VIRION
Enveloped virion of which the membrane is surrounded by a capsid with an icosahedral symmetry (T=169), 100-170 nm in diameter. Dense material are present at each 5-fold symmetry vertex
Source: Van Etten 2003 (Pubmed)
GENOME
Linear, dsDNA genome of 120-485 kb with crosslinked hairpin ends.
GENE EXPRESSION
ENZYMES
- DNA-directed DNA polymerase
- Cell-type capping
- Protease (Peptidase S74)
- Ribonucleoside-diphosphate reductase
REPLICATION
NUCLEO-CYTOPLASMIC
- Virus attaches to host receptors , inducing release of viral genome into the cell.
- Migration of the DNA core to the nucleus?
- Synthesis of early proteins.
- Replication of genomic DNA..
- Late proteins synthesis, assembly of new virions in the cytoplasm
- Cell lysis and virion release in the extracellular space.