Alphaflexiviridae (taxid:675064)
VIRION
Non-enveloped, flexuous, filamentous, 470-800 nm or more long and 12-13 nm in diameter.
GENOME
Linear ssRNA(+) genome of 5.4-9 kb in size. The 3' terminus is polyadenylated and, in some genera, the 5' end is capped. Encodes 1 to 6 proteins.
GENE EXPRESSION
The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA-dependent RNA polymerase (RdRp) is translated directly from the genomic RNA. The other ORFS, when present, are transcribed presumably as monocistronic subgenomic mRNAs (sgRNAs). TGB3 is expressed by leaky scanning of the TGB2 subgenomic mRNA.
ENZYMES
REPLICATION
CYTOPLASMIC
- Virus penetrates into the host cell.
- Uncoating, and release of the viral genomic RNA into the cytoplasm.
- The viral RNA is translated as a monocistronic mRNA to produce the RdRp (encoded by the 5'-proximal ORF).
- Replication occurs in viral factories recruited by TGB1. A dsRNA genome is synthesized from the genomic ssRNA(+).
- The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
- Internal subgenomic promoters are used to transcribe the sgRNAs. Traduction of these sgRNAs yields the capsid and movement proteins.
- Assembly of new virus particles.
- Triple gene block proteins (TGBp) allow cell-to-cell and long-distance movement.
Host-virus interaction
Suppression of RNA silencing
Potato virus X TGBp1 protein functions as a suppressor of RNA silencing inhibiting the PTGS pathway
.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)95 entries grouped by protein
21 entries
Coat protein (Capsid protein) (CP)
1 entry
Uncharacterized ORF2 protein
2 entries
Uncharacterized ORF4 protein
1 entry
Uncharacterized ORF5 protein
1 entry
Uncharacterized ORF6 protein
16 entries
RNA replication protein (165 kDa protein) (ORF1 protein)
15 entries
Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block 1 protein) (TGBp1)
15 entries
Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
16 entries
Movement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
2 entries
14.7 kDa protein (Putative nucleic acid-binding protein)
1 entry
Uncharacterized 12.4 kDa protein
1 entry
Uncharacterized 14.1 kDa protein in ORF1 coding strand
1 entry
Uncharacterized 14.7 kDa protein in coat protein coding strand
1 entry
Uncharacterized 5.8 kDa protein
1 entry
Uncharacterized 10 kDa protein (ORF 6)
Arachis pintoi virus taxid:1921009
| Protein | ModelArchive |
| 40 kDa protein | ma-jd-viral-52228 |
| CP | ma-jd-viral-15972 |
| RdRp | ma-jd-viral-34102 |
| TGBp1 | ma-jd-viral-22828 |
| TGBp2 | ma-jd-viral-31076 |
Asparagus virus 3 taxid:445435
Blackberry virus E taxid:1043184
| Protein | ModelArchive |
| Coat protein | ma-jd-viral-15973 |
| Replication-associated polyprotein | ma-jd-viral-34097 |
| Serine-rich p40 protein | ma-jd-viral-52229 |
| TGB-1 | ma-jd-viral-22906 |
| TGB-2 | ma-jd-viral-51962 |
Botrytis virus X (isolate Botrytis cinerea/New Zealand/Howitt/2006) taxid:686947
Cactus virus X taxid:112227
Citrus yellow vein clearing virus taxid:1214459
Donkey orchid symptomless virus taxid:1400526
Garlic virus A taxid:12433
Garlic virus B taxid:12432
| Protein | ModelArchive |
| 40kDa protein | ma-jd-viral-52230 |
| Coat protein | ma-jd-viral-15964 |
| NABP | ma-jd-viral-09286 |
| TGB1 | ma-jd-viral-22890 |
| TGB2 | ma-jd-viral-31088 |
Garlic virus C taxid:12431
| Protein | ModelArchive |
| 11kDa protein | ma-jd-viral-51952 |
| 15kDa protein | ma-jd-viral-09284 |
| 27kDa protein | ma-jd-viral-22884 |
| 40kDa protein | ma-jd-viral-52235 |
| Viral coat protein | ma-jd-viral-15989 |
Garlic virus D taxid:12430
Garlic virus E taxid:150285
Garlic virus X taxid:150284
| Protein | ModelArchive |
| 12 kDa protein | ma-jd-viral-51963 |
| 32 kDa protein | ma-jd-viral-52232 |
| Coat protein | ma-jd-viral-15971 |
| Helicase | ma-jd-viral-22889 |
| Nucleic acid binding protein | ma-jd-viral-09291 |
Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) taxid:651357
Lettuce virus X taxid:447171
Lolium latent virus (isolate Lolium/USA/US1/-) taxid:686945
Pepino mosaic virus taxid:112229
Phaius virus X taxid:457382
Pitaya virus X taxid:1176736
| Protein | ModelArchive |
| CP | ma-jd-viral-15990 |
| Movement protein TGBp3 (Triple gene block 3 protein) | ma-jd-viral-44044 |
| TGB1 | ma-jd-viral-22874 |
| TGB2 | ma-jd-viral-31087 |
Plantain virus X taxid:1331744
Potexvirus alternantherae taxid:85454
Potexvirus ecsallii taxid:317027
| Protein | ModelArchive |
| Coat protein | ma-jd-viral-15974 |
| Movement protein TGBp3 (Triple gene block 3 protein) | ma-jd-viral-08951 |
| Tgb1 | ma-jd-viral-22896 |
| Tgb2 | ma-jd-viral-31101 |
Senna mosaic virus taxid:1881013
| Protein | ModelArchive |
| CP | ma-jd-viral-15979 |
| TGB1 | ma-jd-viral-22830 |
| TGB2 | ma-jd-viral-31082 |
| TGB3 | ma-jd-viral-49528 |
Tamus red mosaic virus taxid:1081702
| Protein | ModelArchive |
| Coat protein | ma-jd-viral-16004 |
| Movement protein TGBp3 (Triple gene block 3 protein) | ma-jd-viral-08950 |
| Tgb1 | ma-jd-viral-22852 |
| Tgb2 | ma-jd-viral-31110 |