Actin-dependent outward viral transport
Several viruses induce propulsive actin comet tails in order to exit the cell they invaded
. They achieve this by recruiting factors for actin nucleation, the Arp2/3 complex, and polymerization regulators from the host cytoplasm. Filoviridae and baculoviridae use actin polymers to move from replication viral factories to cellular membrane. Poxviridae use actin polymerization to help budding out of host cell, and propel the virion particle outward after budding.
Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions.
Transport of Ebolavirus Nucleocapsids Is Dependent on Actin Polymerization: Live-Cell Imaging Analysis of Ebolavirus-Infected Cells
Gordian Schudt, Olga Dolnik, Larissa Kolesnikova, Nadine Biedenkopf, Astrid Herwig, Stephan Becker
J. Infect. Dis. June 2, 2015;
Gordian Schudt, Olga Dolnik, Larissa Kolesnikova, Nadine Biedenkopf, Astrid Herwig, Stephan Becker
J. Infect. Dis. June 2, 2015;
Live-cell imaging of Marburg virus-infected cells uncovers actin-dependent transport of nucleocapsids over long distances
Gordian Schudt, Larissa Kolesnikova, Olga Dolnik, Beate Sodeik, Stephan Becker
Proc. Natl. Acad. Sci. U.S.A. August 27, 2013; 110: 14402?14407
Gordian Schudt, Larissa Kolesnikova, Olga Dolnik, Beate Sodeik, Stephan Becker
Proc. Natl. Acad. Sci. U.S.A. August 27, 2013; 110: 14402?14407
Vaccinia virus motility
Geoffrey L. Smith, Brendan J. Murphy, Mansun Law
Annu. Rev. Microbiol. 2003; 57: 323?342
Geoffrey L. Smith, Brendan J. Murphy, Mansun Law
Annu. Rev. Microbiol. 2003; 57: 323?342
Actin-based motility drives baculovirus transit to the nucleus and cell surface
Taro Ohkawa, Loy E. Volkman, Matthew D. Welch
J. Cell Biol. July 26, 2010; 190: 187?195
Taro Ohkawa, Loy E. Volkman, Matthew D. Welch
J. Cell Biol. July 26, 2010; 190: 187?195
Viruses that ride on the coat-tails of actin nucleation
Timothy P. Newsome, N. Bishara Marzook
Semin. Cell Dev. Biol. October 2015; 46: 155?163
Timothy P. Newsome, N. Bishara Marzook
Semin. Cell Dev. Biol. October 2015; 46: 155?163
Migration of Nucleocapsids in Vesicular Stomatitis Virus-Infected Cells Is Dependent on both Microtubules and Actin Filaments
Shalane K. Yacovone, Amanda M. Smelser, Jed C. Macosko, George Holzwarth, David A. Ornelles, Douglas S. Lyles
J. Virol. July 1, 2016; 90: 6159?6170
Shalane K. Yacovone, Amanda M. Smelser, Jed C. Macosko, George Holzwarth, David A. Ornelles, Douglas S. Lyles
J. Virol. July 1, 2016; 90: 6159?6170