP
Venezuelan equine encephalitis virus (strain P676) (VEEV)
POLN_EEVVT
Venezuelan equine encephalitis virus (strain Trinidad donkey) (VEEV)
POLN_GETV
Getah virus (GETV)
POLN_MAYAB
Mayaro virus (strain Brazil) (MAYV)
POLN_ONNVG
O'nyong-nyong virus (strain Gulu) (ONNV)
POLN_ONNVI
O'nyong-nyong virus (strain Igbo Ora) (ONNV) (Igbo Ora virus)
POLN_ONNVS
O'nyong-nyong virus (strain SG650) (ONNV)
POLN_RRVN
Ross river virus (strain NB5092) (RRV)
POLN_SAGV
Sagiyama virus (SAGV)
POLN_SINDO
Sindbis virus subtype Ockelbo (strain Edsbyn 82-5) (OCKV) (Ockelbo virus)
POLN_SLDV
Sleeping disease virus (SDV)
POLN_SPDV
Salmon pancreas disease virus (SPDV)
POLN_WEEV
Western equine encephalitis virus (WEEV)

99 entries

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)

Select_allDeselect_all
RDRP_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
RDRP_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
RDRP_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
RDRP_INBLE
Influenza B virus (strain B/Lee/1940) reference strain
RDRP_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
RDRP_I000X
Influenza A virus (strain A/X-31 H3N2)
RDRP_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
RDRP_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
RDRP_I01A0
Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
RDRP_I01A3
Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
RDRP_I02A2
Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
RDRP_I02A3
Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
RDRP_I02A4
Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
RDRP_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
RDRP_I02A7
Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)
RDRP_I03A0
Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
RDRP_I03A1
Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
RDRP_I05A1
Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
RDRP_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
RDRP_I07A0
Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
RDRP_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
RDRP_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
RDRP_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
RDRP_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
RDRP_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
RDRP_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
RDRP_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
RDRP_I47A0
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
RDRP_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
RDRP_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
RDRP_I56A0
Influenza A virus (strain A/Beijing/11/1956 H1N1)
RDRP_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
RDRP_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
RDRP_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
RDRP_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
RDRP_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
RDRP_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
RDRP_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2)
RDRP_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
RDRP_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
RDRP_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
RDRP_I66A0
Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
RDRP_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
RDRP_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
RDRP_I67A2
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
RDRP_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
RDRP_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
RDRP_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2)
RDRP_I68A6
Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))
RDRP_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
RDRP_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
RDRP_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
RDRP_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
RDRP_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
RDRP_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
RDRP_I73A4
Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
RDRP_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
RDRP_I73A6
Influenza A virus (strain A/Dunedin/4/1973 H3N2)
RDRP_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
RDRP_I75A3
Influenza A virus (strain A/Victoria/3/1975 H3N2)
RDRP_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
RDRP_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
RDRP_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
RDRP_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
RDRP_I77AD
Influenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)
RDRP_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
RDRP_I78A3
Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
RDRP_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
RDRP_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
RDRP_I78AC
Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
RDRP_I79A4
Influenza A virus (strain A/Kiev/59/1979 H1N1)
RDRP_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
RDRP_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
RDRP_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
RDRP_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
RDRP_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
RDRP_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
RDRP_I80AD
Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
RDRP_I81A4
Influenza A virus (strain A/Swine/Ontario/2/1981 H1N1)
RDRP_I82A4
Influenza A virus (strain A/Swine/Hong Kong/126/1982 H3N2)
RDRP_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
RDRP_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
RDRP_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
RDRP_I83A6
Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)
RDRP_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
RDRP_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
RDRP_I86A3
Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
RDRP_I88A3
Influenza A virus (strain A/Memphis/8/1988 H3N2)
RDRP_I88A7
Influenza A virus (strain A/Wisconsin/3523/1988 H1N1)
RDRP_I93A0
Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
RDRP_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
RDRP_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
RDRP_I97A0
Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
RDRP_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
RDRP_INBAC
Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])
RDRP_INBAD
Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])
RDRP_INBP9
Influenza B virus (strain B/Panama/45/1990)
RDRP_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
RDRP_INCJJ
Influenza C virus (strain C/JJ/1950)