VIRION
Enveloped virion of which the membrane is surrounded by a capsid with an icosahedral symmetry (T=169), 100-220 nm in diameter. Dense material are present at each 5-fold symmetry vertex
Source: Van Etten 2003 (Pubmed)
GENOME
Linear, dsDNA genome of about 330 kb with crosslinked hairpin ends. PBCV-1 genome encode for approximately 700 ORFs.
GENE EXPRESSION
ENZYMES
- DNA-directed DNA polymerase B [F8TTZ2] [P30321]
- Cell-type capping
- Endonuclease [P31117]
- HNH nuclease [Q84584] [Q84668] [Q98474]
- DNA ligase [O41026]
- Exonuclease [Q84486]
- Helicase [Q84473] [Q84561] [Q98507] [O41030]
- Ribonucleoside-diphosphate reductase
- Thymidylate synthase [O41156]
- Deoxyuridine 5'-triphosphate nucleotidohydrolase [O41033]
- Deoxynucleoside kinase [Q98468]
- CMP/dCMP-type deaminase [O41078] [Q84520]
- UDP-glucose 6-dehydrogenase [O41091]
- RNAse [Q98514]
- tRNA(Ile)-lysidine synthetase [O41036]
- Protease (Peptidase S33) [Q84588]
- Protease Q84668
- Aspartate carbamoyltransferase [Q84489]
- Glutamine amidotransferase [Q84421]
- Arginine/Ornithine decarboxylase [Q84527]
- Protein kinase [O41099] [O41096] [Q84595] [Q89369] [Q84599] [Q89566] [Q84605] [Q84594]
- Protein phosphatase [Q84621]
- Superoxide dismutase [Q90023]
- Sulfhydryl oxidase [Q98515] [Q98523]
- Glycosyltransferase [Q84542] [O41028]
- D-lactate dehydrogenase [Q89388]
REPLICATION
NUCLEO-CYTOPLASMIC
- Virus attaches to host receptors , inducing release of viral genome into the cell.
- Migration of the DNA core to the nucleus?
- Synthesis of early proteins.
- Replication of genomic DNA..
- Late proteins synthesis, assembly of new virions in the cytoplasm
- Cell lysis and virion release in the extracellular space.