Inhibition of host apoptosis by viral BCL2-like protein (kw:KW-1081)
Cellular Bcl-2 family proteins regulate critical steps in programmed cell death pathway by modulating mitochondrial permeability and function. They can be divided on two distinct groups, anti-apoptotic members such as Bcl-2 and Bcl-Xl that prevent cell death and pro-apoptotic elements like Bax and Bak that promote apoptosis.
Bcl-2 family proteins are also encoded by several large DNA viruses, including all known gamma herpesviruses, adenoviruses, and several other unrelated viruses. Viral Bcl-2 proteins can prevent cell death but often escape cellular regulatory mechanisms that govern their cellular counterparts. Compared to the cellular Bcl-2, viral Bcl-2 members are shorter and are often devoid of a membrane-anchored domain. Even with low level of homology with Bcl-2 such as adenovirus E1B19K, all viral Bcl-2 proteins analyzed so far are able to block apoptosis.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)37 entries grouped by strain
1 entry
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain
1 entry
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain
1 entry
Canarypox virus (CNPV) reference strain
1 entry
Canine adenovirus serotype 2 (strain Toronto A 26-61) (CAdV-2) (Canine adenovirus 2 (strain Toronto A 26-61)) reference strain
1 entry
Deerpox virus (strain Mule deer/United States/W-848-83/1983) (DPV) reference strain
1 entry
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
1 entry
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
1 entry
Fowlpox virus (strain NVSL) (FPV) reference strain
1 entry
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain
1 entry
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain
1 entry
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain
1 entry
Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40) reference strain
1 entry
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
1 entry
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain
1 entry
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
1 entry
Vaccinia virus (strain Copenhagen) (VACV) reference strain
1 entry
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
1 entry
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
1 entry
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
1 entry
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)
1 entry
African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)
1 entry
African swine fever virus (strain E-70 MS44) (ASFV)
1 entry
Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))
1 entry
Canine adenovirus serotype 1 (strain Glaxo) (CAdV-1) (Canine adenovirus 1 (strain Glaxo))
1 entry
Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))
1 entry
Canine adenovirus serotype 2 (CAdV-2) (Canine adenovirus 2)
1 entry
Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)
1 entry
Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)
1 entry
Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)
1 entry
Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)
1 entry
Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)
1 entry
Rabbitpox virus (strain Utrecht) (RPV)
1 entry
Simian adenovirus serotype 7 (SAdV-7) (Simian adenovirus 7)
1 entry
Tree shrew adenovirus serotype 1 (TSAdV-1) (Tupaia adenovirus 1)
1 entry
Vaccinia virus (strain Ankara) (VACV)
1 entry
Vaccinia virus (strain Tian Tan) (VACV)
1 entry