Belongs to the DEDDh/DEEDh exonuclease family.
Coronavirus proofreading exoribonuclease (ExoN)
Enzyme reactions:
- Exonucleolytic cleavage EC=3.1.13.-;
Mechanism
| SARS-CoV-2 NSP14 |
RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex
Micka?l Bouvet, Isabelle Imbert, Lorenzo Subissi, Laure Gluais, Bruno Canard, Etienne Decroly
Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9372-7
Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN
Nicholas H Moeller, Ke Shi, ?zlem Demir, Christopher Belica, Surajit Banerjee, Lulu Yin, Cameron Durfee, Rommie E Amaro, Hideki Aihara
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2106379119
Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U
Meredith N Frazier, Lucas B Dillard, Juno M Krahn, Lalith Perera, Jason G Williams, Isha M Wilson, Zachary D Stewart, Monica C Pillon, Leesa J Deterding, Mario J Borgnia, Robin E Stanley
Nucleic Acids Res. 2021 Sep 27;49(17):10136-10149
Recent insights into the structure and function of coronavirus ribonucleases
Meredith N Frazier, Amanda A Riccio, Isha M Wilson, William C Copeland, Robin E Stanley
FEBS Open Bio. 2022 Sep;12(9):1567-1583