Geminiviridae

VIRION

Non-enveloped, about 38 nm in length and 22 nm in diameter (for MSV), twinned (geminate) incomplete T=1 icosahedral symmetry capsid that contains 22 pentameric capsomers made of 110 capsid proteins (CP). Each geminate particle contains only a single circular ssDNA.

GENOME

Mono-, or bipartite, circular, ssDNA genome (+) of about 2.5-3.0 (monopartite) or 4.8-5.6 kb (bipartite). The number of genome segments depends on the genera. 3' terminus has no poly(A) tract. There are coding regions in both the virion (positive) and complementary (negative) sense strands.
The genome is replicated through double-stranded intermediates. The replication (Rep) protein initiates and terminates rolling circle replication, the host DNA polymerase being used for DNA replication itself. There is a potential stem-loop structure in the intergenic region that includes a conserved nona-nucleotide sequence (TAATATTAC) where ssDNA synthesis is initiated.

GENE EXPRESSION

Transcription is bidirectional (c-sense and v-sense). Most of the time, proteins encoded on the c-sense are involved in DNA replication, in regulation of transcription and in interfering with cellular processes, whereas proteins encoded on the v-sense have movement and structural functions.

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors.
  4. bidirectional dsDNA transcription from the IR promoter produces viral mRNAs and translation of viral proteins.
  5. Replication is initiated by cleavage of the(+)strand by REP, and occurs by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.
    c) be transported outside the nucleus, to a neighboring cell through plasmodesmata (cell-cell movement) with the help of viral movement proteins.

Host-virus interaction

Cell-cycle modulation

Begomovirus protein Rep and mastrevirus protein RepA are responsible for inhibiting host retinoblastoma protein and inducing transition from the G1 to S phase in preparation for virus replication since the virus targets differentiated non-dividing cells. .

Suppression of host silencing-mediated antiviral defense

Geminiviruses viral proteins are able to suppress host cell RNA silencing


Begomovirus:

Curtovirus:

Matching UniProtKB/Swiss-Prot entries

198 entries grouped by strain (browse by keywords)

All proteins are shown (view only 197 complete proteome entries)

8 entries

African cassava mosaic virus (isolate West Kenyan 844) (ACMV) (Cassava latent virus (isolate West Kenyan 844)) reference strain

Select_allDeselect_all
REP_CLVK Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (40.4 kDa protein) (Protein AC1) ...
TRAP_CLVK Transcriptional activator protein (TrAP) (15.2 kDa protein) (Protein AC2) (Protein AL2)
REN_CLVK Replication enhancer protein (REn) (15.9 kDa protein) (Protein AC3) (Protein AL3)
CAPSD_CLVK Capsid protein (Coat protein) (CP)
AV2_CLVK Protein AV2
AC4_CLVK Protein AC4 (Protein AL4)
NSP_CLVK Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)
MVP_CLVK Movement protein BC1 (33.7 kDa protein) (Movement protein BL1)

8 entries

Mungbean yellow mosaic virus (strain Vigna) (MYMV) reference strain

Select_allDeselect_all
CAPSD_MYMVV Capsid protein (Coat protein) (CP)
REP_MYMVV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein AC1) (Protein AL1)
TRAP_MYMVV Transcriptional activator protein (TrAP) (Protein AC2) (Protein AL2)
REN_MYMVV Replication enhancer protein (REn) (Protein AC3) (Protein AL3)
AV2_MYMVV Protein AV2
AC4_MYMVV Protein AC4 (Protein AL4)
NSP_MYMVV Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)
MVP_MYMVV Movement protein BC1 (Movement protein BL1)

7 entries

Abutilon mosaic virus (isolate West India) (AbMV) reference strain

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REN_ABMVW Replication enhancer protein (REn) (Protein AC3) (Protein AL3)
TRAP_ABMVW Transcriptional activator protein (TrAP) (Protein AC2) (Protein AL2)
REP_ABMVW Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein AC1) (Protein AL1)
CAPSD_ABMVW Capsid protein (Coat protein) (CP)
AC4_ABMVW Protein AC4 (Protein AL4)
NSP_ABMVW Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)
MVP_ABMVW Movement protein BC1 (Movement protein BL1)

7 entries

Bean golden yellow mosaic virus (isolate Puerto Rico) (BGYMV) (Bean golden mosaic virus (isolate Puerto Rico)) reference strain

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TRAP_BGYMV Transcriptional activator protein (TrAP) (19.6 kDa protein) (Protein AC2) (Protein AL2)
REN_BGYMV Replication enhancer protein (REn) (15.6 kDa protein) (Protein AC3) (Protein AL3)
REP_BGYMV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (40.2 kDa protein) (Protein AC1) ...
CAPSD_BGYMV Capsid protein (Coat protein) (CP)
AC4_BGYMV Protein AC4 (Protein AL4)
NSP_BGYMV Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)
MVP_BGYMV Movement protein BC1 (Movement protein BL1)

7 entries

Bean golden yellow mosaic virus (isolate Puerto Rico-Japan) (BGYMV) reference strain

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CAPSD_BGYMJ Capsid protein (Coat protein) (CP)
REP_BGYMJ Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (40.2 kDa protein) (Protein AC1) ...
TRAP_BGYMJ Transcriptional activator protein (TrAP) (19.6 kDa protein) (Protein AC2) (Protein AL2)
REN_BGYMJ Replication enhancer protein (REn) (15.6 kDa protein) (Protein AC3) (Protein AL3)
AC4_BGYMJ Protein AC4 (Protein AL4)
NSP_BGYMJ Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)
MVP_BGYMJ Movement protein BC1 (Movement protein BL1)

7 entries

Beet curly top virus (strain California/Logan) (BCTV) reference strain

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REP_BCTVC Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (40.8 kDa protein) (Protein C1)
REN_BCTVC Replication enhancer (REn) (16.1 kDa protein) (Protein C3) (Protein L3)
C2_BCTVC Protein C2 (Protein L2)
CAPSD_BCTVC Capsid protein (Coat protein) (CP)
V2_BCTVC Protein V2 (12.1 kDa protein)
AC4_BCTVC Protein C4 (Protein L4)
MP_BCTVC Movement protein (MP)

6 entries

Pepper huasteco yellow vein virus (PHYVV) (Pepper huasteco virus) reference strain

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REP_PHUV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein AC1) (Protein AL1)
TRAP_PHUV Transcriptional activator protein (TrAP) (Protein AC2) (Protein AL2)
REN_PHUV Replication enhancer protein (REn) (Protein AC3) (Protein AL3)
CAPSD_PHUV Capsid protein (Coat protein) (CP)
AC4_PHUV Protein AC4 (Protein AL4)
NSP_PHUV Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)

6 entries

Tomato mottle virus (isolate Florida) (ToMoV) reference strain

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TRAP_TMOV Transcriptional activator protein (TrAP) (Protein AC2) (Protein AL2)
REN_TMOV Replication enhancer protein (REn) (Protein AC3) (Protein AL3)
REP_TMOV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein AC1) (Protein AL1)
CAPSD_TMOV Capsid protein (Coat protein) (CP)
BC1_TMOV Movement protein BC1 (Movement protein BL1)
NSP_TMOV Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)

6 entries

Tomato pseudo-curly top virus (TPCTV) reference strain

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REP_TPCTV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein C1)
REN_TPCTV Replication enhancer protein (REn) (16.1 kDa protein) (Protein C3) (Protein L3)
C2_TPCTV Protein C2 (Protein L2)
CAPSD_TPCTV Capsid protein (Coat protein) (CP)
AC4_TPCTV Protein C4 (Protein L4)
MP_TPCTV Putative movement protein (MP)

6 entries

Tomato yellow leaf curl China virus (TYLCCNV) reference strain

Select_allDeselect_all
TRAP_TYLCC Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)
REP_TYLCC Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein C1)
REN_TYLCC Replication enhancer protein (REn) (Protein C3) (Protein L3)
CAPSD_TYLCC Capsid protein (Coat protein) (CP)
AV2_TYLCC Protein V2
AC4_TYLCC Protein C4 (10.9 kDa protein) (Protein L4)

6 entries

Tomato yellow leaf curl Sardinia virus (isolate Spain-2) (TYLCSV) reference strain

Select_allDeselect_all
TRAP_TYCS2 Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)
REP_TYCS2 Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein C1)
REN_TYCS2 Replication enhancer protein (REn) (Protein C3) (Protein L3)
CAPSD_TYCS2 Capsid protein (Coat protein) (CP)
AV2_TYCS2 Protein V2
AC4_TYCS2 Protein C4 (10.9 kDa protein) (Protein L4)

6 entries

Tomato yellow leaf curl virus (strain Israel) (TYLCV) reference strain

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TRAP_TYLCI Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)
REP_TYLCI Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein C1)
REN_TYLCI Replication enhancer protein (REn) (15.6 kDa protein) (Protein C3) (Protein L3)
CAPSD_TYLCI Capsid protein (Coat protein) (CP)
AV2_TYLCI Protein V2
AC4_TYLCI Protein C4 (10.9 kDa protein) (Protein L4)

4 entries

Bean yellow dwarf virus (BeYDV) reference strain

Select_allDeselect_all
REP_BEYDV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
REPA_BEYDV Replication-associated protein A (RepA) (EC 3.1.21.-)
CAPSD_BEYDV Capsid protein (Coat protein) (CP)
MP_BEYDV Movement protein (MP)

4 entries

Maize streak virus genotype A (isolate South Africa) (MSV) reference strain

Select_allDeselect_all
REPA_MSVS Replication-associated protein A (RepA) (EC 3.1.21.-)
REP_MSVS Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
CAPSD_MSVS Capsid protein (Coat protein) (CP)
MP_MSVS Movement protein (MP)

4 entries

Maize streak virus genotype D (isolate Raw) (MSV) reference strain

Select_allDeselect_all
CAPSD_MSVRA Capsid protein (Coat protein) (CP)
REP_MSVRA Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
REPA_MSVRA Replication-associated protein A (RepA) (EC 3.1.21.-)
MP_MSVRA Movement protein (MP)

4 entries

Miscanthus streak virus (isolate 91) (MiSV) reference strain

Select_allDeselect_all
REPA_MISV9 Replication-associated protein A (RepA) (EC 3.1.21.-)
REP_MISV9 Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
CAPSD_MISV9 Capsid protein (Coat protein) (CP)
MP_MISV9 Putative movement protein (MP)

4 entries

Panicum streak virus (isolate Kenya) (PanSV) reference strain

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REPA_PASVK Replication-associated protein A (RepA) (EC 3.1.21.-)
REP_PASVK Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
MP_PASVK Movement protein (MP)
CAPSD_PASVK Capsid protein (Coat protein) (CP)

4 entries

Sugarcane streak virus (isolate South Africa) (SSV) (Sugarcane streak virus (isolate Natal)) reference strain

Select_allDeselect_all
REPA_SSVN Replication-associated protein A (RepA) (EC 3.1.21.-)
REP_SSVN Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
CAPSD_SSVN Capsid protein (Coat protein) (CP)
MP_SSVN Movement protein (MP)

4 entries

Wheat dwarf virus (isolate Sweden) (WDV) reference strain

Select_allDeselect_all
CAPSD_WDVS Capsid protein (Coat protein) (CP)
REP_WDVS Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
REPA_WDVS Replication-associated protein A (RepA) (EC 3.1.21.-)
MP_WDVS Movement protein (MP)

3 entries

Chloris striate mosaic virus (CSMV) reference strain

Select_allDeselect_all
REPA_CSMV Replication-associated protein A (RepA) (EC 3.1.21.-)
REP_CSMV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
CAPSD_CSMV Capsid protein (Coat protein) (CP)

9 entries

Indian cassava mosaic virus (ICMV)

Select_allDeselect_all
REP_ICMV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein AC1) (Protein AL1)
TRAP_ICMV Transcriptional activator protein (TrAP) (Protein AC2) (Protein AL2)
YAL4_ICMV Putative uncharacterized protein AC5
REN_ICMV Replication enhancer protein (REn) (Protein AC3) (Protein AL3)
CAPSD_ICMV Capsid protein (Coat protein) (CP)
AV2_ICMV Protein AV2
AC4_ICMV Protein AC4 (Protein AL4)
NSP_ICMV Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)
MVP_ICMV Movement protein BC1 (Movement protein BL1)

8 entries

African cassava mosaic virus (isolate Nigerian) (ACMV) (Cassava latent virus (isolate Nigerian))

Select_allDeselect_all
TRAP_CLVN Transcriptional activator protein (TrAP) (15.2 kDa protein) (Protein AC2) (Protein AL2)
REP_CLVN Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (40.4 kDa protein) (Protein AC1) ...
REN_CLVN Replication enhancer protein (REn) (15.9 kDa protein) (Protein AC3) (Protein AL3)
CAPSD_CLVN Capsid protein (Coat protein) (CP)
AV2_CLVN Uncharacterized 13.1 kDa protein
AC4_CLVN Protein AC4 (Protein AL4)
NSP_CLVN Nuclear shuttle protein (NSP) (29.4 kDa protein) (Protein BR1) (Protein BV1)
MVP_CLVN Movement protein BC1 (33.7 kDa protein) (Movement protein BL1)

7 entries

Cabbage leaf curl virus (isolate Jamaica) (CaLCuV)

Select_allDeselect_all
TRAP_CALCV Transcriptional activator protein (TrAP) (Protein AC2) (Protein AL2)
REN_CALCV Replication enhancer protein (REn) (15.6 kDa protein) (Protein AC3) (Protein AL3)
REP_CALCV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (40.2 kDa protein) (Protein AC1) ...
CAPSD_CALCV Capsid protein (Coat protein) (CP)
AC4_CALCV Protein AC4 (Protein AL4)
NSP_CALCV Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)
MVP_CALCV Movement protein BC1 (Movement protein BL1)

7 entries

Potato yellow mosaic virus (isolate Venezuela) (PYMV)

Select_allDeselect_all
TRAP_PYMVV Transcriptional activator protein (TrAP) (Protein AC2) (Protein AL2)
REP_PYMVV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein AC1) (Protein AL1)
REN_PYMVV Replication enhancer protein (REn) (Protein AC3) (Protein AL3)
CAPSD_PYMVV Capsid protein (Coat protein) (CP)
AC4_PYMVV Protein AC4 (Protein AL4)
NSP_PYMVV Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)
MVP_PYMVV Movement protein BC1 (Movement protein BL1)

7 entries

Squash leaf curl virus (SLCV)

Select_allDeselect_all
TRAP_SLCV Transcriptional activator protein (TrAP) (Protein AC2) (Protein AL2)
REN_SLCV Replication enhancer protein (REn) (Protein AC3) (Protein AL3)
REP_SLCV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein AC1) (Protein AL1)
CAPSD_SLCV Capsid protein (Coat protein) (CP)
AC4_SLCV Protein AC4 (Protein AL4)
NSP_SLCV Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)
MVP_SLCV Movement protein BC1 (Movement protein BL1)

7 entries

Tomato golden mosaic virus (strain Yellow vein) (TGMV)

Select_allDeselect_all
CAPSD_TGMVY Capsid protein (Coat protein) (CP)
TRAP_TGMVY Transcriptional activator protein (TrAP) (Protein AC2) (Protein AL2)
REN_TGMVY Replication enhancer protein (REn) (Protein AC3) (Protein AL3)
REP_TGMVY Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein AC1) (Protein AL1)
BC1_TGMVY Movement protein BC1 (Movement protein BL1)
AC4_TGMVY Protein AC4 (Protein AL4)
NSP_TGMVY Nuclear shuttle protein (NSP) (Protein BR1) (Protein BV1)

6 entries

Tomato leaf curl virus (strain Australia) (ToLCV)

Select_allDeselect_all
TRAP_TLCVA Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)
REP_TLCVA Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein C1)
REN_TLCVA Replication enhancer protein (REn) (Protein C3) (Protein L3)
CAPSD_TLCVA Capsid protein (Coat protein) (CP)
AV2_TLCVA Protein V2
AC4_TLCVA Protein C4 (10.9 kDa protein) (Protein L4)

6 entries

Tomato yellow leaf curl Sardinia virus (TYLCSV)

Select_allDeselect_all
CAPSD_TYCSV Capsid protein (Coat protein) (CP)
REN_TYCSV Replication enhancer protein (REn) (Protein C3) (Protein L3)
TRAP_TYCSV Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)
REP_TYCSV Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein C1)
AV2_TYCSV Protein V2
AC4_TYCSV Protein C4 (11.1 kDa protein) (Protein L4)

6 entries

Tomato yellow leaf curl Sardinia virus (isolate Spain-1) (TYLCSV)

Select_allDeselect_all
CAPSD_TYCS1 Capsid protein (Coat protein) (CP)
TRAP_TYCS1 Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)
REP_TYCS1 Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (Protein C1)
REN_TYCS1 Replication enhancer protein (REn) (Protein C3) (Protein L3)
AV2_TYCS1 Protein V2
AC4_TYCS1 Protein C4 (10.9 kDa protein) (Protein L4)

4 entries

Maize streak virus genotype A (isolate Kenya) (MSV)

Select_allDeselect_all
REP_MSVK Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
REPA_MSVK Replication-associated protein A (RepA) (EC 3.1.21.-)
CAPSD_MSVK Capsid protein (Coat protein) (CP)
MP_MSVK Movement protein (MP)

4 entries

Maize streak virus genotype A (isolate Nigeria) (MSV)

Select_allDeselect_all
REP_MSVN Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
REPA_MSVN Replication-associated protein A (RepA) (EC 3.1.21.-)
CAPSD_MSVN Capsid protein (Coat protein) (CP)
MP_MSVN Movement protein (MP)

4 entries

Maize streak virus genotype B (isolate Tas) (MSV)

Select_allDeselect_all
REPA_MSVTA Replication-associated protein A (RepA) (EC 3.1.21.-)
REP_MSVTA Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
CAPSD_MSVTA Capsid protein (Coat protein) (CP)
MP_MSVTA Movement protein (MP)

4 entries

Maize streak virus genotype C (isolate Set) (MSV)

Select_allDeselect_all
CAPSD_MSVSE Capsid protein (Coat protein) (CP)
REPA_MSVSE Replication-associated protein A (RepA) (EC 3.1.21.-)
REP_MSVSE Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
MP_MSVSE Movement protein (MP)

4 entries

Maize streak virus genotype E (isolate Pat) (MSV)

Select_allDeselect_all
REPA_MSVPA Replication-associated protein A (RepA) (EC 3.1.21.-)
REP_MSVPA Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
CAPSD_MSVPA Capsid protein (Coat protein) (CP)
MP_MSVPA Movement protein (MP)

4 entries

Tobacco yellow dwarf virus (strain Australia) (TYDV)

Select_allDeselect_all
REP_TYDVA Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-)
REPA_TYDVA Replication-associated protein A (RepA) (EC 3.1.21.-)
CAPSD_TYDVA Capsid protein (Coat protein) (CP)
MP_TYDVA Movement protein (MP)