Demerecviridae (taxid:2731690)

VIRION

Non-enveloped, head-tail structure with Sipho-type morphology. The capsid is about 90 nm in diameter, with a T=13 icosahedral symmetry . It is composed of 11 pentamers at the vertices and 120 hexamers on the faces. The tail is about 160 nm in length and 9 nm in width, with a subterminal disk and 3 long kinked fibers (120 nm). There is also a conical tip with a single straight central fiber (50 nm).

GENOME

Linear, dsDNA genome of about 121 kb, containing about 160 genes.

GENE EXPRESSION

ENZYMES

DNA-directed DNA polymerase A [P19822]
Serine protease (Peptidase S78) [Q6QGD7]
Serine protease (Peptidase S74) [P13390]
Exonuclease [P06229], P19822]
Ribonuclease H [Q6QGJ6]
DNA ligase [Q6QGH1]

REPLICATION

CYTOPLASMIC

Adsorption: The phage attaches to target cell adhesion receptors through its tail fibers.
Viral exolysin degrades host cell wall locally.
Ejection by long flexible tail ejection system: viral DNA is injected in host cell cytoplasm.
Transcription and translation of early genes.
Replication of genomic DNA by DNA strand displacement replication.
Transcription and translation of late genes
Assembly of an empty procapsid and packaging of the genome.
Viral tail fibers assembly and viral tail assembly.
Mature virions are released from the cell by lysis.

DB LINKS

TAXONOMY Group I: dsDNA viruses

Realm:	Duplodnaviria
Kingdom:	Heunggongvirae
Phylum:	Uroviricota
Class:	Caudoviricetes
Order:	Unassigned
Family:	Demerecviridae
Genus:	Novosibvirus Pogseptimavirus Priunavirus Shenzhenvirus Sugarlandvirus Ermolyevavirinae Cetovirus Jesfedecavirus Thalassavirus Vipunavirus Epseptimavirus Haartmanvirus Tequintavirus Hongcheonvirus Myunavirus

VIRUS

REFERENCE STRAIN Enterobacteria phage T5
Sequence | Genome assembly | Proteome

Host

NATURAL HOSTS Bacteria.

Ecology and disease

GEOGRAPHY Worldwide

TRANSMISSION Passive diffusion through medium

ANTIVIRAL DRUGS None

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

46 entries grouped by protein

reorder by strain

1 entry

Protein A1

2 entries

Protein A2

A2_BPT5

Escherichia phage T5 (Enterobacteria phage T5) reference strain

A2_BPBF2

Escherichia phage Bf23 (Enterobacteria phage BF23)

Protein A2-A3

1 entry

DNA-(apurinic or apyrimidinic site) endonuclease (EC 3.1.-.-) (AP endonuclease) (Apurinic-apyrimidinic endonuclease) (Protein 015)

1 entry

Baseplate tube protein p140 (p140) (Minor tail protein p140) (Tail protein p140)

1 entry

Baseplate hub protein pb3 (BHP-pb3) (Tail protein pb3)

1 entry

Major capsid protein (Capsid protein pb8) (Major head protein)

1 entry

Collar protein p132 (p132) (Tail protein p132)

1 entry

Tail completion protein p143 (Tail protein p143)

1 entry

Protein D14

1 entry

Putative transcription factor D5

1 entry

Decoration protein (Capsid protein pb10)

1 entry

Distal tail protein pb9 (DTP-pb9) (Dit) (Tail protein pb9)

1 entry

5'-deoxynucleotidase (EC 3.1.3.89) (Deoxynucleoside-5'-monophosphatase) (5'-dNMPase) (Protein dmp)

1 entry

Deoxynucleoside-5'-monophosphate kinase (EC 2.7.4.13)

1 entry

DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-)

1 entry

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

1 entry

Putative endonuclease (EC 3.1.-.-)

1 entry

Putative endonuclease (EC 3.1.-.-)

1 entry

Nicking endonuclease (EC 3.1.21.-)

1 entry

L-alanyl-D-glutamate peptidase (EC 3.4.24.-) (Endolysin) (Lysozyme)

1 entry

Probable exonuclease subunit 1 (EC 3.1.11.-) (D12)

1 entry

Probable exonuclease subunit 2 (EC 3.1.11.-) (D13)

1 entry

Flap endonuclease (FEN) (EC 3.1.11.-) (5'-3' exonuclease) (Exodeoxyribonuclease) (EC 3.1.11.3)

1 entry

Straight fiber protein pb4 (pb4) (Tail protein pb4)

1 entry

Side tail fiber protein pb1 (STF-pb1) (EC 3.4.21.-) (LTF-pb1) (Tail protein pb1)

1 entry

Dihydrofolate reductase (EC 1.5.1.3)

1 entry

Head completion protein (HCP) (p144)

1 entry

Probable helicase D10 (EC 3.6.4.-) (Protein D10)

1 entry

Holin

1 entry

Lytic conversion lipoprotein

1 entry

Putative replication origin binding protein (D2 helicase)

1 entry

Portal protein (Capsid protein pb7)

1 entry

Prohead protease (EC 3.4.21.-)

1 entry

Receptor-binding protein pb5 (RBP-pb5) (Tail protein pb5)

1 entry

Probable ssDNA-binding protein (Protein D11)

1 entry

Terminase, large subunit (DNA-packaging protein)

1 entry

Probable terminase, small subunit

1 entry

H-N-H endonuclease F-TflI (EC 3.1.21.-) (HNH endodeoxyribonuclease F-TflI) (HNH endonuclease F-TflI)

1 entry

H-N-H endonuclease F-TflII (EC 3.1.21.-) (HNH endodeoxyribonuclease F-TflII) (HNH endonuclease F-TflII)

1 entry

H-N-H endonuclease F-TflIV (EC 3.1.21.-) (HNH endodeoxyribonuclease F-TflIV) (HNH endonuclease F-TflIV)

1 entry

Probable thymidylate synthase (EC 2.1.1.45)

1 entry

Tape measure protein pb2 precursor (TMP-pb2) (Pore-forming protein pb2) (Tail protein pb2)

1 entry

Tail tube terminator protein p142 (TrP-142) (Tail protein p142) (Tail-to-head joining protein p142) (THJP)

1 entry

Tail tube protein pb6 (TTP-pb6) (Major tail protein pb6) (MTP pb6) (Tail protein pb6)

1 entry

Demerecviridae (taxid:2731690)

VIRION

GENOME

GENE EXPRESSION

ENZYMES

REPLICATION

Host

Ecology and disease

Matching UniProtKB/Swiss-Prot entries

Protein A1

Protein A2

DNA-(apurinic or apyrimidinic site) endonuclease (EC 3.1.-.-) (AP endonuclease) (Apurinic-apyrimidinic endonuclease) (Protein 015)

Baseplate tube protein p140 (p140) (Minor tail protein p140) (Tail protein p140)

Baseplate hub protein pb3 (BHP-pb3) (Tail protein pb3)

Major capsid protein (Capsid protein pb8) (Major head protein)

Collar protein p132 (p132) (Tail protein p132)

Tail completion protein p143 (Tail protein p143)

Protein D14

Putative transcription factor D5

Decoration protein (Capsid protein pb10)

Distal tail protein pb9 (DTP-pb9) (Dit) (Tail protein pb9)

5'-deoxynucleotidase (EC 3.1.3.89) (Deoxynucleoside-5'-monophosphatase) (5'-dNMPase) (Protein dmp)

Deoxynucleoside-5'-monophosphate kinase (EC 2.7.4.13)

DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-)

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

Putative endonuclease (EC 3.1.-.-)

Putative endonuclease (EC 3.1.-.-)

Nicking endonuclease (EC 3.1.21.-)

L-alanyl-D-glutamate peptidase (EC 3.4.24.-) (Endolysin) (Lysozyme)

Probable exonuclease subunit 1 (EC 3.1.11.-) (D12)

Probable exonuclease subunit 2 (EC 3.1.11.-) (D13)

Flap endonuclease (FEN) (EC 3.1.11.-) (5'-3' exonuclease) (Exodeoxyribonuclease) (EC 3.1.11.3)

Straight fiber protein pb4 (pb4) (Tail protein pb4)

Side tail fiber protein pb1 (STF-pb1) (EC 3.4.21.-) (LTF-pb1) (Tail protein pb1)

Dihydrofolate reductase (EC 1.5.1.3)

Head completion protein (HCP) (p144)

Probable helicase D10 (EC 3.6.4.-) (Protein D10)

Holin

Lytic conversion lipoprotein

Putative replication origin binding protein (D2 helicase)

Portal protein (Capsid protein pb7)

Prohead protease (EC 3.4.21.-)

Receptor-binding protein pb5 (RBP-pb5) (Tail protein pb5)

Probable ssDNA-binding protein (Protein D11)

Terminase, large subunit (DNA-packaging protein)

Probable terminase, small subunit

H-N-H endonuclease F-TflI (EC 3.1.21.-) (HNH endodeoxyribonuclease F-TflI) (HNH endonuclease F-TflI)

H-N-H endonuclease F-TflII (EC 3.1.21.-) (HNH endodeoxyribonuclease F-TflII) (HNH endonuclease F-TflII)

H-N-H endonuclease F-TflIV (EC 3.1.21.-) (HNH endodeoxyribonuclease F-TflIV) (HNH endonuclease F-TflIV)

Probable thymidylate synthase (EC 2.1.1.45)

Tape measure protein pb2 precursor (TMP-pb2) (Pore-forming protein pb2) (Tail protein pb2)

Tail tube terminator protein p142 (TrP-142) (Tail protein p142) (Tail-to-head joining protein p142) (THJP)

Tail tube protein pb6 (TTP-pb6) (Major tail protein pb6) (MTP pb6) (Tail protein pb6)

Uncharacterized 9.2 kDa protein