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Inhibition of host STAT1 by virus (kw:KW-1105)

The signal transducer and activator of transcription STAT1 protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT1 in IFN-γ and IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. While IFN-γ induces STAT1 homodimerization, IFN-α/β mainly stimulates heterodimerization of STAT1 and STAT2, both leading to STAT1 activation and nuclear localization.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 e1a P vh1 V C

Many viruses modulate the interferon mediated response by acting on STAT1 using different strategies. The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation. Sendai virus C protein also physically associates with STAT1 and send it to degradation. Vaccinia VH1 phosphatase instead reverses STAT1 activation by interacting with and dephosphorylating STAT1.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Inhibition of interferon signaling Inhibition of host STAT1
Inhibition of host STAT2
Inhibition of host IRF9
Inhibition of host TYK2
Inhibition of host JAK1
Inhibition of host interferon receptors
Links Uniprot Keyword: KW-1105
GO ontology: GO:0039563
Virus Human Parainfluenza Virus 2
(Paramyxoviridae, Rubulavirus)

-Nipah virus
(Paramyxoviridae, Henipavirus)

-Adenovirus
(Adenoviridae, Mastadenovirus)

-Hepatitis delta virus
(Deltavirus)

-Measles virus
(Paramyxoviridae, Morbillivirus)

-Mumps virus
(Paramyxoviridae, Rubulavirus)

-Rabies virus
(Rhabdoviridae, Lyssavirus)

-HCV
(Flaviviridae, Hepacivirus)

-HEV
(Hepaciviridae, Hepevirus)

-Sendai virus
(Paramyxoviridae, Respirovirus)

-Vaccinia virus
(Poxviridae, Orthopoxvirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

153 entries grouped by strain

1 entry

African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain

3609L_ASFB7 Protein MGF 360-9L

1 entry

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

PHOSP_ABLVB Phosphoprotein (Protein P) (Protein M1)

1 entry

Canine adenovirus serotype 2 (strain Toronto A 26-61) (CAdV-2) (Canine adenovirus 2 (strain Toronto A 26-61)) reference strain

E1A_ADECT Early E1A protein (Early E1A 25 kDa protein)

1 entry

Chikungunya virus (strain S27-African prototype) (CHIKV) reference strain

POLN_CHIKS Polyprotein P1234 (P1234) (Non-structural polyprotein) [Cleaved into: Polyprotein P123 (P123); ...

pdb 3GPG; 3GPO; 3GPQ; 3TRK; 4TU0; 5I22; 6VUQ; 6W7H; 6W8K; 6W8M; 6W8Q; 6W8Y; 6W8Z; 6W91; 6Z0U; 6Z0V; 7DOP; 7FGG; 7FGH; 7FGI; 7H6J; 7H6K; 7H6L; 7H6M; 7H6N; 7H6O; 7H6P; 7H6Q; 7H6R; 7H6S; 7H6T; 7H6U; 7H6V; 7H6W; 7H6X; 7H6Y; 7H6Z; 7H70; 7H71; 7H72; 7H73; 7H74; 7H75; 7H76; 7H77; 7H78; 7H79; 7H7A; 7H7B; 7H7C; 7H7D; 7H7E; 7H7F; 7H7G; 7H7H; 7H7I; 7H7J; 7H7K; 7H7L; 7H7M; 7H7N; 7H7O; 7H7P; 7H7Q; 7H7R; 7H7S; 7H7T; 7H7U; 7H7V; 7H7W; 7H7X; 7H7Y; 7H7Z; 7H80; 7H81; 7H82; 7H83; 7H84; 7H85; 7H86; 7H87; 7H88; 7H89; 7H8A; 7H8B; 7H8C; 7H8D; 7H8E; 7H8F; 7H8G; 7H8H; 7H8I; 7H8J; 7H8K; 7H8L; 7H8M; 7H8N; 7H8O; 7H8P; 7H8Q; 7H8R; 7H8S; 7H8T; 7H8U; 7H8V; 7H8W; 7H8X; 7H8Y; 7H8Z; 7H90; 7H91; 7H92; 7H93; 7H94; 7H95; 7H96; 7H97; 7H98; 7H99; 7H9A; 7H9B; 7H9C; 7H9D; 7H9E; 7H9F; 7H9G; 7H9H; 7H9I; 7H9J; 7HIA; 7HIB; 7HIC; 7HID; 7HIE; 7HIF; 7HIG; 7HIH; 7HII; 7HIJ; 7HIK; 7HIL; 7HIM; 7HIN; 7HIO; 7HIP; 7HIQ; 7HIR; 7HIS; 7HIT; 7HIU; 7HIV; 7HIW; 7HIX; 7P27; 7X01; 8AOV; 8AOW; 8AOX; 8APX; 8AXV; 8JCE; 8PHZ; 8PK7

1 entry

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

CEP2_EBVA8 Cytoplasmic envelopment protein 2 (Tegument protein BGLF2)

1 entry

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

CEP2_EBVB9 Cytoplasmic envelopment protein 2 (Tegument protein BGLF2)

1 entry

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

PHOSP_EBLV1 Phosphoprotein (Protein P) (Protein M1)

1 entry

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

PHOSP_EBLV2 Phosphoprotein (Protein P) (Protein M1)

1 entry

Fowlpox virus (strain NVSL) (FPV) reference strain

DUSP_FOWPN Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)

1 entry

Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

V_HENDH Non-structural protein V

1 entry

Hepatitis C virus genotype 1a (isolate H77) (HCV) reference strain

POLG_HCV77 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1A1R; 1A1V; 1CWX; 1HEI; 1JR6; 1N1L; 1ONB; 1R7C; 1R7D; 1R7E; 1R7F; 1R7G; 1RGQ; 2A4R; 2F9V; 2HD0; 2JXF; 2KDR; 2N1P; 2O8M; 2OBO; 2OBQ; 2OC0; 2OC1; 2OC7; 2OC8; 2OIN; 2P59; 2QV1; 2XI2; 2XI3; 2XNI; 3RC4; 3RC5; 4CL1; 4JZN; 4JZO; 4MWF; 4N0Y; 4Q0X; 4XVJ; 4Z0X; 5EOC; 5ERW; 5FGB; 5FGC; 5JZI; 5YXN; 5YXU; 6BQJ; 6BQK; 6BZU; 6BZV; 6BZW; 6BZY; 6UYD; 6WO5; 6WOQ; 7DUU

1 entry

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain

E1A_ADE12 Early E1A protein (Early E1A 29.5 kDa protein)

1 entry

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

E1A_ADE02 Early E1A protein (Early E1A 32 kDa protein)

1 entry

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

E1A_ADE05 Early E1A protein (Early E1A 32 kDa protein)

pdb 2KJE; 2R7G; 6H6D; 6H6H

1 entry

Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40) reference strain

E1A_ADE40 Early E1A protein (Early E1A 27 kDa protein)

1 entry

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

UL23_HCMVA Tegument protein UL23

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

ICP22_HHV2H E3 ubiquitin ligase ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

1 entry

Mokola virus (MOKV) reference strain

PHOSP_MOKV Phosphoprotein (Protein P) (Protein M1)

pdb 2WZL

1 entry

Monkeypox virus reference strain

DUSP_MONPV Dual specificity protein phosphatase OPG106 (EC 3.1.3.-) (EC 3.1.3.48)

pdb 8GZ4

1 entry

Mumps virus genotype B (strain Miyahara vaccine) (MuV) reference strain

V_MUMPM Non-structural protein V (Non-structural protein NS1)

1 entry

Myxoma virus (strain Lausanne) (MYXV) reference strain

DUSP_MYXVL Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)

1 entry

Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

V_PIV5 Non-structural protein V

pdb 2B5L; 2HYE; 2K48; 4I1S

1 entry

Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain

RPOA_PRRSL Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

PHOSP_RABVP Phosphoprotein (Protein P) (Protein M1)

pdb 3OA1

1 entry

Semliki forest virus (SFV) reference strain

POLN_SFV Polyprotein P1234 (P1234) (Non-structural polyprotein) [Cleaved into: Polyprotein P123' (P123'); ...

pdb 1FW5; 5DRV; 5FW5

1 entry

Sendai virus (strain Ohita) (SeV) reference strain

C_SENDO Protein C'

1 entry

Severe acute respiratory syndrome coronavirus (SARS-CoV) reference strain

NS6_SARS ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3)

pdb 7F90; 7VPG

1 entry

Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

NS6_SARS2 ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3)

pdb 7F60; 7VPH

1 entry

Simian virus 41 (SV41) reference strain

V_SV41 Non-structural protein V

1 entry

Sindbis virus (SINV) reference strain

POLN_SINDV Polyprotein P1234 (P1234) (Non-structural polyprotein) (p270 nonstructural polyprotein) [Cleaved ...

pdb 4GUA; 7VB4; 7VW5

1 entry

Vaccinia virus (strain Copenhagen) (VACV) reference strain

DUSP_VACCC Dual specificity protein phosphatase OPG106 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)

1 entry

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

DUSP_VACCW Dual specificity protein phosphatase OPG106 (EC 3.1.3.-) (EC 3.1.3.48) (Dual specificity protein ...

pdb 2Q05; 2RF6; 3CM3

1 entry

Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

DUSP_VAR67 Dual specificity protein phosphatase OPG106 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)

pdb 2P4D

1 entry

West Caucasian bat virus (WCBV) reference strain

PHOSP_WCBV Phosphoprotein (Protein P) (Protein M1)

1 entry

Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain

VP24_EBOZM Membrane-associated protein VP24 (Ebola VP24) (eVP24)

pdb 4M0Q; 4U2X; 6EHM; 8USN; 8UST; 8Y9J

1 entry

Zika virus (ZIKV) reference strain

POLG_ZIKV Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

pdb 5GJ4; 5GPI; 5GXJ; 5JPS; 5JRZ; 5K6K; 5RHG; 5RHH; 5RHI; 5RHJ; 5RHK; 5RHL; 5RHM; 5RHO; 5RHP; 5RHQ; 5RHR; 5RHS; 5RHT; 5RHU; 5RHV; 5RHW; 5RHX; 5RHY; 5T1V; 5TFN; 5TFO; 5TFR; 5TMH; 5U04; 5U0B; 5U0C; 5VI7; 5VIM; 5W41; 5Y4Z; 5YOD; 5YOF; 5Z0R; 5Z0V; 5ZMQ; 5ZMS; 5ZOB; 6ADW; 6ADX; 6ADY; 6JPW; 6KK2; 6KK3; 6KK4; 6KK5; 6KK6; 6KPQ; 6L50; 6MH3; 6UX2; 6WCZ; 6Y3B; 7G9K; 7G9L; 7G9M; 7G9N; 7G9O; 7G9P; 7G9Q; 7G9R; 7G9S; 7G9T; 7G9U; 7G9V; 7G9W; 7G9X; 7G9Y; 7G9Z; 7GA0; 7GA1; 7GA2; 7GA3; 7GA4; 7GA5; 7GA6; 7GA7; 7H1H; 7H1I; 7H1J; 7H1K; 7H1L; 7H1M; 7H1N; 7H1O; 7H1P; 7H1Q; 7H1R; 7H1S; 7H1T; 7H1U; 7H1V; 7H1W; 7H1X; 7H1Y; 7H1Z; 7H20; 7H21; 7H22; 7H23; 7H24; 7H25; 7H26; 7H27; 7H28; 7H29; 7H2A; 7H2B; 7H2C; 7H2D; 7H2E; 7H2F; 7H2G; 7H2H; 7H2I; 7H2J; 7H2K; 7H2L; 7H2M; 7H2N; 7H2O; 7H2P; 7H2Q; 7H2R; 7H2S; 7HOJ; 7HOK; 7HOL; 7HOM; 7HOP; 7HOQ; 7HOR; 7HOS; 7HOT; 7HOU; 7HOV; 7HOW; 7HOX; 7HOZ; 7HP0; 7HP1; 7HP2; 7HP4; 7HP5; 7HP6; 7HP7; 7HP8; 7HP9; 7HPA; 7HPB; 7HPC; 7HPD; 7HPE; 7HPF; 7HPG; 7HPH; 7I1K; 7I1L; 7I1M; 7I1N; 7I1O; 7I1P; 7I1Q; 7I1S; 7I1T; 7I1V; 7I1W; 7I1Y; 7I1Z; 7I20; 7I21; 7I22; 7O2M; 7O55; 7OBV; 7OC2; 7PFQ; 7PFY; 7PFZ; 7PG1; 7PGC; 7VLG; 7VLH; 7VLI; 7VXX; 7VXY; 7ZLC; 7ZLD; 7ZMI; 7ZNO; 7ZPD; 7ZQ1; 7ZQF; 7ZTM; 7ZUM; 7ZV4; 7ZVV; 7ZW5; 7ZWK; 7ZYS; 8A15; 8AQA; 8AQB; 8AQK; 8PEM; 8PN6; 8UM3; 8V7R; 8V7U; 8WN8; 8WNP; 8WNU; 8WO0; 8WO4

1 entry

African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)

3609L_ASFK5 Protein MGF 360-9L

1 entry

African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)

3609L_ASFM2 Protein MGF 360-9L

1 entry

African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)

3609L_ASFWA Protein MGF 360-9L

1 entry

Alkhumra hemorrhagic fever virus (ALKV) (Alkhurma hemorrhagic fever virus)

POLG_ALKV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Aravan virus (ARAV)

PHOSP_ARAV Phosphoprotein (Protein P) (Protein M1)

1 entry

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

PHOSP_ABLVH Phosphoprotein (Protein P) (Protein M1)

1 entry

Banzi virus (BANV)

POLG_BANV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Bovine parainfluenza 3 virus (BPIV-3)

C_PI3B Protein C

1 entry

Bussuquara virus (BUSV)

POLG_BUSV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))

E1A_ADECC Early E1A protein (Early E1A 25 kDa protein)

1 entry

Canine adenovirus serotype 1 (strain Glaxo) (CAdV-1) (Canine adenovirus 1 (strain Glaxo))

E1A_ADECG Early E1A protein (Early E1A 20 kDa protein)

1 entry

Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))

E1A_ADECR Early E1A protein (Early E1A 20 kDa protein)

1 entry

Canine adenovirus serotype 2 (CAdV-2) (Canine adenovirus 2)

E1A_ADEC2 Early E1A protein (Early E1A 20 kDa protein)

1 entry

Duvenhage virus (DUVV)

PHOSP_DUVV Phosphoprotein (Protein P) (Protein M1)

pdb 7C21

1 entry

Edge Hill virus (EHV)

POLG_EHV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)

CEP2_EBVG Cytoplasmic envelopment protein 2 (Tegument protein BGLF2)

1 entry

Hepatitis C virus genotype 1a (isolate 1) (HCV)

POLG_HCV1 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1RTL; 2A4G; 2GVF; 3EYD; 3HKW; 3KN2; 3QGH; 3QGI; 3RC4; 3RC5; 3SU4; 6MVO; 6N4N; 6VDO; 7MM3; 7MM4; 7MM9; 7MMA; 7MMB; 7MMC; 7MMD; 7MME; 7MMK; 7MML

1 entry

Hepatitis C virus genotype 1b (isolate BK) (HCV)

POLG_HCVBK Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1A1Q; 1BT7; 1C2P; 1CSJ; 1CU1; 1GX5; 1GX6; 1JXP; 1NHU; 1NHV; 1NS3; 1OS5; 1QUV; 2AWZ; 2AX0; 2AX1; 2BRK; 2BRL; 2DXS; 2GIQ; 2GIR; 2HAI; 2HWH; 2HWI; 2I1R; 2JC0; 2JC1; 2O5D; 2WCX; 2WHO; 2WRM; 2XWY; 2ZKU; 3BR9; 3BSA; 3BSC; 3CDE; 3CIZ; 3CJ0; 3CJ2; 3CJ3; 3CJ4; 3CJ5; 3CO9; 3CVK; 3CWJ; 3D28; 3D5M; 3E51; 3FQK; 3FRZ; 3G86; 3GYN; 3H2L; 3H59; 3H5S; 3H5U; 3H98; 3IGV; 3MF5; 3RVB; 3UA7; 3UDL; 3VQS; 4A92; 4B6E; 4B6F; 4B71; 4B73; 4B74; 4B75; 4B76; 4DGV; 4DGY; 4EO6; 4EO8; 4IH5; 4IH6; 4IH7; 4K8B; 4KAI; 4KB7; 4KBI; 4KE5; 4MIA; 4MIB; 4MK7; 4MK8; 4MK9; 4MKA; 4MKB; 4TN2; 4WXP; 5FPS; 5FPT; 5FPY; 5KZP; 5W2E; 6MVP; 6W4G; 8OHM

1 entry

Hepatitis C virus genotype 1b (isolate Con1) (HCV)

POLG_HCVCO Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1ZH1; 2JY0; 2KWT; 2KWZ; 3FQL; 3FQM; 3FQQ; 3KN2; 3KQH; 3KQK; 3KQL; 3KQN; 3KQU; 3Q0Z; 3QGD; 3QGE; 3QGF; 3QGG; 4NLD; 4U01; 5E4F; 5PZK; 5PZL; 5PZM; 5PZN; 5PZO; 5PZP; 5TRH; 5TRI; 5TRJ; 5TRK; 5TWN

1 entry

Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)

POLG_HCVJ1 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 2KNU; 3MRG; 3MRH; 3MRI; 3MRJ; 3MRL

1 entry

Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)

POLG_HCVJT Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 1b (isolate HCR6) (HCV)

POLG_HCVR6 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 1b (isolate Japanese) (HCV)

POLG_HCVJA Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1DXP; 1DY8; 1DY9; 1W3C; 2K8J; 3OYP; 3P8N; 3P8O; 4A1T; 4A1V; 4A1X; 4I31; 4I32; 4I33; 4JMY; 4KTC

1 entry

Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)

POLG_HCVTW Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1N64; 2ZJO

1 entry

Hepatitis C virus genotype 1b (strain HC-J4) (HCV)

POLG_HCVJ4 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1NB4; 1NB6; 1NB7; 2F55; 2MTS; 2XHU; 2XHV; 2XHW; 2YOJ; 3CSO; 3GNV; 3GNW; 3GOL; 3HKY; 3LKH; 3MWV; 3MWW; 3SKA; 3SKE; 3SKH; 3TYQ; 3TYV; 3U4O; 3U4R; 3UPH; 3UPI; 4DRU; 4EAW; 4GMC; 4IZ0; 4J02; 4J04; 4J06; 4J08; 4J0A; 4JJS; 4JJU; 4JTW; 4JTY; 4JTZ; 4JU1; 4JU2; 4JU3; 4JU4; 4JU6; 4JU7; 4JVQ; 4JY0; 4JY1; 4MZ4; 4OOW; 4RY4; 4RY5; 4RY6; 4RY7; 5CZB; 5NPH; 5NPI

1 entry

Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)

POLG_HCVH9 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 1c (isolate India) (HCV)

POLG_HCVIN Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)

POLG_HCVJ6 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1YUY; 1YV2; 1YVX; 1YVZ; 2XWH; 4ADP

1 entry

Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)

POLG_HCVJF Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 2KZQ; 2LIF; 2LVG; 2XXD; 2XYM; 3I5K; 4AEP; 4AEX; 4E76; 4E78; 4E7A; 4J1V; 4OBC; 4WT9; 4WTA; 4WTC; 4WTD; 4WTE; 4WTF; 4WTG; 4WTI; 4WTJ; 4WTK; 4WTL; 4WTM; 5NPJ; 5QJ0; 5QJ1; 5TWM; 5UJ2; 6HT4

1 entry

Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)

POLG_HCVJ8 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 1XCQ; 1XCT; 1XF5; 3GSZ; 3HVO

1 entry

Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)

POLG_HCVJP Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)

POLG_HCVBB Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 2k (isolate VAT96) (HCV)

POLG_HCVVA Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 3a (isolate NZL1) (HCV)

POLG_HCVNZ Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 6P6S

1 entry

Hepatitis C virus genotype 3a (isolate k3a) (HCV)

POLG_HCVK3 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)

POLG_HCVTR Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 3k (isolate JK049) (HCV)

POLG_HCVJK Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 4a (isolate ED43) (HCV)

POLG_HCVED Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 6P6Z

1 entry

Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)

POLG_HCVEV Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

pdb 2M6X

1 entry

Hepatitis C virus genotype 5a (isolate SA13) (HCV)

POLG_HCVSA Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6a (isolate 6a33) (HCV)

POLG_HCV6A Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)

POLG_HCVEU Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6b (isolate Th580) (HCV)

POLG_HCVT5 Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6d (isolate VN235) (HCV)

POLG_HCVVN Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6g (isolate JK046) (HCV)

POLG_HCVJL Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6h (isolate VN004) (HCV)

POLG_HCVVP Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Hepatitis C virus genotype 6k (isolate VN405) (HCV)

POLG_HCVVO Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core ...

1 entry

Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

E1A_ADE07 Early E1A protein (Early E1A 28 kDa protein)

1 entry

Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

E1A_ADE04 Early E1A protein (Early E1A 28 kDa protein)

1 entry

Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

E1A_ADE41 Early E1A protein (Early E1A 27 kDa protein)

1 entry

Human parainfluenza 1 virus (strain C35) (HPIV-1)

C_PI1HB Protein C

1 entry

Human parainfluenza 1 virus (strain C39) (HPIV-1)

C_PI1HC Protein C

1 entry

Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)

C_PI1HE Protein C

1 entry

Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)

C_PI1HD Protein C

1 entry

Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

C_PI3H4 Protein C (VP18 protein)

1 entry

Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)

V_PI4HA Non-structural protein V

1 entry

Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)

V_PI4HB Non-structural protein V

1 entry

Ilheus virus (ILHV)

POLG_ILHV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 7WD4

1 entry

Irkut virus (IRKV)

PHOSP_IRKV Phosphoprotein (Protein P) (Protein M1)

1 entry

Japanese encephalitis virus (strain Jaoars982) (JEV)

POLG_JAEVJ Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 5YWO; 5YWP

1 entry

Japanese encephalitis virus (strain M28) (JEV)

POLG_JAEVM Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Japanese encephalitis virus (strain SA(v)) (JEV)

POLG_JAEV5 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Japanese encephalitis virus (strain SA-14) (JEV)

POLG_JAEV1 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2Z83; 3P54; 4HDG; 4HDH; 4K6M; 4MTP; 5MV1; 5MV2; 5O19; 5O36; 5OW2; 5WSN; 5YWO; 5YWP

1 entry

Khujand virus (KHUV)

PHOSP_KHUV Phosphoprotein (Protein P) (Protein M1)

1 entry

Kokobera virus (KOKV)

POLG_KOKV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2V6I; 2V6J

1 entry

Kunjin virus (strain MRM61C)

POLG_KUNJM Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1SFK; 2HCN; 2HCS; 2HFZ; 2OF6; 2QEQ

1 entry

Kyasanur forest disease virus (KFDV)

POLG_KFDV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 7V4Q; 7V4R

1 entry

Lagos bat virus (LBV)

PHOSP_LBV Phosphoprotein (Protein P) (Protein M1)

1 entry

Langat virus (strain TP21)

POLG_LANVT Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1Z66; 2GG1; 7WNJ; 8YNJ; 9FK0; 9H28

1 entry

Louping ill virus (Li)

POLG_LIV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 6J5C

1 entry

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASE Non-structural protein V

1 entry

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASA Non-structural protein V

1 entry

Mosquito cell fusing agent (CFA flavivirus)

POLG_MCFA Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM; ...

1 entry

Mumps virus (strain Enders) (MuV)

V_MUMPE Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus (strain SBL) (MuV)

V_MUMPS Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus (strain SBL-1) (MuV)

V_MUMP1 Non-structural protein V (Non-structural protein NS1)

1 entry

Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)

E1A_ADEM1 Early E1A 21 kDa protein

1 entry

Murray valley encephalitis virus (strain MVE-1-51) (MVEV)

POLG_MVEV5 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 2PX2; 2PX4; 2PX5; 2PX8; 2PXA; 2PXC; 2V8O; 2WV9

1 entry

Nipah virus

V_NIPAV Non-structural protein V

1 entry

Omsk hemorrhagic fever virus (OHFV)

POLG_OHFV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Phocine distemper virus (PDV)

V_PHODV Non-structural protein V

1 entry

Porcine reproductive and respiratory syndrome virus (PRRSV)

RPOA_PRRSV Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)

RPOA_PRRSS Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)

RPOA_PRRS1 Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

pdb 5EYI; 5YLX

1 entry

Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV)

RPOA_PRRSB Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)

RPOA_PRRSR Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Rabies virus (strain CVS-11) (RABV)

PHOSP_RABVC Phosphoprotein (Protein P) (Protein M1)

pdb 1VYI; 8B8V

1 entry

Rabies virus (strain China/DRV) (RABV)

PHOSP_RABVD Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain China/MRV) (RABV)

PHOSP_RABVR Phosphoprotein (Protein P) (Protein M1)

pdb 3L32

1 entry

Rabies virus (strain ERA) (RABV)

PHOSP_RABVE Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain HEP-Flury) (RABV)

PHOSP_RABVH Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain India) (RABV)

PHOSP_RABVI Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain Nishigahara RCEH) (RABV)

PHOSP_RABVN Phosphoprotein (Protein P) (Protein M1)

pdb 7C20; 7T5G; 7T5H

1 entry

Rabies virus (strain PM) (RABV)

PHOSP_RABVM Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain PM1503/AVO1) (RABV)

PHOSP_RABVA Phosphoprotein (Protein P) (Protein M1)

pdb 8FUQ

1 entry

Rabies virus (strain SAD B19) (RABV)

PHOSP_RABVS Phosphoprotein (Protein P) (Protein M1)

pdb 6UEB

1 entry

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

PHOSP_RABVB Phosphoprotein (Protein P) (Protein M1)

1 entry

Raccoon poxvirus (RCN)

DUSP_RACVI Probable dual specificity protein phosphatase OPG106 (EC 3.1.3.-) (EC 3.1.3.48)

1 entry

Rinderpest virus (strain Kabete O) (RDV)

V_RINDK Non-structural protein V

1 entry

Rocio virus (ROCV)

POLG_ROCV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Sendai virus (strain 6/94) (SeV)

C_SEND6 Protein C'

1 entry

Sendai virus (strain Fushimi) (SeV)

C_SENDF Protein C'

1 entry

Sendai virus (strain Hamamatsu) (SeV)

C_SENDA Protein C'

1 entry

Sendai virus (strain Harris) (SeV)

C_SENDH Protein C'

1 entry

Sendai virus (strain Nagoya) (SeV)

C_SENDN Protein C'

1 entry

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

C_SENDZ C' protein

pdb 3WWT; 6KP3

1 entry

Simian adenovirus serotype 7 (SAdV-7) (Simian adenovirus 7)

E1A_ADES7 Early E1A protein (Early E1A 28 kDa protein)

1 entry

Tick-borne encephalitis virus (strain Hypr) (TBEV)

POLG_TBEVH Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 5O6A; 5O6V; 7JNO; 7QS9; 7QSA; 8ECH; 8QRH

1 entry

Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)

POLG_TBEVW Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1N6G; 1NA4; 1SVB; 1URZ; 6J5G; 6S8C; 7BLV; 7BM0; 7LSF; 7LSG; 7NXU; 7OJ4; 7QRE; 7QRF; 7QRG; 7YWQ

1 entry

Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)

POLG_TBEVS Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1K4R; 7LSE; 8QRH; 8R2L; 8R8L

1 entry

Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)

POLG_POWVL Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 7SGT

1 entry

Usutu virus (USUV)

POLG_USUV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 6A0P; 6S92; 6S93; 6S94; 8B51; 8B52

1 entry

Variola virus

DUSP_VARV Dual specificity protein phosphatase H1 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)

1 entry

Wesselsbron virus (WSLV)

POLG_WSLV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

West Nile virus (WNV)

POLG_WNV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 2FP7; 2GGV; 2IJO; 2P5P; 2YOL; 3E90; 3I50; 5IDK

1 entry

West Nile virus (strain NY-99) (WNV) (West Nile virus (strain NY-1999))

POLG_WNV9 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 2OY0; 3I50; 3IYW; 3J0B; 3LKZ; 4O6C; 4O6D; 4OIE; 4OII; 6UTE; 7E4K; 8CO8

1 entry

Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)

POLG_ZIKVF Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

pdb 5GOZ; 5GP1; 5H30; 5H32; 5H37; 5IRE; 5IZ7; 5JMT; 5KQR; 5KQS; 5KVE; 5LBS; 5LBV; 5LCV; 5M5B; 5MRK; 5NJU; 5NJV; 5U4W; 5UHY; 5ULP; 5Y0A; 5Y6M; 5Y6N; 6CO8; 6I7P; 6JFH; 6JFI; 6LD1; 6LD2; 6LD3; 6LD4; 6LD5; 6NIP; 6NIU; 6PLK; 6RWZ; 6S0J; 6UM3; 7A3N; 7A3U; 7BSD; 7BU8; 7BUA; 7M1V; 7T17; 7V2Z; 7YAR; 7YW7; 7YW8; 8EE5; 8EE8; 8EED; 8EEE