DNA strand displacement replication

Related to: Adenoviridae, Asfarviridae, Iridoviridae, Mimiviridae(?), Phycodnaviridae(?), Poxviridae, Tectiviridae, Phi29likevirus.

Location: In host cell nucleus (Adenoviridae) or cytoplasm (Nucleo-Cytoplasmic Large DNA viruses).

Replication events:

During strand displacement replication, only one strand is replicated at a time. This synthesis releases a single-stranded DNA, which in turn is copied into a double-stranded DNA.

Replication of Adenoviridae is initiated by a pre-terminal protein (pTP), replication of Nucleo-cytoplasmic Large DNA viruses is initiated by a repeated loop at the genomic ends and produces concatemers that are processed after replication.

Function	Adenoviridae	Poxviridae	Asfarviridae	Iridoviridae
Initiation	Terminal Protein	Endonuclease	Endonuclease	Endonuclease
Topoisomerase	Pol	D5	?	?
Polymerase	Pol	E9	?	?
Processivity factor	-	A20-D4	?	?
ssDNA binding	ssDBP	I3	?	?