Superantigen (kw:KW-0766)
Super Antigens (SAgs) are molecule able to activate non specific immune repertoire, by bridging together T-cell receptors with non-specific partners.Initially this cause lymphocyte activation but then result in clonal deletion and anergy, leading to immune tolerance.
Some viruses would encode superantigens that may help them survive against host innate immunity.
Virus-encoded superantigens.
B T Huber, P N Hsu, N Sutkowski
Microbiol Rev September 1996; 60: 473?482
B T Huber, P N Hsu, N Sutkowski
Microbiol Rev September 1996; 60: 473?482
Epstein-Barr virus would transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen, thereby gaining the advantages of immune escape
Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen
N Sutkowski, B Conrad, D A Thorley-Lawson, B T Huber
Immunity October 2001; 15: 579?589
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N Sutkowski, B Conrad, D A Thorley-Lawson, B T Huber
Immunity October 2001; 15: 579?589
Superantigens of mouse mammary tumor virus
H Acha-Orbea, H R MacDonald
Annu. Rev. Immunol. 1995; 13: 459-486
H Acha-Orbea, H R MacDonald
Annu. Rev. Immunol. 1995; 13: 459-486
Superantigen related to rabies
M Lafon, A Galelli
Springer Semin. Immunopathol. 1996; 17: 307-318
M Lafon, A Galelli
Springer Semin. Immunopathol. 1996; 17: 307-318
Evidence for Ebola virus superantigen activity
Eric M Leroy, Pierre Becquart, Nadia Wauquier, Sylvain Baize
J. Virol. April 2011; 85: 4041-4042
Eric M Leroy, Pierre Becquart, Nadia Wauquier, Sylvain Baize
J. Virol. April 2011; 85: 4041-4042
Murine Vbeta3+ and Vbeta7+ T cell subsets are specific targets for the HERV-K18 Env superantigen
Albert K Tai, Miao Lin, Francesca Chang, Gang Chen, Francis Hsiao, Natalie Sutkowski, Brigitte T Huber
J. Immunol. September 1, 2006; 177: 3178-3184
Albert K Tai, Miao Lin, Francesca Chang, Gang Chen, Francis Hsiao, Natalie Sutkowski, Brigitte T Huber
J. Immunol. September 1, 2006; 177: 3178-3184
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)31 entries grouped by protein
25 entries
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
3 entries
Protein PR73
1 entry
Protein PR73 5'-endogenous
1 entry
Protein PR73 3'-endogenous
1 entry