Pore-mediated penetration of viral genome into host cell


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Some non-enveloped viruses inject their genome into the host cytoplasm through creation of a pore in the host membrane. This is mediated by a viral pore-forming peptide associated with the viral capsid.

The icosahedric capsid of picornaviridae is able to create a pore either at plasma or endosomal membrane to inject their genomic RNA.

Papillomaviridae and polyomaviridae seem to enter the endoplasmic reticulum where their icosahedric capsid is disassembled, releasing pore forming proteins that induce injection of genomic DNA into cell cytoplasm.

Prokaryotic viruses such as caudovirales eject their genome into the host cytoplasm through a complex ejection apparatus. This mechanism often involves pore formation in the host membrane(s).

Matching UniProtKB/Swiss-Prot entries

50 entries grouped by strain (browse by keywords)

1 entry

Bacillus phage Nf (Bacteriophage Nf) reference strain

DIT9_BPNF Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9) (Tail protein)

1 entry

Bacillus phage PZA (Bacteriophage PZA) reference strain

DIT9_BPPZA Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

1 entry

Bacillus phage phi29 (Bacteriophage phi-29) reference strain

DIT9_BPPH2 Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

1 entry

Escherichia phage P2 (Bacteriophage P2) reference strain

SPIKE_BPP2 Spike protein (Baseplate assembly protein gpV) (Gene V protein) (GpV)

1 entry

Escherichia phage T5 (Enterobacteria phage T5) reference strain

TMP_BPT5 Probable tape measure protein (Tail protein pb2)

1 entry

Human rhinovirus A serotype 89 (strain 41467-Gallo) (HRV-89) reference strain

POLG_HRV8A Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 1 (strain Mahoney) reference strain

POLG_POL1M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Salmonella phage P22 (Bacteriophage P22) reference strain

NEEDL_BPP22 Tail needle protein gp26 (Head completion protein) (Packaged DNA stabilization protein) (Tail ...

1 entry

Bacillus phage B103 (Bacteriophage B103)

DIT9_BPB03 Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

1 entry

Bovine enterovirus (strain VG-5-27) (BEV)

POLG_BOVEV Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A16 (strain G-10)

POLG_CX16G Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A16 (strain Tainan/5079/98)

POLG_CX16T Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A21 (strain Coe)

POLG_CXA21 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A24 (strain EH24/70)

POLG_CXA24 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A9 (strain Griggs)

POLG_CXA9 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B1 (strain Japan)

POLG_CXB1J Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid ...

1 entry

Coxsackievirus B2 (strain Ohio-1)

POLG_CXB2O Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B3 (strain Nancy)

POLG_CXB3N Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B3 (strain Woodruff)

POLG_CXB3W Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B4 (strain E2)

POLG_CXB4E Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B4 (strain JVB / Benschoten / New York/51)

POLG_CXB4J Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B5 (strain Peterborough / 1954/UK/85)

POLG_CXB5P Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B6 (strain Schmitt)

POLG_CXB6S Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)

POLG_EC01F Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 11 (strain Gregory)

POLG_EC11G Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 12 (strain Travis)

POLG_EC12T Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 30 (strain Bastianni)

POLG_EC30B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 5 (strain Noyce)

POLG_EC05N Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 6 (strain Charles)

POLG_EC06C Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 9 (strain Barty)

POLG_EC09B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 9 (strain Hill)

POLG_EC09H Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus 70 (strain J670/71) (EV70) (EV-70)

POLG_HE701 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus 71 (EV71) (EV-71)

POLG_HE71 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus 71 (strain 7423/MS/87) (EV71) (EV-71)

POLG_HE71M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus 71 (strain USA/BrCr/1970) (EV71) (EV-71)

POLG_HE71B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus D68 (EV68) (EV-68)

POLG_HED68 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 14 (HRV-14)

POLG_HRV14 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 16 (HRV-16)

POLG_HRV16 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 1A (HRV-1A)

POLG_HRV1A Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 1B (HRV-1B)

POLG_HRV1B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 2 (HRV-2)

POLG_HRV2 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 3 (HRV-3)

POLG_HRV3 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 1 (strain Sabin)

POLG_POL1S Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 2 (strain Lansing)

POLG_POL2L Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 2 (strain W-2)

POLG_POL2W Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 3 (strain 23127)

POLG_POL32 Genome polyprotein [Cleaved into: P3; Protein 3AB; P1; Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

POLG_POL3L Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Porcine enterovirus 9 (strain UKG/410/73)

POLG_PEV9U Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Swine vesicular disease virus (strain H/3 '76) (SVDV)

POLG_SVDVH Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Swine vesicular disease virus (strain UKG/27/72) (SVDV)

POLG_SVDVU Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...