Herelleviridae (taxid:2560065)
VIRION
Non-enveloped, head-tail structure with Myo-type morphology. Heads are about 84-94 nm in diameter and and tails 140-219 in length. The tail is contractile with globular structures at its tip, has 6 long terminal fibers, 6 short spikes and a double base plate. The capsid has a T=16 symmetry (SPO1-like viruses).
GENOME
Linear, dsDNA genome of 130-140 kb, encoding for about 190-215 proteins.
GENE EXPRESSION
Genes are transcribed by operons. Some Twortvirus might have circularly permuted genomes.
ENZYMES
- DNA-directed DNA polymerase A [B6V2J7]
- Cysteine protease (Peptidase C51) [I7DJZ5]
- Serine protease (Peptidase S78) [B6V2N5]
- Metalloprotease (Peptidase M15) [B6V2R4]
- Metalloprotease (Peptidase M23) [A0A8S5RV49]
- Ribonucleoside reductase [B6V2M9]
- Deoxyuridylate hydroxymethyltransferase [P31654]
- DNA ligase [B6V2K8]
REPLICATION
CYTOPLASMIC
- Adsorption: the phage attaches to the target cell through its tail fibers.
- Ejection of the viral DNA into host cell cytoplasm by contraction of the tail sheath.
- Transcription and translation of early genes.
- Replication of genomic DNA. Transcription and translation of late genes.
- Assembly of an empty procapsid and packaging of the genome.
- Viral tail fibers assembly and viral tail assembly.
- Mature virions are released from the cell by lysis.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)63 entries grouped by protein
3 entries
Anti-Pycsar protein Apyc1 (Apyc1)
2 entries
Anti-Pycsar protein Apyc1 (Apyc1)
1 entry
Virion protein 3 (Gene product 40) (gp40)
3 entries
Major capsid protein (Major head protein)
1 entry
DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-)
1 entry
Deoxyuridylate hydroxymethyltransferase (Deoxyuridylate hydroxymethylase) (EC 2.1.2.-) (Gp29) (dUMP hydroxymethylase) (dUMP-HMase)
4 entries
Endolysin (EC 3.5.1.28) (Probable N-acetylmuramoyl-L-alanine amidase)
1 entry
Gene product 168 (gp168)
1 entry
Gene 27 protein
1 entry
Gene 30 protein (GP30)
1 entry
Gene 33 protein
1 entry
Putative gene 37 protein
1 entry
Putative gene 38 protein
1 entry
Putative gene 39 protein
1 entry
Gene 40 protein
1 entry
Putative gene 41 protein
1 entry
Putative gene 42 protein
1 entry
E22 protein (Gene 43 protein)
1 entry
E3 protein (Gene 44 protein)
1 entry
Putative gene 45 protein
1 entry
Inhibitor of histone-like protein HU (Gene 46 protein) (Gp46) (Gene product 46)
1 entry
Putative gene 47 protein
1 entry
Putative gene 48 protein
1 entry
Putative gene 49 protein
1 entry
Putative gene 50 protein
1 entry
Putative gene 51 protein
1 entry
Putative gene 52 protein
1 entry
Putative gene 53 protein
1 entry
Putative gene 54 protein
1 entry
Putative gene 55 protein
1 entry
Inhibitor of host cell division protein (Gene 56 protein) (Gp56)
1 entry
Putative gene 57 protein
1 entry
Putative gene 58 protein
1 entry
Putative gene 59 protein
1 entry
Putative gene 60 protein
1 entry
Hachiman anti-defense 1 (Had1)
1 entry
5-hmdU DNA kinase (5-hydroxymethyluracil DNA kinase) (P-loop kinase) (gp186)
1 entry
DNA endonuclease I-HmuI (EC 3.1.-.-) (HNH homing endonuclease I-HmuI)
3 entries
Probable portal protein
1 entry
RNA polymerase sigma GP28 factor
1 entry
RNA polymerase sigma GP34 factor
1 entry
Thoeris anti-defense 1 (Tad1)
1 entry
Thoeris anti-defense 2 (Tad2)
1 entry
Transcription factor 1
2 entries
Tail sheath protein (TSP)
1 entry
Putative tail sheath protein
1 entry
Putative major capsid protein
1 entry
Virion protein 4
1 entry
Virion protein 5
1 entry
Virion protein 6
1 entry
Tail fiber protein
1 entry