| Process | Activity | Enzyme | Type | Rhea | Antiviral |
|---|---|---|---|---|---|
| Viral replication | Polymerase | RNA dependent RNA polymerase (RNA replicase) | Riboviria | Rhea:21248 | Nucleoside inhibitor |
| Viral replication | Polymerase | DNA dependent DNA polymerase (DNA replicase) | CelldsDNA | Rhea:22508 | Nucleoside inhibitor |
| Viral replication | Polymerase | RNA dependent DNA polymerase (Reverse transcriptase) | RT | Rhea:22508 | Nucleoside-RT inhibitors, Non-Nucleoside-RT inhibitors |
| Viral replication | Initiation | Primase | CelldsDNA | ||
| Viral replication | Initiation | Protein-primed initiation of DNA replication | dsDNA | ||
| Viral replication | Initiation | Protein-primed initiation of RNA replication (=VPG capping) | Riboviria | ||
| Viral replication | Initiation | Cress-type Endonuclease | dsDNA | ||
| Viral replication | Initiation | Ribozyme Endonuclease | Riboviria | ||
| Viral replication | Elongation | RNA-DNA duplex dependent endoribonuclease (RNase H) | RT | ||
| Viral replication | Topology | DNA topoisomerase | dsDNA | ||
| Viral replication | Topology | DNA ligase | dsDNA | ||
| Viral replication | Topology | Helicase | dsDNA | ||
| Viral replication | Topology | Holliday junction resolvase | dsDNA | ||
| Viral replication | Topology | Integrase | dsDNART | ||
| Viral replication | Topology | Transposase (DDE recombinase) | dsDNA | ||
| Viral replication | Nucleotide metabolism | Thymidine kinase | dsDNA | Rhea:19129 | |
| Viral replication | Nucleotide metabolism | Thymidylate synthase | dsDNA | Rhea:12104 | |
| Viral replication | Nucleotide metabolism | Thymidylate kinase | dsDNA | Rhea:13517 | |
| Viral replication | Nucleotide metabolism | dUTP diphosphatase | dsDNA | Rhea:10248 | |
| Viral replication | Nucleotide metabolism | dihydrofolate reductase | dsDNA | Rhea:15009 | |
| Viral replication | Nucleotide metabolism | Ribonucleotide reductase | dsDNA | Rhea:23252 | |
| Viral replication | Regulation | E3 SUMO-protein ligase | dsDNARiboviria | ||
| Viral transcription | Transcriptase | DNA dependent RNA polymerase (Transcriptase) | dsDNA | Rhea:21248 | |
| Viral transcription | Transcriptase | RNA dependent RNA polymerase (RNA replicase/transcriptase) | Riboviria | Rhea:21248 | |
| Viral transcription | Transcriptase | Proofreading exoribonuclease (ExoN) | Riboviria | ||
| Viral transcription | Viral mRNA capping | Cell-type capping | CelldsDNARiboviria | Rhea:67004 Rhea:67012 Rhea:67008 Rhea:67020 | |
| Viral transcription | Viral mRNA capping | Alpha type capping | Riboviria | ||
| Viral transcription | Viral mRNA capping | Nido-type capping | Riboviria | ||
| Viral transcription | Viral mRNA capping | Mononega-type capping | Riboviria | ||
| Viral transcription | Viral mRNA capping | VPG capping | Riboviria | ||
| Viral transcription | Viral mRNA capping | Cap snatching | Riboviria | ||
| Viral transcription | Viral mRNA capping | Toti-type cap snatching | Riboviria | ||
| Viral transcription | Viral mRNA capping | FAD capping | Riboviria | ||
| Viral transcription | PolyAdenylation | Poly(A) polymerase | dsDNA | Rhea:11332 | |
| Viral transcription | PolyAdenylation | RNA polymerase stuttering | Riboviria | Rhea:11332 | |
| Protein modification | Proteases | Cys/Ser-proteases | dsDNARiboviria | ||
| Protein modification | Proteases | Asp-proteases | dsDNART | ||
| Protein modification | Proteases | Metallo-proteases | dsDNA | ||
| Protein modification | Proteases | Asparagine-proteases | dsDNARiboviria | ||
| Protein modification | Post translational modification | Beta-1,6-N-acetyl-glucosaminyl transferase | |||
| Protein modification | Post translational modification | Peptide N-myristoyl transferase | Rhea:15521 | ||
| Protein modification | Post translational modification | thiol oxidase | |||
| Exit | Budding | Phospholipase | dsDNA | ||
| Exit | Virion release | Neuraminidase | Riboviria | Neuraminidase inhibitors | |
| Viral-Host modulation | Anti-viral evasion | Polyuridine endonuclease | Riboviria | ||
| Viral-Host modulation | Anti-viral evasion | Viral ADP-Ribosylhydrolase | Riboviria | ||
| Viral-Host modulation | Anti-viral evasion | Asparagine deaminase | |||
| Viral-Host modulation | Anti-viral evasion | Ser/Thr kinase | |||
| Viral-Host modulation | Anti-viral evasion | Tyr kinase | |||
| Viral-Host modulation | Anti-viral evasion | Ubiquitin transferase=Ubiquitin-conjugating enzyme E2 | |||
| Viral-Host modulation | Anti-viral evasion | ubiquitinyl hydrolase | |||
| Viral-Host modulation | Anti-viral evasion | Tyr/ser/thr phosphatase | |||
| Viral-Host modulation | Anti-viral evasion | 2',3'-cGAMP endonuclease | Rhea:59473 | ||
| Viral-Host modulation | Anti-viral evasion | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase | |||
| Viral-Host modulation | Anti-viral evasion | ADP-ribose hydrolase | Rhea:24076 | ||
| Viral-Host modulation | Host shut off | mRNA-decapping |
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